AR037973A1 - 4-arilquinazolinas - Google Patents
4-arilquinazolinasInfo
- Publication number
- AR037973A1 AR037973A1 ARP020105062A ARP020105062A AR037973A1 AR 037973 A1 AR037973 A1 AR 037973A1 AR P020105062 A ARP020105062 A AR P020105062A AR P020105062 A ARP020105062 A AR P020105062A AR 037973 A1 AR037973 A1 AR 037973A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- hal
- compounds
- phenyl
- polysubstituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos de la fórmula (1), y al uso de los mismos como inhibidores de NHE-3, procedimiento de preparación, preparación farmacéutica, medicamentos. Reivindicación 1: Compuestos de la fórmula (1) donde: Ar es fenilo o naftilo X-sustituido, que está adicionalmente sustituido por R3 y R4, Y es fórmula (2), (3) ó (4); X es H, NR6R7 o un anillo saturado de 5-7 miembros que tiene dos átomos de N; R1, R2, R3 y R4 son cada uno, independientemente entre sí, H, A, OA, Hal, CF3, OH, NO2, NH2, NHA, NA2, NH-CO-A, NH-CO-Ph, SA, SO-A, SO2-A, SO2-Ph, CN, OCF3, CO-A, CO2H, CO2A, CO-NH2, CO-NHA, CO-NA2, SO2NH2, SO2NHA, SO2NA2 o fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3; A es alquilo que tiene 1, 2, 3, 4, 5 ó 6 átomos de carbono; Hal es F, Cl, Br ó I; R5 es H, A, OH, NO2, fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3, un grupo de protección amino ó fórmula (5); R6 y R7 son cada uno, independientemente entre sí, H, A, fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3, bencilo, un grupo de protección amino ó -(CH2)nNR10R11; R8 y R9 son cada uno, independientemente entre sí, H ó A; R10 y R11 son cada uno, independientemente entre sí, H, A, fenilo que está insustituido ó monosustituido ó polisustituido por A, OA, Hal ó CF3, bencilo o un grupo de protección amino; z es 0 ó 1; y n es 2, 3 ó 4; y sales solvatos y estereoisómeros de los mismos, incluyendo las mezclas de los mismos en todas las relaciones, y derivados de los mismos de uso farmacéutico, en particular, sales y solvatos de los mismos de tolerancia fisiológica, con la condición de que queden excluidos los compuestos de la fórmula (1) donde X es H y, simultáneamente, z es 0. Reivindicación 15: Uso de los compuestos de la fórmula (1) de acuerdo con una o varias de las reivindicaciones 1 a 11 y/o sus sales y/o solvatos fisiológicamente aceptables para preparar un medicamento para el tratamiento y la profilaxis de hipertonía, trombosis, estados isquémicos del corazón, del sistema nervioso periférico y central y de apoplejías, estados isquémicos de órganos y miembros periféricos, y para el tratamiento de estados de shock. Reivindicación 16: Uso de los compuestos de la fórmula (1) de acuerdo con una o varias de las reivindicaciones 1 a 11 y/o sus sales y/o solvatos fisiológicamente aceptables para preparar un medicamento para usar en operaciones quirúrgicas y trasplantes de órganos y para preservar y almacenar trasplantes para medidas quirúrgicas. Reivindicación 17: Uso de los compuestos de la fórmula (1) de acuerdo con una o varias de las reivindicaciones 1 a 11 y/o sus sales y/o solvatos fisiológicamente aceptables para preparar un medicamento para el tratamiento y la profilaxis de enfermedades en las cuales la proliferación celular representa una causa primaria o secundaria, para el tratamiento o la profilaxis de trastornos del metabolismo de las grasas o el impulso respiratorio alterado.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10163992A DE10163992A1 (de) | 2001-12-24 | 2001-12-24 | 4-Aryl-chinazoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037973A1 true AR037973A1 (es) | 2004-12-22 |
Family
ID=7710890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020105062A AR037973A1 (es) | 2001-12-24 | 2002-12-20 | 4-arilquinazolinas |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20050020612A1 (es) |
| EP (1) | EP1458396A1 (es) |
| KR (1) | KR20040066856A (es) |
| AR (1) | AR037973A1 (es) |
| AU (1) | AU2002356762A1 (es) |
| BR (1) | BR0215294A (es) |
| CA (1) | CA2471524A1 (es) |
| DE (1) | DE10163992A1 (es) |
| MX (1) | MXPA04006193A (es) |
| PL (1) | PL369855A1 (es) |
| WO (1) | WO2003055490A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10043667A1 (de) * | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline |
| US7629967B2 (en) | 2003-02-14 | 2009-12-08 | Next Holdings Limited | Touch screen signal processing |
| US8508508B2 (en) | 2003-02-14 | 2013-08-13 | Next Holdings Limited | Touch screen signal processing with single-point calibration |
| US8456447B2 (en) | 2003-02-14 | 2013-06-04 | Next Holdings Limited | Touch screen signal processing |
| US7241775B2 (en) | 2003-03-24 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines |
| DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| US7538759B2 (en) | 2004-05-07 | 2009-05-26 | Next Holdings Limited | Touch panel display system with illumination and detection provided from a single edge |
| GB0526515D0 (en) * | 2005-12-28 | 2006-02-08 | Merck Sharp & Dohme | Modulation of signalling pathways |
| WO2008094706A2 (en) * | 2007-02-01 | 2008-08-07 | Cook Incorporated | Closure device and method of closing a bodily opening |
| WO2008128096A2 (en) * | 2007-04-11 | 2008-10-23 | Next Holdings, Inc. | Touch screen system with hover and click input methods |
| AU2008280952A1 (en) | 2007-08-30 | 2009-03-19 | Next Holdings Ltd | Low profile touch panel systems |
| AU2008280953A1 (en) * | 2007-08-30 | 2009-03-19 | Next Holdings Ltd | Optical touchscreen with improved illumination |
| US20090213093A1 (en) * | 2008-01-07 | 2009-08-27 | Next Holdings Limited | Optical position sensor using retroreflection |
| US20090207144A1 (en) * | 2008-01-07 | 2009-08-20 | Next Holdings Limited | Position Sensing System With Edge Positioning Enhancement |
| US8405636B2 (en) * | 2008-01-07 | 2013-03-26 | Next Holdings Limited | Optical position sensing system and optical position sensor assembly |
| WO2010039663A2 (en) * | 2008-10-02 | 2010-04-08 | Next Holdings, Inc. | Stereo optical sensors for resolving multi-touch in a touch detection system |
| CA2748607A1 (en) | 2008-12-31 | 2010-07-08 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
| US20110199387A1 (en) * | 2009-11-24 | 2011-08-18 | John David Newton | Activating Features on an Imaging Device Based on Manipulations |
| CN102713794A (zh) * | 2009-11-24 | 2012-10-03 | 奈克斯特控股公司 | 用于手势识别模式控制的方法和装置 |
| CN102741782A (zh) * | 2009-12-04 | 2012-10-17 | 奈克斯特控股公司 | 用于位置探测的方法和系统 |
| US20110234542A1 (en) * | 2010-03-26 | 2011-09-29 | Paul Marson | Methods and Systems Utilizing Multiple Wavelengths for Position Detection |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| KR102138390B1 (ko) | 2012-08-21 | 2020-07-27 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 ｎｈｅ-매개된 역수송 저해를 위한 화합물 및 방법 |
| EP3988120A1 (en) | 2013-04-12 | 2022-04-27 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
| LT3173408T (lt) | 2014-07-25 | 2018-12-27 | Taisho Pharmaceutical Co., Ltd. | Fenilo tetrahidroizochinolino junginys, turintis heteroarilo pakaitų |
| CA3049679A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Inhibitors of nhe-mediated antiport |
| KR102669987B1 (ko) | 2017-01-09 | 2024-05-31 | 알데릭스, 인코포레이티드 | 위장관 장애를 치료하는 데 유용한 화합물 |
| IL272443B2 (en) | 2017-08-04 | 2024-02-01 | Ardelyx Inc | History of glycyrrhizinic acid for the treatment of excess potassium in the blood |
| WO2020163642A1 (en) | 2019-02-07 | 2020-08-13 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3131187A (en) * | 1964-04-28 | Certain z-guantoino-x-aryl-quinazolines | ||
| FR2460224A1 (fr) * | 1979-06-29 | 1981-01-23 | Renault | Regulateur d'allure pour vehicule automobile |
| FR2685667B1 (fr) * | 1991-12-26 | 1994-07-29 | Landerretche Alain | Dispositif d'assistance au controle de la puissance de vehicules equipes d'un moteur a combustion interne. |
| DE10019062A1 (de) * | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren |
| DE10043667A1 (de) * | 2000-09-05 | 2002-03-14 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline |
-
2001
- 2001-12-24 DE DE10163992A patent/DE10163992A1/de not_active Withdrawn
-
2002
- 2002-11-29 CA CA002471524A patent/CA2471524A1/en not_active Abandoned
- 2002-11-29 US US10/499,972 patent/US20050020612A1/en not_active Abandoned
- 2002-11-29 KR KR10-2004-7008400A patent/KR20040066856A/ko not_active Application Discontinuation
- 2002-11-29 AU AU2002356762A patent/AU2002356762A1/en not_active Abandoned
- 2002-11-29 BR BR0215294-0A patent/BR0215294A/pt not_active Application Discontinuation
- 2002-11-29 WO PCT/EP2002/013530 patent/WO2003055490A1/de not_active Application Discontinuation
- 2002-11-29 PL PL02369855A patent/PL369855A1/xx unknown
- 2002-11-29 EP EP02805750A patent/EP1458396A1/de not_active Withdrawn
- 2002-11-29 MX MXPA04006193A patent/MXPA04006193A/es unknown
- 2002-12-20 AR ARP020105062A patent/AR037973A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002356762A1 (en) | 2003-07-15 |
| WO2003055490A1 (de) | 2003-07-10 |
| PL369855A1 (en) | 2005-05-02 |
| BR0215294A (pt) | 2005-02-09 |
| EP1458396A1 (de) | 2004-09-22 |
| DE10163992A1 (de) | 2003-07-03 |
| US20050020612A1 (en) | 2005-01-27 |
| KR20040066856A (ko) | 2004-07-27 |
| CA2471524A1 (en) | 2003-07-10 |
| MXPA04006193A (es) | 2004-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |