AR070856A1 - Derivados de sulfonamidas substituidos - Google Patents
Derivados de sulfonamidas substituidosInfo
- Publication number
- AR070856A1 AR070856A1 ARP090100764A ARP090100764A AR070856A1 AR 070856 A1 AR070856 A1 AR 070856A1 AR P090100764 A ARP090100764 A AR P090100764A AR P090100764 A ARP090100764 A AR P090100764A AR 070856 A1 AR070856 A1 AR 070856A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- aryl
- heteroaryl
- cycloalkyl
- linked
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente está relacionada con derivados de sulfonamida sustituida, medicamentos que contienen estos compuestos y el uso de los derivados de sulfonamida sustituida para la preparacion de medicamentos. Reivindicacion 1: Derivados de sulfonamida sustituida de formula general 1 caracterizado porque n representa 0, 1 o 2; o representa 1, 2 o 3; p representa 1 o 2; q representa 0 o 1; 3 representa 0 o 1; Q representa un enlace simple, -O- o -CH2-; R1 representa arilo o heteroarilo o indica un arilo o heteroarilo ligado mediante un grupo de C1-3-alquilenos; R2 y R3 se definen segun la siguiente descripcion (i) o (ii); (i) R2 representa H, C1-6-alquilo, C3-8cicloalquilo, arilo o heteroarilo; o indica un C3-8cicloalquilo, arilo o heteroarilo ligado mediante un grupo de C1-6-alquilenos, un grupo de C2-6-alquenilenos o un grupo de C2-6-alquinilenos; R3 representa H, C1-6alquilo, arilo o heteroarilo: o indica un arilo o heteroarilo ligado mediante un grupo de C1-6-alquilenos, un grupo de C2-6-alquenilenos o un grupo de C2-6-alquinilenos; o (ii) R2 y R3 juntos forman un anillo heterocíclico, que puede fusionarse con un radical de arilo o heteroarilo, caracterizado porque el anillo heterocíclico es saturado o al menos monosaturado, pero no aromático, tiene 4, 5, 6 o 7 miembros, puede contener, además del heteroátomo N al que está ligado el radical R2, al menos un heteroátomo o grupo de heteroátomos adicional que se escoge del grupo que consiste en N, NR12, O, S, S=O o S(=O)2; caracterizado porque el radical R12 representa H, C1-6-alquilo, -C(=O)-R13, C3-8-cicloalquilo, arilo, heteroarilo o un C3-8-cicloalquilo, arilo o heteroarilo ligado mediante un grupo de C1-3-alquilenos, y R13 indica C1-6-alquilo, C3-8-cicloalquilo, arilo, heteroarilo o un C3-8-cicloalquilo, arilo o heteroarilo ligado mediante un grupo de C1-3-alquilenos, R4 y R5, independientes uno del otro, representan H, C1-6-alquilo, C2-8-alquenilo, C2-6- alquinilo, C3-8-cicloalquilo, heterocicloalquilo, arilo o heteroarilo de 3 a 8 miembros o un C3-8-cicloalquilo, heterocicloalquilo, arilo o heteroarilo de 3 a 8 miembros ligado mediante un grupo de C1-3-alquilenos; o R4 y R5 juntos forman un anillo heterocíclico no sustituido o monosustituido o polisustituido, que puede fusionarse con un sistema de anillos no sustituidos o monosustituidos o polisustituídos saturados, al menos monosaturados o aromáticos, caracterizado porque el anillo heterocíclico es saturado, al menos monosaturado, pero no aromático, tiene 4, 5, 6 o 7 miembros, puede contener, además del heteroátomo N al que están ligados los radicales R4 y R5, al menos un heteroátomo o grupo de heteroátomos que se escoge del grupo que consiste en N, NR8, O, S, S=O y S(=O)2; el sistema de anillos tiene 4, 5, 6 o 7 miembros, puede contener al menos un heteroátomo o grupo de heteroátomos que se escoge del grupo que consiste en N, NR17, O, S, S=O y S(=O)2, R8 representa un radical que se escoge del grupo que consiste en H, C1-8-alquilo, C3-8-cicloalquilo, arilo, heteroarilo o un arilo, heteroarilo o C3-8-cicloalquilo ligado mediante un grupo de C1-3-alquilenos y R17 representa un radical que se escoge del grupo que consiste en H, C1-6-alquilo, C3-8-cicloalquilo, arilo, heteroarilo o un arilo, heteroarilo o C3-8-cicloalquilo ligado mediante un grupo de C1-3-alquilenos; R6 representa H, C1-6-alquilo o un C3-8-cicloalquilo ligado mediante un grupo de C1-3-alquilenos, un arilo ligado mediante un grupo de C1-3-alquilenos o un heteroarilo ligado mediante un grupo de C1-3-alquilenos, y R7 representa C1-6-alquilo, C2-6-alquenilo o C2-6-alquinilo, C3-8-cicloaIquilo, arilo o heteroarilo, o indica un C3-8-cicloalquilo, arilo o heteroarilo ligado mediante un grupo de C1-6-alquilenos, o R6 y R7, con la inclusion del grupo -N-C(=O), forman un anillo del tipo (2) caracterizado porque d representa 0 o 1 y R14 y R15 juntos representan un radical de arilo o heteroarilo no sustituido o sustituido fusionado; caracterizado porque los radicales antes mencionados C1-6-alquiIo, C1-6-alquileno, C2-6-alquenileno, C2-6-alquiniIeno, C3-8-cicloalquilo, C3-8-heterocicloalquilo, arilo y heteroarilo pueden en cada caso ser no sustituidos o sustituidos una o varias veces por radicales idénticos o diferentes y los radicales antes mencionados C1-6-alquilo, C1-6-alquileno, C2-6-alquenileno y C2-6-alquinileno pueden en cada caso ser ramificados o no ramificados; en la forma de un enantiomero individual o de un diastereomero individual, del racemato, de los enantiomeros, de los diastereomeros, mezclas de los enantiomeros y/o diastereomeros, y en cada caso en la forma de sus bases y/o sales fisiologicamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08004073 | 2008-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR070856A1 true AR070856A1 (es) | 2010-05-12 |
Family
ID=39672037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090100764A AR070856A1 (es) | 2008-03-05 | 2009-03-04 | Derivados de sulfonamidas substituidos |
Country Status (9)
Country | Link |
---|---|
US (1) | US8541573B2 (es) |
EP (1) | EP2254867A1 (es) |
JP (1) | JP2011514344A (es) |
AR (1) | AR070856A1 (es) |
CA (1) | CA2717604A1 (es) |
CL (1) | CL2009000519A1 (es) |
PE (1) | PE20091807A1 (es) |
TW (1) | TW200940528A (es) |
WO (1) | WO2009109364A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2664810A1 (en) * | 2006-09-29 | 2008-04-10 | Gruenenthal Gmbh | Substituted sulfonamide derivatives |
US8318769B2 (en) * | 2008-04-08 | 2012-11-27 | Gruenethal Gmbh | Substituted sulfonamide compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002080928A1 (en) * | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
WO2004092164A1 (en) * | 2003-04-10 | 2004-10-28 | Amgen, Inc. | Cyclic amine derivatives and their use in the treatment of inflammation-related disorders mediated by bradykinin |
EP1631542A1 (en) * | 2003-04-10 | 2006-03-08 | Amgen, Inc. | Bicyclic compounds having bradykinin receptors affinity and pharmaceutical compositions thereof |
WO2007101007A2 (en) | 2006-02-23 | 2007-09-07 | Neurogen Corporation | Aryl sulfonyl heterocycles |
-
2009
- 2009-02-20 TW TW098105367A patent/TW200940528A/zh unknown
- 2009-03-03 PE PE2009000321A patent/PE20091807A1/es not_active Application Discontinuation
- 2009-03-04 EP EP09717566A patent/EP2254867A1/en not_active Withdrawn
- 2009-03-04 WO PCT/EP2009/001520 patent/WO2009109364A1/en active Application Filing
- 2009-03-04 CA CA2717604A patent/CA2717604A1/en not_active Abandoned
- 2009-03-04 JP JP2010549051A patent/JP2011514344A/ja not_active Ceased
- 2009-03-04 US US12/397,771 patent/US8541573B2/en not_active Expired - Fee Related
- 2009-03-04 AR ARP090100764A patent/AR070856A1/es not_active Application Discontinuation
- 2009-03-05 CL CL2009000519A patent/CL2009000519A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA2717604A1 (en) | 2009-09-11 |
PE20091807A1 (es) | 2009-11-21 |
CL2009000519A1 (es) | 2010-03-05 |
TW200940528A (en) | 2009-10-01 |
US20090298812A1 (en) | 2009-12-03 |
JP2011514344A (ja) | 2011-05-06 |
EP2254867A1 (en) | 2010-12-01 |
WO2009109364A1 (en) | 2009-09-11 |
US8541573B2 (en) | 2013-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |