WO2013003315A3 - Methods for preparing isoquinolines - Google Patents

Methods for preparing isoquinolines Download PDF

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Publication number
WO2013003315A3
WO2013003315A3 PCT/US2012/044141 US2012044141W WO2013003315A3 WO 2013003315 A3 WO2013003315 A3 WO 2013003315A3 US 2012044141 W US2012044141 W US 2012044141W WO 2013003315 A3 WO2013003315 A3 WO 2013003315A3
Authority
WO
WIPO (PCT)
Prior art keywords
isoquinolines
preparing
methods
isoquinoline
cortistatins
Prior art date
Application number
PCT/US2012/044141
Other languages
French (fr)
Other versions
WO2013003315A2 (en
Inventor
Andrew G. Myers
Chong Si
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Publication of WO2013003315A2 publication Critical patent/WO2013003315A2/en
Publication of WO2013003315A3 publication Critical patent/WO2013003315A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided herein are novel synthetic methods of making isoquinolines comprising coupling a metalated N-(2-methylbenzylidene)amine with a nitrile, followed by cyclization, to provide a substituted isoquinoline compound. This new methodology for preparing isoquinolines may be used to prepare pharmaceutical agents, such as cortistatins, which include a isoquinoline moiety.
PCT/US2012/044141 2011-06-26 2012-06-26 Methods for preparing isoquinolines WO2013003315A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161501232P 2011-06-26 2011-06-26
US61/501,232 2011-06-26

Publications (2)

Publication Number Publication Date
WO2013003315A2 WO2013003315A2 (en) 2013-01-03
WO2013003315A3 true WO2013003315A3 (en) 2013-03-07

Family

ID=47424759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/044141 WO2013003315A2 (en) 2011-06-26 2012-06-26 Methods for preparing isoquinolines

Country Status (1)

Country Link
WO (1) WO2013003315A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104478799B (en) * 2014-11-18 2016-11-16 上海交通大学 The preparation method of 1,4-diallyl isoquinolin
PE20200008A1 (en) 2017-03-30 2020-01-06 Hoffmann La Roche ISOQUINOLINS AS INHIBITORS OF HPK1
CN110204481B (en) * 2018-02-28 2021-01-19 中国农业大学 Polysubstituted nitrogen-containing aromatic heterocyclic compound and preparation method and application thereof
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
CN111808023B (en) * 2020-06-30 2022-10-21 四川大学 Method for preparing 3-aryl isoquinoline derivative
CN115974919B (en) * 2022-11-14 2024-04-16 石河子大学 2- (Triphenylphosphine) benzenesulfonate derivative and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024931A1 (en) * 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003080596A2 (en) * 2002-03-19 2003-10-02 E. I. Du Pont De Nemours And Company Bicyclic fused pyridinyl amides and advantageous compositions thereof for use as fungicides
WO2004108681A1 (en) * 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
US20060233705A1 (en) * 2005-04-19 2006-10-19 Schuller Hildegard M Diagnosis by determination of hyperactivity or increased expression of members of cell signaling pathways
WO2007097929A1 (en) * 2006-02-16 2007-08-30 Fibrogen, Inc. Compounds and methods for treatment of stroke

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003024931A1 (en) * 2001-09-14 2003-03-27 Merck & Co., Inc. Tyrosine kinase inhibitors
WO2003080596A2 (en) * 2002-03-19 2003-10-02 E. I. Du Pont De Nemours And Company Bicyclic fused pyridinyl amides and advantageous compositions thereof for use as fungicides
WO2004108681A1 (en) * 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin
US20060233705A1 (en) * 2005-04-19 2006-10-19 Schuller Hildegard M Diagnosis by determination of hyperactivity or increased expression of members of cell signaling pathways
WO2007097929A1 (en) * 2006-02-16 2007-08-30 Fibrogen, Inc. Compounds and methods for treatment of stroke

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JACQUELINE E. VAN MUIJLWIJK-KOEZEN ET AL.: "Isoquinoline and Quinazoline Urea Analogues as Antagonists for the Human Adenosine A3 Receptor", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 11, 2000, pages 2227 - 2238 *
POINDEXTER, GRAHAM S.: "Convenient preparation of 3-Substituted 1(2H)- Isoquinolinones.", JOURNAL OF ORGANIC CHEMISTRY, vol. 47, no. 19, 1982, pages 3787 - 3788 *
STEFANO MORO ET AL.: "Autocorrelation of Molecular Electrostatic Potential Surface Properties Combined with Partial Least Squares Analysis as New Strategy for the Predection of the Activity of Human a3 Adenosine Receptor Antagonists.", J. MED. CHEM., vol. 48, no. 18, 2005, pages 5698 - 5704 *
YANJUN WAN ET AL.: "Aminoisoquinolines as colorimetric Hg2+ sensors: the importance of molecular structure and sacrificial base", TETRAHEDRON, vol. 65, no. 22, 2009, pages 4293 - 4297 *

Also Published As

Publication number Publication date
WO2013003315A2 (en) 2013-01-03

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