AR039224A1 - Derivados de estrona y procedimientos para producirlos - Google Patents

Derivados de estrona y procedimientos para producirlos

Info

Publication number
AR039224A1
AR039224A1 ARP030101148A ARP030101148A AR039224A1 AR 039224 A1 AR039224 A1 AR 039224A1 AR P030101148 A ARP030101148 A AR P030101148A AR P030101148 A ARP030101148 A AR P030101148A AR 039224 A1 AR039224 A1 AR 039224A1
Authority
AR
Argentina
Prior art keywords
group
compound
estrona
producers
procedures
Prior art date
Application number
ARP030101148A
Other languages
English (en)
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of AR039224A1 publication Critical patent/AR039224A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto de fórmula (1) (en donde X1 y X2 representan independientemente un átomo de hidrógeno o un grupo de fórmula (2); R1 representa un grupo halogenoalquilo lineal o ramificado que posee C1-7; Ra representa un grupo hidroxilo y Rb representa un grupo alquinilo lineal o ramificado que posee C2-5, o Ra y Rb, cuando se toman junto con el carbono al cual están unidos, representan un grupo carbonilo; m es un entero de valor 2-14; n es un entero de valor 2-7; con la condición que X1 y X2 no sean ambos un átomo de hidrógeno y, estereoisómeros del compuesto, o hidratos, sales o ésteres del mismo, así como una composición farmacéutica que contiene una cantidad terapéuticamente eficaz del compuesto.
ARP030101148A 2002-04-02 2003-04-02 Derivados de estrona y procedimientos para producirlos AR039224A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002100158 2002-04-02

Publications (1)

Publication Number Publication Date
AR039224A1 true AR039224A1 (es) 2005-02-09

Family

ID=29241253

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101148A AR039224A1 (es) 2002-04-02 2003-04-02 Derivados de estrona y procedimientos para producirlos

Country Status (7)

Country Link
US (1) US20060063944A1 (es)
EP (1) EP1491551A4 (es)
JP (1) JP4481660B2 (es)
AR (1) AR039224A1 (es)
AU (1) AU2003220822A1 (es)
TW (1) TW200306198A (es)
WO (1) WO2003087120A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114716496B (zh) * 2022-04-29 2024-04-02 香港中文大学（深圳） 氟维司群衍生物及氟维司群衍生物制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
US4757062A (en) * 1985-11-01 1988-07-12 E. I. Du Pont De Nemours And Company Substituted benzoate ester prodrugs of estrogens
JPH068432B2 (ja) * 1987-06-22 1994-02-02 高砂香料工業株式会社 香料組成物
EP1361205A1 (en) * 1999-12-13 2003-11-12 Chugai Seiyaku Kabushiki Kaisha Compounds with hydroxycarbonyl-halogenalkyl side chains
JPWO2003004515A1 (ja) * 2001-07-06 2004-10-28 中外製薬株式会社 エストラジオール誘導体の製造方法、当該方法で用いる中間体及びその製造方法

Also Published As

Publication number Publication date
WO2003087120A1 (fr) 2003-10-23
TW200306198A (en) 2003-11-16
AU2003220822A1 (en) 2003-10-27
EP1491551A1 (en) 2004-12-29
JPWO2003087120A1 (ja) 2005-08-18
JP4481660B2 (ja) 2010-06-16
EP1491551A4 (en) 2009-06-24
US20060063944A1 (en) 2006-03-23

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal