AR077924A1 - Procesos para preparar pemetrexed - Google Patents

Procesos para preparar pemetrexed

Info

Publication number
AR077924A1
AR077924A1 ARP100102999A ARP100102999A AR077924A1 AR 077924 A1 AR077924 A1 AR 077924A1 AR P100102999 A ARP100102999 A AR P100102999A AR P100102999 A ARP100102999 A AR P100102999A AR 077924 A1 AR077924 A1 AR 077924A1
Authority
AR
Argentina
Prior art keywords
pyrrolo
pyrimidin
dihydro
oxo
ethyl
Prior art date
Application number
ARP100102999A
Other languages
English (en)
Inventor
Nageshwar Gunda
Rajasekhar Kadaboina
Veerender Murki
Amarendhar Manda
Sekhar Munaswamy Nariyam
Vinjamuri Raghupati Rama Subrahmanyam
Original Assignee
Reddys Lab Inc Dr
Reddys Lab Ltd Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Inc Dr, Reddys Lab Ltd Dr filed Critical Reddys Lab Inc Dr
Publication of AR077924A1 publication Critical patent/AR077924A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se relaciona con pemetrexed disodio sustancialmente libre de impurezas relacionadas con el proceso. El pemetrexed es util como antineoplásico. También se reivindica la sal de p-toluensulfonato libre de impurezas y pemetrexed disodio libre de impurezas. Reivindicacion 1. Un proceso para preparar sal p-toluensulfonato del éster dialquílico del ácido N-[4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-iI)etil]benzoil]-L-glutámico de formula (1), donde R = alquilo caracterizado porque comprende: a) hacer reaccionar ácido 4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-iI)etil] benzoico de Formula (2) con glutamato de L-dialquilo HCI, en presencia de N-metilpirrolidona (NMP), para obtener éster dialquílico del ácido N-[4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-il)etil]benzoil]-L-glutámico; y b) hacer reaccionar el éster dialquílico del ácido N-[4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-iI)etil] benzoil]-L-glutámico con ácido p-toluenosulfonico, en un solvente orgánico.
ARP100102999A 2009-08-13 2010-08-13 Procesos para preparar pemetrexed AR077924A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1932CH2009 2009-08-13
US30412910P 2010-02-12 2010-02-12

Publications (1)

Publication Number Publication Date
AR077924A1 true AR077924A1 (es) 2011-10-05

Family

ID=43586858

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102999A AR077924A1 (es) 2009-08-13 2010-08-13 Procesos para preparar pemetrexed

Country Status (5)

Country Link
US (1) US20130165654A1 (es)
EP (1) EP2464650A4 (es)
AR (1) AR077924A1 (es)
TW (1) TW201118098A (es)
WO (1) WO2011019986A2 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9254123B2 (en) 2009-04-29 2016-02-09 Hansen Medical, Inc. Flexible and steerable elongate instruments with shape control and support elements
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed
WO2012111027A2 (en) * 2011-02-15 2012-08-23 Hetero Research Foundation Process for pemetrexed disodium
US9051322B2 (en) * 2011-03-23 2015-06-09 Scinopharm Taiwan, Ltd. Process for the production of a pemetrexed salt
KR101767713B1 (ko) * 2011-03-25 2017-08-11 시노팜 타이완 리미티드 페메트렉세드 염의 제조 방법
TR201113223A2 (tr) 2011-12-29 2012-06-21 Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem.
CN103086912A (zh) * 2012-11-14 2013-05-08 湖北一半天制药有限公司 用于制备培美曲塞及其中间体的方法
KR101372788B1 (ko) 2013-08-12 2014-03-10 제일약품주식회사 고순도의 페메트렉시드 이나트륨 염의 제조방법
CN103884784B (zh) * 2013-09-29 2015-07-22 山东新时代药业有限公司 一种培美曲塞二钠中间体的分析检测方法
CN104515815A (zh) * 2013-10-06 2015-04-15 山东新时代药业有限公司 L-谷氨酸二乙酯的分析检测方法
CN104292232A (zh) * 2014-10-01 2015-01-21 山东铂源药业有限公司 一种培美曲塞二钠的杂质a的中间体的合成方法
BR112019002497A2 (pt) 2016-08-12 2019-05-14 L.E.A.F. Holdings Group Llc antifolatos poliglutamatados alfa e gama-d e seus usos
WO2019157129A1 (en) 2018-02-07 2019-08-15 L.E.A.F. Holdings Group Llc Alpha polyglutamated pralatrexate and uses thereof
JP7491572B2 (ja) 2018-02-07 2024-05-28 エル．イー．エー．エフ． ホールディングス グループ エルエルシー アルファポリグルタミン酸化ペメトレキセドおよびその使用
CA3090875A1 (en) 2018-02-14 2019-08-22 L.E.A.F. Holdings Group Llc Gamma polyglutamated lometrexol and uses thereof
CN112521405A (zh) * 2019-09-17 2021-03-19 鲁南制药集团股份有限公司 一种培美曲塞二钠杂质化合物
CN111333658A (zh) * 2020-05-06 2020-06-26 贵州联科中贝制药科技有限公司 一种培美曲塞二钠水合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
AU6890800A (en) * 1999-08-23 2001-03-19 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
EP2334685A4 (en) * 2008-09-08 2011-10-26 Reddys Lab Ltd Dr AMORPHOUS PEMETREXED DISODIUM

Also Published As

Publication number Publication date
EP2464650A4 (en) 2012-12-26
TW201118098A (en) 2011-06-01
US20130165654A1 (en) 2013-06-27
WO2011019986A2 (en) 2011-02-17
WO2011019986A3 (en) 2011-06-30
EP2464650A2 (en) 2012-06-20

Similar Documents

Publication Publication Date Title
AR077924A1 (es) Procesos para preparar pemetrexed
GT201300236A (es) Derivados de pirrolo (2,3-d) pirimidina como inhibidores de quinasa relacionados con tropomiosina
CO7170131A2 (es) Compuestos de heterociclilo
GT201300091A (es) Compuestos de furo (3,2-d) pirimidina
AR107550A1 (es) Un trifluoroacetato de agonista de tlr7, la forma cristalina b, proceso de preparación y su utilización
UY33226A (es) Compuestos de pirrolopirimidina deuterada como inhibidores de la cdk4/6
CR20140132A (es) Derivados de pirrolopirimidina y purina
BR112014000471A2 (pt) processo para preparo de derivados de diamida de ácido antranílico substituídos com tetrazol por meio da reação de ácidos pirazóis com ésteres antranílicos
PE20230156A1 (es) Sal de acido clorhidrico de (r)-4-(3-((s)-1-(4-amino-3-metil-1h pirazolo[3,4-d]pirimidin-1-il)etil)-5-cloro-2-etoxi-6-fluorofenil)pirrolidin-2-ona
EA201490912A1 (ru) Производные [1,2,3]триазоло[4,5-d]пиримидина в качестве агонистов каннабиноидного рецептора 2
PE20121180A1 (es) (heteroarilmetil) tiohidantoinas sustituidas como drogas anticancer
CO6351780A2 (es) Nuevas benzamidas, su preparaccion y su uso como medicamentos
UY31870A (es) Receptor metabotrópico de glutamato potenciadores 286
CY1119452T1 (el) Μια μεθοδος παρασκευης 2-αιθοξυ-1-(2'-((υδροξυamino) ιμινομεθυλο) διφαινυλ-4-υλο) μεθυλο)-1η- βενζο (d) ιμιδαζολο-7-καρβοξυλικο οξυ και τους εστερες αυτου
EA201891768A1 (ru) Кристаллическая форма a агониста tlr7, ее способ получения и использование
UY32381A (es) Derivados de quinazolinona utiles como antagonistas de vanillioides
CR11452A (es) 5-((3,3,3-trifluoro-2-hidroxi-1-arilpropil)amino)-1h-quinolin-2-onas, un proceso para su produccion y su uso como agentes antiflamatorios
DOP2016000276A (es) 2-AMINO-6-METIL-4,4a,5,6-TETRAHIDROPIRANO[3,4-d][1,3]TIAZIN-8a(8H)-IL-1,3-TIAZOL-4-ILAMIDAS
MX2014001789A (es) Procedimiento para preparar derivados de diamida de acido antranilico sustituida con tetrazol haciendo reaccionar benzoxazinonas con aminas.
BR112013001721A2 (pt) processo de síntese de compostos de ureia substituída
ECSP13012548A (es) Inhibidores de oxadiazol de la producción de leucotrienos.
CO6630110A2 (es) Procedimiento para la preparación de ditiino- tetracarboximidas
CU20110108A7 (es) [4-(1-amino-etil)-ciclohexil]-metil-aminas como antibacterianos
WO2012111027A3 (en) Process for pemetrexed disodium
MA34990B1 (fr) Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Legal Events

Date Code Title Description
FB Suspension of granting procedure