AR036898A1 - Derivados de hidroxialquilo indolocarbazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen - Google Patents
Derivados de hidroxialquilo indolocarbazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienenInfo
- Publication number
- AR036898A1 AR036898A1 ARP020103953A ARP020103953A AR036898A1 AR 036898 A1 AR036898 A1 AR 036898A1 AR P020103953 A ARP020103953 A AR P020103953A AR P020103953 A ARP020103953 A AR P020103953A AR 036898 A1 AR036898 A1 AR 036898A1
- Authority
- AR
- Argentina
- Prior art keywords
- represent
- indolocarbazol
- hydroxialquilo
- derivatives
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuesto de fórmula (1), en la cual: R1 y R2, representan cada uno un grupo elegido entre hidrógeno, alquilo, arilalquilo, hidroxi, hidroxialquilo, dihidroxialquilo, alcoxi, alcoxialquilo, amino y aminoalquilo (eventualmente sustituidos); Ra y Rb, representan cada uno, una cadena alquileno; X1, X2 y X3, representan cada uno, un grupo elegido entre hidroxi, alcoxi, ariloxi, arilalcoxi, alquilo, amino (eventualmente sustituido, halógeno, alquilcarboniloxi y azido; X4, representa un grupo metilideno o un grupo de fórmula -RcX1 tal como se ha definido en la descripción; sus isómeros así como sus sales de adición con un ácido o con una base farmacéuticamente aceptable. Medicamentos útiles como inhibidores de la glicógeno sintetasa quinasa GSK-3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0113576A FR2831169B1 (fr) | 2001-10-22 | 2001-10-22 | Nouveaux derives d'hydroxyalkyle indolocarbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036898A1 true AR036898A1 (es) | 2004-10-13 |
Family
ID=8868539
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103953A AR036898A1 (es) | 2001-10-22 | 2002-10-21 | Derivados de hidroxialquilo indolocarbazol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040242508A1 (es) |
| EP (1) | EP1438320A1 (es) |
| JP (1) | JP2005509641A (es) |
| KR (1) | KR100588222B1 (es) |
| CN (1) | CN1253463C (es) |
| AR (1) | AR036898A1 (es) |
| BR (1) | BR0213403A (es) |
| CA (1) | CA2463923A1 (es) |
| EA (1) | EA006201B1 (es) |
| FR (1) | FR2831169B1 (es) |
| HK (1) | HK1072774A1 (es) |
| HU (1) | HUP0401885A2 (es) |
| MX (1) | MXPA04003741A (es) |
| NO (1) | NO20041761L (es) |
| NZ (1) | NZ532365A (es) |
| PL (1) | PL368237A1 (es) |
| WO (1) | WO2003035663A1 (es) |
| ZA (1) | ZA200402626B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005097127A2 (en) | 2004-04-02 | 2005-10-20 | Merck & Co., Inc. | Method of treating men with metabolic and anthropometric disorders |
| TWI499414B (zh) | 2006-09-29 | 2015-09-11 | Lexicon Pharmaceuticals Inc | 鈉與葡萄糖第２型共同運輸體（ｃｏ-ｔｒａｎｓｐｏｒｔｅｒ ２）的抑制物與其應用方法 |
| US7846945B2 (en) * | 2007-03-08 | 2010-12-07 | Lexicon Pharmaceuticals, Inc. | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| CN104031052B (zh) * | 2014-05-20 | 2016-06-08 | 中国科学院南海海洋研究所 | 抗生素Indimicins A–E及其制备方法和在制备抗肿瘤药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000064917A2 (en) * | 1999-04-26 | 2000-11-02 | Advanced Life Sciences Inc. | Synthetic indolocarbazole regioisomers and uses thereof |
| US6703373B1 (en) * | 1999-09-10 | 2004-03-09 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives and antitumor agents |
| FR2801054B1 (fr) * | 1999-11-17 | 2003-06-13 | Adir | Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2001
- 2001-10-22 FR FR0113576A patent/FR2831169B1/fr not_active Expired - Fee Related
-
2002
- 2002-10-21 HU HU0401885A patent/HUP0401885A2/hu unknown
- 2002-10-21 AR ARP020103953A patent/AR036898A1/es unknown
- 2002-10-21 JP JP2003538176A patent/JP2005509641A/ja not_active Ceased
- 2002-10-21 PL PL02368237A patent/PL368237A1/xx not_active Application Discontinuation
- 2002-10-21 KR KR1020047005995A patent/KR100588222B1/ko not_active IP Right Cessation
- 2002-10-21 BR BR0213403-9A patent/BR0213403A/pt not_active IP Right Cessation
- 2002-10-21 WO PCT/FR2002/003592 patent/WO2003035663A1/fr not_active Application Discontinuation
- 2002-10-21 MX MXPA04003741A patent/MXPA04003741A/es not_active Application Discontinuation
- 2002-10-21 CA CA002463923A patent/CA2463923A1/fr not_active Abandoned
- 2002-10-21 CN CNB02820784XA patent/CN1253463C/zh not_active Expired - Fee Related
- 2002-10-21 EA EA200400533A patent/EA006201B1/ru unknown
- 2002-10-21 EP EP02796813A patent/EP1438320A1/fr not_active Withdrawn
- 2002-10-21 NZ NZ532365A patent/NZ532365A/en unknown
- 2002-10-21 US US10/492,876 patent/US20040242508A1/en not_active Abandoned
-
2004
- 2004-04-02 ZA ZA2004/02626A patent/ZA200402626B/en unknown
- 2004-04-29 NO NO20041761A patent/NO20041761L/no not_active Application Discontinuation
-
2005
- 2005-04-07 HK HK05102890A patent/HK1072774A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2831169A1 (fr) | 2003-04-25 |
| EA200400533A1 (ru) | 2004-08-26 |
| FR2831169B1 (fr) | 2003-12-12 |
| CN1571793A (zh) | 2005-01-26 |
| ZA200402626B (en) | 2005-06-29 |
| US20040242508A1 (en) | 2004-12-02 |
| NZ532365A (en) | 2005-07-29 |
| KR100588222B1 (ko) | 2006-06-12 |
| KR20040054735A (ko) | 2004-06-25 |
| JP2005509641A (ja) | 2005-04-14 |
| EA006201B1 (ru) | 2005-10-27 |
| BR0213403A (pt) | 2004-11-03 |
| EP1438320A1 (fr) | 2004-07-21 |
| CN1253463C (zh) | 2006-04-26 |
| NO20041761L (no) | 2004-04-29 |
| HUP0401885A2 (hu) | 2004-12-28 |
| CA2463923A1 (fr) | 2003-05-01 |
| PL368237A1 (en) | 2005-03-21 |
| MXPA04003741A (es) | 2004-07-23 |
| HK1072774A1 (en) | 2005-09-09 |
| WO2003035663A1 (fr) | 2003-05-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |