AR037678A1 - Un procedimiento para preparar una mezcla de rotameros o pares de rotameros de una sal de 4-[(4-bromofenil)(etoximino)metil]-1'-[(2,4-dimetil-1-oxido-3-piridinil)carbonil]-4'-metil-1,4'-bipiperidina, una mezcla de rotámeros preparada por dicho procedimiento y sales de dicho compuesto basico - Google Patents
Un procedimiento para preparar una mezcla de rotameros o pares de rotameros de una sal de 4-[(4-bromofenil)(etoximino)metil]-1'-[(2,4-dimetil-1-oxido-3-piridinil)carbonil]-4'-metil-1,4'-bipiperidina, una mezcla de rotámeros preparada por dicho procedimiento y sales de dicho compuesto basicoInfo
- Publication number
- AR037678A1 AR037678A1 ARP020104559A ARP020104559A AR037678A1 AR 037678 A1 AR037678 A1 AR 037678A1 AR P020104559 A ARP020104559 A AR P020104559A AR P020104559 A ARP020104559 A AR P020104559A AR 037678 A1 AR037678 A1 AR 037678A1
- Authority
- AR
- Argentina
- Prior art keywords
- rotamers
- salt
- pairs
- basic compound
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para preparar una mezcla de rotámeros o pares de rotámeros de una sal de un compuesto básico donde dicha mezcla comprende uno o más rotámeros o pares de rotámeros de dicha sal en un porcentaje molar superior al de sus otros correspondientes rotámeros o pares de rotámeros de dicha sal, donde dicho procedimiento comprende hacer reaccionar dicho compuesto básico con un ácido en mezcla con un solvente. Se describe un procedimiento para preparar directamente una relación desigual de rotámeros o pares rotaméricos preferidos de una sal de ácido de un compuesto básico, mediante la elección creativa de un medio solvente. El procedimiento es particularmente útil para la preparación de los rotámeros deseados de sales farmacéuticamente útiles. Una mezcla de rotámeros o pares de rotámeros de una sal de compuesto básico donde dicha mezcla comprende uno o más rotámeros o pares de rotámeros de la sal en un porcentaje molar superior al de los otros correspondientes rotámeros o pares de rotámeros de la sal, donde dicha sal se prepara mediante un procedimiento que comprende hacer reaccionar dicho compuesto básico con un ácido en mezcla con un solvente y dicha mezcla en donde el compuesto básico es el 4-{(4-bromofenil)(etoximino)metil}-1´-{(2,4-dimetil-1-oxido-3-piridinil)carbonil}-4´-metil-1,4´-bipiperidina de fórmula 1, y sales de ácido de dicho compuesto básico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33433001P | 2001-11-29 | 2001-11-29 | |
| US37377802P | 2002-04-19 | 2002-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037678A1 true AR037678A1 (es) | 2004-12-01 |
Family
ID=27737326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104559A AR037678A1 (es) | 2001-11-29 | 2002-11-27 | Un procedimiento para preparar una mezcla de rotameros o pares de rotameros de una sal de 4-[(4-bromofenil)(etoximino)metil]-1'-[(2,4-dimetil-1-oxido-3-piridinil)carbonil]-4'-metil-1,4'-bipiperidina, una mezcla de rotámeros preparada por dicho procedimiento y sales de dicho compuesto basico |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6936718B2 (es) |
| EP (1) | EP1448528A2 (es) |
| JP (2) | JP2005518424A (es) |
| CN (1) | CN100436449C (es) |
| AR (1) | AR037678A1 (es) |
| AU (1) | AU2002365439A1 (es) |
| CA (1) | CA2467555A1 (es) |
| MX (1) | MXPA04005155A (es) |
| WO (1) | WO2003066593A2 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
| RU2369604C2 (ru) | 2004-04-13 | 2009-10-10 | Инсайт Корпорейшн | Производные пиперазинилпиперидина в качестве антагонистов хемокинового рецептора |
| US7244765B2 (en) * | 2004-06-25 | 2007-07-17 | Cytokine Pharmasciences, Inc | Guanylhydrazone salts, compositions, processes of making and methods of using |
| EP1775283A4 (en) * | 2004-07-14 | 2008-12-10 | Japan Tobacco Inc | 3-AMINOBENZAMIDE COMPOUND AND INHIBITORS OF THE ACTIVITY OF VANILLOID RECEPTOR 1 (VR1) |
| CN1984906A (zh) | 2004-07-15 | 2007-06-20 | 日本烟草产业株式会社 | 稠合苯甲酰胺化合物和香草素受体1(vr1)活性抑制剂 |
| JP2008526862A (ja) * | 2005-01-06 | 2008-07-24 | シェーリング コーポレイション | ピペラジン化合物の薬学的な塩の調製 |
| US7906508B2 (en) | 2005-12-28 | 2011-03-15 | Japan Tobacco Inc. | 3,4-dihydrobenzoxazine compounds and inhibitors of vanilloid receptor subtype 1 (VRI) activity |
| JP5647002B2 (ja) * | 2007-12-13 | 2014-12-24 | サイトジェル ファーマ リミテッド ライアビリティ カンパニー | μ−オピエート受容体ペプチドの有利な塩 |
| US20110065648A1 (en) * | 2009-09-15 | 2011-03-17 | Maione Theodore E | Advantageous mu-opiate receptor peptide compounds |
| EP3090755A1 (en) | 2010-05-21 | 2016-11-09 | Cytogel Pharma, LLC | Materials and methods for treatment of inflammation |
| UA109290C2 (uk) * | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| CN105567738A (zh) * | 2016-01-18 | 2016-05-11 | 南开大学 | 使用基因组编辑技术CRISPR-Cas9诱导CCR5Δ32缺失的方法 |
| US10975121B2 (en) | 2017-06-24 | 2021-04-13 | Cytogel Pharma, Llc | Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2344821A (en) * | 1998-12-17 | 2000-06-21 | Merck & Co Inc | Crystalline pharmaceutically acceptable salt of an oxazolidinone derivative |
| SK286968B6 (sk) * | 1999-05-04 | 2009-08-06 | Schering Corporation | Piperidín-piperidinyl ako CCR5 antagonista, farmaceutický prostriedok s jeho obsahom a jeho použitie |
| US6387930B1 (en) * | 1999-05-04 | 2002-05-14 | Schering Corporation | Piperidine derivatives useful as CCR5 antagonists |
-
2002
- 2002-11-26 EP EP02805708A patent/EP1448528A2/en not_active Withdrawn
- 2002-11-26 US US10/305,100 patent/US6936718B2/en not_active Expired - Fee Related
- 2002-11-26 AU AU2002365439A patent/AU2002365439A1/en not_active Abandoned
- 2002-11-26 MX MXPA04005155A patent/MXPA04005155A/es active IP Right Grant
- 2002-11-26 JP JP2003565967A patent/JP2005518424A/ja active Pending
- 2002-11-26 CN CNB028239350A patent/CN100436449C/zh not_active Expired - Fee Related
- 2002-11-26 CA CA002467555A patent/CA2467555A1/en not_active Abandoned
- 2002-11-26 WO PCT/US2002/037708 patent/WO2003066593A2/en active Application Filing
- 2002-11-27 AR ARP020104559A patent/AR037678A1/es unknown
-
2010
- 2010-03-03 JP JP2010047165A patent/JP2010174022A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002365439A1 (en) | 2003-09-02 |
| MXPA04005155A (es) | 2004-08-11 |
| JP2005518424A (ja) | 2005-06-23 |
| US20030139446A1 (en) | 2003-07-24 |
| WO2003066593A2 (en) | 2003-08-14 |
| US6936718B2 (en) | 2005-08-30 |
| EP1448528A2 (en) | 2004-08-25 |
| WO2003066593A3 (en) | 2003-12-18 |
| CA2467555A1 (en) | 2003-08-14 |
| CN100436449C (zh) | 2008-11-26 |
| AU2002365439A8 (en) | 2003-09-02 |
| CN1599610A (zh) | 2005-03-23 |
| JP2010174022A (ja) | 2010-08-12 |
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| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |