AR054707A1 - DERIVATIVES OF OCTAHIDROPIRROLO 3,4-C PIRROL, A PROCEDURE FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT - Google Patents
DERIVATIVES OF OCTAHIDROPIRROLO 3,4-C PIRROL, A PROCEDURE FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCTInfo
- Publication number
- AR054707A1 AR054707A1 ARP050104891A ARP050104891A AR054707A1 AR 054707 A1 AR054707 A1 AR 054707A1 AR P050104891 A ARP050104891 A AR P050104891A AR P050104891 A ARP050104891 A AR P050104891A AR 054707 A1 AR054707 A1 AR 054707A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- manufacture
- preparation
- octahidropirrolo
- pirrol
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Procedimientos para la preparacion del compuesto, composiciones farmacéuticas que los contienen y uso del compuesto para la fabricacion de un medicamento. Estos compuestos son apropiados para el tratamiento de enfermedades inflamatorias como artritis reumatoide, asma, psoriasis y otras. Reivindicacion 1: Un compuesto de formula (1) o sales y solvatos farmacéuticamente aceptables del mismo, en la que: R1 es H o alquilo C1-4 opcionalmente sustituido con un hidroxi, X es N o C-R9 donde R9 es H o metilo; Y es O o NH; R6 es H o metilo; y R2, R3, R4 y R5 se seleccionan independientemente entre H, halo, ciano, alquilo C1-4, alcoxi C1-4, trifluorometilo, trifluorometoxi, hidroxi,. (CH2)n-C(O)O-R7, (CH2)n-O-(CH2) m-R8 y (CH2)n-R8, donde n y m son ambos independientemente 0 o 1; R7 es H o alquilo C1-4 y R8 es fenilo.Procedures for the preparation of the compound, pharmaceutical compositions containing them and use of the compound for the manufacture of a medicament. These compounds are suitable for the treatment of inflammatory diseases such as rheumatoid arthritis, asthma, psoriasis and others. Claim 1: A compound of formula (1) or pharmaceutically acceptable salts and solvates thereof, wherein: R1 is H or C1-4 alkyl optionally substituted with a hydroxy, X is N or C-R9 where R9 is H or methyl ; Y is O or NH; R6 is H or methyl; and R2, R3, R4 and R5 are independently selected from H, halo, cyano, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, trifluoromethoxy, hydroxy ,. (CH2) n-C (O) O-R7, (CH2) n-O- (CH2) m-R8 and (CH2) n-R8, where n and m are both independently 0 or 1; R7 is H or C1-4 alkyl and R8 is phenyl.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106044A EP1671972A1 (en) | 2004-11-24 | 2004-11-24 | Octahydropyrrolo[3,4-c]pyrrole derivatives |
| EP05100474 | 2005-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054707A1 true AR054707A1 (en) | 2007-07-11 |
Family
ID=35985757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050104891A AR054707A1 (en) | 2004-11-24 | 2005-11-22 | DERIVATIVES OF OCTAHIDROPIRROLO 3,4-C PIRROL, A PROCEDURE FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND USE OF THE COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1846409A1 (en) |
| JP (1) | JP2008520644A (en) |
| AR (1) | AR054707A1 (en) |
| CA (1) | CA2587141A1 (en) |
| GT (1) | GT200500340A (en) |
| NL (1) | NL1030503C2 (en) |
| PA (1) | PA8653801A1 (en) |
| PE (1) | PE20061055A1 (en) |
| SV (1) | SV2007002315A (en) |
| TW (1) | TW200626600A (en) |
| UY (1) | UY29221A1 (en) |
| WO (1) | WO2006056848A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5650404B2 (en) | 2006-12-28 | 2015-01-07 | ライジェル ファーマシューティカルズ， インコーポレイテッド | N-substituted heterocycloalkyloxybenzamide compounds and methods of use thereof |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| US20120277238A1 (en) * | 2009-07-31 | 2012-11-01 | Shionogi & Co., Ltd | Pharmaceutical composition containing fused hetero-ring derivative |
| PL2491038T3 (en) | 2009-10-23 | 2016-10-31 | Disubstituted octahy - dropyrrolo [3,4-c]pyrroles as orexin receptor modulators | |
| JP5847087B2 (en) | 2009-10-23 | 2016-01-20 | ヤンセン ファーマシューティカ エヌ．ベー． | Fused heterocyclic compounds as orexin receptor modulators |
| WO2011050202A1 (en) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
| WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
| DK2858647T3 (en) | 2012-06-08 | 2018-08-20 | Sensorion | H4 RECEPTOR INHIBITORS FOR TINNITUS TREATMENT |
| HUE058759T2 (en) | 2016-03-10 | 2022-09-28 | Janssen Pharmaceutica Nv | Methods of treating depression using orexin-2 receptor antagonists |
| WO2019152883A1 (en) * | 2018-02-02 | 2019-08-08 | Padforward Llc | Inhibitors of protein arginine deiminases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2620341A (en) * | 1949-03-24 | 1952-12-02 | Burroughs Wellcome Co | N,n-dialkyl-quinoline-4-carboxamidines |
| PT828741E (en) * | 1995-05-11 | 2002-02-28 | Upjohn Co | OXAZOLIDINONES OF SPIROCYCLIC AND BICYCLE DIAZINYL AND CARBAZINYL |
| GB9902453D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| CA2440803A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| US6803362B2 (en) * | 2001-03-09 | 2004-10-12 | Ortho-Mcneil Pharmaceutical Inc. | Heterocyclic compounds |
| WO2004021999A2 (en) * | 2002-09-06 | 2004-03-18 | Janssen Pharmaceutica, N.V. | Use of histamine h4 receptor modulators for the treatment of allergy and asthma |
| AU2003272285A1 (en) * | 2002-09-06 | 2004-03-29 | Janssen Pharmaceutica, N.V. | Thienopyrrolyl and furanopyrrolyl compounds and their use as histamine h4 receptor ligands |
| KR20050033662A (en) * | 2002-09-06 | 2005-04-12 | 얀센 파마슈티카 엔.브이. | Heterocyclic compounds |
-
2005
- 2005-11-10 JP JP2007542155A patent/JP2008520644A/en active Pending
- 2005-11-10 WO PCT/IB2005/003478 patent/WO2006056848A1/en active Application Filing
- 2005-11-10 EP EP05824102A patent/EP1846409A1/en not_active Withdrawn
- 2005-11-10 CA CA002587141A patent/CA2587141A1/en not_active Abandoned
- 2005-11-21 PE PE2005001360A patent/PE20061055A1/en not_active Application Discontinuation
- 2005-11-21 UY UY29221A patent/UY29221A1/en not_active Application Discontinuation
- 2005-11-22 AR ARP050104891A patent/AR054707A1/en unknown
- 2005-11-23 NL NL1030503A patent/NL1030503C2/en not_active IP Right Cessation
- 2005-11-23 GT GT200500340A patent/GT200500340A/en unknown
- 2005-11-23 TW TW094141134A patent/TW200626600A/en unknown
- 2005-11-24 PA PA20058653801A patent/PA8653801A1/en unknown
- 2005-11-24 SV SV2005002315A patent/SV2007002315A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008520644A (en) | 2008-06-19 |
| SV2007002315A (en) | 2007-02-16 |
| NL1030503C2 (en) | 2006-11-28 |
| UY29221A1 (en) | 2006-06-30 |
| CA2587141A1 (en) | 2006-06-01 |
| PE20061055A1 (en) | 2006-11-09 |
| TW200626600A (en) | 2006-08-01 |
| WO2006056848A1 (en) | 2006-06-01 |
| NL1030503A1 (en) | 2006-05-29 |
| GT200500340A (en) | 2006-07-13 |
| EP1846409A1 (en) | 2007-10-24 |
| PA8653801A1 (en) | 2006-06-02 |
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| FB | Suspension of granting procedure |