AR061444A1 - Compuestos terapeuticos derivados de bencimidazol y un metodo para prepararlos - Google Patents
Compuestos terapeuticos derivados de bencimidazol y un metodo para prepararlosInfo
- Publication number
- AR061444A1 AR061444A1 ARP070102564A ARP070102564A AR061444A1 AR 061444 A1 AR061444 A1 AR 061444A1 AR P070102564 A ARP070102564 A AR P070102564A AR P070102564 A ARP070102564 A AR P070102564A AR 061444 A1 AR061444 A1 AR 061444A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- heterocyclyl
- heterocycloalkyl
- cycloalkenyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
- -1 cyano, nitro methoxy, ethoxy, methyl Chemical group 0.000 abstract 8
- 229910052736 halogen Inorganic materials 0.000 abstract 8
- 150000002367 halogens Chemical class 0.000 abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 2
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P19/00—Drugs for skeletal disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula (1), una sal aceptable para uso farmacéutico del mismo, un diastereomero, un enantiomero o una mezcla de los mismo donde R1 está seleccionado entre alquilo C1-10, alquenilo C-1-10, alcoxi C1-10, aril C6- 10-alquilo C1-6 aril C6-10-C(=O)-alquilo C1-6, cicloalquil C3-10alquilo C1-6, cicloalquenil C4-8-alquilo C1-6, heterociclil C3-6-alquilo C1-6, heterociclil C3-8-C(O)-alquilo C1-6, arilo C6-10, aril C6-10-C(=O)-, cicloalquilo C3-10, cicloalquenilo C4- 8, heterociclilo C3-6 y heterociclil C3-6-C()-; donde dicho alquilo C1-10 alquenilo C2-10, alcoxi C1-10, aril C6-10-alquilo C1-6, aril6-10-C(=O)-alquilo C-6, cicloalquil C3-10-alquilo C1-6, cicloalquenil C4-8-alquilo C1-6, heterociclil C3-6-alquilo C1-6, heterociclil C3-6-C(=O)-alquilo C1-6, arilo C6-10, aril C6-10-C(O)-, cicloalquilo C3-10, cicloalquenilo C4-8, heterociclilo C3-6 o heterociclil C3-6-C(=O)- está optativamente sustituido con uno o más grupos seleccionados entre carboxi, -(C=O)- NH2, halogeno, ciano, nitro metoxi, etoxi, metilo, etilo, hidroxi, -N(R6)-C(O)R5 , -S(=O)2-NR5R6, -C(=O)-NR5R6, -NH-C(=O)-NR5R6 y -NR5R6; R2 está seleccionado del grupo formado por alquilo C1-10, alquenilo C2-10, alquinilo C2-10, cicloalquilo C3-8, cicloalquil C3-8-alquilo C1-6 cicloalquenilo C4-8-alquilo C1-6, heterocicloalquil C3-6-alquilo C1-6, cicloalquenilo C4-8 y heterocicloalquilo C3-6, donde dicho alquilo C1-10, alquenilo C2-10, alquinilo C2-10 cicloalquilo C3-8 cicloalquil C3-8- alquilo C1-6, cicloalquenil C4-8-alquilo C1-6, heterocicloalquil C3-6-alquilo C1-6, cicloalquenilo C4-8 o heterocicloalquilo C3-6utilizado en la definicion de R2 está optativamente sustituido con uno o más grupos seleccionados entre carboxi, -(=O)- NH2, halogeno, ciano, nitro, metoxi etoxi, metilo, etilo, hidroxi y -NR5 y R6; R3 está seleccionado entre alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-4, heteroarilo C2-5, heteroaril C2-5-alquilo C1-4, heterocicloalquilo C2-5, heterocicloalquil C2-5-alquilo C1-4, fenilo y bencilo, donde dicho alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-4, heteroarilo C2-5, heteroaril C2-5-alquilo C1-4, heterocicloalquilo C2-5, heterocicloalquil C2-5-alquilo C1-4, fenilo o bencilo está optativamente sustituido con uno o más grupos seleccionados entre alquilo C1-6, carboxi, halogeno, ciano, nitro, metoxi, etoxi, hidroxi, y NR5R6; y R4 está seleccionado entre alquilo 1-6, carboxi, halogeno, ciano, nitro, metoxi, etoxi, hidroxi y -NR5R6; el anillo a es un heterociclo de 4,5,o 6 miembros que optativamente contiene uno o dos heteroátomos más seleccionados entre O, S y N en su anillo, además del nitrogeno ilustrado; X está seleccionado entre -O-C(=O)-, -C(=O)-NH-, -NH-C(=O)-, -NHR7-C(=O)-, -C(=O)NHCH2-, -NH-C(=O)CH2, -NH-C(=O)-NH, -O-C(=O)-NH-, NH-(CH2)m-, -C(O)-O- y -NH-C(=O)-O-; donde R5 y R6 están independientemente seleccionados entre -H, alquilo C1-6 optativamente sustituido con -OH, metoxi, etoxi o halogeno, cicloalquil C3-6-alquilo C0-m optativamente sustituido con -OH, metoxi, etoxi o halogeno, alquenilo C2-6 optativamente sustituido con -OH, metoxi, etoxi o halogeno, y un alquileno C1-6 bivalente optativamente sustituido con -OH, metoxi, etoxi o halogeno que, junto con otro R5 y R6 bivalente, forma una porcion de un anillo; R7 es alquilo C1-6 y m es , 1, 2, o 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US80459906P | 2006-06-13 | 2006-06-13 |
Publications (1)
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AR061444A1 true AR061444A1 (es) | 2008-08-27 |
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ARP070102564A AR061444A1 (es) | 2006-06-13 | 2007-06-12 | Compuestos terapeuticos derivados de bencimidazol y un metodo para prepararlos |
Country Status (19)
Country | Link |
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US (1) | US20100305140A1 (es) |
EP (1) | EP2035409A4 (es) |
JP (1) | JP2009539972A (es) |
KR (1) | KR20090021216A (es) |
CN (1) | CN101501022A (es) |
AR (1) | AR061444A1 (es) |
AU (1) | AU2007259425B2 (es) |
BR (1) | BRPI0712305A2 (es) |
CA (1) | CA2654250A1 (es) |
CL (1) | CL2007001715A1 (es) |
EC (1) | ECSP088968A (es) |
IL (1) | IL195426A0 (es) |
MX (1) | MX2008015157A (es) |
NO (1) | NO20090125L (es) |
RU (1) | RU2008148905A (es) |
TW (1) | TW200808772A (es) |
UY (1) | UY30412A1 (es) |
WO (1) | WO2007145563A1 (es) |
ZA (1) | ZA200809977B (es) |
Families Citing this family (3)
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SE0302573D0 (sv) * | 2003-09-26 | 2003-09-26 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
US20110086853A1 (en) * | 2009-10-08 | 2011-04-14 | William Brown | Therapeutic Compounds |
US20230391752A1 (en) * | 2020-10-22 | 2023-12-07 | Chulalongkorn University | Pyrrolidine-3-carboxamide derivatives and related uses |
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JP3295277B2 (ja) * | 1994-06-01 | 2002-06-24 | 呉羽化学工業株式会社 | 抗腎疾患剤及びベンズイミダゾール誘導体 |
US6348032B1 (en) * | 1998-11-23 | 2002-02-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with benzimidazole derivatives |
PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
SE0101387D0 (sv) * | 2001-04-20 | 2001-04-20 | Astrazeneca Ab | Novel compounds |
SE0301699D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
SE0301698D0 (sv) * | 2003-06-10 | 2003-06-10 | Astrazeneca Ab | Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof |
EP1797078A4 (en) * | 2004-09-24 | 2009-04-01 | Astrazeneca Ab | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THESE DERIVATIVES, PREPARATION AND USES THEREOF |
-
2007
- 2007-06-04 TW TW096119997A patent/TW200808772A/zh unknown
- 2007-06-11 CN CNA2007800302283A patent/CN101501022A/zh active Pending
- 2007-06-11 CA CA002654250A patent/CA2654250A1/en not_active Abandoned
- 2007-06-11 BR BRPI0712305-1A patent/BRPI0712305A2/pt not_active IP Right Cessation
- 2007-06-11 RU RU2008148905/04A patent/RU2008148905A/ru not_active Application Discontinuation
- 2007-06-11 KR KR1020097000549A patent/KR20090021216A/ko not_active Application Discontinuation
- 2007-06-11 JP JP2009515341A patent/JP2009539972A/ja active Pending
- 2007-06-11 US US12/303,643 patent/US20100305140A1/en not_active Abandoned
- 2007-06-11 AU AU2007259425A patent/AU2007259425B2/en not_active Expired - Fee Related
- 2007-06-11 WO PCT/SE2007/000562 patent/WO2007145563A1/en active Application Filing
- 2007-06-11 EP EP07748225A patent/EP2035409A4/en not_active Withdrawn
- 2007-06-11 MX MX2008015157A patent/MX2008015157A/es not_active Application Discontinuation
- 2007-06-12 AR ARP070102564A patent/AR061444A1/es unknown
- 2007-06-12 CL CL2007001715A patent/CL2007001715A1/es unknown
- 2007-06-13 UY UY30412A patent/UY30412A1/es unknown
-
2008
- 2008-11-20 IL IL195426A patent/IL195426A0/en unknown
- 2008-11-24 ZA ZA200809977A patent/ZA200809977B/xx unknown
- 2008-12-12 EC EC2008008968A patent/ECSP088968A/es unknown
-
2009
- 2009-01-09 NO NO20090125A patent/NO20090125L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ECSP088968A (es) | 2009-01-30 |
EP2035409A4 (en) | 2012-01-04 |
AU2007259425B2 (en) | 2011-09-08 |
NO20090125L (no) | 2009-03-09 |
CA2654250A1 (en) | 2007-12-21 |
IL195426A0 (en) | 2009-08-03 |
US20100305140A1 (en) | 2010-12-02 |
JP2009539972A (ja) | 2009-11-19 |
CN101501022A (zh) | 2009-08-05 |
KR20090021216A (ko) | 2009-02-27 |
WO2007145563A1 (en) | 2007-12-21 |
TW200808772A (en) | 2008-02-16 |
MX2008015157A (es) | 2008-12-12 |
AU2007259425A1 (en) | 2007-12-21 |
AU2007259425A8 (en) | 2009-01-29 |
WO2007145563A8 (en) | 2008-11-13 |
RU2008148905A (ru) | 2010-07-20 |
EP2035409A1 (en) | 2009-03-18 |
UY30412A1 (es) | 2008-01-31 |
BRPI0712305A2 (pt) | 2012-01-17 |
ZA200809977B (en) | 2010-04-28 |
CL2007001715A1 (es) | 2008-01-18 |
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