AR073527A1 - Forma cristalina de un acido alcoxiimidazol-1-ilmetil bifenil carboxilico - Google Patents

Forma cristalina de un acido alcoxiimidazol-1-ilmetil bifenil carboxilico

Info

Publication number
AR073527A1
AR073527A1 ARP090103788A ARP090103788A AR073527A1 AR 073527 A1 AR073527 A1 AR 073527A1 AR P090103788 A ARP090103788 A AR P090103788A AR P090103788 A ARP090103788 A AR P090103788A AR 073527 A1 AR073527 A1 AR 073527A1
Authority
AR
Argentina
Prior art keywords
alcoxiimidazol
bifenil
ilmetil
crystalline form
crystalline compound
Prior art date
Application number
ARP090103788A
Other languages
English (en)
Inventor
Robert S Chao
Weijiang Zhang
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of AR073527A1 publication Critical patent/AR073527A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Composiciones farmacéuticas que comprenden el compuesto cristalino, procesos e intermediarios para preparar el compuesto cristalino y usos del compuesto cristalino para tratar enfermedades tales como la hipertension. Reivindicacion 1: Una base libre cristalina de ácido 4'-{2-etoxi-4-etil-5-[((S)-2-mercapto-4-metilpentanoilamino)metil]imidazol-1-ilmetil}-3-fluorobifenil-2-carboxílico, caracterizado porque tiene un patron de difraccion de rayos X en polvo que comprende picos de difraccion en valores 2q de 6,66 +- 0,20, 9,8 +- 0,20 y 18,12 +- 0,20.
ARP090103788A 2008-09-30 2009-09-30 Forma cristalina de un acido alcoxiimidazol-1-ilmetil bifenil carboxilico AR073527A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19476208P 2008-09-30 2008-09-30

Publications (1)

Publication Number Publication Date
AR073527A1 true AR073527A1 (es) 2010-11-10

Family

ID=41572476

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103788A AR073527A1 (es) 2008-09-30 2009-09-30 Forma cristalina de un acido alcoxiimidazol-1-ilmetil bifenil carboxilico

Country Status (17)

Country Link
US (3) US7855221B2 (es)
EP (1) EP2350019B1 (es)
JP (1) JP5495396B2 (es)
KR (1) KR20110060958A (es)
CN (1) CN102171193A (es)
AR (1) AR073527A1 (es)
AU (1) AU2009298634A1 (es)
CA (1) CA2736102A1 (es)
CO (1) CO6351775A2 (es)
ES (1) ES2426688T3 (es)
MX (1) MX2011003321A (es)
MY (1) MY150817A (es)
NZ (1) NZ591870A (es)
RU (1) RU2011117635A (es)
TW (1) TW201014830A (es)
WO (1) WO2010039719A1 (es)
ZA (1) ZA201102124B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
TWI545114B (zh) * 2009-09-29 2016-08-11 施萬生物製藥研發Ｉｐ有限責任公司 製備聯苯基咪唑化合物之方法
WO2011109579A1 (en) 2010-03-04 2011-09-09 Theravance, Inc. Crystalline alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid and methods for preparing thereof
CN103189362B (zh) * 2010-11-10 2015-03-11 施万生物制药研发Ip有限责任公司 烷氧基咪唑-1-基甲基联苯羧酸的结晶形式
EP2462922A1 (en) * 2010-12-10 2012-06-13 Bioprojet New form of administration of enkephalinase inhibitor
US20160002223A1 (en) * 2013-02-21 2016-01-07 Pfizer Inc. Solid forms of a selective cdk4/6 inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238688A (en) * 1990-06-28 1992-05-26 Smithkline Beecham Corp Substituted histidines: pharmaceutical compositions, preparation and uses thereof
DE69425250D1 (de) 1993-03-24 2000-08-17 Searle & Co 1-phenyl-imidazol-2-on bipehenylmethyl verbindungen zur behandlung von kreislaufstörungen
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
WO2011109579A1 (en) * 2010-03-04 2011-09-09 Theravance, Inc. Crystalline alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid and methods for preparing thereof

Also Published As

Publication number Publication date
RU2011117635A (ru) 2012-11-10
CO6351775A2 (es) 2011-12-20
WO2010039719A1 (en) 2010-04-08
US8455530B2 (en) 2013-06-04
CN102171193A (zh) 2011-08-31
MX2011003321A (es) 2011-06-16
ZA201102124B (en) 2011-11-30
US8153675B2 (en) 2012-04-10
JP2012504145A (ja) 2012-02-16
EP2350019B1 (en) 2013-07-24
EP2350019A1 (en) 2011-08-03
KR20110060958A (ko) 2011-06-08
JP5495396B2 (ja) 2014-05-21
MY150817A (en) 2014-02-28
ES2426688T3 (es) 2013-10-24
TW201014830A (en) 2010-04-16
US20100081697A1 (en) 2010-04-01
US20110224272A1 (en) 2011-09-15
US20120309805A1 (en) 2012-12-06
AU2009298634A1 (en) 2010-04-08
US7855221B2 (en) 2010-12-21
NZ591870A (en) 2012-09-28
CA2736102A1 (en) 2010-04-08

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Legal Events

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