AR090489A1 - Derivados de n-cicloalquil-n-biciclicometilen-carboxamida fungicidas e intermediarios para su preparacion - Google Patents

Derivados de n-cicloalquil-n-biciclicometilen-carboxamida fungicidas e intermediarios para su preparacion

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AR090489A1
AR090489A1 ARP130100964A ARP130100964A AR090489A1 AR 090489 A1 AR090489 A1 AR 090489A1 AR P130100964 A ARP130100964 A AR P130100964A AR P130100964 A ARP130100964 A AR P130100964A AR 090489 A1 AR090489 A1 AR 090489A1
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substituted
unsubstituted
alkyl
halogen atoms
different
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ARP130100964A
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Desbordes Philippe
Gary Stephanie
Lachaise Helene
Rinolfi Philippe
Wachendorff-Neumann Ulrike
Benting Jrgen
Dahmen Peter
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Bayer Ip Gmbh
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Publication of AR090489A1 publication Critical patent/AR090489A1/es

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Derivados de N-cicloalquil-N-bicíclicometilen-carboxamida o tiocarboxamida, a su procedimiento de preparación, preparación de compuestos intermedios, a su uso como agentes activos fungicidas, en particular en forma de composiciones fungicidas y a métodos para el control de hongos fitopatogénicos, en particular de plantas, usando estos compuestos o composiciones. Reivindicación 1: Un compuesto de fórmula (1) en la que T representa O ó S; X¹ y X², que pueden ser iguales o diferentes, representan un átomo de cloro o de flúor; Z¹ representa un cicloalquilo C₃₋₇ no sustituido o un cicloalquilo C₃₋₇ sustituido con hasta 10 átomos o grupos que pueden ser iguales o diferentes y que se pueden seleccionar de la lista que consiste en átomos de halógeno, ciano, alquilo C₁₋₈, halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈, halógenoalcoxi C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈-carbonilo, halógenoalcoxi C₁₋₈-carbonilo que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alquil C₁₋₈-aminocarbonilo, di-alquil C₁₋₈-aminocarbonilo o carbamoilo; Z² representa un átomo de hidrógeno, un átomo de halógeno, grupo hidroxilo, ciano, alquilo C₁₋₈ sustituido o sin sustituir, alcoxi C₁₋₈ sustituido o sin sustituir, halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes o amino o alquilamino C₁₋₈; Y¹ e Y² representan independientemente un átomo de hidrógeno, un átomo de halógeno, ciano, alquilo C₁₋₈ sustituido o sin sustituir, halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈ sustituido o sin sustituir, halógenoalcoxi C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxicarbonilo C₁₋₈ sustituido o sin sustituir, halógenoalcoxi C₁₋₈-carbonilo que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alquil C₁₋₈-aminocarbonilo sustituido o sin sustituir, di-alquil C₁₋₈-aminocarbonilo sustituido o sin sustituir o carbamoilo; L¹ y L² representan independientemente CZ⁴Z⁵, NZ⁶, O, S, S(O) o S(O)₂; m representa 1, 2 ó 3; p representa 1, 2 ó 3; W representa CZ⁷ o N; Z³ y Z⁷ representan independientemente un átomo de hidrógeno, un átomo de halógeno; nitro; ciano; isonitrilo; hidroxi; amino; sulfanilo; pentafluoro-l⁶-sulfanilo; formilo; formiloxi; formilamino; (hidroxiimino)-alquilo C₁₋₈ sustituido o sin sustituir; alcoxiimino C₁₋₈-alquilo C₁₋₈ sustituido o no sustituido; (alqueniloxi C₂₋₈-imino)-alquilo C₁₋₈ sustituido o sin sustituir; (alquiniloxi C₂₋₈-imino)-alquilo C₁₋₈ sustituido o sin sustituir; (benciloxiimino)-alquilo C₁₋₈ sustituido o no sustituido; carboxi; carbamoilo; N-hidroxicarbamoilo; carbamato; alquilo C₁₋₈ sustituido o no sustituido; halógenoalquilo C₁₋₈ que tiene de 1 a 9 átomos de halógeno; alquenilo C₂₋₈ sustituido o no sustituido; halógenoalquenilo C₂₋₈ que tiene de 1 a 9 átomos de halógeno; alquinilo C₂₋₈ sustituido o no sustituido; halógenoalquinilo C₂₋₈ que tiene de 1 a 9 átomos de halógeno; alcoxi C₁₋₈ sustituido o no sustituido; halógenoalcoxi C₁₋₈ que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-sulfanilo sustituido o no sustituido; halógenoalquil C₁₋₈-sulfanilo que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₆-sulfinilo sustituido o no sustituido; halógenoalquil C₁₋₈-sulfinilo que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-sulfonilo sustituido o no sustituido; halógenoalquil C₁₋₈-sulfonilo que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-amino sustituido o no sustituido; dialquil C₁₋₈-amino sustituido o no sustituido; alqueniloxi C₂₋₈ sustituido o no sustituido; halógenoalqueniloxi C₁₋₆ que tiene de 1 a 9 átomos de halógeno; alquiniloxi C₃₋₈ sustituido o no sustituido; halógenoalquiniloxi C₂₋₈ que tiene de 1 a 9 átomos de halógeno; cicloalquilo C₃₋₇ sustituido o no sustituido; halógenocicloalquilo C₃₋₇ que tiene de 1 a 9 átomos de halógeno; cicloalquenilo C₄₋₇ sustituido o sin sustituir; halógenocicloalquenilo C₄₋₇ que tiene de 1 a 9 átomos de halógeno; cicloalquil C₃₋₇-alquilo C₁₋₈ sustituido o sin sustituir; cicloalquil C₃₋₇-alquenilo C₂₋₈ sustituido o sin sustituir; cicloalquil C₃₋₇-alquinilo C₂₋₈ sustituido o sin sustituir; tri(alquil C₁₋₈) sililo sustituido o no sustituido; tri(alquil C₁₋₈) sililo-alquilo C₁₋₈ sustituido o sin sustituir; alquil C₁₋₈-carbonilo sustituido o no sustituido; halógenoalquil C₁₋₈-carbonilo que tiene de 1 a 9 átomos de halógeno; alquil-C₁₋₈-carboniloxi sustituido o sin sustituir; halógenoalquil C₁₋₈-carboniloxi que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-carbonilamino sustituido o sin sustituir; halógenoalquil C₁₋₈-carbonilamino que tiene de 1 a 9 átomos de halógeno; alcoxi C₁₋₈-carbonilo sustituido o no sustituido; halógenoalcoxi C₁₋₈-carbonilo que tiene de 1 a 9 átomos de halógeno; alquiloxi C₁₋₈-carboniloxi sustituido o sin sustituir; halógenoalcoxi C₁₋₅-carboniloxi que tiene de 1 a 9 átomos de halógeno; alquil C₁₋₈-carbamoilo sustituido o no sustituido; dialquil C₁₋₈-carbamoilo sustituido o no sustituido; alquil C₁₋₈-aminocarboniloxi sustituido o sin sustituir; dialquil C₁₋₈-aminocarboniloxi sustituido o sin sustituir; N-(alquil C₁₋₈)hidroxicarbamoilo sustituido o sin sustituir; alcoxi C₁₋₈-carbamoilo sustituido o sin sustituir; N-(alquil C₁₋₈)-alcoxi C₁₋₈-carbamoilo sustituido o sin sustituir; arilo que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilalquilo C₁₋₈ que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilalquenilo C₂₋₈ que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilalquinilo C₂₋₈ que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; ariloxi que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilsulfanilo que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilamino que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilalquiloxi C₁₋₈ que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilalquilsulfanilo C₁₋₈ que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; arilalquilamino C₁₋₈ que puede estar sustituido con hasta 6 grupos Q que pueden ser iguales o diferentes; piridinilo que puede estar sustituido por hasta 4 grupos Q; o piridiniloxi que puede estar sustituido por hasta 4 grupos Q; Z⁴ y Z⁵ representa independientemente un átomo de hidrógeno, un átomo de halógeno, ciano, nitro, alquilo C₁₋₈ sustituido o sin sustituir, halógenoalquilo C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈ sustituido o sin sustituir, halógenoalcoxi C₁₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alcoxi C₁₋₈-alquilo C₁₋₈ sustituido o sin sustituir, alquenilo C₂₋₈ sustituido o sin sustituir, halógenoalquenilo C₂₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alquinilo C₂₋₈ sustituido o sin sustituir, halógenoalquinilo C₂₋₈ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, cicloalquilo C₃₋₇ sustituido o sin sustituir, cicloalquil C₃₋₇-alquilo C₁₋₈ sustituido o sin sustituir, halógenocicloalquilo C₃₋₇ que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, formilo, alquilcarbonilo C₁₋₈ sustituido o sin sustituir, halógenoalquil C₁₋₈-carbonilo que comprende hasta 9 átomos de halógeno que pueden ser iguales o diferentes, alquilsulfanilo C₁₋₈ sustituido o sin sustituir, halógenoalquilsulfanilo C₁₋
ARP130100964A 2012-03-26 2013-03-25 Derivados de n-cicloalquil-n-biciclicometilen-carboxamida fungicidas e intermediarios para su preparacion AR090489A1 (es)

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EP3181550B1 (en) * 2010-07-20 2019-11-20 Bayer Intellectual Property GmbH Benzocycloalkenes as antifungal agents
US9374998B2 (en) 2012-03-26 2016-06-28 Bayer Intellectual Property Gmbh N-cycloalkyl-N-[(cycloalkenylphenyl)methylene]-(thio)carboxamide derivatives
BR112017022000A2 (pt) * 2015-04-13 2018-07-03 Bayer Cropscience Ag derivados de n-cicloalquil-n-(biheterocicliletileno)-(tio)carboxamida.

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AR056882A1 (es) * 2006-02-01 2007-10-31 Bayer Cropscience Sa Derivados del fungicida n- cicloalquil- bencil- amida
JP5592398B2 (ja) 2009-01-28 2014-09-17 バイエル・クロップサイエンス・アーゲー 殺菌剤ｎ−シクロアルキル−ｎ−二環式メチレン−カルボキサミド誘導体
US9374998B2 (en) 2012-03-26 2016-06-28 Bayer Intellectual Property Gmbh N-cycloalkyl-N-[(cycloalkenylphenyl)methylene]-(thio)carboxamide derivatives

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