AR098444A1 - Compuestos derivados de piridina o pirimidina como plaguicidas - Google Patents

Compuestos derivados de piridina o pirimidina como plaguicidas

Info

Publication number
AR098444A1
AR098444A1 ARP140104314A ARP140104314A AR098444A1 AR 098444 A1 AR098444 A1 AR 098444A1 AR P140104314 A ARP140104314 A AR P140104314A AR P140104314 A ARP140104314 A AR P140104314A AR 098444 A1 AR098444 A1 AR 098444A1
Authority
AR
Argentina
Prior art keywords
halo
mono
radical
alkylthiol
alkylaminosulfonyl
Prior art date
Application number
ARP140104314A
Other languages
English (en)
Inventor
Gauvry Nolle
Pautrat Franois
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR098444A1 publication Critical patent/AR098444A1/es

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Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)

Abstract

Estos ingredientes activos tienen propiedades plaguicidas ventajosas. En especial, son apropiados para controlar los endoparásitos en los animales de sangre caliente. Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) donde cada uno de Z¹ y Z² es independientemente N o CR¹; cada uno de R¹ y R¹ es independientemente H, un halógeno o un radical ciano, nitro, C₁₋₄-alquilo, C₁₋₄-haloalquilo, C₁₋₄-alcoxilo, C₁₋₃-haloalcoxilo, C₁₋₄-alquiltiol, halo-C₁₋₄-alquiltiol, SF₅, amino, N-mono o N,N-di-C₁₋₄-alquilamino, aminosulfonilo, N-mono o N,N-di-C₁₋₄-alquilaminosulfonilo, N-mono o N,N-di-halo-C₁₋₄-alquilaminosulfonilo, C₁₋₄-alquilsulfonilo, C₁₋₄-alquilsulfinilo, C₁₋₄-alquilsulfonilamino, halo-C₁₋₄-alquilsulfonilo, halo-C₁₋₄-alquilsulfinilo, halo-C₁₋₄-alquilsulfonilamino o bencilsulfonilamino; Q es Ar¹ o -C(O)-(O)ₘ-R²; m es 0 ó 1; R² es C₁₋₆-alquilo o C₃₋₈-cicloalquilo; Ar¹ (i) es un radical fenilo sustituido con 1 ó 2 sustituyentes idénticos o diferentes que se seleccionan del grupo que consiste en un halógeno o un radical ciano, nitro, C₁₋₄-alquilo, C₁₋₄-haloalquilo, C₁₋₄-alcoxilo, C₁₋₄-haloalcoxilo, C₁₋₄-alquiltiol, halo-C₁₋₄-alquiltiol, SF₅, amino, N-mono o N,N-di-C₁₋₄-alquilamino, aminosulfonilo, N-mono o N,N-di-C₁₋₄-alquilaminosulfonilo, N-mono o N,N-di-halo-C₁₋₄-alquilaminosulfonilo, C₁₋₄-alquilsulfonilo, C₁₋₄-alquilsulfinilo, C₁₋₄-alquilsulfonilamino, bencilsulfonilamino, halo-C₁₋₄-alquilsulfonilo, halo-C₁₋₄-alquilsulfinilo o halodioxolilo; o (ii) es un radical heteroarilo que se selecciona del grupo que consiste en un radical 2, 3 ó 4-piridilo o 2 ó 3-tiofenilo que puede estar sustituido o no sustituido, por ejemplo, con un halógeno o con un radical metilo, etilo, CF₃ o carboxilo; Ar² es un radical fenilo sustituido con entre 1 y 3 sustituyentes idénticos o diferentes que se seleccionan del grupo que consiste en un halógeno o un radical ciano, nitro, C₁₋₄-alquilo, C₁₋₄-haloalquilo, C₁₋₄-alcoxilo, C₁₋₄-haloalcoxilo, C₁₋₄-alquiltiol, halo-C₁₋₄-alquiltiol, SF₅, amino, N-mono o N,N-di-C₁₋₄-alquilamino, aminosulfonilo, N-mono o N,N-di-C₁₋₄-alquilaminosulfonilo, N-mono o N,N-di-halo-C₁₋₄-alquilaminosulfonilo, C₁₋₄-alquilsulfonilo, C₁₋₄-alquilsulfinilo, C₁₋₄-alquilsulfonilamino, bencilsulfonilamino, halo-C₁₋₄-alquilsulfonilo, halo-C₁₋₄-alquilsulfinilo o halodioxolilo; L¹ es un radical que actúa como un conector bifuncional de fórmula (2), (3) ó (4); L² es un radical que actúa como un conector bifuncional de fórmula (5), (6) ó (7); cada uno de A y B es independientemente un C₃₋₈-hetero-cicloalquileno o un C₅₋₁₀-hetero-bicicloalquileno que comprende dos átomos de N y que puede estar sustituido o no sustituido con un C₁₋₂-alquilo; cada uno de A¹, A², B¹ y B² es independientemente un C₃₋₈-hetero-cicloalquileno que comprende un átomo de N; cada uno de R y R es independientemente H o un C₁₋₄-alquilo; o una sal de este aceptable desde el punto de vista fisiológico.
ARP140104314A 2013-11-18 2014-11-18 Compuestos derivados de piridina o pirimidina como plaguicidas AR098444A1 (es)

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CH19182013 2013-11-18

Publications (1)

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AR098444A1 true AR098444A1 (es) 2016-05-26

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US (1) US9820488B2 (es)
EP (1) EP3071559B1 (es)
JP (1) JP6140373B2 (es)
KR (1) KR101759458B1 (es)
CN (1) CN105960401B (es)
AR (1) AR098444A1 (es)
AU (1) AU2014350172B2 (es)
BR (1) BR112016010596B1 (es)
CA (1) CA2926700C (es)
DK (1) DK3071559T3 (es)
EA (1) EA029727B1 (es)
ES (1) ES2659023T3 (es)
HU (1) HUE036713T2 (es)
MX (1) MX369104B (es)
NO (1) NO3071559T3 (es)
PL (1) PL3071559T3 (es)
PT (1) PT3071559T (es)
WO (1) WO2015071417A1 (es)

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CA2949511A1 (en) 2014-05-19 2015-11-26 Merial, Inc. Anthelmintic compounds
MX2017009408A (es) 2015-01-20 2017-10-02 Merial Inc Compuestos antihelminticos, composiciones y metodo para usar los mismos.
US10414727B2 (en) * 2016-11-08 2019-09-17 Navitor Pharmaceuticals, Inc. Phenyl amino piperidine mTORC inhibitors and uses thereof

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
ES2378153T3 (es) 2005-09-27 2012-04-09 Irm Llc Conpuestos y composiciones que contienen diarilamina, y su uso como moduladores de receptores c-kit
WO2009071500A2 (en) 2007-12-03 2009-06-11 Novartis Ag Organic compounds
EP2072501A1 (en) * 2007-12-21 2009-06-24 Bayer CropScience AG Aminobenzamide derivatives as useful agents for controlling animal parasites
CN102089278A (zh) 2008-06-11 2011-06-08 Irm责任有限公司 用于治疗疟疾的化合物和组合物
MX2011011510A (es) 2009-04-27 2011-11-18 Dow Agrosciences Llc Compuestos insecticidas de piridina.
JP2013526507A (ja) * 2010-05-12 2013-06-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用
UY34104A (es) * 2011-05-31 2013-01-03 Syngenta Participations Ag ?compuestos derivados benzamídicos heterocíclicos, procesos e intermedios para su preparación, composiciones y métodos para su uso?.
WO2013182612A1 (en) * 2012-06-07 2013-12-12 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors

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AU2014350172A1 (en) 2016-05-05
ES2659023T3 (es) 2018-03-13
NZ718739A (en) 2021-01-29
BR112016010596B1 (pt) 2022-07-12
KR101759458B1 (ko) 2017-07-18
HUE036713T2 (hu) 2018-07-30
CA2926700A1 (en) 2015-05-21
MX369104B (es) 2019-10-29
US20160251335A1 (en) 2016-09-01
EP3071559B1 (en) 2018-01-10
JP2016537351A (ja) 2016-12-01
KR20160068955A (ko) 2016-06-15
WO2015071417A1 (en) 2015-05-21
CA2926700C (en) 2018-03-20
EA029727B1 (ru) 2018-05-31
MX2016006507A (es) 2017-01-18
AU2014350172B2 (en) 2017-04-20
BR112016010596A2 (es) 2017-08-08
NO3071559T3 (es) 2018-06-09
US9820488B2 (en) 2017-11-21
EA201690797A1 (ru) 2016-09-30
JP6140373B2 (ja) 2017-05-31
PT3071559T (pt) 2018-02-05
EP3071559A1 (en) 2016-09-28
PL3071559T3 (pl) 2018-06-29
DK3071559T3 (en) 2018-02-12
CN105960401B (zh) 2018-06-08
CN105960401A (zh) 2016-09-21

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