AR036335A1 - Compuestos sustituidos de 1-fenetilpiperidina, procedimiento para prepararlo, medicamento y su uso para preparar un medicamento - Google Patents

Compuestos sustituidos de 1-fenetilpiperidina, procedimiento para prepararlo, medicamento y su uso para preparar un medicamento

Info

Publication number
AR036335A1
AR036335A1 ARP020102525A ARP020102525A AR036335A1 AR 036335 A1 AR036335 A1 AR 036335A1 AR P020102525 A ARP020102525 A AR P020102525A AR P020102525 A ARP020102525 A AR P020102525A AR 036335 A1 AR036335 A1 AR 036335A1
Authority
AR
Argentina
Prior art keywords
monosubstituted
radical
optionally
aryl
monounsaturated
Prior art date
Application number
ARP020102525A
Other languages
English (en)
Inventor
Bernd Sundermann
Lambert Hoenen
Helmut Heinrich Buschmann
Babette-Yvonne Koegel
Elmar Friderichs
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR036335A1 publication Critical patent/AR036335A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compuestos sustituidos de 1-fenetilpiperidina de la fórmula general (1), donde X es un grupo metilen-(CH2)- o carbonil-(C=O), preferentemente, es un grupo metilen-(CH2)-; R1 es un radical arilo o heteroarilo eventualmente al menos monosustituido, preferentemente, un radical arilo eventualmente al menos monosustituido; R2 es H, COR5, SO2R5, un radical C1-10 alifático ramificado o no ramificado, saturado, eventualmente al menos monosustituido, un radical C2-10 alifático ramificado o no ramificado, eventualmente al menos monosustituido, al menos monoinsaturado, un radical C3-8 cicloalifático eventualmente al menos monosustituido, saturado o al menos monoinsaturado, un radical arilo o heteroarilo eventualmente al menos monosustituido o un radical arilo o heteroarilo eventualmente al menos monosustituido unido a través de un grupo alquileno C1-3, preferentemente, H, COR5, SO2R5 o un radical alquilo C1-6, de preferencia particular, H o COR5; R3 y R4 son, en cada caso, H o juntos son una unión, preferentemente son, en cada caso, H, R5 es un radical C1-10 alifático ramificado o no ramificado, saturado, eventualmente al menos monosustituido, un radical C2-10 alifático ramificado o no ramificado, eventualmente al menos monosustituido, al menos monoinsaturado, un radical C3-8 cicloalifático eventualmente al menos monosustituido, saturado o al menos monoinsaturado, un radical arilo o heteroarilo eventualmente al menos monosustituido o un radical arilo o heteroarilo eventualmente al menos monosustituido unido a través de un grupo alquileno C1-3 preferentemente un radical alquilo C1-6 o un radical arilo eventualmente al menos monosustituido, como base libre o la sal correspondiente aceptable desde el punto de vista fisiológico y los correspondientes racematos, enantiómeros y diastereómeros. También se revela un proceso para preparar dichos compuestos, el medicamento que los comprende y el uso de los mismos para la preparación de medicamentos útiles para combatir el dolor, para el tratamiento de migrana, diarrea, incontinencia urinaria, prurito, reacciones inflamatorias, reacciones alérgicas, dependencia del alcohol y/o de drogas y/o medicamentos, abuso del alcohol y/o las drogas y/o los medicamentos, inflamaciones o anestesia local.
ARP020102525A 2001-07-05 2002-07-05 Compuestos sustituidos de 1-fenetilpiperidina, procedimiento para prepararlo, medicamento y su uso para preparar un medicamento AR036335A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10132746A DE10132746A1 (de) 2001-07-05 2001-07-05 Substituierte 1-Phenethylpiperidinverbindungen

Publications (1)

Publication Number Publication Date
AR036335A1 true AR036335A1 (es) 2004-09-01

Family

ID=7690808

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020102525A AR036335A1 (es) 2001-07-05 2002-07-05 Compuestos sustituidos de 1-fenetilpiperidina, procedimiento para prepararlo, medicamento y su uso para preparar un medicamento

Country Status (10)

Country Link
US (1) US20040171640A1 (es)
EP (1) EP1406623B1 (es)
AR (1) AR036335A1 (es)
AT (1) ATE380549T1 (es)
CY (1) CY1107230T1 (es)
DE (2) DE10132746A1 (es)
DK (1) DK1406623T3 (es)
ES (1) ES2298379T3 (es)
PT (1) PT1406623E (es)
WO (1) WO2003004026A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20030972A1 (it) * 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
NZ567629A (en) 2005-09-23 2011-08-26 Ms Science Corp Piperazine derivatives useful in the treatment of discorders of the central nervous system
ES2355607T3 (es) 2006-01-27 2011-03-29 M's Science Corporation Derivados de piperidina y piperazina.
CA2641913A1 (en) * 2006-02-17 2007-08-23 Neurosearch A/S 1-phenethylpiperidine derivatives and their use as opioid receptor ligands
CN101600693A (zh) * 2007-01-31 2009-12-09 诺瓦提斯公司 用于治疗炎性或过敏性疾病的哌啶-乙酰胺衍生物
MX2010001075A (es) * 2007-08-02 2010-03-09 Neurosearch As Derivados de n-piperidin-4-ilmetil-amida y su uso como inhibidores de recaptacion del neurotransmisor de monoamina.
US8895551B2 (en) 2009-04-02 2014-11-25 Shionogi & Co., Ltd. Acrylamide compounds and the use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH536314A (fr) * 1971-09-07 1973-04-30 Buskine Sa Procédé de synthèse du oxa-1, oxo-2, diaza-3,8, phénéthyl-8, spiro(4,5)-décane
US4248877A (en) * 1973-06-22 1981-02-03 Sandoz Ltd. Organic compounds
US4399286A (en) * 1981-07-16 1983-08-16 Mead Johnson & Company Antiarrhythmic phenethylpiperidine compounds
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO2000061558A1 (fr) * 1999-04-09 2000-10-19 Mochida Pharmaceutical Co., Ltd. Remedes pour douleurs neurogenes
US6677332B1 (en) * 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6956046B2 (en) * 2001-05-25 2005-10-18 Mochida Pharmaceutical Co., Ltd. 4-hydroxypiperidine derivatives having analgesic activity

Also Published As

Publication number Publication date
CY1107230T1 (el) 2012-11-21
DK1406623T3 (da) 2008-04-21
EP1406623A1 (de) 2004-04-14
PT1406623E (pt) 2008-02-18
ES2298379T3 (es) 2008-05-16
DE10132746A1 (de) 2003-02-06
US20040171640A1 (en) 2004-09-02
ATE380549T1 (de) 2007-12-15
EP1406623B1 (de) 2007-12-12
WO2003004026A1 (de) 2003-01-16
DE50211365D1 (de) 2008-01-24

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Legal Events

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