AR071069A1 - Derivados sustituidos de pirazol y su uso para la prevencion o el tratamiento de cancer - Google Patents

Derivados sustituidos de pirazol y su uso para la prevencion o el tratamiento de cancer

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Publication number
AR071069A1
AR071069A1 ARP090101059A ARP090101059A AR071069A1 AR 071069 A1 AR071069 A1 AR 071069A1 AR P090101059 A ARP090101059 A AR P090101059A AR P090101059 A ARP090101059 A AR P090101059A AR 071069 A1 AR071069 A1 AR 071069A1
Authority
AR
Argentina
Prior art keywords
group
atom
conh
formula
hydrogen atom
Prior art date
Application number
ARP090101059A
Other languages
English (en)
Inventor
Mitsuhiro Ito
Naoki Tomita
Tomohiko Suzaki
Tomohiro Kaku
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR071069A1 publication Critical patent/AR071069A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicacion 1: Un compuesto caracterizado por la formula (1) en donde R1' es (1) un átomo de hidrogeno, (2) un grupo a través de un átomo de carbono, (3) un grupo a través de un átomo de N; (4) un grupo a través de un átomo de oxígeno o (5) un grupo a través de un átomo de azufre; R2' es un grupo de anillo aromático que opcionalmente tiene sustituyentes; R3' es (1) un átomo de hidrogeno, (2) un grupo a través de un átomo de carbono, (3) un grupo a través de un átomo de nitrogeno, (4) un grupo a través de un átomo de oxígeno o (5) un grupo a través de un átomo de azufre; R4' es un grupo de cianofenilo que opcionalmente tiene sustituyentes; X' es (1) -Y'-CR5'R6'-Z'- en donde R5' y R6' son iguales o diferentes y cada uno es un átomo de hidrogeno, un grupo a través de un átomo de carbono, un grupo a través de un átomo de nitrogeno, un grupo a través de un átomo de oxígeno o un grupo a través de un átomo de azufre o -CR5'R6'- es -C(alquilideno)-; Y' es un enlace, -COCO-, -CONH-, -COCONH- u -O-; y Z' es un enlace, -CH2-, -CONH-, -O-, -OCH2-, -S-, -SO-, -SO2-, -CON(C6H5)- o un compuesto de formula (2), (2) -CO(CONH)n- en donde n es 0 o 1, (3) -NHCO-, (4) -CONH-, (5) -O-, (6) -CH=CH- o (7) -O(alquilen C1-3)O-; excluyendo los compuestos de formulas (3), un compuesto representado por la formula (4) en donde uno de Rd, Rd1 y Rd2 es un grupo ciano y los otros dos grupos son iguales o diferentes y cada uno es un átomo de hidrogeno, un átomo de cloro o un grupo metilo y un compuesto representado por la formula (5) en donde Re1 es un grupo metilo, un grupo etilo o un grupo metoximetilo, uno de Re2 y Re3 es un grupo ciano y el otro es un átomo de hidrogeno, o una de sus sales. Reivindicacion 2: Un compuesto caracterizado por la formula (6) en donde R1 es (1) un átomo de hidrogeno, (2) un grupo a través de un átomo de carbono, (3) un grupo a través de un átomo de nitrogeno, (4) un grupo a través de un átomo de oxígeno o (5) un grupo a través de un átomo de azufre; R2 es un grupo de anillo aromático que opcionalmente tiene sustituyentes; R3 es (1) un átomo de hidrogeno, (2) un grupo a través de un átomo de carbono, (3) un grupo a través de un átomo de nitrogeno, (4) un grupo a través de un átomo de oxígeno o (5) un grupo a través de un átomo de azufre; R4 es un grupo de cianofenilo que opcionalmente tiene sustituyentes; X es (1) -Y-CR5R6-Z- en donde R5 y R6 son iguales o diferentes y cada uno es un átomo de hidrogeno, un grupo a través de un átomo de carbono, un grupo a través de un átomo de nitrogeno, un grupo a través de un átomo de oxígeno o un grupo a través de un átomo de azufre o -CR5R6- es -C(alquilideno)-; Y es un enlace, -COCO-, -CONH-, -COCONH- u -O-; y Z es un enlace, -CH2-, -CONH-, -O-, -OCH2-, -S-, -SO-, o -SO2-, (2) -CO(CONH)n- en donde n es 0 o 1, (3) -NHCO-, (4) -CONH-, (5) -O- o (6) -CH=CH-; excluyendo los siguientes compuestos de formulas (3); un compuesto representado por la formula (4) en donde uno de Rd, Rd1 y Rd2 es un grupo ciano y los otros dos grupos son iguales o diferentes y cada uno es un átomo de hidrogeno, un átomo de cloro o un grupo metilo y un compuesto representado por la formula (5) en donde Re1 es un grupo metilo, un grupo etilo o un grupo metoximetilo, uno de Re2 y Re3 es un grupo ciano y el otro es un átomo de hidrogeno, o una de sus sales.
ARP090101059A 2008-03-26 2009-03-25 Derivados sustituidos de pirazol y su uso para la prevencion o el tratamiento de cancer AR071069A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2008082029 2008-03-26

Publications (1)

Publication Number Publication Date
AR071069A1 true AR071069A1 (es) 2010-05-26

Family

ID=40934870

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090101059A AR071069A1 (es) 2008-03-26 2009-03-25 Derivados sustituidos de pirazol y su uso para la prevencion o el tratamiento de cancer

Country Status (6)

Country Link
US (1) US20090270361A1 (es)
AR (1) AR071069A1 (es)
PE (1) PE20091653A1 (es)
TW (1) TW200944506A (es)
UY (1) UY31736A (es)
WO (1) WO2009119880A1 (es)

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AR078793A1 (es) 2009-10-27 2011-12-07 Orion Corp Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros
US8697911B2 (en) 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
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KR102736865B1 (ko) 2017-06-21 2024-12-03 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
JP7407461B2 (ja) 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物
KR102504830B1 (ko) * 2020-07-14 2023-03-02 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 새로운 구조의 화합물 및 이를 포함하는 약제학적 조성물
KR102685058B1 (ko) 2020-09-02 2024-07-15 주식회사 종근당 히스톤 탈아세틸화효소 6 억제제로서의 새로운 구조의 화합물 및 이를 포함하는 약제학적 조성물
CN113861186B (zh) * 2021-09-10 2023-08-25 浙江师范大学 基于异恶唑取代苯甲酰胺类衍生物及抗前列腺癌药物应用
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CN116496218B (zh) * 2023-04-27 2025-07-22 河南大学 一种n-乙烯基吡唑类化合物的合成方法

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Also Published As

Publication number Publication date
TW200944506A (en) 2009-11-01
UY31736A (es) 2009-11-10
US20090270361A1 (en) 2009-10-29
PE20091653A1 (es) 2009-11-14
WO2009119880A1 (en) 2009-10-01

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