TW200626565A - Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition - Google Patents

Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition

Info

Publication number
TW200626565A
TW200626565A TW094142936A TW94142936A TW200626565A TW 200626565 A TW200626565 A TW 200626565A TW 094142936 A TW094142936 A TW 094142936A TW 94142936 A TW94142936 A TW 94142936A TW 200626565 A TW200626565 A TW 200626565A
Authority
TW
Taiwan
Prior art keywords
serotonin reuptake
combination
reuptake inhibition
phenylpiperazine derivatives
receptor agonism
Prior art date
Application number
TW094142936A
Other languages
Chinese (zh)
Inventor
Roelof W Feenstra
Axel Stoit
Jan-Willem Terpstra
Maria L Pras-Raves
Andrew C Mccreary
Vliet Bernard J Van
Mayke B Hesselink
Cornelis G Kruse
Scharrenburg Gustaaf J M Van
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of TW200626565A publication Critical patent/TW200626565A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1): wherein the symbols have the meanings given in the specification. And tautomers, stereoisomers and N-oxides thereof, as well as pharmacologically acceptable salts, hydrates and solvates of said compounds of formula (1) and its tautomers, stereoisomers and N-oxides.
TW094142936A 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition TW200626565A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04106394 2004-12-08

Publications (1)

Publication Number Publication Date
TW200626565A true TW200626565A (en) 2006-08-01

Family

ID=34930019

Family Applications (4)

Application Number Title Priority Date Filing Date
TW094142941A TW200634009A (en) 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
TW094142952A TW200628457A (en) 2004-12-08 2005-12-06 Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
TW094142937A TW200634008A (en) 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
TW094142936A TW200626565A (en) 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition

Family Applications Before (3)

Application Number Title Priority Date Filing Date
TW094142941A TW200634009A (en) 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
TW094142952A TW200628457A (en) 2004-12-08 2005-12-06 Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
TW094142937A TW200634008A (en) 2004-12-08 2005-12-06 Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition

Country Status (7)

Country Link
CN (4) CN101072559A (en)
AR (4) AR052259A1 (en)
BR (3) BRPI0518862A2 (en)
MX (4) MX2007006815A (en)
SA (2) SA05260391B1 (en)
TW (4) TW200634009A (en)
ZA (2) ZA200704217B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103360342B (en) * 2012-04-09 2015-12-16 江苏恩华药业股份有限公司 3-cyano-aniline alkylaryl bridged piperazine derivatives and preparing the application in medicine
CN103073524B (en) * 2013-01-25 2015-06-10 宁波市微循环与莨菪类药研究所 4-[4-(substituted phenyl) piperazine piperazinyl-1]-butylcarbamic acid substituted aromatic ester derivative and preparation method thereof

Also Published As

Publication number Publication date
ZA200704217B (en) 2008-12-31
MX2007006815A (en) 2007-11-09
ZA200704219B (en) 2008-05-28
BRPI0518862A2 (en) 2008-12-09
AR052261A1 (en) 2007-03-07
SA05260391B1 (en) 2009-04-01
BRPI0518621A2 (en) 2008-12-02
CN101119722A (en) 2008-02-06
SA05260387B1 (en) 2009-07-29
MX2007006818A (en) 2007-11-09
TW200634008A (en) 2006-10-01
BRPI0518620A2 (en) 2008-12-02
CN101072558A (en) 2007-11-14
AR052147A1 (en) 2007-03-07
AR052259A1 (en) 2007-03-07
MX2007006816A (en) 2007-07-24
CN101072559A (en) 2007-11-14
MX2007006817A (en) 2007-07-24
AR052260A1 (en) 2007-03-07
CN101072560A (en) 2007-11-14
TW200634009A (en) 2006-10-01
TW200628457A (en) 2006-08-16

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