AR063574A1 - Compuestos basados en el (s)- fenil ( heterociclo ) metanol, composiciones que los comprenden y metodos para su uso - Google Patents

Compuestos basados en el (s)- fenil ( heterociclo ) metanol, composiciones que los comprenden y metodos para su uso

Info

Publication number
AR063574A1
AR063574A1 ARP070104929A ARP070104929A AR063574A1 AR 063574 A1 AR063574 A1 AR 063574A1 AR P070104929 A ARP070104929 A AR P070104929A AR P070104929 A ARP070104929 A AR P070104929A AR 063574 A1 AR063574 A1 AR 063574A1
Authority
AR
Argentina
Prior art keywords
heterocycle
alkyl
rarb
ora
optionally substituted
Prior art date
Application number
ARP070104929A
Other languages
English (en)
Inventor
Joseph Barbosa
Yingzhi Bi
Cynthia Anne Fink
Michael Alan Green
Jian Cheng Wang
Original Assignee
Lexicon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lexicon Pharmaceuticals Inc filed Critical Lexicon Pharmaceuticals Inc
Publication of AR063574A1 publication Critical patent/AR063574A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto estereoméricamente puro de fórmula (1), una sale o un solvato farmacéuticamente aceptable del mismo, donde: A es un heterociclo no aromático opcionalmente sustituido; cada uno de D1 y D2 es independientemente N o CR1; cada uno de E1, E2 y E3 es independientemente N o CR2; X es heteroarilo opcionalmente sustituido; cada R1 es de manera independiente hidrógeno, halógeno, ciano, RA, ORA, C(O)RA, C(O)ORA, C(O)N(RARB), N(RARB) o SO2RA; cada R2 es de manera independiente hidrógeno, halógeno, ciano, RA, ORA, C(O)RÁ, C(O)ORA, C(O)N(RARB), N(RARB) o SO2RA; cada RA es independientemente hidrógeno, o alquilo, arilo, arilalquilo, alquilarilo, heterociclo, heterociclo-alquilo o alquil-heterociclo, opcionalmente sustituidos; y cada RB es independientemente hidrógeno, o alquilo, arilo, arilalquilo, alquilarilo, heterociclo, heterociclo-alquilo o alquilo-heterociclo opcionalmente sustituidos.
ARP070104929A 2006-11-07 2007-11-06 Compuestos basados en el (s)- fenil ( heterociclo ) metanol, composiciones que los comprenden y metodos para su uso AR063574A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85745406P 2006-11-07 2006-11-07

Publications (1)

Publication Number Publication Date
AR063574A1 true AR063574A1 (es) 2009-02-04

Family

ID=39277309

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104929A AR063574A1 (es) 2006-11-07 2007-11-06 Compuestos basados en el (s)- fenil ( heterociclo ) metanol, composiciones que los comprenden y metodos para su uso

Country Status (7)

Country Link
US (2) US20080146600A1 (es)
EP (1) EP2084145A2 (es)
AR (1) AR063574A1 (es)
AU (1) AU2007325494A1 (es)
CA (1) CA2668808A1 (es)
TW (1) TW200823193A (es)
WO (1) WO2008067120A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580775A (en) * 1992-05-01 1996-12-03 Emory University High affinity, brain-specific nucleic acids encoding a L-proline transporter, and vectors, and host cells comprising the same
EP0690854B1 (en) * 1993-03-24 2000-07-12 G.D. Searle & Co. 1-phenyl-imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders
US6313127B1 (en) * 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
US6448242B1 (en) * 1998-02-19 2002-09-10 Kowa Co., Ltd. Cyclic amide compounds
US7208497B2 (en) * 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
ATE552253T1 (de) * 2002-11-08 2012-04-15 Novartis Int Pharm Ltd 3-substituierte-6-aryl- pyridin derivate als liganden für c5a-rezeptoren
CA2573920A1 (en) * 2004-07-21 2006-02-02 Pfizer Products Inc. Histamine-3 receptor antagonists
US20060258691A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Methods and compositions for improving cognition
US20060258672A1 (en) * 2005-05-13 2006-11-16 Joseph Barbosa Multicyclic compounds and methods of their use
EP1919482A1 (en) * 2005-08-24 2008-05-14 Lexicon Pharmaceuticals, Inc. Pyrrolopyridine, pyrrolopyrimidine and pyrazolopyridine compounds, compositions comprising them, and methods of their use
EP2086547A2 (en) * 2006-08-04 2009-08-12 Lexicon Pharmaceuticals, Inc. Solid forms of (3'-chlorobiphenyl-4-yl)(1-(pyrimidin-2-yl)piperidin-4-yl)methanone and methods of their use

Also Published As

Publication number Publication date
TW200823193A (en) 2008-06-01
CA2668808A1 (en) 2008-06-05
US20090181992A1 (en) 2009-07-16
EP2084145A2 (en) 2009-08-05
WO2008067120A3 (en) 2008-10-02
US20080146600A1 (en) 2008-06-19
AU2007325494A1 (en) 2008-06-05
WO2008067120A2 (en) 2008-06-05

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