AR061111A1 - ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCER - Google Patents
ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCERInfo
- Publication number
- AR061111A1 AR061111A1 ARP070102233A ARP070102233A AR061111A1 AR 061111 A1 AR061111 A1 AR 061111A1 AR P070102233 A ARP070102233 A AR P070102233A AR P070102233 A ARP070102233 A AR P070102233A AR 061111 A1 AR061111 A1 AR 061111A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- amino
- alkoxy
- halogenated
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Composiciones farmacéuticas, usos y proceso de obtencion. Son utiles en terapia, en particular en el manejo del dolor. Reivindicacion 1: Un compuesto de formula 1, una sal del mismo aceptable para uso farmacéutico, un diastereomero, un enantiomero, o una mezcla de los mismos: donde R1 se selecciona independientemente entre hidrogeno, halogeno, ciano, amino, acetilamino, acetoxi hidroxilo, alcoxi C1-6, hidroxi- alcoxi C1-6, benciloxi-OCH2-C(=O)-R4, -OS(=O)2R4, alquilo C1-6, alcoxi C1-6 halogenado, alquileno C2-6, alquilo C1-6 halogenado, alquenilo C2-6 halogenado, alquilamino C1-6, di-alquil C1-6-amino y amino; R2 se selecciona entre los compuestos de formulas (2) donde dicho grupo utilizado para definir R2 están opcionalmente sustituidos con uno o más grupos seleccionados entre halogeno, alquilo C1-6 halogenado, alquilo C1-6, alcoxi C1-6 halogenado, ciano, nitro, alcoxi C1-6, hidroxi, hidroxi-alquilo C1-6, amino, alquil C1-6arilo-C6-10, alcoxi C1-6-alquilo C1-6, alquil C1-6-carbonilo, alcoxi C1-6-carbonilo, alquil C1-6-amino, di-alquil C1-6-amino, di-alquil C1-6-amino- alquilo C1-6, amino-alquilo C1-6, alquil C1-6-amino-carbonilo, heteroaril C2-5-carbonilo, heterocicloalquil C2-5-carbonilo, aril C6-10-carbonilo, heterocicloalquilo C2-5, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-6, heteroarilo C2-5, heteroaril C2-5- alquilo C1-6, arilo C6-10 y aril C6-10-alquilo C1-6; R3 se selecciona entre alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, cicloalquenilo C4-6, alcoxi C1-6, y heterocicloalquilo C2-5; donde dicho alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, cicloalquenilo C4-65, alcoxi C1-6, y heterocicloalquilo C2-5 utilizado para definir R3 están opcionalmente sustituidos con uno o más grupos seleccionados entre halogeno, alquilo C1-6 halogenado, alquilo C1-6, alcoxi C1-6 halogenado, ciano, nitro, alcoxi C1-6, hidroxi, hidroxi-alquilo C1-6, amino, alquil C1-6-arilo C6-10, alcoxi C1-6-alquilo C1-6, alquil C1-6-carbonilo, alcoxi C1-6- carbonilo, alquil C1-6-amino, di-alquil C1-6-amino, di-alquil C1-6-amino-alquilo C1-6, amino-alquilo C1-6, alquil C1-6-amino-carbonilo, heteroaril C2-5-carbonilo, heterociclo C2-5 alquil-carbonilo, aril C6-10-carbonilo, heterociclo-alquilo C2-5, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-6, heteroarilo C2-5, heteroaril C2-5-alquilo C1-6, arilo C6-10 y aril C6-10-alquilo C1-6; R4 se selecciona entre alquilo C1-6, alquilo C1-6 halogenado, hidroxi, hidroxialquil C1-6-amino, amino, alcoxi C1-6, alquil C1-6-amino, di-alquil C1-6-amino, hidroxiamino, alcoxi C1-6-amino, bencilamino, heterociclo C2-5-alquilo, heteroarilo C2-5 y heteroaril C2-5-alquilo C1-6; X se selecciona entre -C(=O)- y -CH2-; y m y n se seleccionan independientemente entre 0, 1, 2, 3, 4 y 5, con la condicion de que R3 no sea un 2,6-dioxopiperidin-3-ilo opcionalmente sustituido.Pharmaceutical compositions, uses and process of obtaining. They are useful in therapy, particularly in pain management. Claim 1: A compound of formula 1, a salt thereof acceptable for pharmaceutical use, a diastereomer, an enantiomer, or a mixture thereof: wherein R1 is independently selected from hydrogen, halogen, cyano, amino, acetylamino, acetoxy hydroxyl, C1-6 alkoxy, hydroxy- C1-6 alkoxy, benzyloxy-OCH2-C (= O) -R4, -OS (= O) 2R4, C1-6 alkyl, halogenated C1-6 alkoxy, C2-6 alkylene, C1 alkyl -6 halogenated, halogenated C2-6 alkenyl, C1-6 alkylamino, di- C1-6 alkyl amino and amino; R2 is selected from the compounds of formulas (2) where said group used to define R2 are optionally substituted with one or more groups selected from halogen, halogenated C1-6 alkyl, C1-6 alkyl, halogenated C1-6 alkoxy, cyano, nitro , C1-6 alkoxy, hydroxy, hydroxy C1-6 alkyl, amino, C1-6 alkyl-C6-10 alkyl, C1-6 alkoxy-C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6-amino alkyl, di-C1-6-alkyl-amino, di-C1-6-alkyl-amino-C1-6 alkyl, amino-C1-6 alkyl, C1-6-alkyl-aminocarbonyl, C2-5 heteroaryl -carbonyl, C2-5 heterocycloalkylcarbonyl, C6-10 -carbonyl, C2-5 heterocycloalkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, C2-5 heteroaryl, C2-5 heteroaryl- C1- 6, C6-10 aryl and C6-10 aryl-C1-6 alkyl; R3 is selected from C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, C4-6 cycloalkenyl, C1-6 alkoxy, and C2-5 heterocycloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, C4-65 cycloalkenyl, C1-6 alkoxy, and C2-5 heterocycloalkyl used to define R3 are optionally substituted with one or more groups selected from halogen, C1 alkyl -6 halogenated, C1-6 alkyl, halogenated C1-6 alkoxy, cyano, nitro, C1-6 alkoxy, hydroxy, hydroxy C1-6 alkyl, amino, C1-6 alkyl-C6-10 aryl, C1-6 alkoxy C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkyl, amino C 1-6 alkyl, diC 1-6 alkyl aminoC 1-6 alkyl, amino -C 1-6 alkyl, C 1-6 alkyl aminocarbonyl, C2-5 heteroaryl carbonyl, C2-5 heterocycle alkylcarbonyl, C6-10 arylcarbonyl, heterocycle C2-5 alkyl, C3-6 cycloalkyl, cycloalkyl C3-6-C1-6 alkyl, C2-5 heteroaryl, C2-5 heteroaryl-C1-6 alkyl, C6-10 aryl and C6-10 aryl-C1-6 alkyl; R4 is selected from C1-6 alkyl, halogenated C1-6 alkyl, hydroxy, C1-6 hydroxyalkyl amino, amino, C1-6 alkoxy, C1-6-amino alkyl, di- C1-6-amino alkyl, hydroxyamino, alkoxy C1-6-amino, benzylamino, C2-5-alkyl heterocycle, C2-5 heteroaryl and C2-5 heteroaryl-C1-6 alkyl; X is selected from -C (= O) - and -CH2-; and m and n are independently selected from 0, 1, 2, 3, 4 and 5, with the proviso that R3 is not an optionally substituted 2,6-dioxopiperidin-3-yl.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80324206P | 2006-05-26 | 2006-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR061111A1 true AR061111A1 (en) | 2008-08-06 |
Family
ID=38778884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102233A AR061111A1 (en) | 2006-05-26 | 2007-05-23 | ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCER |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2029535A1 (en) |
JP (1) | JP2009538296A (en) |
CN (1) | CN101495450A (en) |
AR (1) | AR061111A1 (en) |
CL (1) | CL2007001517A1 (en) |
TW (1) | TW200806625A (en) |
UY (1) | UY30363A1 (en) |
WO (1) | WO2007139464A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
US20110319411A1 (en) * | 2008-12-08 | 2011-12-29 | Sirtis Pharmaceuticals, Inc. | Isoindolinone and related analogs as sirtuin modulators |
US20130203756A1 (en) * | 2010-10-29 | 2013-08-08 | Jamie L. Bunda | Isoindoline pde10 inhibitors |
US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
US9403802B2 (en) | 2012-03-02 | 2016-08-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use therefor |
JP6211530B2 (en) | 2012-11-19 | 2017-10-11 | 武田薬品工業株式会社 | Nitrogen-containing heterocyclic compounds |
PL3134386T3 (en) | 2014-04-23 | 2020-11-16 | Takeda Pharmaceutical Company Limited | Isoindoline-1-one derivatives as cholinergic muscarinic m1 receptor positive alloesteric modulator activity for the treatment of alzheimers disease |
JP6531093B2 (en) | 2014-05-16 | 2019-06-12 | 武田薬品工業株式会社 | Nitrogen-containing heterocyclic compound |
KR101846475B1 (en) * | 2015-04-27 | 2018-04-09 | 주식회사 녹십자 | COMPOUNDS AS TNIK, IKKε AND TBK1 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030045552A1 (en) * | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
DE10134482A1 (en) * | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituted isoindoles and their use |
DE10137163A1 (en) * | 2001-07-30 | 2003-02-13 | Bayer Ag | New thiophenecarboxamido-substituted isoindole derivatives, useful as Factor XIa inhibitors for treatment or prophylaxis of, e.g. thromboembolic diseases, atherosclerosis, arthritis, Alzheimer's disease or cancer |
US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
US7405237B2 (en) * | 2004-07-28 | 2008-07-29 | Celgene Corporation | Isoindoline compounds and methods of their use |
-
2007
- 2007-05-21 TW TW096117988A patent/TW200806625A/en unknown
- 2007-05-23 AR ARP070102233A patent/AR061111A1/en not_active Application Discontinuation
- 2007-05-24 UY UY30363A patent/UY30363A1/en not_active Application Discontinuation
- 2007-05-24 CN CNA2007800284618A patent/CN101495450A/en active Pending
- 2007-05-24 WO PCT/SE2007/000503 patent/WO2007139464A1/en active Application Filing
- 2007-05-24 JP JP2009511980A patent/JP2009538296A/en active Pending
- 2007-05-24 EP EP07748167A patent/EP2029535A1/en not_active Withdrawn
- 2007-05-25 CL CL2007001517A patent/CL2007001517A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN101495450A (en) | 2009-07-29 |
UY30363A1 (en) | 2008-01-02 |
JP2009538296A (en) | 2009-11-05 |
EP2029535A1 (en) | 2009-03-04 |
WO2007139464A1 (en) | 2007-12-06 |
TW200806625A (en) | 2008-02-01 |
CL2007001517A1 (en) | 2008-01-25 |
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