AR072239A1 - 5-[1'-(decahidro-7-hidroxi-1,1,3a,7-tetrametil-1h-ciclopropa[a]naftalen-4-il)-3'-metilbutil]-2,4,6-trihidroxi-1,3-benzenodicarboxaldehido como medicamentos - Google Patents

5-[1'-(decahidro-7-hidroxi-1,1,3a,7-tetrametil-1h-ciclopropa[a]naftalen-4-il)-3'-metilbutil]-2,4,6-trihidroxi-1,3-benzenodicarboxaldehido como medicamentos

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Publication number
AR072239A1
AR072239A1 ARP090100133A ARP090100133A AR072239A1 AR 072239 A1 AR072239 A1 AR 072239A1 AR P090100133 A ARP090100133 A AR P090100133A AR P090100133 A ARP090100133 A AR P090100133A AR 072239 A1 AR072239 A1 AR 072239A1
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AR
Argentina
Prior art keywords
disorders
diseases
disorder
cyclopropa
neurological
Prior art date
Application number
ARP090100133A
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English (en)
Inventor
Philippe Joulia
Christel Fiorini-Puybaret
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of AR072239A1 publication Critical patent/AR072239A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/57Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups polycyclic
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pain & Pain Management (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Psychiatry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Psychology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
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  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)

Abstract

La presente se refiere a compuestos de formula (1) así como a su utilizacion como medicamentos. Preferentemente, dichos compuestos se utilizan para la preparacion de un medicamento o de un complemento alimenticio destinado al tratamiento y/o a la prevencion de las afecciones o patologías que derivan de un desorden de la recaptura de los neuromediadores siguientes: dopamina, serotonina y/o noradrenalina. Reivindicacion 1: Compuestos de formula (1') extendiéndose que las formas siguientes están excluidas: 5-[(1'R)-1'-[1aS,3aS,4S,7R,7aR,7bS)-decahidro-7-hidroxi-1,1,3a,7-tetrametil-1H-ciclopropa[a]naftalen-4-il]-3'-metilbutil]-2,4,6-trihidroxi-1,3-bencenodicarboxaldehído; y 5-[(1'S)-1'-[(1aS,3aS,4S,7R,7aR,7bS)-decahidro-7-hidroxi-1,1,3a,7-tetrametil-1H-ciclopropa[a]naftalen-4-il]-3'-metilbutil]-2,4,6-trihidroxi-1,3-bencenodicarboxaldehído. Reivindicacion 11: Utilizacion segun la reivindicacion 9, caracterizada porque la patología o la afeccion neurologica, psiquiátrica o trastorno asociado, el trastorno somático funcional o la dependencia a las sustancias adictivas se selecciona del grupo que comprende: las enfermedades neurologicas, tales como las enfermedades neurodegenerativas (enfermedad de Alzheimer, corea de Huntington, enfermedad de Parkinson, accidentes vasculares cerebrales, traumatismo craneal), la esclerosis lateral amiotrofica, las demencias seniles, las demencias fronto-temporales, las demencias vasculares, la jaqueca, los dolores neuropáticos de origen central; las enfermedades psiquiátricas, tales como la depresion (endogena, resistente, reactiva o yatrogena), el estado depresivo, la esquizofrenia, el trastorno bipolar, la ansiedad generalizada, las enfermedades ligadas al estrés, los ataques de pánico, los trastornos obsesivos compulsivos, los síndromes de estrés pos-traumáticos, los trastornos de la atencion y la hiperactividad, los trastornos de conductas alimenticias (principalmente la bulimia y la anorexia), la fobia (principalmente la agorafobia), el autismo; los trastornos de la memoria, de la atencion y de la vigilancia asociados a enfermedades, afecciones o trastornos neurologicos y psiquiátricos; los trastornos somáticos funcionales tales como el síndrome de la fatiga cronica, la fibromialgia, el síndrome del colon irritable, los reflujos gastro-esofaríngeos, la pérdida de la libido, los trastornos de la ereccion, las incontinencias urinarias; las dependencias a sustancias adictivas principalmente a la nicotina, al alcohol, a los opiáceos, a los cannabinoides y a los psicoestimulantes.
ARP090100133A 2008-01-18 2009-01-16 5-[1'-(decahidro-7-hidroxi-1,1,3a,7-tetrametil-1h-ciclopropa[a]naftalen-4-il)-3'-metilbutil]-2,4,6-trihidroxi-1,3-benzenodicarboxaldehido como medicamentos AR072239A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0800276A FR2926547B1 (fr) 2008-01-18 2008-01-18 5-°1-(decahydro-7-hydroxy-1,1,3a,7-tetramethyl-1h- cyclopropa°a!naphtalen-4-yl)-3-methylbutyl!-2,4,6-trihydroxy -1,3-benzenedicarboxaldehyde en tant que medicaments.

Publications (1)

Publication Number Publication Date
AR072239A1 true AR072239A1 (es) 2010-08-18

Family

ID=39764878

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100133A AR072239A1 (es) 2008-01-18 2009-01-16 5-[1'-(decahidro-7-hidroxi-1,1,3a,7-tetrametil-1h-ciclopropa[a]naftalen-4-il)-3'-metilbutil]-2,4,6-trihidroxi-1,3-benzenodicarboxaldehido como medicamentos

Country Status (18)

Country Link
US (1) US20100286284A1 (es)
EP (1) EP2230933A1 (es)
JP (1) JP2011509979A (es)
KR (1) KR20100103852A (es)
CN (1) CN101909462A (es)
AR (1) AR072239A1 (es)
AU (1) AU2009220011A1 (es)
BR (1) BRPI0907229A2 (es)
CA (1) CA2710996A1 (es)
FR (1) FR2926547B1 (es)
IL (1) IL206772A0 (es)
MA (1) MA31933B1 (es)
MX (1) MX2010005607A (es)
RU (1) RU2453527C2 (es)
TN (1) TN2010000242A1 (es)
TW (1) TW200944193A (es)
WO (1) WO2009106769A1 (es)
ZA (1) ZA201003818B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107986951B (zh) * 2017-12-15 2021-04-23 中国科学院昆明植物研究所 新型拓扑异构酶i抑制剂及其药物组合物与其制备方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4447336C2 (de) * 1994-12-31 1996-12-19 Goebel Hartmut J Dr Med Habil Verwendung eines Gemisches aus Cineol und Menthol
JP3957952B2 (ja) * 1999-06-10 2007-08-15 花王株式会社 セラミド産生促進剤
RU2274468C2 (ru) * 2004-06-07 2006-04-20 Кубанский государственный технологический университет Способ получения масляных экстрактов из растительного сырья
FR2904557B1 (fr) * 2006-08-01 2010-04-30 Pf Medicament Nouvel extrait d'eucalyptus, son procede de preparation et ses utilisations therapeutiques
EP1939166A1 (en) * 2006-12-19 2008-07-02 InterMed Discovery GmbH Plants extracts for use in brain modulation

Also Published As

Publication number Publication date
IL206772A0 (en) 2010-12-30
BRPI0907229A2 (pt) 2015-07-14
EP2230933A1 (fr) 2010-09-29
KR20100103852A (ko) 2010-09-28
AU2009220011A1 (en) 2009-09-03
MA31933B1 (fr) 2010-12-01
RU2453527C2 (ru) 2012-06-20
CA2710996A1 (fr) 2009-09-03
ZA201003818B (en) 2011-03-30
WO2009106769A1 (fr) 2009-09-03
TW200944193A (en) 2009-11-01
CN101909462A (zh) 2010-12-08
FR2926547A1 (fr) 2009-07-24
FR2926547B1 (fr) 2010-04-23
TN2010000242A1 (fr) 2011-11-11
US20100286284A1 (en) 2010-11-11
RU2010134420A (ru) 2012-02-27
MX2010005607A (es) 2010-06-22
JP2011509979A (ja) 2011-03-31

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