AR083677A1 - PREACHING THE ADVANCED MACULAR DEGENERATION STEP RELATED TO AGE USING A POLYGENIC SCORE - Google Patents

PREACHING THE ADVANCED MACULAR DEGENERATION STEP RELATED TO AGE USING A POLYGENIC SCORE

Info

Publication number
AR083677A1
AR083677A1 ARP110104052A ARP110104052A AR083677A1 AR 083677 A1 AR083677 A1 AR 083677A1 AR P110104052 A ARP110104052 A AR P110104052A AR P110104052 A ARP110104052 A AR P110104052A AR 083677 A1 AR083677 A1 AR 083677A1
Authority
AR
Argentina
Prior art keywords
age
macular degeneration
preaching
polygenic score
advanced macular
Prior art date
Application number
ARP110104052A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US40903910P priority Critical
Priority to US201161573602P priority
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR083677A1 publication Critical patent/AR083677A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Abstract

La presente solicitud se relaciona con métodos para la identificación de individuos con degeneración macular intermedia relacionada con la edad (AMD) quienes tienen un mayor riesgo de pasar a la AMD avanzada, utilizando una puntuación poligénica calculada sobre la base de los resultados de los estudios de asociación génica en todo el genoma, que utiliza miles de polimorfismos de un solo nucleótido (SNP).The present application relates to methods for the identification of individuals with age-related intermediate macular degeneration (AMD) who have a higher risk of moving to advanced AMD, using a polygenic score calculated on the basis of the results of the studies of Gene association across the genome, which uses thousands of single nucleotide polymorphisms (SNPs).
ARP110104052A 2010-11-01 2011-11-01 PREACHING THE ADVANCED MACULAR DEGENERATION STEP RELATED TO AGE USING A POLYGENIC SCORE AR083677A1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US40903910P true 2010-11-01 2010-11-01
US201161573602P true 2011-09-09 2011-09-09

Publications (1)

Publication Number Publication Date
AR083677A1 true AR083677A1 (es) 2013-03-13

Family

ID=45002128

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104052A AR083677A1 (es) 2010-11-01 2011-11-01 PREACHING THE ADVANCED MACULAR DEGENERATION STEP RELATED TO AGE USING A POLYGENIC SCORE

Country Status (22)

Country Link
US (3) US20120107315A1 (es)
EP (2) EP3170905A1 (es)
JP (4) JP2013544512A (es)
KR (1) KR20130130732A (es)
CN (1) CN103201393B (es)
AR (1) AR083677A1 (es)
AU (2) AU2011323487B2 (es)
BR (1) BR112013010769A2 (es)
CA (1) CA2816805A1 (es)
DK (1) DK2635704T3 (es)
ES (1) ES2628806T3 (es)
HU (1) HUE032938T2 (es)
IL (1) IL226063D0 (es)
MX (1) MX348025B (es)
NZ (1) NZ610067A (es)
PL (1) PL2635704T3 (es)
RU (2) RU2016127684A3 (es)
SG (2) SG10201605904PA (es)
SI (1) SI2635704T1 (es)
TW (1) TW201250003A (es)
WO (1) WO2012061421A1 (es)
ZA (1) ZA201303001B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140067355A1 (en) * 2012-09-06 2014-03-06 Ancestry.Com Dna, Llc Using Haplotypes to Infer Ancestral Origins for Recently Admixed Individuals
WO2015017536A1 (en) * 2013-07-31 2015-02-05 The Board Of Trustees Of The Leland Stanford Junior University Method and system for evaluating progression of age-related macular degeneration
WO2015023596A1 (en) 2013-08-12 2015-02-19 Genentech, Inc. Compositions and method for treating complement-associated conditions
EA201692109A1 (ru) 2014-05-01 2017-03-31 Дженентек, Инк. Варианты антител к фактору d и их применение
RU2559090C1 (ru) * 2014-08-27 2015-08-10 Александр Владимирович Кулик Способ прогнозирования персонифицированного риска развития макулодистрофии
CN108289951A (zh) 2015-10-30 2018-07-17 豪夫迈·罗氏有限公司 抗-因子d抗体和缀合物
EP3368090A1 (en) 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
JP2019506159A (ja) 2016-01-20 2019-03-07 ヴィトリサ セラピューティクス, インコーポレイテッド D因子を阻害するための組成物および方法
CN106086222A (zh) * 2016-08-24 2016-11-09 厦门美因生物科技有限公司 基于qPCR分型技术的运动基因检测评估方法及系统
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
WO2018209222A1 (en) * 2017-05-12 2018-11-15 Massachusetts Institute Of Technology Systems and methods for crowdsourcing, analyzing, and/or matching personal data

Family Cites Families (25)

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
AT297465T (de) 1991-11-25 2005-06-15 Enzon Inc Verfahren zur herstellung von multivalenten antigenbindenden proteinen
EP0946749A1 (en) * 1996-11-20 1999-10-06 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
US7419663B2 (en) 1998-03-20 2008-09-02 Genentech, Inc. Treatment of complement-associated disorders
US6956107B2 (en) 1998-02-20 2005-10-18 Tanox, Inc. Inhibitors of complement activation
US7112327B2 (en) 1998-02-20 2006-09-26 Tanox, Inc. Inhibition of complement activation
US7071300B2 (en) 2001-03-14 2006-07-04 Genentech, Inc. IGF antagonist peptides
RU2186392C1 (ru) * 2001-04-26 2002-07-27 Должич Галина Ивановна Способ диагностики сенильной макулярной дистрофии сетчатки
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
US7127355B2 (en) * 2004-03-05 2006-10-24 Perlegen Sciences, Inc. Methods for genetic analysis
CN1950826A (zh) * 2004-03-05 2007-04-18 佩勒根科学有限公司 遗传分析的方法
US7527970B2 (en) 2004-10-15 2009-05-05 The United States Of America As Represented By The Department Of Health And Human Services Method of identifying active chromatin domains
JP5068175B2 (ja) * 2005-01-04 2012-11-07 日立化成工業株式会社 プライマー生成ローリングサークル型増幅
EP2357257B1 (en) * 2005-02-14 2019-07-31 University of Iowa Research Foundation Methods and reagents for treatment and diagnosis of age-related macular degeneration
US7695909B2 (en) * 2005-06-08 2010-04-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Susceptibility genes for age-related maculopathy (ARM) on chromosome 10q26
MX337061B (es) 2005-11-04 2016-02-11 Genentech Inc USE OF COMPLEMENT INHIBITORS TO TREAT EYE DISEASES.
US20080146501A1 (en) * 2006-02-13 2008-06-19 University Of Iowa Research Foundation Protective complement proteins and age-related macular degeneration
EP2158330A2 (en) * 2007-05-11 2010-03-03 Tufts Medical Center Polynucleotides associated with age-related macular degeneration and methods for evaluating patient risk
AR066660A1 (es) 2007-05-23 2009-09-02 Genentech Inc Prevencion y tratamiento de condiciones del ojo asociadas con su complemento
WO2009029587A2 (en) * 2007-08-24 2009-03-05 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating macular degeneration
US20110177957A1 (en) * 2008-04-18 2011-07-21 Tufts Medical Center, Inc., (f/k/a/ New England Medical Center Hospitals, Inc.) Polymorphisms Associated With Age-Related Macular Degeneration And Methods For Evaluating Patient Risk
AT506998B1 (de) * 2008-06-30 2010-03-15 Fronius Int Gmbh Kontaktrohr für einen schweissbrenner
WO2010075519A2 (en) * 2008-12-23 2010-07-01 Massachusetts Eye & Ear Infirmary Allelic variants associated with advanced age-related macular degeneration
WO2010085542A2 (en) * 2009-01-23 2010-07-29 Novartis Ag Biomarkers related to age-related macular degeneration (amd)

Also Published As

Publication number Publication date
KR20130130732A (ko) 2013-12-02
EP3170905A1 (en) 2017-05-24
CN103201393B (zh) 2019-01-18
ZA201303001B (en) 2014-10-29
RU2593954C2 (ru) 2016-08-10
NZ610067A (en) 2015-05-29
SG10201605904PA (en) 2016-09-29
RU2013125230A (ru) 2014-12-10
JP2019216732A (ja) 2019-12-26
US20180163262A1 (en) 2018-06-14
AU2011323487A1 (en) 2013-06-13
MX348025B (es) 2017-05-24
WO2012061421A1 (en) 2012-05-10
US20140286947A1 (en) 2014-09-25
ES2628806T3 (es) 2017-08-04
CA2816805A1 (en) 2012-05-10
AU2016256692A1 (en) 2016-11-24
BR112013010769A2 (pt) 2019-09-24
CN103201393A (zh) 2013-07-10
JP2013544512A (ja) 2013-12-19
RU2016127684A (ru) 2018-12-06
MX2013004879A (es) 2013-07-02
HUE032938T2 (hu) 2017-11-28
SG190078A1 (en) 2013-06-28
PL2635704T3 (pl) 2017-09-29
EP2635704B1 (en) 2017-04-19
DK2635704T3 (en) 2017-06-19
JP2016154538A (ja) 2016-09-01
RU2016127684A3 (es) 2018-12-06
IL226063D0 (en) 2013-06-27
US20120107315A1 (en) 2012-05-03
JP2018068285A (ja) 2018-05-10
AU2011323487B2 (en) 2016-08-11
TW201250003A (en) 2012-12-16
SI2635704T1 (sl) 2017-07-31
EP2635704A1 (en) 2013-09-11

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