AR077924A1 - Procesos para preparar pemetrexed - Google Patents
Procesos para preparar pemetrexedInfo
- Publication number
- AR077924A1 AR077924A1 ARP100102999A ARP100102999A AR077924A1 AR 077924 A1 AR077924 A1 AR 077924A1 AR P100102999 A ARP100102999 A AR P100102999A AR P100102999 A ARP100102999 A AR P100102999A AR 077924 A1 AR077924 A1 AR 077924A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyrrolo
- pyrimidin
- dihydro
- oxo
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se relaciona con pemetrexed disodio sustancialmente libre de impurezas relacionadas con el proceso. El pemetrexed es util como antineoplásico. También se reivindica la sal de p-toluensulfonato libre de impurezas y pemetrexed disodio libre de impurezas. Reivindicacion 1. Un proceso para preparar sal p-toluensulfonato del éster dialquílico del ácido N-[4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-iI)etil]benzoil]-L-glutámico de formula (1), donde R = alquilo caracterizado porque comprende: a) hacer reaccionar ácido 4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-iI)etil] benzoico de Formula (2) con glutamato de L-dialquilo HCI, en presencia de N-metilpirrolidona (NMP), para obtener éster dialquílico del ácido N-[4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-il)etil]benzoil]-L-glutámico; y b) hacer reaccionar el éster dialquílico del ácido N-[4-[2-(2-amino-4,7-dihidro-4-oxo-1H-pirrolo[2,3-d]pirimidin-5-iI)etil] benzoil]-L-glutámico con ácido p-toluenosulfonico, en un solvente orgánico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1932CH2009 | 2009-08-13 | ||
US30412910P | 2010-02-12 | 2010-02-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR077924A1 true AR077924A1 (es) | 2011-10-05 |
Family
ID=43586858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100102999A AR077924A1 (es) | 2009-08-13 | 2010-08-13 | Procesos para preparar pemetrexed |
Country Status (5)
Country | Link |
---|---|
US (1) | US20130165654A1 (es) |
EP (1) | EP2464650A4 (es) |
AR (1) | AR077924A1 (es) |
TW (1) | TW201118098A (es) |
WO (1) | WO2011019986A2 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9254123B2 (en) | 2009-04-29 | 2016-02-09 | Hansen Medical, Inc. | Flexible and steerable elongate instruments with shape control and support elements |
WO2012056285A1 (en) * | 2010-10-25 | 2012-05-03 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of pemetrexed |
EP2675808A4 (en) * | 2011-02-15 | 2014-07-09 | Hetero Research Foundation | PROCESS FOR OBTAINING DISODIUM PEMETREXED |
US9051322B2 (en) * | 2011-03-23 | 2015-06-09 | Scinopharm Taiwan, Ltd. | Process for the production of a pemetrexed salt |
EP2688888B1 (en) * | 2011-03-25 | 2017-06-14 | Scinopharm Taiwan, Ltd. | Process for the production of disodium pemetrexed |
TR201113223A2 (tr) | 2011-12-29 | 2012-06-21 | Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. | Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem. |
CN103086912A (zh) * | 2012-11-14 | 2013-05-08 | 湖北一半天制药有限公司 | 用于制备培美曲塞及其中间体的方法 |
KR101372788B1 (ko) | 2013-08-12 | 2014-03-10 | 제일약품주식회사 | 고순도의 페메트렉시드 이나트륨 염의 제조방법 |
CN103884784B (zh) * | 2013-09-29 | 2015-07-22 | 山东新时代药业有限公司 | 一种培美曲塞二钠中间体的分析检测方法 |
CN104515815A (zh) * | 2013-10-06 | 2015-04-15 | 山东新时代药业有限公司 | L-谷氨酸二乙酯的分析检测方法 |
CN104292232A (zh) * | 2014-10-01 | 2015-01-21 | 山东铂源药业有限公司 | 一种培美曲塞二钠的杂质a的中间体的合成方法 |
JP7227123B2 (ja) | 2016-08-12 | 2023-02-21 | エル.イー.エー.エフ. ホールディングス グループ エルエルシー | αおよびγ-Dポリグルタミン酸化抗葉酸剤およびその使用 |
US11730738B2 (en) | 2018-02-07 | 2023-08-22 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
CN111954531A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化培美曲塞及其用途 |
EP3752157A4 (en) | 2018-02-14 | 2022-07-06 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED LOMETREXOLE AND USES THEREOF |
CN112521405A (zh) * | 2019-09-17 | 2021-03-19 | 鲁南制药集团股份有限公司 | 一种培美曲塞二钠杂质化合物 |
CN111333658A (zh) * | 2020-05-06 | 2020-06-26 | 贵州联科中贝制药科技有限公司 | 一种培美曲塞二钠水合物的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5416211A (en) * | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
WO2001014379A2 (en) * | 1999-08-23 | 2001-03-01 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
EP2334685A4 (en) * | 2008-09-08 | 2011-10-26 | Reddys Lab Ltd Dr | AMORPHOUS PEMETREXED DISODIUM |
-
2010
- 2010-08-09 TW TW099126443A patent/TW201118098A/zh unknown
- 2010-08-13 AR ARP100102999A patent/AR077924A1/es unknown
- 2010-08-13 WO PCT/US2010/045429 patent/WO2011019986A2/en active Application Filing
- 2010-08-13 EP EP10808801A patent/EP2464650A4/en not_active Withdrawn
-
2012
- 2012-02-13 US US13/371,546 patent/US20130165654A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20130165654A1 (en) | 2013-06-27 |
WO2011019986A3 (en) | 2011-06-30 |
EP2464650A2 (en) | 2012-06-20 |
WO2011019986A2 (en) | 2011-02-17 |
TW201118098A (en) | 2011-06-01 |
EP2464650A4 (en) | 2012-12-26 |
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