AR099692A1 - Derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil)tetrahidrofuran-2-il)-3-aminopropan-2-ol - Google Patents

Derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil)tetrahidrofuran-2-il)-3-aminopropan-2-ol

Info

Publication number
AR099692A1
AR099692A1 ARP150100686A ARP150100686A AR099692A1 AR 099692 A1 AR099692 A1 AR 099692A1 AR P150100686 A ARP150100686 A AR P150100686A AR P150100686 A ARP150100686 A AR P150100686A AR 099692 A1 AR099692 A1 AR 099692A1
Authority
AR
Argentina
Prior art keywords
group
tosilmetil
tetrahidrofuran
metoxi
alil
Prior art date
Application number
ARP150100686A
Other languages
English (en)
Inventor
E S Souza Fabio
Orprecio Ricardo
Pan Ming
Original Assignee
Alphora Res Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alphora Res Inc filed Critical Alphora Res Inc
Publication of AR099692A1 publication Critical patent/AR099692A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reivindicación 1: La sal de fórmula (1) en donde, R¹ es -CH₂-CH=CR⁸R⁸, -CH₂-C(=O)-R⁹ o -CH₂-CH₂-O-R¹⁰, en donde R⁸ y R⁸ cada uno independientemente es H o un grupo hidrocarbonado, teniendo opcionalmente el grupo hidrocarbonado uno o más heteroátomos; R⁹ es OR¹¹, en donde R¹¹ es H o un grupo hidrocarbonado, teniendo opcionalmente el grupo hidrocarbonado uno o más heteroátomos; R¹⁰ es H o un grupo protector de alcohol; R² es H o un grupo protector de alcohol; R³ y R⁴ cada uno independientemente es H, alilo, bencilo o un grupo bencilo sustituido; o R² y uno de R³ y R⁴ juntos forman -C(R¹²)(R¹³)- y el otro R³ y R⁴ es H, alilo, bencilo o un grupo bencilo sustituido, en donde R¹² y R¹³ cada uno independientemente es H o un grupo hidrocarbonado, teniendo opcionalmente e grupo hidrocarbonado uno o más heteroátomos; uno de R⁵ y R⁶ es H y el otro es -CH₂OR¹⁴ o -CH₂SO₂-Ar, o R⁵ y R⁶ tomados juntos forman =CH-SO₂-Ar, donde R¹⁴ es H o un grupo protector de alcohol; y Ar es un grupo arilo; y R⁷ es H, alquilo C₁₋₃ o haloalquilo C₁₋₃; y HX es un ácido.
ARP150100686A 2014-03-06 2015-03-06 Derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil)tetrahidrofuran-2-il)-3-aminopropan-2-ol AR099692A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461948875P 2014-03-06 2014-03-06

Publications (1)

Publication Number Publication Date
AR099692A1 true AR099692A1 (es) 2016-08-10

Family

ID=54054307

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100686A AR099692A1 (es) 2014-03-06 2015-03-06 Derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil)tetrahidrofuran-2-il)-3-aminopropan-2-ol

Country Status (10)

Country Link
US (1) US10301274B2 (es)
EP (1) EP3114112B1 (es)
JP (1) JP6528251B2 (es)
CN (1) CN106458947B (es)
AR (1) AR099692A1 (es)
AU (1) AU2015226806B2 (es)
CA (1) CA2940609A1 (es)
TW (1) TW201617326A (es)
UY (1) UY36023A (es)
WO (1) WO2015131286A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20181953A1 (es) 2016-03-02 2018-12-17 Eisai Randd Man Co Ltd Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL139960A0 (en) * 1998-06-17 2002-02-10 Eisai Co Ltd Macrocylic analogs and methods of their use and preparation
IL142218A0 (en) * 1998-09-23 2002-03-10 Lonza Ag PROCESS FOR THE PREPARATION OF (-) -α- DIFLUORMETHYLORNITHINE MONOHYDROCHLORIDE MONOHYDRATE
CA2935786C (en) 2004-06-03 2019-02-12 Eisai R & D Management Co., Ltd. Intermediates for the preparation of analogs of halichondrin b
RU2517167C2 (ru) 2008-04-04 2014-05-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Аналоги галихондрина в
IN2014MN01521A (es) 2011-12-29 2015-05-01 Alphora Res Inc
AU2013239290B2 (en) * 2012-03-30 2017-08-03 Sandoz Ag Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein
CN105431438A (zh) 2013-07-03 2016-03-23 阿方拉研究股份有限公司 用于制备软海绵素b 的大环c1-酮基类似物的合成方法和可用于其中的中间体、包括含有-so2-(对甲苯基)基团的中间体

Also Published As

Publication number Publication date
EP3114112A1 (en) 2017-01-11
EP3114112B1 (en) 2021-12-15
US10301274B2 (en) 2019-05-28
CN106458947A (zh) 2017-02-22
US20170066735A1 (en) 2017-03-09
JP6528251B2 (ja) 2019-06-12
TW201617326A (zh) 2016-05-16
AU2015226806B2 (en) 2018-11-08
JP2017507159A (ja) 2017-03-16
CN106458947B (zh) 2021-01-12
AU2015226806A1 (en) 2016-08-25
EP3114112A4 (en) 2017-10-04
CA2940609A1 (en) 2015-09-11
UY36023A (es) 2015-10-30
WO2015131286A1 (en) 2015-09-11

Similar Documents

Publication Publication Date Title
AR110922A1 (es) Compuestos inhibidores del vih
AR103138A1 (es) Compuestos de heteroarilo como inhibidores de la irak y usos de los mismos
AR104176A1 (es) Inhibidores de ido (indolamina-2,3-dioxigenasa)
AR099995A1 (es) Piridilamidinas fungicidas
AR103969A1 (es) Inmunomoduladores
AR100058A1 (es) DERIVADOS DE PIRIMIDIN-PIRAZINAS FUSIONADAS MODULADORES DE RORg
AR103561A1 (es) Fenilpiridinas herbicidas
AR101189A1 (es) Heterociclos nitrogenados antiproliferativos y sus métodos de uso
AR100251A1 (es) Inhibidores de la dematilasa-1 especifica de lisina
AR100886A1 (es) 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas
AR091193A1 (es) HETEROCICLOS DE 5 MIEMBROS QUE CONTIENEN NITROGENO SUSTITUIDO POR CARBOXAMIDA O SULFONAMIDA COMO MODULADORES PARA EL RECEPTOR NUCLEAR HUERFANO RORg
AR106604A1 (es) Compuestos de criptoficina y productos conjugados, su preparación y su uso terapéutico
AR106258A1 (es) Compuestos de piridina
AR109776A1 (es) Compuestos de p2x₃ y/o p2x₂/₃ y métodos
AR095040A1 (es) Antagonistas de h3 que contienen un núcleo estructural de fenoxipiperidina
AR110351A1 (es) COMPUESTOS DE HETEROARILO SUSTITUIDOS CON FOSFINÓXIDO ALQUILAMIDA COMO MODULADORES DE RESPUESTAS DE IL-12, IL-23 Y/O IFNa
AR100940A1 (es) Derivados de 1,2,4-triazoles plaguicidas, y sus intermediarios, composiciones y sus procesos relacionados
AR101798A1 (es) Quinolinas herbicidas
AR107570A1 (es) Compuestos químicos
AR096827A1 (es) Uso de piridoncarboxamidas seleccionadas o sus sales como ingredientes activos contra estrés abiótico en plantas
AR103024A1 (es) Piridoncarboxamidas seleccionadas o sus sales como sustancias activas contra estrés abiótico de las plantas
AR099692A1 (es) Derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil)tetrahidrofuran-2-il)-3-aminopropan-2-ol
AR111474A1 (es) Compuestos químicos
AR104431A1 (es) Compuestos herbicidas
AR102501A1 (es) Piridilamidinas fungicidas

Legal Events

Date Code Title Description
FB Suspension of granting procedure