AR042855A1 - Procedimiento mejorado de preparacion de lactamas policiclicas fusionadas con arilos - Google Patents
Procedimiento mejorado de preparacion de lactamas policiclicas fusionadas con arilosInfo
- Publication number
- AR042855A1 AR042855A1 ARP040100091A ARP040100091A AR042855A1 AR 042855 A1 AR042855 A1 AR 042855A1 AR P040100091 A ARP040100091 A AR P040100091A AR P040100091 A ARP040100091 A AR P040100091A AR 042855 A1 AR042855 A1 AR 042855A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- hydrogenation catalyst
- fused
- alkyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/26—Benzomorphans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para la preparación de lactamas policíclicas fusionadas con arilos que son intermediarios útiles en la síntesis de compuestos azapolicíclicos fusionados con arilos como agentes para el tratamiento de trastornos neurológicos y psicológicos. Reivindicación 1: Un procedimiento de preparación de un compuesto de fórmula (1) caracterizado porque comprende hidrogenar un compuesto de fórmula (2) con H gas y un alcohol que tiene la fórmula R3OH en presencia de un catalizador de hidrogenación y un ácido; en el que R1 y R2 se seleccionan de manera independiente de H, alquilo C1-6, alcoxi C1-5, trifluorometilo, halógeno, sulfonilalquilo, alquilamino, amida, éster, aril-alquilo, heteroalquilo y aril-alcoxi; o R1 y R2 junto con los átomos de C a los que están unidos forman un anillo monocíclico o bicíclico; y R3 es alquilo C1-6; y a) el catalizador de hidrogenación comprende aproximadamente 5% a aproximadamente 10% de paladio sobre carbono; b) el catalizador de hidrogenación está presente en una relación en peso de catalizador respecto del compuesto de fórmula (2) en el intervalo de aproximadamente 1:99 a aproximadamente 10:90, c) el catalizador de hidrogenación comprende aproximadamente 30% a aproximadamente 60% en peso de agua; d) el grupo nitrilo se reduce al correspondiente grupo amino; y e) el ácido está presente en una relación de equivalentes de ácido respecto a grupo amino de aproximadamente 1:1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44026603P | 2003-01-15 | 2003-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR042855A1 true AR042855A1 (es) | 2005-07-06 |
Family
ID=32713537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040100091A AR042855A1 (es) | 2003-01-15 | 2004-01-14 | Procedimiento mejorado de preparacion de lactamas policiclicas fusionadas con arilos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20070066827A1 (es) |
| EP (1) | EP1587794A1 (es) |
| JP (1) | JP2006517202A (es) |
| KR (2) | KR20070087258A (es) |
| CN (1) | CN100363350C (es) |
| AR (1) | AR042855A1 (es) |
| AU (1) | AU2004203983A1 (es) |
| BR (1) | BRPI0406670A (es) |
| CA (1) | CA2513293A1 (es) |
| CL (1) | CL2004000041A1 (es) |
| HK (1) | HK1085204A1 (es) |
| IL (1) | IL169479A0 (es) |
| MX (1) | MXPA05007565A (es) |
| PL (1) | PL379373A1 (es) |
| RS (1) | RS20050513A (es) |
| RU (1) | RU2291862C2 (es) |
| TW (1) | TW200420286A (es) |
| WO (1) | WO2004063164A1 (es) |
| ZA (1) | ZA200505103B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS20050393A (en) | 2002-11-25 | 2007-12-31 | Pfizer Products Inc., | Improved process for the preparation of 1,3-substituted indenes |
| EP2268639A2 (en) * | 2008-05-22 | 2011-01-05 | Teva Pharmaceutical Industries Ltd. | Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate |
| WO2009155403A2 (en) * | 2008-06-19 | 2009-12-23 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of varenicline and intermediates thereof |
| WO2010151524A1 (en) | 2009-06-22 | 2010-12-29 | Teva Pharmaceutical Industries Ltd | Solid states forms of varenicline salts and processes for preparation thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL136727A0 (en) * | 1997-12-31 | 2001-06-14 | Pfizer Prod Inc | Aryl fused azapolycyclic compounds |
| US6605610B1 (en) * | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| BR0208992A (pt) * | 2001-04-20 | 2004-04-27 | Pfizer Prod Inc | Processo para a preparação de indenos 1,3-substituìdos e compostos azapolicìclicos fundidos com arila |
-
2004
- 2004-01-08 MX MXPA05007565A patent/MXPA05007565A/es unknown
- 2004-01-08 EP EP04700747A patent/EP1587794A1/en not_active Withdrawn
- 2004-01-08 KR KR1020077018129A patent/KR20070087258A/ko not_active Application Discontinuation
- 2004-01-08 CA CA002513293A patent/CA2513293A1/en not_active Abandoned
- 2004-01-08 CN CNB2004800022895A patent/CN100363350C/zh not_active Expired - Fee Related
- 2004-01-08 RS YUP-2005/0513A patent/RS20050513A/sr unknown
- 2004-01-08 PL PL379373A patent/PL379373A1/pl not_active Application Discontinuation
- 2004-01-08 JP JP2006500307A patent/JP2006517202A/ja not_active Withdrawn
- 2004-01-08 BR BR0406670-7A patent/BRPI0406670A/pt not_active IP Right Cessation
- 2004-01-08 US US10/547,619 patent/US20070066827A1/en not_active Abandoned
- 2004-01-08 KR KR1020057013036A patent/KR20050101177A/ko not_active Application Discontinuation
- 2004-01-08 AU AU2004203983A patent/AU2004203983A1/en not_active Abandoned
- 2004-01-08 RU RU2005122406/04A patent/RU2291862C2/ru not_active IP Right Cessation
- 2004-01-08 WO PCT/IB2004/000152 patent/WO2004063164A1/en active Application Filing
- 2004-01-12 CL CL200400041A patent/CL2004000041A1/es unknown
- 2004-01-14 AR ARP040100091A patent/AR042855A1/es not_active Application Discontinuation
- 2004-01-14 TW TW093100889A patent/TW200420286A/zh unknown
-
2005
- 2005-06-23 ZA ZA200505103A patent/ZA200505103B/en unknown
- 2005-06-30 IL IL169479A patent/IL169479A0/en unknown
-
2006
- 2006-03-24 HK HK06103719A patent/HK1085204A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004203983A1 (en) | 2004-07-29 |
| US20070066827A1 (en) | 2007-03-22 |
| BRPI0406670A (pt) | 2005-12-20 |
| WO2004063164A1 (en) | 2004-07-29 |
| CN100363350C (zh) | 2008-01-23 |
| RU2005122406A (ru) | 2006-01-27 |
| RS20050513A (en) | 2007-11-15 |
| KR20050101177A (ko) | 2005-10-20 |
| ZA200505103B (en) | 2006-11-29 |
| MXPA05007565A (es) | 2005-09-21 |
| IL169479A0 (en) | 2007-07-04 |
| JP2006517202A (ja) | 2006-07-20 |
| PL379373A1 (pl) | 2006-08-21 |
| CN1738803A (zh) | 2006-02-22 |
| TW200420286A (en) | 2004-10-16 |
| EP1587794A1 (en) | 2005-10-26 |
| CA2513293A1 (en) | 2004-07-29 |
| WO2004063164A8 (en) | 2005-05-26 |
| KR20070087258A (ko) | 2007-08-27 |
| HK1085204A1 (en) | 2006-08-18 |
| RU2291862C2 (ru) | 2007-01-20 |
| CL2004000041A1 (es) | 2005-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |