AR088638A1 - Lactamas sustituidas por piperidinilo como moduladores de gpr119 - Google Patents

Lactamas sustituidas por piperidinilo como moduladores de gpr119

Info

Publication number
AR088638A1
AR088638A1 ARP120104125A ARP120104125A AR088638A1 AR 088638 A1 AR088638 A1 AR 088638A1 AR P120104125 A ARP120104125 A AR P120104125A AR P120104125 A ARP120104125 A AR P120104125A AR 088638 A1 AR088638 A1 AR 088638A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
alkoxy
independently selected
sulfonyl
Prior art date
Application number
ARP120104125A
Other languages
English (en)
Inventor
M Turner Timothy
Bradford Fell Jay
Roland Benscik Josef
Jay Hinklin Ronald
Pratt Scott
Daniel Aicher Thomas
Singh Ajay
Peter Fischer John
Armen Boyd Steven
Ronald Condroski Kevin
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of AR088638A1 publication Critical patent/AR088638A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Son moduladores de GPR119 y son útiles en el tratamiento o prevención de enfermedades, tales como, de modo no taxativo, diabetes tipo 2, complicaciones diabéticas, síntomas de diabetes, síndrome metabólico, obesidad, dislipidemia y afecciones relacionadas. Reivindicación 1: Un compuesto que tiene la fórmula general (1) o una sal o solvato farmacéuticamente aceptable de este, donde: L es O, NRˣ o CH₂; Rˣ es H o alquilo C₁₋₃; X¹ es N o CR¹, X² es N o CR², y X³ es N o CR³, donde solo uno de X¹ y X² puede ser N; R¹, R², R³ y R⁴ se seleccionan independientemente de H, halógeno, CF₃, alquilo C₁₋₆, CN y alcoxi C₁₋₆; R⁵ es (alquil C₁₋₃)sulfonilo, (cicloalquil C₃₋₆)sulfonilo, (ciclopropilmetil)sulfonilo, fenilsulfonilo, di(alquilo C₁₋₃)NSO₂-, (alquilo C₁₋₃)S-, HOCH₂CH₂NHC(=O)-, RRNCH₂CH₂NRC(O)-, CN, Br, tetrazolilo opcionalmente sustituido por alquilo C₁₋₃ u oxadiazolilo opcionalmente sustituido por alquilo C₁₋₃; R, R y R son independientemente H o alquilo C₁₋₄; R⁷ se selecciona del grupo de fórmulas (2); R⁸ᵃ se selecciona de alquilo C₁₋₆, fluoroalquilo C₁₋₆, difluoroalquilo C₁₋₆, trifluoroalquilo C₁₋₆, (alcoxi C₁₋₃)alquilo C₁₋₆, dihidroxialquilo C₂₋₆, Br, Cic¹, Ar¹, -OAr¹, hetCic¹, hetAr¹ y -OhetAr¹; R⁸ᵇ es alquilo C₁₋₆; Cic¹ es cicloalquilo C₃₋₆ opcionalmente sustituido por CF₃; Ar¹ es fenilo opcionalmente sustituido por uno o más grupos seleccionados independientemente de halógeno, CF₃, alquilo C₁₋₄ y alcoxi C₁₋₄; hetCic¹ es un heterociclo de 5 a 6 miembros que tiene 1 a 2 heteroátomos en el anillo y está opcionalmente sustituido por uno o más grupos seleccionados independientemente de alquilo C₁₋₄; hetAr¹ es un heteroarilo de 5 a 6 miembros que tiene 1 a 2 heteroátomos en el anillo y está opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente de alquilo C₁₋₄, halógeno, CF₃ y alcoxi C₁₋₄; y n es 1, 2 ó 3.
ARP120104125A 2011-11-03 2012-11-02 Lactamas sustituidas por piperidinilo como moduladores de gpr119 AR088638A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161555431P 2011-11-03 2011-11-03

Publications (1)

Publication Number Publication Date
AR088638A1 true AR088638A1 (es) 2014-06-25

Family

ID=47146742

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104125A AR088638A1 (es) 2011-11-03 2012-11-02 Lactamas sustituidas por piperidinilo como moduladores de gpr119

Country Status (4)

Country Link
US (1) US20140256756A1 (es)
AR (1) AR088638A1 (es)
TW (1) TW201326155A (es)
WO (1) WO2013066869A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2571864A1 (en) 2010-05-17 2013-03-27 Array Biopharma, Inc. Piperidinyl-substituted lactams as gpr119 modulators
US9499482B2 (en) 2012-09-05 2016-11-22 Bristol-Myers Squibb Company Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists
AR113206A1 (es) 2017-01-10 2020-02-19 Bayer Cropscience Ag Derivados heterocíclicos como pesticidas
AU2018207776B2 (en) 2017-01-10 2021-06-17 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents
KR20230012597A (ko) 2020-05-19 2023-01-26 칼리오페, 인크. Ampk 활성화제
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター
US20230247994A1 (en) 2020-07-02 2023-08-10 Bayer Aktiengesellschaft Heterocyclene derivatives as pest control agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0507971A (pt) * 2004-02-23 2007-07-24 Tufts College composto, composição farmacêutica, uso de um composto,método para inibir a atividade proteolìtica de uma enzima de clivagem pós-prolina e remédio empacotado
CA2568451A1 (en) * 2004-06-04 2005-12-22 Arena Pharmaceuticals, Inc. Substituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
CA2613236A1 (en) * 2005-06-30 2007-01-11 Prosidion Limited G-protein coupled receptor agonists
BRPI0814294A2 (pt) * 2007-07-19 2015-02-03 Metabolex Inc Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.

Also Published As

Publication number Publication date
TW201326155A (zh) 2013-07-01
WO2013066869A1 (en) 2013-05-10
US20140256756A1 (en) 2014-09-11

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