AR093827A1 - Agentes antibacterianos de tetrahidroquinolina triciclica - Google Patents

Agentes antibacterianos de tetrahidroquinolina triciclica

Info

Publication number
AR093827A1
AR093827A1 ARP130103443A ARP130103443A AR093827A1 AR 093827 A1 AR093827 A1 AR 093827A1 AR P130103443 A ARP130103443 A AR P130103443A AR P130103443 A ARP130103443 A AR P130103443A AR 093827 A1 AR093827 A1 AR 093827A1
Authority
AR
Argentina
Prior art keywords
triciclic
tetrahydroquinoline
antibacterial agents
halo
formula
Prior art date
Application number
ARP130103443A
Other languages
English (en)
Inventor
Laurence Toogood Peter
S Warmus Joseph
Curtis Michael
Allan Johnson Timothy
S Lall Manjinder
Original Assignee
Zoetis Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Llc filed Critical Zoetis Llc
Publication of AR093827A1 publication Critical patent/AR093827A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1), en la que: R¹ es seleccionado del grupo que consiste en los compuestos de fórmula (2), (3), (4) y (5) que están opcionalmente sustituidos con R²; R² es alquilo C₁₋₆ o fenilo opcionalmente sustituido con halo; X e Y son independientemente H, halo o alquilo C₁₋₆; o una sal, solvato o un hidrato del mismo; a condición de que cuando R¹ es resto de fórmula (3) y R² es fenilo, al menos uno de X e Y es halo.
ARP130103443A 2012-09-26 2013-09-25 Agentes antibacterianos de tetrahidroquinolina triciclica AR093827A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261705709P 2012-09-26 2012-09-26

Publications (1)

Publication Number Publication Date
AR093827A1 true AR093827A1 (es) 2015-06-24

Family

ID=49301686

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130103443A AR093827A1 (es) 2012-09-26 2013-09-25 Agentes antibacterianos de tetrahidroquinolina triciclica

Country Status (14)

Country Link
US (2) US8952149B2 (es)
EP (1) EP2900064A1 (es)
JP (1) JP2015531375A (es)
KR (1) KR20150045513A (es)
CN (1) CN104684396A (es)
AR (1) AR093827A1 (es)
AU (1) AU2013323687A1 (es)
BR (1) BR112015006220A2 (es)
CA (1) CA2884850A1 (es)
MX (1) MX2015003770A (es)
PH (1) PH12015500518A1 (es)
UY (1) UY35050A (es)
WO (1) WO2014052387A1 (es)
ZA (1) ZA201501640B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8889671B2 (en) 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections
MX365261B (es) 2014-05-29 2019-05-27 Entasis Therapeutics Ltd Compuestos heteroaromaticos espirociclicos, fusionados para el tratamiento de infecciones bacterianas.
JP7316903B2 (ja) 2018-12-27 2023-07-28 エルジー エナジー ソリューション リミテッド 二次電池用正極活物質及びその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208490B2 (en) 2002-10-07 2007-04-24 Pharmacia & Upjohn Company Llc Tricyclic tetrahydroquinoline antibacterial agents
EP1888597A2 (en) 2005-05-09 2008-02-20 Warner-Lambert Company LLC Antibacterial agents
DOP2006000268A (es) 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
AU2008272693A1 (en) 2007-07-02 2009-01-08 Astrazeneca Ab 3-spiropyrimidinetrione-quinoline derivatives and their use as antibacterial agents

Also Published As

Publication number Publication date
AU2013323687A1 (en) 2015-03-19
US20150111884A1 (en) 2015-04-23
JP2015531375A (ja) 2015-11-02
PH12015500518A1 (en) 2015-04-27
ZA201501640B (en) 2016-01-27
WO2014052387A1 (en) 2014-04-03
CA2884850A1 (en) 2014-04-03
US20140088093A1 (en) 2014-03-27
KR20150045513A (ko) 2015-04-28
BR112015006220A2 (pt) 2017-07-04
US8952149B2 (en) 2015-02-10
EP2900064A1 (en) 2015-08-05
MX2015003770A (es) 2015-07-14
UY35050A (es) 2014-04-30
CN104684396A (zh) 2015-06-03

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