AR074665A2 - Formula cristalina no solvatada de eplerenona (forma l), sustancia farmacologica y composicion farmaceutica que la comprenden - Google Patents
Formula cristalina no solvatada de eplerenona (forma l), sustancia farmacologica y composicion farmaceutica que la comprendenInfo
- Publication number
- AR074665A2 AR074665A2 ARP090104744A ARP090104744A AR074665A2 AR 074665 A2 AR074665 A2 AR 074665A2 AR P090104744 A ARP090104744 A AR P090104744A AR P090104744 A ARP090104744 A AR P090104744A AR 074665 A2 AR074665 A2 AR 074665A2
- Authority
- AR
- Argentina
- Prior art keywords
- eplerenone
- understand
- pharmaceutical composition
- prepare
- crystalline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Developing Agents For Electrophotography (AREA)
Abstract
Una forma cristalina (Forma L) de la droga eplerenona antagonista del receptor de la aldosterona con una estabilidad física relativamente alta a temperaturas normales de almacenamiento y uso. Se proporcionan composiciones farmacéuticas que incluyen la eplerenona de Forma L, opcionalmente acompanada por una o más de otras formas en estado sólido de la eplerenona, en una cantidad total de dosaje unitario de eplerenona de entre aproximadamente 10 y aproximadamente 1000 mg, y que además incluyen uno o más excipientes aceptables para uso farmacéutico. Se proporcionan procesos para preparar eplerenona de Forma L y para preparar composiciones que incluyen a la eplerenona de Forma L. También se proporciona un método para la profilaxis y/o el tratamiento de una condición o trastorno mediados por la aldosterona, que incluye administrar a un sujeto una cantidad de epIerenona eficaz en términos terapéuticos, donde por lo menos una fracción de la eplerenona presente es eplerenona de Forma L. Reivindicación 1: Una forma cristalina no solvatada de eplerenona (Forma L) caracterizada porque comprende: e) una celda unitaria que comprende un sistema cristalino monoclínico y un grupo espacial de P21; y f) un patrón de difracción de Rayos X del polvo que comprende picos a 8,0 ñ 0,2, 12,4 ñ 0,2, 12,8 ñ 0,2, y 13,3 ñ 0,2 grados a 2theta medidos a una longitud de onda de 1,54056 A.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16968399P | 1999-12-08 | 1999-12-08 | |
US16963999P | 1999-12-08 | 1999-12-08 | |
US16955699P | 1999-12-08 | 1999-12-08 | |
US16970799P | 1999-12-08 | 1999-12-08 | |
US16980799P | 1999-12-08 | 1999-12-08 | |
US16960899P | 1999-12-08 | 1999-12-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074665A2 true AR074665A2 (es) | 2011-02-02 |
Family
ID=27558586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090104744A AR074665A2 (es) | 1999-12-08 | 2009-12-07 | Formula cristalina no solvatada de eplerenona (forma l), sustancia farmacologica y composicion farmaceutica que la comprenden |
Country Status (19)
Country | Link |
---|---|
US (1) | US20090149431A1 (es) |
EP (1) | EP1175434A2 (es) |
JP (2) | JP4219105B2 (es) |
KR (1) | KR100584104B1 (es) |
CN (1) | CN100413881C (es) |
AR (1) | AR074665A2 (es) |
AU (1) | AU2041101A (es) |
BR (1) | BR0008054A (es) |
CA (1) | CA2362845A1 (es) |
CO (1) | CO5280205A1 (es) |
EA (1) | EA008449B1 (es) |
HK (1) | HK1057220A1 (es) |
HU (1) | HUP0201457A3 (es) |
IL (2) | IL144757A0 (es) |
MY (1) | MY143571A (es) |
NO (1) | NO20013857L (es) |
NZ (1) | NZ513962A (es) |
PE (1) | PE20010918A1 (es) |
WO (1) | WO2001041535A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20010821A1 (it) * | 2001-04-17 | 2002-10-17 | Gienne Pharma S P A | Impiego di composti derivati dallo spirolattone per inibire l'azione pro-fibrigenetica delle cellule stellate epatiche e delle cellule musco |
US7235655B2 (en) | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
CA2796307A1 (en) | 2010-05-10 | 2011-11-17 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
WO2011157798A1 (en) | 2010-06-16 | 2011-12-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for stimulating reepithelialisation during wound healing |
CN104844681B (zh) * | 2014-02-13 | 2016-06-01 | 合肥久诺医药科技有限公司 | 一种l晶型依普利酮的精制方法 |
JP6835836B2 (ja) | 2015-10-13 | 2021-02-24 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 脈絡膜血管新生の処置のための方法及び医薬組成物 |
EP3490606B8 (en) | 2016-07-26 | 2024-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
CN108059648A (zh) * | 2017-12-30 | 2018-05-22 | 合肥久诺医药科技有限公司 | 一种依普利酮溶剂合物及其制备方法 |
WO2023031277A1 (en) | 2021-08-31 | 2023-03-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of ocular rosacea |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
FR2634376B1 (fr) * | 1988-07-21 | 1992-04-17 | Farmalyoc | Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation |
IT1227626B (it) * | 1988-11-28 | 1991-04-23 | Vectorpharma Int | Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione |
IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
US5552160A (en) * | 1991-01-25 | 1996-09-03 | Nanosystems L.L.C. | Surface modified NSAID nanoparticles |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
NZ248813A (en) * | 1992-11-25 | 1995-06-27 | Eastman Kodak Co | Polymeric grinding media used in grinding pharmaceutical substances |
US5346702A (en) * | 1992-12-04 | 1994-09-13 | Sterling Winthrop Inc. | Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization |
US5298262A (en) * | 1992-12-04 | 1994-03-29 | Sterling Winthrop Inc. | Use of ionic cloud point modifiers to prevent particle aggregation during sterilization |
US5302401A (en) * | 1992-12-09 | 1994-04-12 | Sterling Winthrop Inc. | Method to reduce particle size growth during lyophilization |
US5340564A (en) * | 1992-12-10 | 1994-08-23 | Sterling Winthrop Inc. | Formulations comprising olin 10-G to prevent particle aggregation and increase stability |
US5336507A (en) * | 1992-12-11 | 1994-08-09 | Sterling Winthrop Inc. | Use of charged phospholipids to reduce nanoparticle aggregation |
US5429824A (en) * | 1992-12-15 | 1995-07-04 | Eastman Kodak Company | Use of tyloxapole as a nanoparticle stabilizer and dispersant |
US5352459A (en) * | 1992-12-16 | 1994-10-04 | Sterling Winthrop Inc. | Use of purified surface modifiers to prevent particle aggregation during sterilization |
US5587143A (en) * | 1994-06-28 | 1996-12-24 | Nanosystems L.L.C. | Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
US5585108A (en) * | 1994-12-30 | 1996-12-17 | Nanosystems L.L.C. | Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays |
US5665331A (en) * | 1995-01-10 | 1997-09-09 | Nanosystems L.L.C. | Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers |
US5560932A (en) * | 1995-01-10 | 1996-10-01 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents |
US5662883A (en) * | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
US5569448A (en) * | 1995-01-24 | 1996-10-29 | Nano Systems L.L.C. | Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
US5571536A (en) * | 1995-02-06 | 1996-11-05 | Nano Systems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
US5560931A (en) * | 1995-02-14 | 1996-10-01 | Nawosystems L.L.C. | Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids |
US5503723A (en) * | 1995-02-08 | 1996-04-02 | Eastman Kodak Company | Isolation of ultra small particles |
US5518738A (en) * | 1995-02-09 | 1996-05-21 | Nanosystem L.L.C. | Nanoparticulate nsaid compositions |
US5622938A (en) * | 1995-02-09 | 1997-04-22 | Nano Systems L.L.C. | Sugar base surfactant for nanocrystals |
US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
US5591456A (en) * | 1995-02-10 | 1997-01-07 | Nanosystems L.L.C. | Milled naproxen with hydroxypropyl cellulose as a dispersion stabilizer |
US5573783A (en) * | 1995-02-13 | 1996-11-12 | Nano Systems L.L.C. | Redispersible nanoparticulate film matrices with protective overcoats |
US5510118A (en) * | 1995-02-14 | 1996-04-23 | Nanosystems Llc | Process for preparing therapeutic compositions containing nanoparticles |
US5580579A (en) * | 1995-02-15 | 1996-12-03 | Nano Systems L.L.C. | Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers |
US5565188A (en) * | 1995-02-24 | 1996-10-15 | Nanosystems L.L.C. | Polyalkylene block copolymers as surface modifiers for nanoparticles |
US5718919A (en) * | 1995-02-24 | 1998-02-17 | Nanosystems L.L.C. | Nanoparticles containing the R(-)enantiomer of ibuprofen |
US5747001A (en) * | 1995-02-24 | 1998-05-05 | Nanosystems, L.L.C. | Aerosols containing beclomethazone nanoparticle dispersions |
US5981744A (en) * | 1995-12-11 | 1999-11-09 | G. D. Searle And Co. | Processes for preparation of 9,11-epoxy steroids and intermediates useful therein |
DK0944644T3 (da) * | 1996-12-11 | 2003-02-03 | Searle & Co | Fremgangsmåde til fremstilling af 3-keto-7-alfa-alkoxycarbonyl-delta-4,5-steroider og mellemprodukter, som er nyttite derfor |
DK1165136T3 (da) * | 1999-03-05 | 2004-01-12 | Searle Llc | Kombinationsterapi af angiotensinomdannende enzyminhibitor og epoxy-steriodal aldosteronantagonist til behandling af cardiovaskulær sygdom |
-
2000
- 2000-12-04 BR BR0008054-3A patent/BR0008054A/pt not_active Application Discontinuation
- 2000-12-04 NZ NZ513962A patent/NZ513962A/en not_active IP Right Cessation
- 2000-12-04 CA CA002362845A patent/CA2362845A1/en not_active Abandoned
- 2000-12-04 EP EP00983683A patent/EP1175434A2/en not_active Withdrawn
- 2000-12-04 WO PCT/US2000/030178 patent/WO2001041535A2/en not_active Application Discontinuation
- 2000-12-04 AU AU20411/01A patent/AU2041101A/en not_active Abandoned
- 2000-12-04 EA EA200100869A patent/EA008449B1/ru not_active IP Right Cessation
- 2000-12-04 CN CNB008057710A patent/CN100413881C/zh not_active Expired - Fee Related
- 2000-12-04 JP JP2001542722A patent/JP4219105B2/ja not_active Expired - Fee Related
- 2000-12-04 HU HU0201457A patent/HUP0201457A3/hu unknown
- 2000-12-04 IL IL14475700A patent/IL144757A0/xx active IP Right Grant
- 2000-12-04 KR KR1020017010042A patent/KR100584104B1/ko not_active IP Right Cessation
- 2000-12-06 CO CO00093237A patent/CO5280205A1/es not_active Application Discontinuation
- 2000-12-06 MY MYPI20005735A patent/MY143571A/en unknown
- 2000-12-06 PE PE2000001302A patent/PE20010918A1/es not_active Application Discontinuation
-
2001
- 2001-08-06 IL IL144757A patent/IL144757A/en not_active IP Right Cessation
- 2001-08-08 NO NO20013857A patent/NO20013857L/no not_active Application Discontinuation
-
2004
- 2004-01-09 HK HK04100148.7A patent/HK1057220A1/xx not_active IP Right Cessation
-
2006
- 2006-09-04 JP JP2006238694A patent/JP2007016043A/ja active Pending
-
2009
- 2009-02-18 US US12/388,228 patent/US20090149431A1/en not_active Abandoned
- 2009-12-07 AR ARP090104744A patent/AR074665A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
PE20010918A1 (es) | 2001-09-10 |
WO2001041535A3 (en) | 2001-11-22 |
WO2001041535A9 (en) | 2002-07-04 |
IL144757A (en) | 2007-07-24 |
EA008449B1 (ru) | 2007-06-29 |
NO20013857L (no) | 2001-10-08 |
NZ513962A (en) | 2004-08-27 |
US20090149431A1 (en) | 2009-06-11 |
EA200100869A1 (ru) | 2002-04-25 |
JP2003515611A (ja) | 2003-05-07 |
JP2007016043A (ja) | 2007-01-25 |
EP1175434A2 (en) | 2002-01-30 |
HK1057220A1 (en) | 2004-03-19 |
KR20020003192A (ko) | 2002-01-10 |
NO20013857D0 (no) | 2001-08-08 |
CA2362845A1 (en) | 2001-06-14 |
JP4219105B2 (ja) | 2009-02-04 |
KR100584104B1 (ko) | 2006-05-30 |
AU2041101A (en) | 2001-06-18 |
CN100413881C (zh) | 2008-08-27 |
CO5280205A1 (es) | 2003-05-30 |
BR0008054A (pt) | 2002-03-12 |
IL144757A0 (en) | 2002-06-30 |
MY143571A (en) | 2011-05-31 |
CN1433427A (zh) | 2003-07-30 |
HUP0201457A2 (en) | 2002-08-28 |
HUP0201457A3 (en) | 2003-07-28 |
WO2001041535A2 (en) | 2001-06-14 |
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Legal Events
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FB | Suspension of granting procedure |