AR083677A1 - Prediccion del paso a degeneracion macular avanzada relacionada con la edad utilizando una puntuacion poligenica - Google Patents

Prediccion del paso a degeneracion macular avanzada relacionada con la edad utilizando una puntuacion poligenica

Info

Publication number
AR083677A1
AR083677A1 ARP110104052A ARP110104052A AR083677A1 AR 083677 A1 AR083677 A1 AR 083677A1 AR P110104052 A ARP110104052 A AR P110104052A AR P110104052 A ARP110104052 A AR P110104052A AR 083677 A1 AR083677 A1 AR 083677A1
Authority
AR
Argentina
Prior art keywords
age
macular degeneration
preaching
polygenic score
step related
Prior art date
Application number
ARP110104052A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR083677A1 publication Critical patent/AR083677A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

La presente solicitud se relaciona con métodos para la identificación de individuos con degeneración macular intermedia relacionada con la edad (AMD) quienes tienen un mayor riesgo de pasar a la AMD avanzada, utilizando una puntuación poligénica calculada sobre la base de los resultados de los estudios de asociación génica en todo el genoma, que utiliza miles de polimorfismos de un solo nucleótido (SNP).
ARP110104052A 2010-11-01 2011-11-01 Prediccion del paso a degeneracion macular avanzada relacionada con la edad utilizando una puntuacion poligenica AR083677A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40903910P 2010-11-01 2010-11-01
US201161573602P 2011-09-09 2011-09-09

Publications (1)

Publication Number Publication Date
AR083677A1 true AR083677A1 (es) 2013-03-13

Family

ID=45002128

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104052A AR083677A1 (es) 2010-11-01 2011-11-01 Prediccion del paso a degeneracion macular avanzada relacionada con la edad utilizando una puntuacion poligenica

Country Status (22)

Country Link
US (3) US20120107315A1 (es)
EP (2) EP3170905A1 (es)
JP (4) JP2013544512A (es)
KR (1) KR20130130732A (es)
CN (1) CN103201393B (es)
AR (1) AR083677A1 (es)
AU (2) AU2011323487B2 (es)
BR (1) BR112013010769A2 (es)
CA (1) CA2816805A1 (es)
DK (1) DK2635704T3 (es)
ES (1) ES2628806T3 (es)
HU (1) HUE032938T2 (es)
IL (1) IL226063A0 (es)
MX (1) MX348025B (es)
NZ (1) NZ610067A (es)
PL (1) PL2635704T3 (es)
RU (2) RU2016127684A (es)
SG (2) SG190078A1 (es)
SI (1) SI2635704T1 (es)
TW (1) TW201250003A (es)
WO (1) WO2012061421A1 (es)
ZA (1) ZA201303001B (es)

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EP2893478A1 (en) * 2012-09-06 2015-07-15 Ancestry.com DNA, LLC Using haplotypes to infer ancestral origins for recently admixed individuals
US9737205B2 (en) 2013-07-31 2017-08-22 The Board Of Trustees Of The Leland Stanford Junior University Method and system for evaluating progression of age-related macular degeneration
JP6463359B2 (ja) 2013-08-12 2019-01-30 ジェネンテック， インコーポレイテッド 補体関連病態を治療するための組成物及び方法
CN106536561A (zh) 2014-05-01 2017-03-22 豪夫迈·罗氏有限公司 抗‑因子d抗体变体及其用途
RU2559090C1 (ru) * 2014-08-27 2015-08-10 Александр Владимирович Кулик Способ прогнозирования персонифицированного риска развития макулодистрофии
CN108289951A (zh) 2015-10-30 2018-07-17 豪夫迈·罗氏有限公司 抗-因子d抗体和缀合物
US10654932B2 (en) 2015-10-30 2020-05-19 Genentech, Inc. Anti-factor D antibody variant conjugates and uses thereof
CN108934169A (zh) 2016-01-20 2018-12-04 维特里萨医疗公司 用于抑制因子d的组合物和方法
CN106086222A (zh) * 2016-08-24 2016-11-09 厦门美因生物科技有限公司 基于qPCR分型技术的运动基因检测评估方法及系统
CN110088301A (zh) * 2016-10-30 2019-08-02 塔利亚兹有限公司 用于预测受试者对抗抑郁治疗的响应的方法和系统
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
CN110915165B (zh) 2017-05-12 2023-05-26 麻省理工学院 用于共享私有数据的计算机实现的方法和装置
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
CN109585017B (zh) * 2019-01-31 2023-12-12 上海宝藤生物医药科技股份有限公司 一种年龄相关性黄斑变性的风险预测算法模型和装置
CA3189030A1 (en) * 2020-07-07 2022-01-13 Kanaph Therapeutics Inc. Fusion protein including complement pathway inhibitor and angiogenesis inhibitor and use thereof
RU2758662C1 (ru) * 2021-03-19 2021-11-01 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) Способ определения показаний к антиангиогенной терапии при подозрении на влажную форму возрастной макулярной дегенерации

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DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
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Also Published As

Publication number Publication date
IL226063A0 (en) 2013-06-27
WO2012061421A1 (en) 2012-05-10
EP3170905A1 (en) 2017-05-24
AU2011323487B2 (en) 2016-08-11
AU2016256692A1 (en) 2016-11-24
JP2018068285A (ja) 2018-05-10
SG10201605904PA (en) 2016-09-29
EP2635704A1 (en) 2013-09-11
MX348025B (es) 2017-05-24
BR112013010769A2 (pt) 2019-09-24
RU2016127684A3 (es) 2018-12-06
US20140286947A1 (en) 2014-09-25
JP2013544512A (ja) 2013-12-19
US20120107315A1 (en) 2012-05-03
JP2019216732A (ja) 2019-12-26
RU2013125230A (ru) 2014-12-10
HUE032938T2 (hu) 2017-11-28
SG190078A1 (en) 2013-06-28
CN103201393B (zh) 2019-01-18
MX2013004879A (es) 2013-07-02
DK2635704T3 (en) 2017-06-19
RU2016127684A (ru) 2018-12-06
ES2628806T3 (es) 2017-08-04
ZA201303001B (en) 2014-10-29
JP2016154538A (ja) 2016-09-01
TW201250003A (en) 2012-12-16
AU2011323487A1 (en) 2013-06-13
NZ610067A (en) 2015-05-29
US20180163262A1 (en) 2018-06-14
RU2593954C2 (ru) 2016-08-10
CA2816805A1 (en) 2012-05-10
SI2635704T1 (sl) 2017-07-31
EP2635704B1 (en) 2017-04-19
PL2635704T3 (pl) 2017-09-29
KR20130130732A (ko) 2013-12-02
CN103201393A (zh) 2013-07-10

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