AR044252A1 - Procedimiento para cristalizar sales de guanidinio - Google Patents
Procedimiento para cristalizar sales de guanidinioInfo
- Publication number
- AR044252A1 AR044252A1 ARP040101530A ARP040101530A AR044252A1 AR 044252 A1 AR044252 A1 AR 044252A1 AR P040101530 A ARP040101530 A AR P040101530A AR P040101530 A ARP040101530 A AR P040101530A AR 044252 A1 AR044252 A1 AR 044252A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- mono
- formula
- treatment
- water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Un procedimiento para cristalizar los compuestos de la fórmula (1) o sus sales por adición de ácidos donde: R1 es R4SO2- o A; R2 y R3 son, de modo independiente entre sí, H, Hal, alquilo C1-12, R4SO2-, Ar o Het, R4 es arilo o alquilo C1-12, Het es un radical orgánico insustituido o mono o polisustituido con A, COAr, COHet y/o Hal, saturado, insaturado o aromático, mono o bicíclico, heterocíclico o lineal o ramificado, que contiene uno o varios heteroátomos, Ar es un radical fenilo insustituido o mono o polisustituido con A y/o Hal, OH, OA, COOH, COOA, CONH2, CONA2, CONHA, CN, NO2, NH2, NHA, NA2, NHCOA, CF3 o SO2A, A es alquilo o hidroxialquilo lineal o ramificado C1-10, alquenilo o alcoxialquilo C2-10 y Hal es F, Cl, Br, I, que consiste en la disolución de los correspondientes compuestos de la fórmula (1) o sus mezclas con impurezas a una temperatura dada en agua, que está casi saturada con al menos un solvente no miscible con agua y que eventualmente contiene uno o varios solventes miscibles con agua, y se dejan cristalizar los compuestos de la fórmula (1) a una menor temperatura. En particular, las sulfonil-benzoilguanidinas son inhibidoras del antiportador Na+/H+ celular y que muestran un buen efecto cardioprotector que le confiere aptitud para el tratamiento del infarto agudo de miocardio, la profiláxis del infarto, el tratamiento post-infarto, la insuficiencia cardíaca crónica y el tratamiento de la angina de pecho.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10320016 | 2003-05-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR044252A1 true AR044252A1 (es) | 2005-09-07 |
Family
ID=33426672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040101530A AR044252A1 (es) | 2003-05-06 | 2004-05-05 | Procedimiento para cristalizar sales de guanidinio |
Country Status (19)
Country | Link |
---|---|
US (1) | US7629493B2 (es) |
EP (1) | EP1620394B1 (es) |
JP (1) | JP2006525247A (es) |
KR (1) | KR20060015580A (es) |
CN (1) | CN1784381A (es) |
AR (1) | AR044252A1 (es) |
AT (1) | ATE404533T1 (es) |
AU (1) | AU2004235886B2 (es) |
BR (1) | BRPI0410022A (es) |
CA (1) | CA2524718A1 (es) |
DE (1) | DE502004007841D1 (es) |
DK (1) | DK1620394T3 (es) |
ES (1) | ES2310725T3 (es) |
MX (1) | MXPA05011840A (es) |
PL (1) | PL1620394T3 (es) |
PT (1) | PT1620394E (es) |
RU (1) | RU2374224C2 (es) |
WO (1) | WO2004099125A1 (es) |
ZA (1) | ZA200509867B (es) |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3975533A (en) * | 1970-04-29 | 1976-08-17 | Shell Oil Company | Therapeutic agents |
US4113776A (en) * | 1976-04-15 | 1978-09-12 | Hoffmann-La Roche Inc. | 1-(2-Aminoethyl)-3-(2,6-dihalophenyl)guanidines |
JPS61129159A (ja) * | 1984-11-28 | 1986-06-17 | Nippon Zeon Co Ltd | 保護化アミノ酸アミド化合物の精製法 |
ATE147375T1 (de) * | 1992-09-22 | 1997-01-15 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, sowie ihre verwendung als antiarrhythmika |
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4328352A1 (de) * | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4430861A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Heterocyclyl-benzoylguanidine |
DE4430916A1 (de) * | 1994-08-31 | 1996-03-07 | Merck Patent Gmbh | Alkyl-benzoylguanidin-Derivate |
DE19529612A1 (de) * | 1995-08-11 | 1997-02-13 | Merck Patent Gmbh | Sulfonyl- oder Sulfinyl-benzoylguanidin-Derivate |
DE19737224A1 (de) * | 1997-08-27 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen |
DE19738604A1 (de) * | 1997-09-04 | 1999-03-11 | Hoechst Marion Roussel De Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe |
US6147098A (en) * | 1998-05-11 | 2000-11-14 | Novo Nordisk A/S | Substituted guanidines and diaminonitroethenes, their preparation and use |
DE19951418A1 (de) * | 1999-10-26 | 2001-05-03 | Merck Patent Gmbh | Verfahren zur Herstellung von N-(4,5-Bismethansulfonyl-2-methyl-benzoyl) -guanidin, Hydrochlorid |
-
2004
- 2004-04-10 BR BRPI0410022-0A patent/BRPI0410022A/pt not_active IP Right Cessation
- 2004-04-10 KR KR1020057021022A patent/KR20060015580A/ko not_active Application Discontinuation
- 2004-04-10 DE DE502004007841T patent/DE502004007841D1/de not_active Expired - Lifetime
- 2004-04-10 JP JP2006505089A patent/JP2006525247A/ja not_active Ceased
- 2004-04-10 MX MXPA05011840A patent/MXPA05011840A/es active IP Right Grant
- 2004-04-10 WO PCT/EP2004/003838 patent/WO2004099125A1/de active IP Right Grant
- 2004-04-10 DK DK04726856T patent/DK1620394T3/da active
- 2004-04-10 EP EP04726856A patent/EP1620394B1/de not_active Expired - Lifetime
- 2004-04-10 AU AU2004235886A patent/AU2004235886B2/en not_active Ceased
- 2004-04-10 PT PT04726856T patent/PT1620394E/pt unknown
- 2004-04-10 US US10/555,789 patent/US7629493B2/en not_active Expired - Fee Related
- 2004-04-10 PL PL04726856T patent/PL1620394T3/pl unknown
- 2004-04-10 RU RU2005137821/04A patent/RU2374224C2/ru not_active IP Right Cessation
- 2004-04-10 CN CNA2004800118578A patent/CN1784381A/zh active Pending
- 2004-04-10 CA CA002524718A patent/CA2524718A1/en not_active Abandoned
- 2004-04-10 ES ES04726856T patent/ES2310725T3/es not_active Expired - Lifetime
- 2004-04-10 AT AT04726856T patent/ATE404533T1/de not_active IP Right Cessation
- 2004-05-05 AR ARP040101530A patent/AR044252A1/es unknown
-
2005
- 2005-12-05 ZA ZA200509867A patent/ZA200509867B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP1620394B1 (de) | 2008-08-13 |
PT1620394E (pt) | 2008-11-24 |
KR20060015580A (ko) | 2006-02-17 |
AU2004235886B2 (en) | 2010-07-01 |
DE502004007841D1 (de) | 2008-09-25 |
ZA200509867B (en) | 2006-12-27 |
ATE404533T1 (de) | 2008-08-15 |
BRPI0410022A (pt) | 2006-04-25 |
CN1784381A (zh) | 2006-06-07 |
US20070055064A1 (en) | 2007-03-08 |
DK1620394T3 (da) | 2008-11-24 |
AU2004235886A1 (en) | 2004-11-18 |
PL1620394T3 (pl) | 2008-12-31 |
JP2006525247A (ja) | 2006-11-09 |
MXPA05011840A (es) | 2006-01-26 |
RU2374224C2 (ru) | 2009-11-27 |
ES2310725T3 (es) | 2009-01-16 |
US7629493B2 (en) | 2009-12-08 |
WO2004099125A1 (de) | 2004-11-18 |
CA2524718A1 (en) | 2004-11-18 |
EP1620394A1 (de) | 2006-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |