AR098201A1 - Composiciones de liberación continua basadas sobre ácido hialurónico y aplicaciones terapéuticas de esas composiciones - Google Patents
Composiciones de liberación continua basadas sobre ácido hialurónico y aplicaciones terapéuticas de esas composicionesInfo
- Publication number
- AR098201A1 AR098201A1 ARP140104026A ARP140104026A AR098201A1 AR 098201 A1 AR098201 A1 AR 098201A1 AR P140104026 A ARP140104026 A AR P140104026A AR P140104026 A ARP140104026 A AR P140104026A AR 098201 A1 AR098201 A1 AR 098201A1
- Authority
- AR
- Argentina
- Prior art keywords
- compositions
- plga
- conditions
- acid
- glycolic
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 9
- 239000002253 acid Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- 210000003491 skin Anatomy 0.000 abstract 2
- 208000001860 Eye Infections Diseases 0.000 abstract 1
- 208000023178 Musculoskeletal disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 229920000436 Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide) Polymers 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- 230000002917 arthritic effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 201000003146 cystitis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 210000002615 epidermis Anatomy 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- 208000011323 eye infectious disease Diseases 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000694 mesotherapy Methods 0.000 abstract 1
- 210000004877 mucosa Anatomy 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 1
- -1 polyethylene Polymers 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 239000004626 polylactic acid Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000007634 remodeling Methods 0.000 abstract 1
- 230000009759 skin aging Effects 0.000 abstract 1
- 210000001179 synovial fluid Anatomy 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
- 208000019206 urinary tract infection Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
El presente es concerniente a partículas de polímero con base en polímero de ácido poliláctico co-glicólico (PLGA), en copolímero de ácido poliláctico-co-glicólico - polietileno de glicol - ácido poli(láctico co-glicólico) (PLGA - PEG - PLGA) o a las mezclas de estos, asociadas con moléculas de ácido hialurónico o con sales de ácido hialurónico, y al procedimiento para la preparación de esas composiciones. El presente también tiene como objeto las composiciones farmacéuticas o cosméticas inyectables que comprenden las mencionadas partículas de polímero, el procedimiento para la preparación de las mencionada composiciones y la utilización de esas composiciones en carácter de medicamento, en especial para la prevención o el tratamiento, o ambas cosas al mismo tiempo, de enfermedades músculo-esqueléticas, de enfermedades y de estados traumáticos de la piel, de afecciones bucodentales, de la sequedad de la mucosa vaginal y de infecciones urinarias o cistitis; de la sequedad de la membrana ocular y de las infecciones oculares; y de la obesidad, así como la utilización de aquellas composiciones para la lucha contra el envejecimiento de la piel o para reparar el tejido dérmico (mesoterapia) o para estas dos aplicaciones al mismo tiempo. De modo más particular, a las composiciones que se da a conocer en el presente se las puede destinar como complemento de los líquidos articulares y, en especial, del líquido sinovial, para restablecer las condiciones fisiológicas y reológicas de la articulación patológica como, por ejemplo, artrósica o, aún más, para el cuidado y la reparación de la epidermis por medio de la remodelación, la hidratación y la protección de la piel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2013/066763 WO2015018461A1 (fr) | 2013-08-09 | 2013-08-09 | Compositions therapeutiques comprenant d'acide hyaluronique |
| PCT/IB2014/063744 WO2015019304A2 (fr) | 2013-08-09 | 2014-08-06 | Compositions à libération continue à base d'acide hyaluronique, et leurs applications thérapeutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR098201A1 true AR098201A1 (es) | 2016-05-18 |
Family
ID=49209321
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140104026A AR098201A1 (es) | 2013-08-09 | 2014-10-27 | Composiciones de liberación continua basadas sobre ácido hialurónico y aplicaciones terapéuticas de esas composiciones |
| ARP220101046A AR125407A2 (es) | 2013-08-09 | 2022-04-22 | Procedimiento para la preparación de partículas de polímero farmacéuticas y/o cosméticas, y procedimiento para la preparación de composiciones farmacéuticas y/o cosméticas que comprenden dichas partículas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220101046A AR125407A2 (es) | 2013-08-09 | 2022-04-22 | Procedimiento para la preparación de partículas de polímero farmacéuticas y/o cosméticas, y procedimiento para la preparación de composiciones farmacéuticas y/o cosméticas que comprenden dichas partículas |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10842810B2 (es) |
| EP (1) | EP3030225B1 (es) |
| CN (1) | CN105744929B (es) |
| AR (2) | AR098201A1 (es) |
| CA (1) | CA2926169C (es) |
| ES (1) | ES2835476T3 (es) |
| IL (1) | IL243995B (es) |
| RU (1) | RU2700593C2 (es) |
| WO (2) | WO2015018461A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101637883B1 (ko) * | 2015-09-30 | 2016-07-21 | 선바이오(주) | 폴리에틸렌글리콜 수화젤 주사제 |
| CN110423291B (zh) * | 2019-09-06 | 2020-06-16 | 焦点生物医药有限公司 | 一种速溶透明质酸钠制备方法 |
| BR112022011067A2 (pt) * | 2019-12-10 | 2022-08-23 | Alcon Inc | Insertos oculares poliméricos dissolvíveis com um polímero biodegradável |
| FR3105729B1 (fr) | 2019-12-31 | 2023-07-21 | Mrs Biotech | Composition pour la gestion du poids d’un sujet |
| CN113855849A (zh) * | 2020-06-30 | 2021-12-31 | 孛朗孚(杭州)生物科技有限公司 | 一种敷料组合物及其制备方法和应用 |
| WO2022045823A1 (ko) * | 2020-08-31 | 2022-03-03 | 주식회사 바임 | 생분해성 고분자 분산체, 이를 포함하는 조성물 및 피부 개선용 시스템 |
| CN115501390B (zh) * | 2022-10-18 | 2024-08-27 | 沈阳药科大学 | 一种皮肤美容复合注射液及其制备方法 |
| CN115970051B (zh) * | 2023-02-09 | 2023-08-29 | 辽宁天贺生物科技研究院有限公司 | 可降解组织工程填充材料及其制备方法和用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5972906A (en) * | 1991-07-03 | 1999-10-26 | Hyal Pharmaceutical Corporation | Treatment of mucous membrane disease, trauma or condition and for the relief of pain thereof |
| IN181358B (es) | 1995-02-14 | 1998-05-30 | Bioniche Inc | |
| KR100236771B1 (ko) | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
| US6004573A (en) * | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| TW577758B (en) * | 1997-10-27 | 2004-03-01 | Ssp Co Ltd | Intra-articular preparation for the treatment of arthropathy |
| US7067144B2 (en) | 1998-10-20 | 2006-06-27 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
| US7582311B1 (en) * | 1999-10-15 | 2009-09-01 | Genentech, Inc. | Injection vehicle for polymer-based formulations |
| CA2466642C (en) | 2001-11-14 | 2011-01-18 | Guohua Chen | Injectable depot composition |
| TW200307011A (en) * | 2002-04-18 | 2003-12-01 | Chugai Pharmaceutical Co Ltd | Hyaluronic acid modifier |
| US20080124400A1 (en) * | 2004-06-24 | 2008-05-29 | Angiotech International Ag | Microparticles With High Loadings Of A Bioactive Agent |
| BRPI0515191A (pt) * | 2004-08-13 | 2008-07-08 | Angiotech Internac Ag | composição farmacêutica, método para aumentar osso ou substituir perda óssea, método para reduzir a dor associada com cicatriz pós-cirúrgica, método para prevenir aderência cirúrgicas, método para aumento ou reparo de pele ou tecido, método para manter volume em fluido ocular durante cirurgia ocular, método para reduzir a dor associada com osteoartrite, método para tratar doença de refluxo gastroesofágico, método para tratar ou prevenir incontinência urinária, método para tratar ou prevenir incontinência fecal, implante método e dispositivo médico |
| US20060140988A1 (en) | 2004-12-23 | 2006-06-29 | Guohua Chen | Visco-supplement composition and methods |
| FR2909560B1 (fr) * | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
| AU2008256864A1 (en) * | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Coated hyaluronic acid particles |
| UA111162C2 (uk) * | 2010-08-04 | 2016-04-11 | Флекшен Терап'Ютікс, Інк. | Ін'єкційна композиція ацетоніду триамцинолону для лікування болю |
| KR101304766B1 (ko) | 2011-01-05 | 2013-09-05 | 서울대학교산학협력단 | 히알루론산을 포함하는 인공타액 |
-
2013
- 2013-08-09 WO PCT/EP2013/066763 patent/WO2015018461A1/fr active Application Filing
-
2014
- 2014-08-06 CA CA2926169A patent/CA2926169C/fr active Active
- 2014-08-06 ES ES14780586T patent/ES2835476T3/es active Active
- 2014-08-06 WO PCT/IB2014/063744 patent/WO2015019304A2/fr active Application Filing
- 2014-08-06 RU RU2016105338A patent/RU2700593C2/ru active
- 2014-08-06 EP EP14780586.5A patent/EP3030225B1/fr active Active
- 2014-08-06 CN CN201480055880.0A patent/CN105744929B/zh active Active
- 2014-08-06 US US14/909,909 patent/US10842810B2/en active Active
- 2014-10-27 AR ARP140104026A patent/AR098201A1/es not_active Application Discontinuation
-
2016
- 2016-02-07 IL IL243995A patent/IL243995B/en active IP Right Grant
-
2020
- 2020-10-09 US US17/067,297 patent/US11738039B2/en active Active
-
2022
- 2022-04-22 AR ARP220101046A patent/AR125407A2/es unknown
-
2023
- 2023-02-14 US US18/169,051 patent/US20230190786A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2016105338A (ru) | 2017-09-12 |
| ES2835476T3 (es) | 2021-06-22 |
| AR125407A2 (es) | 2023-07-12 |
| US20230190786A1 (en) | 2023-06-22 |
| IL243995B (en) | 2021-03-25 |
| EP3030225B1 (fr) | 2020-09-02 |
| RU2016105338A3 (es) | 2018-06-07 |
| RU2700593C2 (ru) | 2019-09-18 |
| CA2926169C (fr) | 2023-10-17 |
| CN105744929B (zh) | 2021-09-28 |
| US20210023122A1 (en) | 2021-01-28 |
| CA2926169A1 (fr) | 2015-02-12 |
| US20160175342A1 (en) | 2016-06-23 |
| EP3030225A2 (fr) | 2016-06-15 |
| WO2015019304A3 (fr) | 2015-04-23 |
| US11738039B2 (en) | 2023-08-29 |
| US10842810B2 (en) | 2020-11-24 |
| IL243995A0 (en) | 2016-04-21 |
| WO2015019304A2 (fr) | 2015-02-12 |
| CN105744929A (zh) | 2016-07-06 |
| WO2015018461A1 (fr) | 2015-02-12 |
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