AR052261A1 - DERIVATIVES OF PHENYLPIPERAZINE WITH A COMBINATION OF PARTIAL AGONISM OF THE DOPAMINE RECEIVER -D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES FOR THE TREATMENT OF CENTRAL DISEASE. - Google Patents
DERIVATIVES OF PHENYLPIPERAZINE WITH A COMBINATION OF PARTIAL AGONISM OF THE DOPAMINE RECEIVER -D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES FOR THE TREATMENT OF CENTRAL DISEASE.Info
- Publication number
- AR052261A1 AR052261A1 ARP050105093A ARP050105093A AR052261A1 AR 052261 A1 AR052261 A1 AR 052261A1 AR P050105093 A ARP050105093 A AR P050105093A AR P050105093 A ARP050105093 A AR P050105093A AR 052261 A1 AR052261 A1 AR 052261A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- atom
- phenylpiperazine
- optionally substituted
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Fenilpiperazina con un doble modo de accion, inhibicion de la reabsorcion de serotonina y agonismo parcial de receptores de dopamina-D2. Uso de esto compuesto como medicamento que tiene efectos beneficiosos para el SNC. Reivindicacion 1: Compuestos derivados de fenilpiperazina, caracterizados por la formula general (1) donde: X = S u O, R1 es H, alquilo C1-6, CF3, CH2CF3, OH u O-alquilo C1-6, R2 es H, alquilo C1-6, halogeno o ciano, R3 es H o alquilo C1-6; R4 es H, alquilo C1-6, opcionalmente substituido con un átomo de halogeno; T es una cadena de 2-7 átomos de C saturada o no saturada, donde un átomo de C puede estar reemplazado con un átomo de N, opcionalmente substituido con un grupo alquilo C1-3, CF3 o CH2CF3, un átomo de O o un átomo de S, estando dicha cadena opcionalmente substituida con uno o más substituyentes seleccionados del grupo formado por alquilo C1-3, alcoxi C1-3, halogeno, ciano, trifluorometilo, OCF3, SCF3, OCHF3 y nitro; Ar se selecciona entre los grupos de formulas (2) donde dicho grupo Ar además puede estar opcionalmente substituido con uno o más substituyentes seleccionados del grupo formado por alquilo C1-3, alcoxi C1-3, halogeno, ciano, trifluorometilo, OCF3, SCF3, OCHF2 y nitro, y donde en dichos grupos Ar que contienen un anillo de cinco miembros, la doble ligadura en el anillo de cinco miembros puede estar saturada, y tautomeros, estereoisomeros y N-oxidos de los mismos, como así también las sales, hidratos y solvatos farmacologicamente aceptables de dichos compuestos de formula (1) y sus tautomeros, estereoisomeros y N-oxidos.Phenylpiperazine with a double mode of action, inhibition of serotonin reabsorption and partial agonism of dopamine-D2 receptors. Use of this compound as a medicine that has beneficial effects for the CNS. Claim 1: Compounds derived from phenylpiperazine, characterized by the general formula (1) wherein: X = S or O, R1 is H, C1-6 alkyl, CF3, CH2CF3, OH or O-C1-6 alkyl, R2 is H, C1-6 alkyl, halogen or cyano, R3 is H or C1-6 alkyl; R4 is H, C1-6 alkyl, optionally substituted with a halogen atom; T is a chain of 2-7 saturated or unsaturated C atoms, where a C atom can be replaced with an N atom, optionally substituted with a C1-3, CF3 or CH2CF3 alkyl group, an O atom or a S atom, said chain being optionally substituted with one or more substituents selected from the group consisting of C1-3 alkyl, C1-3 alkoxy, halogen, cyano, trifluoromethyl, OCF3, SCF3, OCHF3 and nitro; Ar is selected from the groups of formulas (2) where said Ar group can also be optionally substituted with one or more substituents selected from the group consisting of C1-3 alkyl, C1-3 alkoxy, halogen, cyano, trifluoromethyl, OCF3, SCF3, OCHF2 and nitro, and where in said Ar groups containing a five-membered ring, the double ligation in the five-membered ring may be saturated, and tautomers, stereoisomers and N-oxides thereof, as well as salts, hydrates and pharmacologically acceptable solvates of said compounds of formula (1) and their tautomers, stereoisomers and N-oxides.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04106394 | 2004-12-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR052261A1 true AR052261A1 (en) | 2007-03-07 |
Family
ID=34930019
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050105091A AR052259A1 (en) | 2004-12-08 | 2005-12-06 | DERIVATIVES OF PHENYLPIPERAZINAS WITH A COMBINATION OF PARTIAL AGONISM OF THE DOPAMINE RECEIVER - D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES FOR THE TREATMENT OF CENTRAL DISEASE. |
ARP050105092A AR052260A1 (en) | 2004-12-08 | 2005-12-06 | DERIVATIVES OF ARYLOXYETHYLAMINE AND PHENYLPIPERAZINE WITH A COMBINATION OF PARTIAL AGONISM OF THE DOPAMINE RECEIVER -D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR EMPLOYMENT AS A CENTRAL NURSING SYSTEM |
ARP050105093A AR052261A1 (en) | 2004-12-08 | 2005-12-06 | DERIVATIVES OF PHENYLPIPERAZINE WITH A COMBINATION OF PARTIAL AGONISM OF THE DOPAMINE RECEIVER -D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES FOR THE TREATMENT OF CENTRAL DISEASE. |
ARP050105094A AR052147A1 (en) | 2004-12-08 | 2005-12-06 | DERIVATIVES OF PHENYLPIPERAZINE WITH A COMBINATION OF PARTIAL AGONISM OF THE RECEIVER OF DOPAMINA-D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES FOR THE TREATMENT OF DISEASE SYSTEMS |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050105091A AR052259A1 (en) | 2004-12-08 | 2005-12-06 | DERIVATIVES OF PHENYLPIPERAZINAS WITH A COMBINATION OF PARTIAL AGONISM OF THE DOPAMINE RECEIVER - D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES FOR THE TREATMENT OF CENTRAL DISEASE. |
ARP050105092A AR052260A1 (en) | 2004-12-08 | 2005-12-06 | DERIVATIVES OF ARYLOXYETHYLAMINE AND PHENYLPIPERAZINE WITH A COMBINATION OF PARTIAL AGONISM OF THE DOPAMINE RECEIVER -D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR EMPLOYMENT AS A CENTRAL NURSING SYSTEM |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050105094A AR052147A1 (en) | 2004-12-08 | 2005-12-06 | DERIVATIVES OF PHENYLPIPERAZINE WITH A COMBINATION OF PARTIAL AGONISM OF THE RECEIVER OF DOPAMINA-D2 AND INHIBITION OF THE REABSORTION OF SEROTONINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS MEDICINES FOR THE TREATMENT OF DISEASE SYSTEMS |
Country Status (7)
Country | Link |
---|---|
CN (4) | CN101072559A (en) |
AR (4) | AR052259A1 (en) |
BR (3) | BRPI0518862A2 (en) |
MX (4) | MX2007006815A (en) |
SA (2) | SA05260391B1 (en) |
TW (4) | TW200634009A (en) |
ZA (2) | ZA200704217B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103360342B (en) * | 2012-04-09 | 2015-12-16 | 江苏恩华药业股份有限公司 | 3-cyano-aniline alkylaryl bridged piperazine derivatives and preparing the application in medicine |
CN103073524B (en) * | 2013-01-25 | 2015-06-10 | 宁波市微循环与莨菪类药研究所 | 4-[4-(substituted phenyl) piperazine piperazinyl-1]-butylcarbamic acid substituted aromatic ester derivative and preparation method thereof |
-
2005
- 2005-12-06 TW TW094142941A patent/TW200634009A/en unknown
- 2005-12-06 AR ARP050105091A patent/AR052259A1/en not_active Application Discontinuation
- 2005-12-06 CN CNA2005800422159A patent/CN101072559A/en active Pending
- 2005-12-06 MX MX2007006815A patent/MX2007006815A/en active IP Right Grant
- 2005-12-06 MX MX2007006816A patent/MX2007006816A/en not_active Application Discontinuation
- 2005-12-06 CN CNA2005800422248A patent/CN101119722A/en active Pending
- 2005-12-06 TW TW094142952A patent/TW200628457A/en unknown
- 2005-12-06 TW TW094142937A patent/TW200634008A/en unknown
- 2005-12-06 CN CNA2005800421758A patent/CN101072558A/en active Pending
- 2005-12-06 MX MX2007006818A patent/MX2007006818A/en not_active Application Discontinuation
- 2005-12-06 BR BRPI0518862-8A patent/BRPI0518862A2/en not_active IP Right Cessation
- 2005-12-06 MX MX2007006817A patent/MX2007006817A/en active IP Right Grant
- 2005-12-06 CN CNA2005800422214A patent/CN101072560A/en active Pending
- 2005-12-06 BR BRPI0518621-8A patent/BRPI0518621A2/en not_active IP Right Cessation
- 2005-12-06 AR ARP050105092A patent/AR052260A1/en not_active Application Discontinuation
- 2005-12-06 BR BRPI0518620-0A patent/BRPI0518620A2/en not_active IP Right Cessation
- 2005-12-06 AR ARP050105093A patent/AR052261A1/en not_active Application Discontinuation
- 2005-12-06 SA SA05260391A patent/SA05260391B1/en unknown
- 2005-12-06 TW TW094142936A patent/TW200626565A/en unknown
- 2005-12-06 AR ARP050105094A patent/AR052147A1/en not_active Application Discontinuation
- 2005-12-06 SA SA05260387A patent/SA05260387B1/en unknown
-
2007
- 2007-05-23 ZA ZA200704217A patent/ZA200704217B/en unknown
- 2007-05-23 ZA ZA200704219A patent/ZA200704219B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200704217B (en) | 2008-12-31 |
MX2007006815A (en) | 2007-11-09 |
ZA200704219B (en) | 2008-05-28 |
BRPI0518862A2 (en) | 2008-12-09 |
SA05260391B1 (en) | 2009-04-01 |
BRPI0518621A2 (en) | 2008-12-02 |
CN101119722A (en) | 2008-02-06 |
SA05260387B1 (en) | 2009-07-29 |
MX2007006818A (en) | 2007-11-09 |
TW200634008A (en) | 2006-10-01 |
BRPI0518620A2 (en) | 2008-12-02 |
CN101072558A (en) | 2007-11-14 |
AR052147A1 (en) | 2007-03-07 |
AR052259A1 (en) | 2007-03-07 |
MX2007006816A (en) | 2007-07-24 |
CN101072559A (en) | 2007-11-14 |
MX2007006817A (en) | 2007-07-24 |
AR052260A1 (en) | 2007-03-07 |
TW200626565A (en) | 2006-08-01 |
CN101072560A (en) | 2007-11-14 |
TW200634009A (en) | 2006-10-01 |
TW200628457A (en) | 2006-08-16 |
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