AR061111A1 - ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCER - Google Patents

ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCER

Info

Publication number
AR061111A1
AR061111A1 ARP070102233A ARP070102233A AR061111A1 AR 061111 A1 AR061111 A1 AR 061111A1 AR P070102233 A ARP070102233 A AR P070102233A AR P070102233 A ARP070102233 A AR P070102233A AR 061111 A1 AR061111 A1 AR 061111A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
alkoxy
halogenated
heteroaryl
Prior art date
Application number
ARP070102233A
Other languages
Spanish (es)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR061111A1 publication Critical patent/AR061111A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composiciones farmacéuticas, usos y proceso de obtencion. Son utiles en terapia, en particular en el manejo del dolor. Reivindicacion 1: Un compuesto de formula 1, una sal del mismo aceptable para uso farmacéutico, un diastereomero, un enantiomero, o una mezcla de los mismos: donde R1 se selecciona independientemente entre hidrogeno, halogeno, ciano, amino, acetilamino, acetoxi hidroxilo, alcoxi C1-6, hidroxi- alcoxi C1-6, benciloxi-OCH2-C(=O)-R4, -OS(=O)2R4, alquilo C1-6, alcoxi C1-6 halogenado, alquileno C2-6, alquilo C1-6 halogenado, alquenilo C2-6 halogenado, alquilamino C1-6, di-alquil C1-6-amino y amino; R2 se selecciona entre los compuestos de formulas (2) donde dicho grupo utilizado para definir R2 están opcionalmente sustituidos con uno o más grupos seleccionados entre halogeno, alquilo C1-6 halogenado, alquilo C1-6, alcoxi C1-6 halogenado, ciano, nitro, alcoxi C1-6, hidroxi, hidroxi-alquilo C1-6, amino, alquil C1-6arilo-C6-10, alcoxi C1-6-alquilo C1-6, alquil C1-6-carbonilo, alcoxi C1-6-carbonilo, alquil C1-6-amino, di-alquil C1-6-amino, di-alquil C1-6-amino- alquilo C1-6, amino-alquilo C1-6, alquil C1-6-amino-carbonilo, heteroaril C2-5-carbonilo, heterocicloalquil C2-5-carbonilo, aril C6-10-carbonilo, heterocicloalquilo C2-5, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-6, heteroarilo C2-5, heteroaril C2-5- alquilo C1-6, arilo C6-10 y aril C6-10-alquilo C1-6; R3 se selecciona entre alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, cicloalquenilo C4-6, alcoxi C1-6, y heterocicloalquilo C2-5; donde dicho alquilo C1-6, alquenilo C2-6, cicloalquilo C3-6, cicloalquenilo C4-65, alcoxi C1-6, y heterocicloalquilo C2-5 utilizado para definir R3 están opcionalmente sustituidos con uno o más grupos seleccionados entre halogeno, alquilo C1-6 halogenado, alquilo C1-6, alcoxi C1-6 halogenado, ciano, nitro, alcoxi C1-6, hidroxi, hidroxi-alquilo C1-6, amino, alquil C1-6-arilo C6-10, alcoxi C1-6-alquilo C1-6, alquil C1-6-carbonilo, alcoxi C1-6- carbonilo, alquil C1-6-amino, di-alquil C1-6-amino, di-alquil C1-6-amino-alquilo C1-6, amino-alquilo C1-6, alquil C1-6-amino-carbonilo, heteroaril C2-5-carbonilo, heterociclo C2-5 alquil-carbonilo, aril C6-10-carbonilo, heterociclo-alquilo C2-5, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-6, heteroarilo C2-5, heteroaril C2-5-alquilo C1-6, arilo C6-10 y aril C6-10-alquilo C1-6; R4 se selecciona entre alquilo C1-6, alquilo C1-6 halogenado, hidroxi, hidroxialquil C1-6-amino, amino, alcoxi C1-6, alquil C1-6-amino, di-alquil C1-6-amino, hidroxiamino, alcoxi C1-6-amino, bencilamino, heterociclo C2-5-alquilo, heteroarilo C2-5 y heteroaril C2-5-alquilo C1-6; X se selecciona entre -C(=O)- y -CH2-; y m y n se seleccionan independientemente entre 0, 1, 2, 3, 4 y 5, con la condicion de que R3 no sea un 2,6-dioxopiperidin-3-ilo opcionalmente sustituido.Pharmaceutical compositions, uses and process of obtaining. They are useful in therapy, particularly in pain management. Claim 1: A compound of formula 1, a salt thereof acceptable for pharmaceutical use, a diastereomer, an enantiomer, or a mixture thereof: wherein R1 is independently selected from hydrogen, halogen, cyano, amino, acetylamino, acetoxy hydroxyl, C1-6 alkoxy, hydroxy- C1-6 alkoxy, benzyloxy-OCH2-C (= O) -R4, -OS (= O) 2R4, C1-6 alkyl, halogenated C1-6 alkoxy, C2-6 alkylene, C1 alkyl -6 halogenated, halogenated C2-6 alkenyl, C1-6 alkylamino, di- C1-6 alkyl amino and amino; R2 is selected from the compounds of formulas (2) where said group used to define R2 are optionally substituted with one or more groups selected from halogen, halogenated C1-6 alkyl, C1-6 alkyl, halogenated C1-6 alkoxy, cyano, nitro , C1-6 alkoxy, hydroxy, hydroxy C1-6 alkyl, amino, C1-6 alkyl-C6-10 alkyl, C1-6 alkoxy-C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6-amino alkyl, di-C1-6-alkyl-amino, di-C1-6-alkyl-amino-C1-6 alkyl, amino-C1-6 alkyl, C1-6-alkyl-aminocarbonyl, C2-5 heteroaryl -carbonyl, C2-5 heterocycloalkylcarbonyl, C6-10 -carbonyl, C2-5 heterocycloalkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, C2-5 heteroaryl, C2-5 heteroaryl- C1- 6, C6-10 aryl and C6-10 aryl-C1-6 alkyl; R3 is selected from C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, C4-6 cycloalkenyl, C1-6 alkoxy, and C2-5 heterocycloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, C4-65 cycloalkenyl, C1-6 alkoxy, and C2-5 heterocycloalkyl used to define R3 are optionally substituted with one or more groups selected from halogen, C1 alkyl -6 halogenated, C1-6 alkyl, halogenated C1-6 alkoxy, cyano, nitro, C1-6 alkoxy, hydroxy, hydroxy C1-6 alkyl, amino, C1-6 alkyl-C6-10 aryl, C1-6 alkoxy C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 alkyl, amino C 1-6 alkyl, diC 1-6 alkyl aminoC 1-6 alkyl, amino -C 1-6 alkyl, C 1-6 alkyl aminocarbonyl, C2-5 heteroaryl carbonyl, C2-5 heterocycle alkylcarbonyl, C6-10 arylcarbonyl, heterocycle C2-5 alkyl, C3-6 cycloalkyl, cycloalkyl C3-6-C1-6 alkyl, C2-5 heteroaryl, C2-5 heteroaryl-C1-6 alkyl, C6-10 aryl and C6-10 aryl-C1-6 alkyl; R4 is selected from C1-6 alkyl, halogenated C1-6 alkyl, hydroxy, C1-6 hydroxyalkyl amino, amino, C1-6 alkoxy, C1-6-amino alkyl, di- C1-6-amino alkyl, hydroxyamino, alkoxy C1-6-amino, benzylamino, C2-5-alkyl heterocycle, C2-5 heteroaryl and C2-5 heteroaryl-C1-6 alkyl; X is selected from -C (= O) - and -CH2-; and m and n are independently selected from 0, 1, 2, 3, 4 and 5, with the proviso that R3 is not an optionally substituted 2,6-dioxopiperidin-3-yl.

ARP070102233A 2006-05-26 2007-05-23 ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCER AR061111A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80324206P 2006-05-26 2006-05-26

Publications (1)

Publication Number Publication Date
AR061111A1 true AR061111A1 (en) 2008-08-06

Family

ID=38778884

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070102233A AR061111A1 (en) 2006-05-26 2007-05-23 ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCER

Country Status (8)

Country Link
EP (1) EP2029535A1 (en)
JP (1) JP2009538296A (en)
CN (1) CN101495450A (en)
AR (1) AR061111A1 (en)
CL (1) CL2007001517A1 (en)
TW (1) TW200806625A (en)
UY (1) UY30363A1 (en)
WO (1) WO2007139464A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
CA2746221A1 (en) * 2008-12-08 2010-07-08 Sirtris Pharmaceuticals, Inc. Isoindolinone and related analogs as sirtuin modulators
EP2632461A4 (en) * 2010-10-29 2014-04-02 Merck Sharp & Dohme Isoindolinone pde10 inhibitors
US9938269B2 (en) 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
JP6211509B2 (en) 2012-03-02 2017-10-11 武田薬品工業株式会社 Heterocyclic compounds and uses thereof
WO2014077401A1 (en) 2012-11-19 2014-05-22 武田薬品工業株式会社 Nitrogen-containing heterocyclic compound
US9868725B2 (en) 2014-04-23 2018-01-16 Takeda Pharmaceutical Company Limited Isoindoline-1-one derivatives as cholinergic muscarinic M1 receptor positive alloesteric modulator activity for the treatment of Alzheimer's disease
JP6531093B2 (en) 2014-05-16 2019-06-12 武田薬品工業株式会社 Nitrogen-containing heterocyclic compound
KR101846475B1 (en) * 2015-04-27 2018-04-09 주식회사 녹십자 COMPOUNDS AS TNIK, IKKε AND TBK1 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045552A1 (en) * 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
DE10134482A1 (en) * 2001-07-16 2003-01-30 Bayer Ag Substituted isoindoles and their use
DE10137163A1 (en) * 2001-07-30 2003-02-13 Bayer Ag New thiophenecarboxamido-substituted isoindole derivatives, useful as Factor XIa inhibitors for treatment or prophylaxis of, e.g. thromboembolic diseases, atherosclerosis, arthritis, Alzheimer's disease or cancer
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
US7405237B2 (en) * 2004-07-28 2008-07-29 Celgene Corporation Isoindoline compounds and methods of their use

Also Published As

Publication number Publication date
UY30363A1 (en) 2008-01-02
CL2007001517A1 (en) 2008-01-25
EP2029535A1 (en) 2009-03-04
JP2009538296A (en) 2009-11-05
TW200806625A (en) 2008-02-01
WO2007139464A1 (en) 2007-12-06
CN101495450A (en) 2009-07-29

Similar Documents

Publication Publication Date Title
AR061111A1 (en) ISOINDOL DERIVATIVES USEFUL TO TREAT PAIN, GASTROINTESTINAL DISORDERS AND CANCER
AR070343A1 (en) PIRIDINIL AMIDAS, A PROCEDURE FOR THE TREATMENT OF SCHIZOPHRENIA IN A MAMMER AND A PHARMACEUTICAL COMPOSITION
PE20220567A1 (en) NEW PIPERIDINIL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR063602A1 (en) DERIVATIVES OF SPIROINDOLINONE, PHARMACEUTICAL FORMULATIONS THAT CONTAIN THEM AND THEIR USE IN THE OBTAINING OF A MEDICINAL PRODUCT FOR THE TREATMENT OF ONCOLOGICAL DISORDERS.
AR059957A1 (en) DERIVATIVES OF SPIROINDOLINONE, METHODS FOR THEIR PREPARATION, A PHARMACEUTICAL COMPOSITION CONTAINING THEM AND THEIR USE IN THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF CANCER.
PE20142456A1 (en) OXAZOLIDIN-2-ONA COMPOUNDS AND USES OF THE SAME AS INHIBITORS OF PI3Ks
AR072906A1 (en) MODIFIED NUCLEOSIDS USEFUL AS ANTIVIRAL
AR049276A1 (en) OPIOOD CARBOXAMID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AR061371A1 (en) AMINO - IMIDAZOLONAS AND ITS USE AS A MEDICINAL PRODUCT FOR ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES.
AR056873A1 (en) DERIVATIVES OF PIRAZOLOPIRIMIDINAS AS QUINASA INHIBITORS OF CYCLINE DEPENDENTS, PHARMACEUTICAL COMPOSITIONS
AR081426A1 (en) PIRAZOL DERIVATIVES INHIBITORS OF THE SIGMA RECEIVER
UY29393A1 (en) NEW DERIVATIVES OF AMIDAS, ACCEPTABLE PHARMACEUTICAL SALTS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION PROCEDURES AND APPLICATIONS.
AR061369A1 (en) PIRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM
HUP0200859A2 (en) Cyclo-alkyl substituted benzimidazoles, pharmaceutical compositions containing them, their preparation and their use
ECSP088457A (en) USEFUL BENZAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETILASE
UY26048A1 (en) DERIVATIVES OF PIRIDOPIRANOACEPINAS, ITS PREPARATION AND ITS THERAPEUTIC APPLICATION
AR046793A1 (en) DERIVADOS DE PIRAZOL, ANTAGONISTS OF THE RECEIVER OF OREXINA
AR078632A1 (en) STEROID COMPOUNDS MODIFIING MELANOGENESIS AND ITS USES
UY27803A1 (en) DERIVATIVES OF BENZOXAZINE AND USES OF THE SAME.
ECSP088257A (en) AMIDA DERIVATIVES
AR054707A1 (en) DERIVATIVES OF OCTAHIDROPIRROLO 3,4-C PIRROL, A PROCEDURE FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
CL2011001050A1 (en) Compound 2-methyl-1- (phenylsulfonyl) -4- (piperazin-1-yl) -1h-benzimidazole, which is a 5-hydroxytryptamine-6 ligand; its pharmaceutical composition; 5-ht6 activity modulator; its use in the treatment of disorders of the central nervous system, such as psychosis, anxiety, depression, epilepsy, among others.
AR064488A1 (en) DERIVATIVES OF 4- (1-AMINO-ETIL) -CICLOHEXILAMINE, A PHARMACEUTICAL COMPOSITION CONTAINING IT AND THE USE OF THEM FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OR PREVENTION OF A BACTERIAL INFECTION
AR072880A1 (en) NITROGEN DERIVATIVES OF PANCRATISTATINE
AR075160A1 (en) DERIVATIVES OF ARIL AND / OR HETEROARIL PIPERIDINES REPLACED, MEDICINES THAT CONTAIN THEM, PROCESS TO PREPARE THEM AND USE OF THE SAME FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal