AR068970A1 - Proceso para preparar topotecano - Google Patents
Proceso para preparar topotecanoInfo
- Publication number
- AR068970A1 AR068970A1 ARP080101529A ARP080101529A AR068970A1 AR 068970 A1 AR068970 A1 AR 068970A1 AR P080101529 A ARP080101529 A AR P080101529A AR P080101529 A ARP080101529 A AR P080101529A AR 068970 A1 AR068970 A1 AR 068970A1
- Authority
- AR
- Argentina
- Prior art keywords
- topotechan
- prepare
- group
- nr1r2
- camptothecin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
Reivindicación 1: Un proceso para preparar topotecano o una de sus sales farmacéuticamente aceptables, caracterizado porque comprende hacer reaccionar 10-hidroxi-camptotecina con una sal de iminio de la fórmula (1): [H₂C=NR¹R²]⁺ X (1) en donde R¹ y R² representan un grupo metilo o un grupo CH₂R³; R³ representa un grupo protector; X representa un anión; en presencia de una base y un solvente orgánico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92291807P | 2007-04-11 | 2007-04-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR068970A1 true AR068970A1 (es) | 2009-12-23 |
Family
ID=39864238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101529A AR068970A1 (es) | 2007-04-11 | 2008-04-11 | Proceso para preparar topotecano |
Country Status (14)
Country | Link |
---|---|
US (1) | US7977483B2 (es) |
EP (1) | EP2148882B8 (es) |
JP (1) | JP5315335B2 (es) |
KR (1) | KR20100015824A (es) |
CN (1) | CN101679450B (es) |
AR (1) | AR068970A1 (es) |
AU (1) | AU2008239680B2 (es) |
CA (1) | CA2683937C (es) |
ES (1) | ES2390388T3 (es) |
HR (1) | HRP20120739T1 (es) |
IL (1) | IL201455A (es) |
NZ (1) | NZ580344A (es) |
TW (1) | TWI360419B (es) |
WO (1) | WO2008127606A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2373172B1 (es) * | 2010-07-16 | 2012-12-10 | Consejo Superior De Investigaciones Científicas (Csic) | Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5004758A (en) | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
ES2137932T3 (es) | 1990-09-28 | 2000-01-01 | Smithkline Beecham Corp | Procedimiento para la preparacion de analogos de camptotecina solubles en agua, asi como los compuestos 10-hidroxi-11-alcoxi-6-camptotecina. |
US6660861B1 (en) | 2003-03-27 | 2003-12-09 | Council Of Scientific And Industrial Research | Process for preparing Topotecan from 10-hydroxy-4-(S) camptothecin |
EP1608660B1 (en) * | 2003-03-31 | 2007-10-10 | Council of Scientific and Industrial Research | Process for preparing topotecan from 10-hydroxy-4-(s) camptothecin |
TWI333492B (en) | 2003-11-12 | 2010-11-21 | Smithkline Beecham Cork Ltd | Crystalline topotecan hydrochloride product and preparation thereof |
US7547785B2 (en) * | 2005-12-26 | 2009-06-16 | Dr. Reddy's Laboratories Limited | Process for preparing topotecan |
-
2008
- 2008-04-09 US US12/082,162 patent/US7977483B2/en not_active Expired - Fee Related
- 2008-04-10 AU AU2008239680A patent/AU2008239680B2/en not_active Ceased
- 2008-04-10 ES ES08742705T patent/ES2390388T3/es active Active
- 2008-04-10 NZ NZ580344A patent/NZ580344A/en not_active IP Right Cessation
- 2008-04-10 WO PCT/US2008/004610 patent/WO2008127606A1/en active Application Filing
- 2008-04-10 TW TW097113081A patent/TWI360419B/zh not_active IP Right Cessation
- 2008-04-10 EP EP08742705A patent/EP2148882B8/en not_active Not-in-force
- 2008-04-10 CA CA2683937A patent/CA2683937C/en not_active Expired - Fee Related
- 2008-04-10 JP JP2010503051A patent/JP5315335B2/ja not_active Expired - Fee Related
- 2008-04-10 CN CN2008800177733A patent/CN101679450B/zh not_active Expired - Fee Related
- 2008-04-10 KR KR1020097022152A patent/KR20100015824A/ko active IP Right Grant
- 2008-04-11 AR ARP080101529A patent/AR068970A1/es unknown
-
2009
- 2009-10-11 IL IL201455A patent/IL201455A/en not_active IP Right Cessation
-
2012
- 2012-09-17 HR HRP20120739AT patent/HRP20120739T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
CN101679450A (zh) | 2010-03-24 |
TW200902004A (en) | 2009-01-16 |
IL201455A0 (en) | 2010-05-31 |
ES2390388T3 (es) | 2012-11-12 |
TWI360419B (en) | 2012-03-21 |
EP2148882B8 (en) | 2013-02-27 |
EP2148882B1 (en) | 2012-06-20 |
US7977483B2 (en) | 2011-07-12 |
US20090221826A1 (en) | 2009-09-03 |
NZ580344A (en) | 2012-02-24 |
JP5315335B2 (ja) | 2013-10-16 |
AU2008239680A1 (en) | 2008-10-23 |
WO2008127606A1 (en) | 2008-10-23 |
KR20100015824A (ko) | 2010-02-12 |
CA2683937A1 (en) | 2008-10-23 |
CA2683937C (en) | 2013-03-26 |
EP2148882A4 (en) | 2010-05-19 |
AU2008239680B2 (en) | 2013-04-04 |
JP2010523672A (ja) | 2010-07-15 |
CN101679450B (zh) | 2012-05-02 |
HRP20120739T1 (hr) | 2012-12-31 |
EP2148882A1 (en) | 2010-02-03 |
IL201455A (en) | 2014-02-27 |
WO2008127606A8 (en) | 2013-02-07 |
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