AR073982A1 - Ligandos de receptores de la hormona tiroidea - Google Patents
Ligandos de receptores de la hormona tiroideaInfo
- Publication number
- AR073982A1 AR073982A1 ARP090104121A ARP090104121A AR073982A1 AR 073982 A1 AR073982 A1 AR 073982A1 AR P090104121 A ARP090104121 A AR P090104121A AR P090104121 A ARP090104121 A AR P090104121A AR 073982 A1 AR073982 A1 AR 073982A1
- Authority
- AR
- Argentina
- Prior art keywords
- groups
- alkyl
- cycloalkyl
- aryl
- branched
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a compuestos de la formula general (1) que son ligandos de receptores de la hormona tiroidea y son preferentemente selectivos del receptor beta de la hormona tiroidea (TR-Beta). Asimismo, la presente se refiere a procesos para preparar tales compuestos, sus formas tautoméricas, intermediarios involucrados en su síntesis, sus sales farmacéuticamente aceptables, métodos para utilizar tales compuestos y composiciones farmacéuticas que los contienen. Reivindicacion 1: Compuestos caracterizados por la formula general (1) en donde R = OR1, NHR1, en donde R1 se selecciona de H, o los grupos seleccionados de grupos alquilo C1-6, cicloalquilo C3-7, acilo, arilo, aralquilo lineales o ramificados, cada uno de estos grupos se sustituye además con sustituyentes adecuados; R2 representa hidrogeno, hidroxilo, halo o los grupos seleccionados de alquilo C1-6, cicloalquilo C3-7, arilo, heteroarilo, acilo, oxo, ariloxi, aralquilo, aralcoxi, ácido carboxílico y sus derivados tal como ésteres y amidas, derivados de sulfenilo, derivados de sulfonilo, ácido sulfonico y sus derivados, cada uno de estos grupos se sustituye además con sustituyentes adecuados; o los grupos -CONR5R6, -SO2NR5R6, en los que R5 y R6 son iguales o diferentes y se seleccionan independientemente de H, o los grupos seleccionados de alquilo C1-6, cicloalquilo C3-7, bicicloalquilo, arilo lineales o ramificados, cada uno de estos grupos se sustituye además con sustituyentes adecuados, o R5 y R6 junto con el átomo nitrogeno al cual están unidos forman un anillo cíclico de cinco a ocho miembros que opcionalmente contiene uno o más heteroátomos seleccionados de N, S, O; R3, R4 se seleccionan independientemente de H, halogeno, grupos alquilo C1-6; X se selecciona de O, -CH2-, CO; R7 se selecciona de H, opcionalmente grupos sustituidos seleccionados de grupos alquilo C1-6, cicloalquilo C3-7, acilo, arilo, aralquilo, heteroarilo lineales o ramificados y 'n' representa enteros entre 0 y 2; R8 se selecciona de H, o los grupos seleccionados de grupos alquilo C1-6 lineales o ramificados, que se pueden sustituir además con sustituyentes adecuados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2312MU2008 | 2008-10-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073982A1 true AR073982A1 (es) | 2010-12-15 |
Family
ID=42045241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104121A AR073982A1 (es) | 2008-10-27 | 2009-10-26 | Ligandos de receptores de la hormona tiroidea |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20110301200A1 (es) |
| EP (1) | EP2346814A2 (es) |
| JP (1) | JP2012506854A (es) |
| KR (1) | KR20110077018A (es) |
| CN (1) | CN102197019A (es) |
| AR (1) | AR073982A1 (es) |
| AU (1) | AU2009309229B2 (es) |
| CA (1) | CA2741517A1 (es) |
| EA (1) | EA201170615A1 (es) |
| IL (1) | IL212283A0 (es) |
| MX (1) | MX2011004347A (es) |
| NZ (1) | NZ592286A (es) |
| TW (1) | TW201029960A (es) |
| WO (1) | WO2010049946A2 (es) |
| ZA (1) | ZA201102730B (es) |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2051038B (en) * | 1978-09-01 | 1983-01-12 | Ciba Geigy Ag | Selective combating of weeds and compositions therefor |
| CA2109426A1 (en) * | 1991-04-30 | 1992-10-31 | Hiroyuki Kouji | Triphenylethylene derivative and pharmaceutical drug containing the same |
| IT1271404B (it) * | 1993-08-09 | 1997-05-28 | Hi Chem S P A | Derivati ossimici dell'acido formilfenilacetamido-cefalosporanico |
| GB9828442D0 (en) * | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
| US6344481B1 (en) | 1999-03-01 | 2002-02-05 | Pfizer Inc. | Thyromimetic antiobesity agents |
| CZ20013117A3 (cs) * | 1999-03-01 | 2002-06-12 | Pfizer Products Inc. | Oxamové kyseliny a jejich deriváty jako ligandy thyreoidního receptoru |
| US6787652B1 (en) | 1999-09-30 | 2004-09-07 | Pfizer, Inc. | 6-Azauracil derivatives as thyroid receptor ligands |
| IL151376A0 (en) | 2000-03-31 | 2003-04-10 | Pfizer Prod Inc | Malonamic acids and derivatives thereof as thyroid receptor ligands |
| US6573262B2 (en) * | 2000-07-10 | 2003-06-03 | Bristol-Myers Sqibb Company | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives |
| US6693126B2 (en) * | 2000-10-27 | 2004-02-17 | Choongwae Pharm. Co., Ltd. | Dihydroxyphenyl derivatives for hepatoprotection and treatment of liver diseases |
| CN1511151A (zh) * | 2001-05-24 | 2004-07-07 | ֮����ҩ��ʽ���� | 3-喹啉-2(1h)-亚基二氢吲哚-2-酮衍生物 |
| TW200504021A (en) | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
| US7557143B2 (en) * | 2003-04-18 | 2009-07-07 | Bristol-Myers Squibb Company | Thyroid receptor ligands |
| MX2007014502A (es) | 2005-05-26 | 2008-02-07 | Metabasis Therapeutics Inc | Tiromimeticos para el tratamiento de enfermedades del higado graso. |
| WO2008035359A2 (en) * | 2006-06-12 | 2008-03-27 | Cadila Healthcare Limited | Oximinophenoxyalkanoic acid and phenylalkanoic acid derivatives |
| EP2061657B2 (en) | 2006-08-15 | 2016-06-08 | Panolam Industries International, Inc | Decorative laminate incorporating multi-colored photoluminescent material |
| WO2008062469A2 (en) * | 2006-10-31 | 2008-05-29 | Cadila Healthcare Limited | Selective tr-beta 1 agonist |
| WO2009089093A1 (en) | 2008-01-04 | 2009-07-16 | Quatrx Pharmaceuticals Company | Thyroid hormone receptor agonists |
-
2009
- 2009-10-22 WO PCT/IN2009/000598 patent/WO2010049946A2/en active Application Filing
- 2009-10-22 US US13/126,167 patent/US20110301200A1/en not_active Abandoned
- 2009-10-22 CA CA2741517A patent/CA2741517A1/en not_active Abandoned
- 2009-10-22 MX MX2011004347A patent/MX2011004347A/es not_active Application Discontinuation
- 2009-10-22 NZ NZ592286A patent/NZ592286A/xx not_active IP Right Cessation
- 2009-10-22 KR KR1020117011919A patent/KR20110077018A/ko not_active Application Discontinuation
- 2009-10-22 EA EA201170615A patent/EA201170615A1/ru unknown
- 2009-10-22 JP JP2011532772A patent/JP2012506854A/ja active Pending
- 2009-10-22 AU AU2009309229A patent/AU2009309229B2/en not_active Ceased
- 2009-10-22 CN CN2009801426808A patent/CN102197019A/zh active Pending
- 2009-10-22 EP EP09810886A patent/EP2346814A2/en not_active Withdrawn
- 2009-10-26 AR ARP090104121A patent/AR073982A1/es not_active Application Discontinuation
- 2009-10-26 TW TW098136171A patent/TW201029960A/zh unknown
-
2011
- 2011-04-12 ZA ZA2011/02730A patent/ZA201102730B/en unknown
- 2011-04-12 IL IL212283A patent/IL212283A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010049946A3 (en) | 2010-07-29 |
| NZ592286A (en) | 2012-08-31 |
| WO2010049946A2 (en) | 2010-05-06 |
| KR20110077018A (ko) | 2011-07-06 |
| ZA201102730B (en) | 2012-07-25 |
| TW201029960A (en) | 2010-08-16 |
| CN102197019A (zh) | 2011-09-21 |
| AU2009309229A1 (en) | 2010-05-06 |
| AU2009309229B2 (en) | 2012-03-15 |
| US20110301200A1 (en) | 2011-12-08 |
| EP2346814A2 (en) | 2011-07-27 |
| IL212283A0 (en) | 2011-06-30 |
| JP2012506854A (ja) | 2012-03-22 |
| EA201170615A1 (ru) | 2011-12-30 |
| MX2011004347A (es) | 2011-05-25 |
| CA2741517A1 (en) | 2010-05-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2624795T3 (es) | Derivados de N-(heteroaril)-1-heteroaril-1H-indol-2-carboxamidas, su preparación y su aplicación en terapéutica | |
| AR119698A2 (es) | Compuesto amida n-urea sustituida derivado de aminoácido | |
| ES2579175T3 (es) | Proceso para la producción de intermediarios de estetrol | |
| AR058073A1 (es) | Derivados de imidazol 5-il-pirimidina, procesos de obtencion, composiciones farmaceuticas y usos | |
| CO6290658A2 (es) | Derivados de azetidina y ciclobutano como inhibidores de jack | |
| AR096979A1 (es) | Derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| UY31608A1 (es) | Derivados de carboxamidas n-azabicíclicas, su preparación y su aplicación en terapéutica | |
| AR083849A1 (es) | Antagonistas de mdm2 de espiro-oxindol | |
| AR094300A1 (es) | Derivados de quinolonas | |
| AR091790A1 (es) | Derivados de isoquinolin-1-ona y sus usos | |
| AR079164A1 (es) | Derivados heterociclicos de indol, composiciones farmaceuticas que los comprenden y uso de los mismos para la profilaxis o tratamiento de enfermedades alergicas, inflamatorias y/o autoinmunes. | |
| AR073622A1 (es) | Compuestos de benzo[d]isoxazol moduladores de receptores de dopamina d3 y de la serotonina 5-ht2a, proceso para prepararlos, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento de trastornos psicoticos | |
| AR059184A1 (es) | Derivados de sulfonamidas, su preparacion y su aplicacion en tarapeutica | |
| AR076235A1 (es) | Compuestos organicos y sus usos | |
| AR083069A1 (es) | Analogos de nucleotidos sustituidos | |
| AR080314A1 (es) | Derivado de 1,3,4,8-tetrahidro-2h-pirido (1,2-a) pirazina y su uso como inhibidor de la hiv integrasa | |
| AR066107A1 (es) | Derivados de triazolopiridin - carboxamidas y triazolopirimidin-carboxamidas, su preparacion y su aplicacion en terapeutica como inhibidores de la enzimamonoacil glicerol lipasa y composiciones qu los contienen. | |
| NI201000124A (es) | Derivados de carboxamidas azabicíclicas, su preparación y su aplicación en terapéutica | |
| CO6700838A2 (es) | Compuestos sustituidos de banzamida | |
| AR105522A1 (es) | Derivados de amida sustituida que tienen actividad multimodal contra el dolor | |
| AR054783A1 (es) | Derivados de pirrolo-quinolinas moduladores selectivos de receptores de androgeno | |
| AR068386A1 (es) | Derivados de 1,2,4,5-tetrahidro-3h-3-benzazepinas, su procedimiento de preparacion, composiciones farmaceuticas que los contienen y usos de los mismos en patologias asociadas a los canales hcn, tales como trastornos del aparato cardiovascular. | |
| AR100713A1 (es) | Derivados de amida de compuestos de 1-oxa-4,9-diazaespiro undeceno que tienen actividad multimodal contra el dolor | |
| AR078164A1 (es) | Derivados de isoxazolidina, proceso para preparar dichos compuestos y composiciones farmaceuticas que los comprenden | |
| AR077510A1 (es) | Derivados de dihidroindolonas, su procedimiento de preparacion y las com-posiciones farmaceuticas que los contienen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |