AR060341A1 - Procedimiento para producir 3-[4-(1,1-dimetil-propil)-fenil]-2-metil-propionaldehido y cis-4-{3-[4-(1,1dimetil-propil)-fenil]-2-metil-propil}-2,6-dimetil-morfolina (amorolfina) - Google Patents

Procedimiento para producir 3-[4-(1,1-dimetil-propil)-fenil]-2-metil-propionaldehido y cis-4-{3-[4-(1,1dimetil-propil)-fenil]-2-metil-propil}-2,6-dimetil-morfolina (amorolfina)

Info

Publication number
AR060341A1
AR060341A1 ARP070101392A ARP070101392A AR060341A1 AR 060341 A1 AR060341 A1 AR 060341A1 AR P070101392 A ARP070101392 A AR P070101392A AR P070101392 A ARP070101392 A AR P070101392A AR 060341 A1 AR060341 A1 AR 060341A1
Authority
AR
Argentina
Prior art keywords
dimethyl
methyl
propil
penyl
propile
Prior art date
Application number
ARP070101392A
Other languages
English (en)
Inventor
Branislav Musicki
Jean-Guy Boiteau
Original Assignee
Galderma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa filed Critical Galderma Sa
Publication of AR060341A1 publication Critical patent/AR060341A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/02—Monocyclic aromatic halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/228—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing six-membered aromatic rings, e.g. phenylacetaldehyde

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicacion 1:Procedimiento para preparar 3-[4-(1,1-dimetil-propil)-fenil]-2-metil-propianaldehído de formula (2) caracterizado porque se hace reaccionar un compuesto de formula general (6) en la cual X es un haluro o un radical de sulfonato de triflurometano (OSO2CF3), en una reaccion de Heck con 2-metil-prop-2-en-1-ol de formula (7) en presencia de un catalizador de paladio y una base de un solvente seleccionado entre N,N-dimetilformamida, solventes orgánicos proticos polares y no polares, a una temperatura que oscila entre 60° y 150°C.
ARP070101392A 2006-04-03 2007-04-03 Procedimiento para producir 3-[4-(1,1-dimetil-propil)-fenil]-2-metil-propionaldehido y cis-4-{3-[4-(1,1dimetil-propil)-fenil]-2-metil-propil}-2,6-dimetil-morfolina (amorolfina) AR060341A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06290532A EP1842848A1 (en) 2006-04-03 2006-04-03 Process for producing 3-[4-(1,1-dimethyl-propyl)-phenyl]2-methyl-propionaldehyde and cis-4{3-[4-(1,1-dimethyl-propyl)-phenyl]2-methyl-propyl}-2,6-dimethyl-morpholine (amorolfine)

Publications (1)

Publication Number Publication Date
AR060341A1 true AR060341A1 (es) 2008-06-11

Family

ID=37012060

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101392A AR060341A1 (es) 2006-04-03 2007-04-03 Procedimiento para producir 3-[4-(1,1-dimetil-propil)-fenil]-2-metil-propionaldehido y cis-4-{3-[4-(1,1dimetil-propil)-fenil]-2-metil-propil}-2,6-dimetil-morfolina (amorolfina)

Country Status (5)

Country Link
US (1) US20090131660A1 (es)
EP (2) EP1842848A1 (es)
AR (1) AR060341A1 (es)
CA (1) CA2647586A1 (es)
WO (1) WO2007113218A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102887872B (zh) * 2011-12-30 2015-06-24 浙江海翔药业股份有限公司 一种盐酸阿莫罗芬的制备方法
CN109232458A (zh) * 2018-06-15 2019-01-18 南通常佑药业科技有限公司 一种手性吗啉化合物的制备方法
CN115093309A (zh) * 2022-06-20 2022-09-23 浙江海翔药业股份有限公司 一种盐酸阿莫罗芬中间体杂质及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1548595A (en) 1921-07-14 1925-08-04 Susannah M Freileweh Suitcase
AT354187B (de) 1976-11-22 1979-12-27 Hoffmann La Roche Fungizides mittel
ZW15780A1 (en) * 1979-08-17 1981-03-18 Hoffmann La Roche Heterocyclic compounds
DE4009411A1 (de) * 1990-03-23 1991-09-26 Basf Ag N-(3-phenyl-2-methylpropyl und -methylprop-2-enyl)-azaheterocyclen

Also Published As

Publication number Publication date
CA2647586A1 (en) 2007-10-11
WO2007113218A1 (en) 2007-10-11
US20090131660A1 (en) 2009-05-21
EP1842848A1 (en) 2007-10-10
EP2007742A1 (en) 2008-12-31

Similar Documents

Publication Publication Date Title
ECSP077271A (es) Derivados de pirimidina
BRPI0613429A2 (pt) inibidores de histona desacetilase
ECSP066889A (es) Derivados de difluorometanosulfonil anilidas utiles como herbicidas
ECSP11011183A (es) Compuestos orgánicos
ECSP11011184A (es) Compuestos orgánicos
CR10662A (es) Compuestos de metilpiridopirimidinona
CR10157A (es) Compuestos químicos
AR069531A1 (es) Derivados de indolinona y procedimiento para su fabricacion
ECSP066637A (es) Biaril sulfonamidas y métodos para su uso
ECSP109922A (es) Compuestos de pirazol y su uso como inhibidores raf
ECSP109942A (es) Nuevos herbicidas
AR066077A1 (es) Tiadiazoliloxifenilamidinas y su uso como fungicidas
ATE445593T1 (de) Acetylenderivate
DOP2006000076A (es) Derivados de ciclopentapiridina y tetrahidroquinolina
CO6160235A2 (es) Isoxazolinas insecticidas
ECSP109945A (es) Nuevos herbicidas
BRPI0815750A2 (pt) processo para recuperar um solvente orgânico e um etanol orgânico de uma mistura de etanol/água.
AR065775A1 (es) Procedimiento para preparar 2,6-dicloro-4-(trifluorometil)-fenilhidracina usando mezclas de dicloro-fluoro-trifluorometilbencenos
EA201100920A1 (ru) Новые гербициды
AR066351A1 (es) Componente estructural a base de un material ceramico
AR051341A1 (es) Proceso para la preparacion de derivados de [1,4,5]-oxadiazepina
AR059286A1 (es) Proceso para preparar voriconazol, una forma polimorfica de un intermediario del mismo y su uso
AR060341A1 (es) Procedimiento para producir 3-[4-(1,1-dimetil-propil)-fenil]-2-metil-propionaldehido y cis-4-{3-[4-(1,1dimetil-propil)-fenil]-2-metil-propil}-2,6-dimetil-morfolina (amorolfina)
EA201000069A1 (ru) Новые гербициды
ATE443046T1 (de) Organische verbindungen

Legal Events

Date Code Title Description
FA Abandonment or withdrawal