AR042630A1 - Derivados de tetrahidroquinolina, composiciones farmaceuticas que los incluyen y su uso como medicamento. - Google Patents

Derivados de tetrahidroquinolina, composiciones farmaceuticas que los incluyen y su uso como medicamento.

Info

Publication number
AR042630A1
AR042630A1 ARP030104729A ARP030104729A AR042630A1 AR 042630 A1 AR042630 A1 AR 042630A1 AR P030104729 A ARP030104729 A AR P030104729A AR P030104729 A ARP030104729 A AR P030104729A AR 042630 A1 AR042630 A1 AR 042630A1
Authority
AR
Argentina
Prior art keywords
alkoxy
derivatives
alkylamino
pharmaceutical compositions
tetrahydroquinoline
Prior art date
Application number
ARP030104729A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Kartens
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of AR042630A1 publication Critical patent/AR042630A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La presente se relaciona con composiciones farmacéuticas que comprenden estos derivados y con la utilización de estos derivados para regular la fertilidad. Reivindicación 1: Un derivado de tetrahidroquinolina, de acuerdo con la fórmula (1), o una sal farmacéuticamente aceptable de él, caracterizado porque R1 y R2 son H o Me; R3 es H, hidroxi, alcoxi (C1-4), (di)alquilamino(C1-4)-alcoxi(C2-4) o heterocicloalquil(C2-6)-alcoxi(C2-4); R4 es H, OH, alcoxi (C1-4) o R7; R5 es H, OH, alcoxi (C1-4) o R7; con la condición de que si R4 es H, R5 no es H, OH o alcoxi (C1-4) y de que si R5 es H, R4 no es H, OH o alcoxi (C1-4); R6 es heteroaril (C2-5), aril(C6), cicloalquil (C3-8), heterocicloalquil C2-6) o alquil (C1-6); R7 es amino, (di)alquilamino (C1-4), arilcarbonilamino(C6), arilcarboniloxi(C6), heteroarilcarbonilamino (C2-5), heteroarilcarboniloxi (C2-5), R8-alquilamino (C2-4), R8-alcoxi (C2-4), R9-metilamino o R9-metoxi; R8 es hidroxi, amino, alcoxi (C1-4), (di)alquilamino (C1-4), heterocicloalquil (C2-6), heterocicloalquilcarbonilamino (C2-6), (di)alquilaminocarbonilamino (C1-4), alcoxicarbonilamino (C1-4) y R9 es aminocarbonil, (di)alquilaminocarbonil (C1-4), heteroaril (C2-5) o aril(C6).
ARP030104729A 2002-12-20 2003-12-19 Derivados de tetrahidroquinolina, composiciones farmaceuticas que los incluyen y su uso como medicamento. AR042630A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02102866 2002-12-20

Publications (1)

Publication Number Publication Date
AR042630A1 true AR042630A1 (es) 2005-06-29

Family

ID=39311811

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104729A AR042630A1 (es) 2002-12-20 2003-12-19 Derivados de tetrahidroquinolina, composiciones farmaceuticas que los incluyen y su uso como medicamento.

Country Status (18)

Country Link
US (1) US7858794B2 (es)
EP (1) EP1578726B1 (es)
JP (1) JP4545001B2 (es)
AR (1) AR042630A1 (es)
AT (1) ATE423771T1 (es)
AU (1) AU2003298363B2 (es)
BR (1) BR0317518A (es)
CA (1) CA2508952C (es)
CL (1) CL2003002685A1 (es)
ES (1) ES2321830T3 (es)
NZ (1) NZ540578A (es)
PE (1) PE20040928A1 (es)
PL (1) PL377318A1 (es)
RS (1) RS51293B (es)
RU (1) RU2328488C2 (es)
TW (1) TWI306855B (es)
UA (1) UA81442C2 (es)
WO (1) WO2004056780A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03011908A (es) * 2001-07-02 2004-06-03 Akzo Nobel Nv Derivados de tetrahidroquinolina.
TWI322012B (en) * 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
TWI306855B (en) 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
US7691848B2 (en) 2005-03-02 2010-04-06 Wyeth Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists
US7687623B2 (en) 2005-05-12 2010-03-30 Wyeth Llc Pyrrolobenzodiazepines and heterocyclic carboxamide derivatives as follicle stimulating hormone receptor (FSH-R) antagonists
US7678787B2 (en) 2005-06-09 2010-03-16 Wyeth Pyrrolobenzodiazepine pyridine carboxamides and derivatives as follicle-stimulating hormone receptor antagonists
RU2008126228A (ru) * 2005-11-30 2010-01-10 Астеллас Фарма Инк. (Jp) 2-аминобензамидное производное
WO2008071455A1 (en) * 2006-12-15 2008-06-19 Bayer Schering Pharma Aktiengesellschaft Bicyclic acyltryptophanols
EP1956016A1 (en) * 2006-12-15 2008-08-13 Bayer Schering Pharma Aktiengesellschaft Bicyclic acyltryptophanols
GB0705656D0 (en) * 2007-03-23 2007-05-02 Addex Pharmaceuticals Sa Novel compounds E1
TW200918058A (en) * 2007-08-31 2009-05-01 Organon Nv TSH receptor antagonizing tetrahydroquinoline compounds
US8071587B2 (en) * 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
US8431564B2 (en) 2009-07-29 2013-04-30 Merck Sharp & Dohme B.V. Ring-annulated dihydropyrrolo[2,1-α]isoquinolines
TW201116531A (en) * 2009-07-29 2011-05-16 Organon Nv Ring-annulated dihydropyrrolo[2,1-a]isoquinolines
US11185569B2 (en) * 2016-05-04 2021-11-30 University Of Cincinnati ActRIIB:Fc to treat infertility in females

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2686182A (en) * 1950-12-07 1954-08-10 Basf Ag O-hydroxy-dihydro-quinoline carboxylic acids
DE19975054I2 (de) 1987-08-08 2000-04-13 Akzo Nobel Nv Kontrazeptives Implantat
HUT78117A (hu) 1994-12-22 1999-11-29 Ligand Pharmaceuticals Incorporated Szteroid receptor modulátor kinolin- és kondenzált kinolinszármazékok, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
DE69931975T2 (de) * 1998-08-07 2006-10-05 Applied Research Systems Ars Holding N.V. FSH Mimetika zur Behandlung von Infertilität
US6200963B1 (en) * 1999-03-31 2001-03-13 American Home Products Corporation Aryl sulfonic acids as FSH antagonists
MXPA03011908A (es) * 2001-07-02 2004-06-03 Akzo Nobel Nv Derivados de tetrahidroquinolina.
TWI306855B (en) 2002-12-20 2009-03-01 Organon Nv Tetrahydroquinoline derivatives
TWI322012B (en) * 2002-12-20 2010-03-21 Organon Nv Tetrahydroquinoline derivatives
TW592127U (en) * 2003-05-19 2004-06-11 Tatung Co Network-type physiology monitoring device

Also Published As

Publication number Publication date
TWI306855B (en) 2009-03-01
NZ540578A (en) 2006-12-22
UA81442C2 (en) 2008-01-10
CL2003002685A1 (es) 2005-04-08
US20060142334A1 (en) 2006-06-29
WO2004056780A2 (en) 2004-07-08
PE20040928A1 (es) 2004-12-25
EP1578726A2 (en) 2005-09-28
TW200418800A (en) 2004-10-01
ES2321830T3 (es) 2009-06-12
JP2006512347A (ja) 2006-04-13
CA2508952A1 (en) 2004-07-08
AU2003298363B2 (en) 2009-09-24
CA2508952C (en) 2011-09-13
ATE423771T1 (de) 2009-03-15
RU2005122946A (ru) 2005-12-20
BR0317518A (pt) 2005-11-16
AU2003298363A1 (en) 2004-07-14
WO2004056780A3 (en) 2004-08-05
PL377318A1 (pl) 2006-01-23
EP1578726B1 (en) 2009-02-25
RS20050457A (en) 2007-08-03
US7858794B2 (en) 2010-12-28
JP4545001B2 (ja) 2010-09-15
RS51293B (sr) 2010-12-31
RU2328488C2 (ru) 2008-07-10

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