AR038309A2 - Bis-arilsulfonas y composicion farmaceutica en base al compuesto - Google Patents
Bis-arilsulfonas y composicion farmaceutica en base al compuestoInfo
- Publication number
- AR038309A2 AR038309A2 ARP030100199A ARP030100199A AR038309A2 AR 038309 A2 AR038309 A2 AR 038309A2 AR P030100199 A ARP030100199 A AR P030100199A AR P030100199 A ARP030100199 A AR P030100199A AR 038309 A2 AR038309 A2 AR 038309A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- bis
- pharmaceutical composition
- arilsulphones
- composite
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Bis-arilsulfonas, que comprenden un compuesto de fórmula (1) o una de sus sales farmacéuticamente aceptables en donde R6 es H, C1-4 alquilo; R7 es H, halo, C1-4 alquilo, o NR6R6; R8 es H, halo, o C1-4 alquilo; R9 es H, C1-4 alquilo, C(=O)R10, S(O)2R10, C(O)NR10R10, CO2R10, o CSR10; y R10 es H, C1-12 alquilo, C1-6 alquilarilo o arilo y una composición farmacéutica que comprende el compuesto. Estos compuestos son útiles en el tratamiento de las enfermedades de trastornos del sistema nervioso central como psicosis, parafrenia, depresión psicótica, manía, esquizofrenia, ansiedad, cefalea por migrana, drogadicción, trastornos de la personalidad, alcoholismo, ataques de pánico y trastornos del sueno.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21289400P | 2000-06-20 | 2000-06-20 | |
| US23702500P | 2000-09-29 | 2000-09-29 | |
| US23971300P | 2000-10-12 | 2000-10-12 | |
| US26826101P | 2001-02-13 | 2001-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR038309A2 true AR038309A2 (es) | 2005-01-12 |
Family
ID=27498914
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102779A AR028705A1 (es) | 2000-06-20 | 2001-06-12 | Bis-arilsulfonas |
| ARP030100199A AR038309A2 (es) | 2000-06-20 | 2003-01-23 | Bis-arilsulfonas y composicion farmaceutica en base al compuesto |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010102779A AR028705A1 (es) | 2000-06-20 | 2001-06-12 | Bis-arilsulfonas |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6579870B2 (es) |
| EP (1) | EP1294701A2 (es) |
| JP (1) | JP2004501141A (es) |
| KR (1) | KR20030011093A (es) |
| CN (1) | CN1217938C (es) |
| AR (2) | AR028705A1 (es) |
| AU (2) | AU6803901A (es) |
| BR (1) | BR0111892A (es) |
| CA (1) | CA2410447A1 (es) |
| MX (1) | MXPA02012626A (es) |
| MY (1) | MY124786A (es) |
| NZ (1) | NZ523314A (es) |
| PE (1) | PE20020063A1 (es) |
| WO (1) | WO2001098279A2 (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020063A1 (es) * | 2000-06-20 | 2002-01-30 | Upjohn Co | Bis-arilsulfonas como ligandos del receptor de 5-ht |
| CN1254469C (zh) | 2001-08-10 | 2006-05-03 | 弗·哈夫曼-拉罗切有限公司 | 具有5－ht6受体亲和性的芳基磺酰基衍生物 |
| US20050255529A1 (en) * | 2002-02-01 | 2005-11-17 | Stefan Golz | Diagnostics and therapeutics for diseases associated with a new human 5-ht6 receptor |
| WO2003080580A2 (en) | 2002-03-27 | 2003-10-02 | Glaxo Group Limited | Quinoline derivatives and their use as 5-ht6 ligands |
| US20040029865A1 (en) * | 2002-05-23 | 2004-02-12 | Acker Brad A. | Bis-arylsulfones |
| DE10224556A1 (de) * | 2002-05-31 | 2004-01-08 | Grünenthal GmbH | 1-Dimethylamino- 3-(3-methoxy-phenyl)2-methyl-pentan-3-ol entaltendes Arzneimittel in verschiedenen Formulierungen |
| AU2003259246A1 (en) * | 2002-07-29 | 2004-02-16 | Rajiv Doshi | Methods for the use of neurotoxin in the treatment of urologic disorders |
| AU2004261582C1 (en) | 2003-07-22 | 2010-01-07 | Arena Pharmaceuticals, Inc. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
| US20050201965A1 (en) * | 2004-03-11 | 2005-09-15 | The Procter & Gamble Company | Personal cleansing compositions |
| CN101203500B (zh) * | 2005-01-25 | 2013-08-21 | 格利尼公司 | 取代的芳胺化合物和它们作为5-ht6调节剂的用途 |
| WO2006081332A1 (en) | 2005-01-25 | 2006-08-03 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
| CN102614179B (zh) | 2006-06-16 | 2015-11-25 | H.隆德贝克有限公司 | 作为用于治疗认知损伤的、具有结合的对血清素再吸收、5-ht3和5-ht1a活性的化合物的1-[2-(2，4-二甲基苯基硫烷基)-苯基]哌嗪 |
| CA2667710A1 (en) | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Arylsulfonyl pyrrolidines as 5-ht6 inhibitors |
| CA2703904A1 (en) | 2007-10-29 | 2009-05-07 | Merck Sharp & Dohme Corp. | Substituted diazepan orexin receptor antagonists |
| US9084742B2 (en) | 2007-12-12 | 2015-07-21 | Axovant Sciences Ltd. | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-Quinoline |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| RU2443697C1 (ru) | 2010-12-21 | 2012-02-27 | Александр Васильевич Иващенко | Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения |
| WO2013049272A2 (en) | 2011-09-29 | 2013-04-04 | Theraceutix, Llc | Composition and method for treatment of symptoms associated with various skin conditions |
| CN109562085A (zh) | 2015-06-12 | 2019-04-02 | 阿速万科学有限责任公司 | 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物 |
| RU2018103338A (ru) | 2015-07-15 | 2019-08-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины для профилактики и лечения галлюцинаций, ассоциированных с нейродегенеративным заболеванием |
| CN110117264B (zh) * | 2018-02-06 | 2023-06-09 | 广东东阳光药业有限公司 | 苯基砜衍生物及其在药物上的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4851423A (en) | 1986-12-10 | 1989-07-25 | Schering Corporation | Pharmaceutically active compounds |
| GB8914660D0 (en) | 1989-06-26 | 1989-08-16 | Fujisawa Pharmaceutical Co | Aniline derivatives,processes for production thereof and pharmaceutical compositions comprising the same |
| WO1992006683A1 (en) | 1990-10-22 | 1992-04-30 | Research Corporation Technologies, Inc. | Aryl and heteroaryl compounds having anti-retrovirus activity |
| CA2102780C (en) | 1991-05-10 | 2007-01-09 | Alfred P. Spada | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase |
| WO1993017682A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| WO1993018035A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
| KR950704245A (ko) | 1992-10-21 | 1995-11-17 | 우에하라 아끼라 | N-t-부틸아닐린유사체 및 그것을 함유한 지질 저하제 |
| DE4238994A1 (de) | 1992-11-19 | 1994-05-26 | Basf Ag | Aniline als Markierungsmittel für Mineralöle |
| JPH0733735A (ja) * | 1993-07-26 | 1995-02-03 | Green Cross Corp:The | 新規ジフェニルスルホン誘導体 |
| WO1997007790A1 (en) | 1995-08-28 | 1997-03-06 | Interlab Corporation | Pharmaceutical compositions for the treatment of infectious diseases |
| HUT76266A (en) * | 1995-10-31 | 1997-07-28 | Egyt Gyogyszervegyeszeti Gyar | New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components |
| KR0183826B1 (ko) | 1996-03-04 | 1999-05-01 | 김광호 | 연마공정 후처리용 세정 용액 및 그를 이용하는 세정 방법 |
| NZ501258A (en) | 1997-07-11 | 2001-07-27 | Smithkline Beecham P | Benzenesulfonamide compounds with 5HT6 receptor antagonist activity for treating anxiety and/or depression |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| US6100291A (en) | 1998-03-16 | 2000-08-08 | Allelix Biopharmaceuticals Inc. | Pyrrolidine-indole compounds having 5-HT6 affinity |
| GB9818914D0 (en) | 1998-08-28 | 1998-10-21 | Smithkline Beecham Plc | Use |
| PE20020063A1 (es) * | 2000-06-20 | 2002-01-30 | Upjohn Co | Bis-arilsulfonas como ligandos del receptor de 5-ht |
-
2001
- 2001-06-04 PE PE2001000513A patent/PE20020063A1/es not_active Application Discontinuation
- 2001-06-08 MX MXPA02012626A patent/MXPA02012626A/es not_active Application Discontinuation
- 2001-06-08 US US09/877,308 patent/US6579870B2/en not_active Expired - Fee Related
- 2001-06-08 KR KR1020027017268A patent/KR20030011093A/ko not_active Application Discontinuation
- 2001-06-08 CA CA002410447A patent/CA2410447A1/en not_active Abandoned
- 2001-06-08 NZ NZ523314A patent/NZ523314A/xx unknown
- 2001-06-08 CN CN01810679XA patent/CN1217938C/zh not_active Expired - Fee Related
- 2001-06-08 WO PCT/US2001/010848 patent/WO2001098279A2/en not_active Application Discontinuation
- 2001-06-08 JP JP2002504235A patent/JP2004501141A/ja active Pending
- 2001-06-08 US US10/312,028 patent/US20030225065A1/en not_active Abandoned
- 2001-06-08 EP EP01945931A patent/EP1294701A2/en not_active Withdrawn
- 2001-06-08 AU AU6803901A patent/AU6803901A/xx active Pending
- 2001-06-08 AU AU2001268039A patent/AU2001268039B2/en not_active Ceased
- 2001-06-08 BR BR0111892-7A patent/BR0111892A/pt not_active IP Right Cessation
- 2001-06-12 AR ARP010102779A patent/AR028705A1/es unknown
- 2001-06-19 MY MYPI20012883 patent/MY124786A/en unknown
-
2003
- 2003-01-23 AR ARP030100199A patent/AR038309A2/es active IP Right Grant
- 2003-04-15 US US10/414,062 patent/US20030207866A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02012626A (es) | 2003-04-25 |
| JP2004501141A (ja) | 2004-01-15 |
| CN1217938C (zh) | 2005-09-07 |
| NZ523314A (en) | 2004-12-24 |
| AR028705A1 (es) | 2003-05-21 |
| US20030225065A1 (en) | 2003-12-04 |
| KR20030011093A (ko) | 2003-02-06 |
| WO2001098279A3 (en) | 2002-08-01 |
| CA2410447A1 (en) | 2001-12-27 |
| US20020037892A1 (en) | 2002-03-28 |
| US6579870B2 (en) | 2003-06-17 |
| AU6803901A (en) | 2002-01-02 |
| MY124786A (en) | 2006-07-31 |
| US20030207866A1 (en) | 2003-11-06 |
| PE20020063A1 (es) | 2002-01-30 |
| CN1433407A (zh) | 2003-07-30 |
| WO2001098279A2 (en) | 2001-12-27 |
| AU2001268039B2 (en) | 2005-06-09 |
| EP1294701A2 (en) | 2003-03-26 |
| BR0111892A (pt) | 2003-07-01 |
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