AR079983A1 - Profarmacos de acido (e) -7- (3-(2-amino-1-fluoroetilideno ) piperidin -1-il)1-ciclopropil -6- fluoro-8-metoxi-4-oxo-1,4- dihidroquinolina -3- carboxilico y su uso en el tratamiento de infecciones bacterianas - Google Patents

Profarmacos de acido (e) -7- (3-(2-amino-1-fluoroetilideno ) piperidin -1-il)1-ciclopropil -6- fluoro-8-metoxi-4-oxo-1,4- dihidroquinolina -3- carboxilico y su uso en el tratamiento de infecciones bacterianas

Info

Publication number
AR079983A1
AR079983A1 ARP110100076A ARP110100076A AR079983A1 AR 079983 A1 AR079983 A1 AR 079983A1 AR P110100076 A ARP110100076 A AR P110100076A AR P110100076 A ARP110100076 A AR P110100076A AR 079983 A1 AR079983 A1 AR 079983A1
Authority
AR
Argentina
Prior art keywords
group
piperidin
oxo
fluoro
amino
Prior art date
Application number
ARP110100076A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR079983A1 publication Critical patent/AR079983A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

Profármacos del ácido (E)-7-(3-(2-amino-1-fluoroetilideno)piperidin-1-il)-1-ciclopropil-6-fluoro-8-metoxi-4-oxo-1,4-dihidroquinolina-3-carboxílico, las composiciones farmacéuticas que los contienen y el uso de dichos profármacos y composiciones farmacéuticas como agentes antimicrobianos contra microorganismos patogenos, particularmente contra microbios resistentes. Reivindicacion 1: Un compuesto de la Formula (1) en donde R1 se selecciona del grupo que consiste del grupo de formulas 2 y -P(O)(OR7)2 R3 se selecciona del grupo que consiste de hidrogeno, alquilo inferior, bencilo, -CH2CO2H, -(CH2)4NH2 y -CH2N(CH3)2; R4 se selecciona del grupo que consiste de hidrogeno y alquilo inferior; R5 se selecciona del grupo que consiste de hidrogeno, y -C(O)-(CH2)2-C(O)-mPEG(2000); R6 se selecciona del grupo que consiste de alquilo inferior y -(CH2)4-NH2 cada R7 se selecciona independientemente de alquilo inferior; y sales farmacéuticamente aceptables de éste.
ARP110100076A 2010-01-11 2011-01-11 Profarmacos de acido (e) -7- (3-(2-amino-1-fluoroetilideno ) piperidin -1-il)1-ciclopropil -6- fluoro-8-metoxi-4-oxo-1,4- dihidroquinolina -3- carboxilico y su uso en el tratamiento de infecciones bacterianas AR079983A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29387010P 2010-01-11 2010-01-11

Publications (1)

Publication Number Publication Date
AR079983A1 true AR079983A1 (es) 2012-03-07

Family

ID=44009816

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100076A AR079983A1 (es) 2010-01-11 2011-01-11 Profarmacos de acido (e) -7- (3-(2-amino-1-fluoroetilideno ) piperidin -1-il)1-ciclopropil -6- fluoro-8-metoxi-4-oxo-1,4- dihidroquinolina -3- carboxilico y su uso en el tratamiento de infecciones bacterianas

Country Status (12)

Country Link
US (1) US20110172193A1 (es)
EP (1) EP2523948A1 (es)
JP (1) JP2013516468A (es)
KR (1) KR20120115367A (es)
CN (1) CN103097373A (es)
AR (1) AR079983A1 (es)
AU (1) AU2011203774A1 (es)
BR (1) BR112012017004A2 (es)
MX (1) MX2012008031A (es)
TW (1) TW201127824A (es)
UY (1) UY33175A (es)
WO (1) WO2011084922A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1675852T3 (pl) * 2003-09-22 2009-07-31 Janssen Pharmaceutica Nv 7-amino-alkilidenylo-heterocykliczne chinolony i naftrydony
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones

Also Published As

Publication number Publication date
AU2011203774A1 (en) 2012-08-02
KR20120115367A (ko) 2012-10-17
JP2013516468A (ja) 2013-05-13
EP2523948A1 (en) 2012-11-21
TW201127824A (en) 2011-08-16
MX2012008031A (es) 2012-11-12
UY33175A (es) 2011-07-29
BR112012017004A2 (pt) 2016-04-05
US20110172193A1 (en) 2011-07-14
CN103097373A (zh) 2013-05-08
WO2011084922A1 (en) 2011-07-14

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