AR068678A1 - Carboxamidas moduladoras de alfa 2 gaba a y una composicion farmaceutica en base al compuesto - Google Patents

Carboxamidas moduladoras de alfa 2 gaba a y una composicion farmaceutica en base al compuesto

Info

Publication number
AR068678A1
AR068678A1 ARP080104355A ARP080104355A AR068678A1 AR 068678 A1 AR068678 A1 AR 068678A1 AR P080104355 A ARP080104355 A AR P080104355A AR P080104355 A ARP080104355 A AR P080104355A AR 068678 A1 AR068678 A1 AR 068678A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
hydrogen
alkoxyalkyl
alkoxy
Prior art date
Application number
ARP080104355A
Other languages
English (en)
Inventor
Ronald J Mattson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR068678A1 publication Critical patent/AR068678A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Estos compuestos y sus composiciones farmacéuticas son utiles en el tratamiento de trastornos del SNC, particularmente como ansiolíticos. Reivindicacion 1: Un compuesto caracterizado porque tiene formula 1 en la que: R1 es fenilo, tienilo o piridinilo, y está sustituido con 0-2 sustituyentes seleccionados de halo, alquilo, ciano y nitro; R2 es hidrogeno, alquilo o cicloalquilo; R3 es hidrogeno, alquilo, cicloalquilo, haloalquilo, alquenilo o alquinilo; R4 es hidrogeno, alquilo, cicloalquilo, (cicloalquil)-alquilo, hidroxialquilo, alcoxialquilo, (alcoxi)2-alquilo, (cicloalquil)-alcoxialquilo, (alquilCO2)-alquilo, (CO2R6)-alquilo, (COR7)-alquilo, (R9)alquilo, (tetrahidrofuranil)alquilo, o (furanil)-alquilo; R5 es hidrogeno, alquilo, cicloalquilo, (cicloalquil)-alquilo, hidroxialquilo, alcoxialquilo, (alcoxi)2-alquilo, (cicloalquil)-alcoxialquilo, (alquilCO2)-alquilo, (CO2R6)-alquilo, (COR7)-alquilo, (R9)alquilo, (tetrahidrofuranil)alquilo, o (furanil)-alquilo; o N(R4)(R5) tomados conjuntamente son azetidinilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, homopiperidinilo, homopiperazinilo u homomorfolinilo y está sustituido con 0-3 sustituyentes seleccionados de oxo, alcoxi, hidroxi, alquilo, piridinilo y pirimidinilo; R6 es hidrogeno o alquilo; R7 es hidrogeno o alquilo; R8 es hidrogeno, alquilo o cicloalquilo; y R9 es amino, alquilamino, dialquilamino, azetidinilo, pirrolidinilo, piperidinilo, piperazinilo, morfolinilo, homopiperidinilo, homopiperazinilo, u homomorfolinilo; o una de sus sales farmacéuticamente aceptables.
ARP080104355A 2007-10-03 2008-10-03 Carboxamidas moduladoras de alfa 2 gaba a y una composicion farmaceutica en base al compuesto AR068678A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97709507P 2007-10-03 2007-10-03

Publications (1)

Publication Number Publication Date
AR068678A1 true AR068678A1 (es) 2009-11-25

Family

ID=40282287

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080104355A AR068678A1 (es) 2007-10-03 2008-10-03 Carboxamidas moduladoras de alfa 2 gaba a y una composicion farmaceutica en base al compuesto

Country Status (5)

Country Link
US (1) US8119629B2 (es)
AR (1) AR068678A1 (es)
PE (1) PE20091009A1 (es)
TW (1) TW200916105A (es)
WO (1) WO2009046004A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47475E1 (en) * 2002-03-28 2019-07-02 Wisys Technology Foundation, Inc. Selective agents for pain suppression
US9006233B2 (en) 2011-04-28 2015-04-14 Uwm Research Foundation, Inc. Gabaergic receptor subtype selective ligands and their uses
WO2016154031A1 (en) * 2015-03-20 2016-09-29 Uwm Research Foundation, Inc. Gabaergic ligands and their uses
EP4129297A1 (en) * 2016-03-18 2023-02-08 UWM Research Foundation, Inc. Treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders with alpha5-containing gabaa receptor agonists
JP7013446B2 (ja) 2016-08-16 2022-02-15 ユーダブリューエム・リサーチ・ファウンデーション，インコーポレーテッド Ｇａｂａ（ａ）受容体モジュレーター、及び、喘息における気道過敏及び炎症を抑制するための方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4280957A (en) * 1974-09-11 1981-07-28 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
US4401597A (en) 1978-05-15 1983-08-30 Hoffmann-La Roche Inc. Imidazodiazepines and processes therefor
DK151808C (da) 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
ZA845757B (en) 1983-08-25 1985-04-24 Hoffmann La Roche Benzodiazepine derivatives
US5317018A (en) * 1992-06-09 1994-05-31 Armin Walser Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
JP4364637B2 (ja) 2001-08-09 2009-11-18 アクテリオン ファーマシューティカルズ リミテッド 新規なベンゾ縮合へテロ環化合物
US6964958B2 (en) 2001-09-28 2005-11-15 James Auta Method of simultaneously treating sensory auditory gating deficit and associated psychosis in schizophrenia and bipolar disorder patients with mania
ATE389640T1 (de) 2002-03-28 2008-04-15 Wisys Technology Found Inc Angstlösende wirkstoffe mit verminderten beruhigenden und ataktischen nebenwirkungen
AU2005260650A1 (en) 2004-06-30 2006-01-12 Wisys Technology Foundation, Inc. Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects

Also Published As

Publication number Publication date
TW200916105A (en) 2009-04-16
PE20091009A1 (es) 2009-07-16
US20090093466A1 (en) 2009-04-09
US8119629B2 (en) 2012-02-21
WO2009046004A1 (en) 2009-04-09

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Legal Events

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FA Abandonment or withdrawal