AR056469A1 - Ibuprofeno solubilizado - Google Patents

Ibuprofeno solubilizado

Info

Publication number
AR056469A1
AR056469A1 ARP060103641A ARP060103641A AR056469A1 AR 056469 A1 AR056469 A1 AR 056469A1 AR P060103641 A ARP060103641 A AR P060103641A AR P060103641 A ARP060103641 A AR P060103641A AR 056469 A1 AR056469 A1 AR 056469A1
Authority
AR
Argentina
Prior art keywords
potassium
ibuprofen
sodium
glycinate
carbonate
Prior art date
Application number
ARP060103641A
Other languages
English (en)
Original Assignee
Losan Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35570762&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR056469(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/EP2006/060973 external-priority patent/WO2006100281A2/en
Application filed by Losan Pharma Gmbh filed Critical Losan Pharma Gmbh
Publication of AR056469A1 publication Critical patent/AR056469A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un proceso para producir un ibuprofeno solubilizado, con preferencia en forma de granulado, el proceso que comprende los pasos de: proporcionar una mezcla que comprende ibuprofeno solido y una primera base seleccionada del grupo que consiste en hidroxido de sodio, hidroxido de potasio, carbonato de socio, carbonato de potasio, glicinato de sodio, glicinato de potasio y fosfatos tribásicos de sodio y de potasio y mezclas de los anteriores, y hacer reaccionar el ibuprofeno y la primera base esencialmente en estado anhidro. El granulado obtenido y las composiciones farmacéuticas y formas de dosificacion que pueden producirse a partir de éste se distinguen por su elevada solubilidad y rápida desintegracion y disolucion en medio acuoso, por sus buenas propiedades de flujo y la compresibilidad, logrando rápidamente el comienzo del efecto analgésico.
ARP060103641A 2005-12-23 2006-08-22 Ibuprofeno solubilizado AR056469A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05028321A EP1800667A1 (en) 2005-12-23 2005-12-23 Rapidly solubilizing ibuprofen granulate
PCT/EP2006/060973 WO2006100281A2 (en) 2005-03-22 2006-03-22 Solubilized ibuprofen

Publications (1)

Publication Number Publication Date
AR056469A1 true AR056469A1 (es) 2007-10-10

Family

ID=35570762

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103641A AR056469A1 (es) 2005-12-23 2006-08-22 Ibuprofeno solubilizado

Country Status (6)

Country Link
EP (1) EP1800667A1 (es)
AR (1) AR056469A1 (es)
CR (1) CR9424A (es)
GT (1) GT200600390A (es)
PE (1) PE20070765A1 (es)
TW (1) TW200738286A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE489077T1 (de) * 2006-09-28 2010-12-15 Losan Pharma Gmbh Schnell lösliche formulierung von nichtsteroidalen antiphlogistika
US9629809B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
US9629806B2 (en) 2008-07-21 2017-04-25 Si Group, Inc. High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms
GB2546513B (en) * 2016-01-20 2020-09-16 Cubic Pharmaceuticals Ltd Process of preparing active pharmaceutical ingredient salts

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1197038B (it) 1986-08-01 1988-11-25 Zambon Spa Composizione farmaceutica ad attivita' analgesica
US4859704A (en) 1987-10-15 1989-08-22 Oratech Pharmaceutical Development Corporation Water soluble ibuprofen compositions and methods of making them
FI89004C (fi) 1988-02-16 1993-08-10 Pertti J Neuvonen Anvaendning av tillsatsmedel foer oekning av absorptionshastigheten av laekemedel i orala laekemedelspreparat
DE3838431A1 (de) 1988-11-12 1990-05-17 Bayer Ag Ibuprofen-brausezubereitungen
DE3922441A1 (de) 1989-07-07 1991-01-17 Pharmatrans Sanaq Ag Ibuprofen- und s-(+)-ibuprofen-zubereitungen und verfahren zu ihrer herstellung
US5262179A (en) 1989-09-13 1993-11-16 Nicholas Kiwi Pty Ltd. Non-effervescent ibuprofen compositions
GB9224021D0 (en) 1992-11-16 1993-01-06 Boots Co Plc Effervescent compositions
ES2134796T3 (es) 1992-12-01 1999-10-16 Spirig Ag Pharmazeutische Prap Composiciones farmaceuticas que contienen s(+)-ibuprofeno.
EP0667149A1 (en) * 1994-02-14 1995-08-16 E-PHARMA TRENTO S.p.A. Ibuprofen based effervescent composition
DE19509807A1 (de) 1995-03-21 1996-09-26 Basf Ag Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen
DE19606151C2 (de) 1996-02-20 1999-05-12 Losan Pharma Gmbh Ibuprofen-Brausezubereitung sowie Verfahren zur Herstellung derselben
GB9603699D0 (en) 1996-02-21 1996-04-17 Boots Co Plc Therapeutic composition
DE19733505A1 (de) 1997-08-01 1999-02-04 Knoll Ag Schnell wirksames Analgeticum
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
FR2785539B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Particules enrobees d'ibuprofene cristallin granule
EP1305008A4 (en) 2001-03-27 2005-02-09 R P Scherer Technologies Inc A Improved forms of pharmaceutical ingredients and method for their preparation
US20020192161A1 (en) 2001-04-10 2002-12-19 Fahkreddin Jamali Animal model for evaluating analgesics
CH693586A8 (de) 2002-10-14 2003-12-15 Roche Consumer Health Ag Darreichungsform von Ibuprofen-Natrium.

Also Published As

Publication number Publication date
CR9424A (es) 2008-01-21
EP1800667A1 (en) 2007-06-27
TW200738286A (en) 2007-10-16
PE20070765A1 (es) 2007-08-10
GT200600390A (es) 2007-05-30

Similar Documents

Publication Publication Date Title
WO2006100281A3 (en) Solubilized ibuprofen
ES2582779T3 (es) Forma de dosificación oral de acetaminofeno/tramadol de liberación prolongada
DOP2011000307A (es) Procedimiento de preparacion de halogenuros de n-alquil-naltrexona
CL2007002851A1 (es) Composicion inyectable que comprende micro o nano -particulas biodegradables que incluyen un agente activo, un polimero biodegardable, un agente para intensificar la viscosidad y excipiente farmaceuticamente aceptables; y procedimientos de preparacion
CY1112831T1 (el) Παραγωγα αζαβιρηενυlαμινοβενζοιc acid σαν παραγοντες καταστολης dhodh
EA201390793A1 (ru) Способ получения фармацевтической композиции, содержащей ипн
CO7350657A2 (es) Formulación de forma de dosificación sólida de desintegración veloz que comprende carbonato de calcio funcionalizado y método para su fabricación
AR056469A1 (es) Ibuprofeno solubilizado
CL2004000782A1 (es) Composicion farmaceutica parenteral que comprende (a) piperacilina, (b) tazobactamo, y un acido aminocarboxilico quelante, que ademas puede contener un tampon, como citrato, y opcionalmente un aminoglicosido; procedimientos para su preparacion; y uso
DK1917339T3 (da) Film med rengøringsmidler
UY30472A1 (es) Nuevos derivados de pirimidina, procesos para su preparacion composiciones farmacéuticas conteniédolos, procesos para su preparacion y aplicaciones.
BRPI0717084A2 (pt) Formulação efervescente de ibuprofeno com alta taxa de dissolução e processo para a sua preparação
CR8529A (es) Nueva forma cristalina v de la agomelatina, su procedimiento de preparacion y las composiciones farmaceuticas que la contiene
ATE489077T1 (de) Schnell lösliche formulierung von nichtsteroidalen antiphlogistika
UY32624A (es) Procedimiento y composición para mejorar la absorción de agentes terapéuticos
AR060264A1 (es) Composicion farmaceutica que contiene lactato y calcio, usos de dicha composicion y metodo de preparacion
CO6630089A2 (es) Composicion de encapsulamiento de liberacion rapida
AR108083A1 (es) Composiciones, kits y métodos para mantener la higiene del párpado
UY32304A (es) Composición de liberación pulsátil de sildenafil y proceso para prepararla
AR070593A1 (es) Composiciones efervescentes
PA8548301A1 (es) Formulacion farmaceutica de sabor enmascarado y procedimiento para su preparacion
CL2008002275A1 (es) Proceso para producir 3-cloro-n-(3-cloro-5-trifluorometil-2-piridil)-a,a,a-trifluoro-2,6-dinitro-p-toluidina usando un solvente del tipo cetonas, nitrilos, esteres y eteres en presencia de 20 a 40% p/p de agua.
AR041332A1 (es) Una composicion detergente para el lavado de la ropa
BRPI0509923A (pt) processo para formação de cálcio de atorvastatina amorfa
AR081891A1 (es) Proceso para elaborar una composicion detergente liquida

Legal Events

Date Code Title Description
FB Suspension of granting procedure