AR062344A1 - Formulaciones de bisfosfonato-unido-a-polimero para inhalar y metodos para usar las mismas - Google Patents
Formulaciones de bisfosfonato-unido-a-polimero para inhalar y metodos para usar las mismasInfo
- Publication number
- AR062344A1 AR062344A1 ARP080100259A ARP080100259A AR062344A1 AR 062344 A1 AR062344 A1 AR 062344A1 AR P080100259 A ARP080100259 A AR P080100259A AR P080100259 A ARP080100259 A AR P080100259A AR 062344 A1 AR062344 A1 AR 062344A1
- Authority
- AR
- Argentina
- Prior art keywords
- bisphosphonate
- methods
- active
- agent
- polymer
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 229940122361 Bisphosphonate Drugs 0.000 abstract 6
- 150000004663 bisphosphonates Chemical class 0.000 abstract 6
- 239000013543 active substance Substances 0.000 abstract 3
- 210000000988 bone and bone Anatomy 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 229920000642 polymer Polymers 0.000 abstract 3
- 238000001179 sorption measurement Methods 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Métodos para la administracion de un agente activo de bisfosfonato a un sujeto que lo necesita. Aspectos de la invencion incluyen la administracion del agente activo de bisfosfonato al sujeto por una vía pulmonar, donde el agente activo de bisfosfonato se une, ya sea directamente o a través de un grupo conector intermediario, a un polímero no peptídico, de modo tal que el agente activo de bisfosfonato es un agente activo de bisfosfonato-unido-a-polímero. También se proporcionan composiciones para usar en la práctica de métodos de acuerdo con las realizaciones de la invencion. Métodos y composiciones de acuerdo con las realizaciones de la invencion son de utilidad en una variedad de aplicaciones diferentes, incluyendo, pero sin limitarse a, el tratamiento de enfermedades que afectan la adsorcion osea. Reivindicacion 28: Un kit para usar en el tratamiento de un sujeto que padece una enfermedad que afecta la adsorcion osea, dicho kit comprende un agente activo de bisfosfonato-unido-a-polímero en una forma para inhalar. Reivindicacion 30: Uso de una composicion de acuerdo con las Reivindicaciones 1 a 27, para la fabricacion de un medicamento para tratar una enfermedad que afecta la adsorcion osea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89755307P | 2007-01-26 | 2007-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062344A1 true AR062344A1 (es) | 2008-11-05 |
Family
ID=39645357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100259A AR062344A1 (es) | 2007-01-26 | 2008-01-22 | Formulaciones de bisfosfonato-unido-a-polimero para inhalar y metodos para usar las mismas |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080182823A1 (es) |
| EP (1) | EP2124964A1 (es) |
| JP (1) | JP2010516762A (es) |
| KR (1) | KR20090104830A (es) |
| CN (1) | CN101588806A (es) |
| AR (1) | AR062344A1 (es) |
| AU (1) | AU2007345280A1 (es) |
| BR (1) | BRPI0719383A2 (es) |
| CA (1) | CA2669406A1 (es) |
| EA (1) | EA200900881A1 (es) |
| IL (1) | IL198520A0 (es) |
| MX (1) | MX2009005855A (es) |
| TW (1) | TW200843782A (es) |
| WO (1) | WO2008091337A1 (es) |
| ZA (1) | ZA200903049B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926081B1 (fr) * | 2008-01-03 | 2010-02-19 | Univ Nantes | Derives d'acide hydroxy-bisphosphonique comme vecteur ciblant le tissu osseux |
| US8834861B2 (en) * | 2011-03-10 | 2014-09-16 | International Business Machines Corporation | Polycarbonates for delivery of drugs and methods of preparation thereof |
| GB201200868D0 (en) * | 2012-01-19 | 2012-02-29 | Depuy Int Ltd | Bone filler composition |
| CN104086763A (zh) * | 2014-04-03 | 2014-10-08 | 西南交通大学 | 用作表面活性剂的含氨基双膦酸盐修饰Brij化合物及其制备方法 |
| CN107011380A (zh) * | 2016-01-28 | 2017-08-04 | 臧伟 | 一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用 |
| WO2018025809A1 (ja) * | 2016-08-01 | 2018-02-08 | 株式会社カネカ | カルシプロテインパーティクルの吸着材、および吸着除去システムとその利用方法 |
| CN114206988B (zh) * | 2019-07-30 | 2024-06-21 | 加特技术公司 | 包含钙结合基团的聚噁唑啉共聚物 |
| CN114652845B (zh) * | 2022-04-01 | 2023-10-13 | 中山莱博瑞辰生物医药有限公司 | 阿仑膦酸盐偶联聚乙烯醇聚合物、其制备方法及用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| JPH02268190A (ja) * | 1989-04-07 | 1990-11-01 | Fujisawa Pharmaceut Co Ltd | 医薬化合物とジホスホン酸誘導体の結合体 |
| US6436386B1 (en) * | 2000-11-14 | 2002-08-20 | Shearwater Corporation | Hydroxyapatite-targeting poly (ethylene glycol) and related polymers |
| BR0209360A (pt) * | 2001-05-02 | 2004-06-08 | Novartis Ag | Método de administração de bisfosfonatos por inalação no tratamento ou prevenção de reabsorção óssea e osteoporose |
| US6756354B2 (en) * | 2001-09-05 | 2004-06-29 | Deanna Jean Nelson | Therapeutic compositions containing oligo (ethylene glycol)-terminated 1,2-dithiolanes and their conjugates |
| EP1758613A2 (en) * | 2004-05-14 | 2007-03-07 | Baylor College Of Medicine | Compositions and methods for modulating bone mass |
-
2007
- 2007-12-21 US US11/963,666 patent/US20080182823A1/en not_active Abandoned
- 2007-12-27 MX MX2009005855A patent/MX2009005855A/es not_active Application Discontinuation
- 2007-12-27 JP JP2009547226A patent/JP2010516762A/ja active Pending
- 2007-12-27 AU AU2007345280A patent/AU2007345280A1/en not_active Abandoned
- 2007-12-27 EA EA200900881A patent/EA200900881A1/ru unknown
- 2007-12-27 ZA ZA200903049A patent/ZA200903049B/xx unknown
- 2007-12-27 KR KR1020097015181A patent/KR20090104830A/ko not_active Application Discontinuation
- 2007-12-27 WO PCT/US2007/026427 patent/WO2008091337A1/en active Application Filing
- 2007-12-27 BR BRPI0719383-1A2A patent/BRPI0719383A2/pt not_active IP Right Cessation
- 2007-12-27 CN CNA2007800504548A patent/CN101588806A/zh active Pending
- 2007-12-27 CA CA002669406A patent/CA2669406A1/en not_active Abandoned
- 2007-12-27 EP EP07868103A patent/EP2124964A1/en not_active Withdrawn
-
2008
- 2008-01-04 TW TW097100268A patent/TW200843782A/zh unknown
- 2008-01-22 AR ARP080100259A patent/AR062344A1/es not_active Application Discontinuation
-
2009
- 2009-05-03 IL IL198520A patent/IL198520A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2124964A1 (en) | 2009-12-02 |
| EA200900881A1 (ru) | 2010-02-26 |
| US20080182823A1 (en) | 2008-07-31 |
| IL198520A0 (en) | 2010-02-17 |
| AU2007345280A1 (en) | 2008-07-31 |
| TW200843782A (en) | 2008-11-16 |
| WO2008091337A1 (en) | 2008-07-31 |
| JP2010516762A (ja) | 2010-05-20 |
| BRPI0719383A2 (pt) | 2014-02-18 |
| KR20090104830A (ko) | 2009-10-06 |
| MX2009005855A (es) | 2009-06-12 |
| CN101588806A (zh) | 2009-11-25 |
| CA2669406A1 (en) | 2008-07-31 |
| ZA200903049B (en) | 2010-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |