AR062205A1 - Un compuesto de pirazolo [1,5-a] pirimidinas, usos de dicho compuesto y composicion farmaceutica que lo comprende - Google Patents
Un compuesto de pirazolo [1,5-a] pirimidinas, usos de dicho compuesto y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR062205A1 AR062205A1 ARP070103433A ARP070103433A AR062205A1 AR 062205 A1 AR062205 A1 AR 062205A1 AR P070103433 A ARP070103433 A AR P070103433A AR P070103433 A ARP070103433 A AR P070103433A AR 062205 A1 AR062205 A1 AR 062205A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- pyrazolo
- pyrimidin
- phenyl
- acetamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se refiere a pirazolo[1,5-a]pirimidinas, las cuales son utiles para tratar o prevenir la ansiedad, epilepsia y los trastornos del sueno incluyendo el insomnio, y para inducir sedacion-hipnosis, anestesia, sueno y relajacion muscular. Se reivindica un compuesto de pirazolo[1,5-a]pirimidinas, caracterizado porque se selecciona del grupo que consiste en: a) N-{2-fluoro-5-[3-nitro-pirazolo[1,5-a]pirimidin-7-iI]-fenil}-N-metil-acetamida; b) N-{2-fluoro-5-[3-ciano-pirazolo[1,5-a]pirimidin-7-il]- fenil}-N-metil-acetamida; c) N-{2-cloro-5-[3-nitro-pirazolo[1,5-a]pirimidin-7-iI]-fenil}-N-metil-acetamida; d) N-{2-cloro-5-[3-ciano-pirazolo[1,5-a]pirimidin-7-il]-fenil}-N-metil-acetamida; e) N-{2-fluoro-5-[3-nitro-pirazolo[1,5-a]pirimidin-7-iI]- fenil}-N-metil-metansulfonamida, f) N-{2-fluoro-5-(3-ciano-pirazolo[1,5-a]pirimidin-7-il]-fenil}-N-metil-metansulfonamida; g) N-{2-cloro-5-[3-nitro-pirazoio[1,5-a]pirimidin-7-il]-fenil}-N-metil-metansulfonamida; h) N-{2cloro-5-[3-ciano-pirazoIo[1,5- a]pirimidin-7-il]-fenil}-N-metiI-metansulfonamida; i) N-{2-fluoro-5-[3-ciano-2-metil-pirazolo[1,5-a]pirimidin-7-iI]-fenil}-N-metil-acetamida; j) N-{2-cloro-5-[3-ciano-2-metil-pirazolo[1,5-a]pirimidin-7-il]-fenil}-N-metil-metansulfonamida, k) N-{2- fluoro-5-[3-ciano-2-metil-pirazolo[1,5-a]pirimidin-7-iI]-fenil}-N-metil-metansulfonamida; l) N-{2-cloro-5-[3-ciano-2-metil-pirazolo[1,5-a]pirimidin-7-i]-fenil}-N-metil-metansulfonamida; m) N-{2-metil-5-[3-(tiofeno-2-carbonil)-pirazolo[1,5- a]pirimidin-7-il)-fenil}-N-metil-acetamida; n) N-{2-metoxi-5-[3-(tiofeno-2-carbonil)-pirazolo[1,5-a]pirimidin-7-il)-fenil}-N-metil-acetamida; o) N-{2,4-difluoro-5-[3-(tiofeno-2-carbonil)-pirazolo[1,5-a]pirimidin-7-il)-fenil}-N-metil-acetamida; p) N- {5-fluoro-2-metoxi-3-[3-(tiofeno-2-carbonil)-pirazolo[1,5-a]pirimidin-7-il)-fenil}-N-metil-acetamida; y las sales farmacéuticamente aceptables e hidrato de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06118454A EP1884516A1 (en) | 2006-08-04 | 2006-08-04 | Pyrazolo[1,5-a]pyrimidines, processes, uses and compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062205A1 true AR062205A1 (es) | 2008-10-22 |
Family
ID=37864479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070103433A AR062205A1 (es) | 2006-08-04 | 2007-08-03 | Un compuesto de pirazolo [1,5-a] pirimidinas, usos de dicho compuesto y composicion farmaceutica que lo comprende |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8158632B2 (es) |
| EP (2) | EP1884516A1 (es) |
| JP (1) | JP2009545568A (es) |
| KR (1) | KR20090046916A (es) |
| CN (1) | CN101641359A (es) |
| AR (1) | AR062205A1 (es) |
| AT (1) | ATE469906T1 (es) |
| AU (1) | AU2007280412A1 (es) |
| BR (1) | BRPI0715169A2 (es) |
| CA (1) | CA2659969A1 (es) |
| CL (1) | CL2007002262A1 (es) |
| CY (1) | CY1110757T1 (es) |
| DE (1) | DE602007006966D1 (es) |
| DK (1) | DK2059521T3 (es) |
| ES (1) | ES2346810T3 (es) |
| HK (1) | HK1129105A1 (es) |
| MX (1) | MX2009001149A (es) |
| NO (1) | NO20090972L (es) |
| PL (1) | PL2059521T3 (es) |
| PT (1) | PT2059521E (es) |
| RU (1) | RU2458063C2 (es) |
| SI (1) | SI2059521T1 (es) |
| TW (1) | TW200815445A (es) |
| UY (1) | UY30521A1 (es) |
| WO (1) | WO2008015253A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009095742A1 (en) | 2008-01-31 | 2009-08-06 | Cellectis | New i-crei derived single-chain meganuclease and uses thereof |
| WO2010053127A1 (ja) * | 2008-11-05 | 2010-05-14 | 協和発酵キリン株式会社 | α1GABAA受容体またはα5GABAA受容体の調整剤 |
| ES2540867T3 (es) * | 2010-02-26 | 2015-07-14 | Mitsubishi Tanabe Pharma Corporation | Compuestos de pirazolopirimidina y su uso como inhibidores de PDE10 |
| CN102807569B (zh) * | 2012-08-21 | 2015-02-25 | 四川大学 | 一种镇静催眠的化合物及其制备方法和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
| US4847256A (en) * | 1986-10-16 | 1989-07-11 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo(1,5-A)-pyrimidines |
| EP0521622B1 (en) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories |
| US6399621B1 (en) * | 1999-08-10 | 2002-06-04 | American Cyanamid Company | N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto |
| TWI252851B (en) * | 2003-07-24 | 2006-04-11 | Ferrer Int | 7-substituted 3-nitro-pyrazolo[1,5-a]pyrimidines and compositions and methods related thereto |
| ES2222813B1 (es) * | 2003-07-24 | 2005-12-16 | Ferrer Internacional, S.A. | N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados. |
| EP1736475A1 (en) | 2005-06-21 | 2006-12-27 | Ferrer Internacional, S.A. | Halogenated pyrazolo[1,5-a]pyrimidines, processes, uses, compositions and intermediates |
| DE102005028765B4 (de) * | 2005-06-22 | 2016-01-21 | Airbus Operations Gmbh | Verfahren zur Herstellung eines Verstärkungsprofils |
| EP1956021A1 (en) * | 2006-10-11 | 2008-08-13 | Ferrer Internacional, S.A. | Process for the manufacture of a crystalline pyrazolo[1,5-a]pyrimidine compound |
-
2006
- 2006-08-04 EP EP06118454A patent/EP1884516A1/en not_active Withdrawn
-
2007
- 2007-08-02 SI SI200730324T patent/SI2059521T1/sl unknown
- 2007-08-02 ES ES07788165T patent/ES2346810T3/es active Active
- 2007-08-02 AT AT07788165T patent/ATE469906T1/de active
- 2007-08-02 CN CN200780037178A patent/CN101641359A/zh active Pending
- 2007-08-02 US US12/376,250 patent/US8158632B2/en not_active Expired - Fee Related
- 2007-08-02 PL PL07788165T patent/PL2059521T3/pl unknown
- 2007-08-02 WO PCT/EP2007/058006 patent/WO2008015253A1/en active Application Filing
- 2007-08-02 AU AU2007280412A patent/AU2007280412A1/en not_active Abandoned
- 2007-08-02 TW TW096128362A patent/TW200815445A/zh unknown
- 2007-08-02 DK DK07788165.4T patent/DK2059521T3/da active
- 2007-08-02 CA CA002659969A patent/CA2659969A1/en not_active Abandoned
- 2007-08-02 BR BRPI0715169-1A patent/BRPI0715169A2/pt not_active IP Right Cessation
- 2007-08-02 UY UY30521A patent/UY30521A1/es unknown
- 2007-08-02 RU RU2009107734/04A patent/RU2458063C2/ru not_active IP Right Cessation
- 2007-08-02 PT PT07788165T patent/PT2059521E/pt unknown
- 2007-08-02 KR KR1020097004479A patent/KR20090046916A/ko not_active Application Discontinuation
- 2007-08-02 EP EP07788165A patent/EP2059521B1/en not_active Not-in-force
- 2007-08-02 DE DE602007006966T patent/DE602007006966D1/de active Active
- 2007-08-02 MX MX2009001149A patent/MX2009001149A/es active IP Right Grant
- 2007-08-02 JP JP2009522280A patent/JP2009545568A/ja not_active Abandoned
- 2007-08-03 AR ARP070103433A patent/AR062205A1/es not_active Application Discontinuation
- 2007-08-03 CL CL2007002262A patent/CL2007002262A1/es unknown
-
2009
- 2009-03-03 NO NO20090972A patent/NO20090972L/no not_active Application Discontinuation
- 2009-08-10 HK HK09107320.7A patent/HK1129105A1/xx not_active IP Right Cessation
-
2010
- 2010-09-01 CY CY20101100804T patent/CY1110757T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2059521A1 (en) | 2009-05-20 |
| RU2009107734A (ru) | 2010-09-10 |
| DK2059521T3 (da) | 2010-09-27 |
| AU2007280412A1 (en) | 2008-02-07 |
| US8158632B2 (en) | 2012-04-17 |
| MX2009001149A (es) | 2009-03-02 |
| US20090264448A1 (en) | 2009-10-22 |
| JP2009545568A (ja) | 2009-12-24 |
| CY1110757T1 (el) | 2015-06-10 |
| TW200815445A (en) | 2008-04-01 |
| SI2059521T1 (sl) | 2010-09-30 |
| KR20090046916A (ko) | 2009-05-11 |
| ATE469906T1 (de) | 2010-06-15 |
| NO20090972L (no) | 2009-04-30 |
| EP1884516A1 (en) | 2008-02-06 |
| ES2346810T3 (es) | 2010-10-20 |
| RU2458063C2 (ru) | 2012-08-10 |
| DE602007006966D1 (de) | 2010-07-15 |
| CA2659969A1 (en) | 2008-02-07 |
| PT2059521E (pt) | 2010-08-26 |
| PL2059521T3 (pl) | 2010-11-30 |
| WO2008015253A1 (en) | 2008-02-07 |
| HK1129105A1 (en) | 2009-11-20 |
| BRPI0715169A2 (pt) | 2013-06-11 |
| CN101641359A (zh) | 2010-02-03 |
| UY30521A1 (es) | 2008-02-29 |
| EP2059521B1 (en) | 2010-06-02 |
| CL2007002262A1 (es) | 2008-01-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2022000096A (es) | Formas cristalinas de un inhibidor de tirosina quinasa de bruton | |
| AR054785A1 (es) | Compuesto que comprende pirazolo (1,5-a) pirimidinas halogenadas, procedimiento para prepararlo uso de dicho compuesto composicion farmaceutica que lo comprende, procedimiento para preparar sus intermedios y compuesto intermedio | |
| AR086656A1 (es) | Combinacion de inhibidores de mek e inhibidores selectivos de la quinasa aurora a | |
| UY28376A1 (es) | Agentes terapéuticos | |
| NZ598907A (en) | Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors | |
| PA8621901A1 (es) | Derivados de sulfonamida para el tratamiento de enfermedades | |
| ECSP077275A (es) | Novedosos derivados de heteroarilsulfamida benzofusionados utiles como agentes anticonvulsivos | |
| ES2653852T3 (es) | Composiciones farmacéuticas que contienen ligandos del receptor de dopamina y procedimientos de tratamiento usando ligandos del receptor de dopamina | |
| NI200600306A (es) | Derivados de sulfamida y sulfamato para el tratamiento de la epilepsia y trastornos relacionados | |
| SV2006002135A (es) | Nucleosidos de 3-beta-d-ribofuranosiltiazolo [4,5-d] pirimidina y usos de los mismos | |
| CR10419A (es) | Derivados de Pirazolo [3,4-D]-Pirimidina útiles para tratar trastornos respiratorios | |
| AR062205A1 (es) | Un compuesto de pirazolo [1,5-a] pirimidinas, usos de dicho compuesto y composicion farmaceutica que lo comprende | |
| GT200000183AA (es) | Aminoacidos biciclicos como agentes farmaceuticos | |
| UY29790A1 (es) | Sales de diariloimidazola-4-carboxamidas, composiciones que las contienen, procesos de preparación y aplicaciones | |
| PA8699501A1 (es) | Tetrahidroquinolinas, su sintesis e intermediarios | |
| Trofimiuk et al. | Stress and ketamine, bimodal influence on cognitive functions | |
| UY29741A1 (es) | Sales de 1,5- diaril pirazol-3-carboxamidas, procesos de preparación, composeciones farmacéuticas que las contienen, aplicaciones y métodos de uso. | |
| UY30529A1 (es) | Compuestos de 1h-quinolin-4-ona, procedimientos, usos y composiciones | |
| GT200100197A (es) | Derivados de triptamina y compuestos analogos, y formulaciones farmaceuticas que lo contienen. | |
| AR063231A1 (es) | Polimorfos de n-{2-fluoro -5 [3-(tiofen -2-carbonil)-pirazolo [1,5-a ]pirimidin-7- il]-fenil}-n-metil-acetamida, procedimientos para su preparacion sus usos y composicion farmaceutica que los comprenden | |
| CL2004001814A1 (es) | COMPUESTOS DERIVADOS DE N-[3-(3-SUSTITUIDOS-PIRAZOLO-[1,5-a PIRIMIDIN-7-IL)-FENIL]-SULFONAMIDAS, PROCEDIMIENTO DE PREPARACION DE DICHO COMPUESTO Y DE INTERMEDIARIO; COMPOSICION FARMACEUTICA Y SU USO PARA TRATAR EPILEPSIA, ANSIEDAD, Y OTRAS. | |
| Hudzik et al. | Effects of anticonvulsants in a novel operant learning paradigm in rats: Comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents | |
| AR058738A1 (es) | Hidrazida del acido imidazo (1,2-a) piridin -3-il- acetico, procedimientos para su preparacion, usos de la misma y composicion farmaceutica que la comprende | |
| ECSP084767A (es) | Pirazolopirimidinas y tiazolopirimidinas sustituidas | |
| DE602006003652D1 (de) | Ocaperidonsalze und pharmazeutische zusammensetzungen, die diese enthalten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |