AR033828A1 - Benzofenonas y sulfonas como inhibidores de la captacion de glicina y composicion farmaceutica - Google Patents
Benzofenonas y sulfonas como inhibidores de la captacion de glicina y composicion farmaceuticaInfo
- Publication number
- AR033828A1 AR033828A1 ARP010103089A ARP010103089A AR033828A1 AR 033828 A1 AR033828 A1 AR 033828A1 AR P010103089 A ARP010103089 A AR P010103089A AR P010103089 A ARP010103089 A AR P010103089A AR 033828 A1 AR033828 A1 AR 033828A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- ring
- amino
- hydrogen
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Compuestos de benzofenona y sulfona sustituidos de fórmula (1) en la que el anillo A es fenilo, naftilo, benzotienilo, benzofuranilo o tienilo; o el anillo A es un anillo de arilo o heteroarilo monocíclico que contiene 0-4 heteroátomos y que no contiene átomos de oxígeno de anillo adyacentes; o el anillo A es un anillo de arilo o heteroarilo bicíclico que contiene de 0-5 heteroátomos y que no contiene átomos de oxígeno de anillo adyacentes; Y es C=O ó SO2 y está unido al grupo fenoxi representado en la fórmula (1) en la posición meta o para; X y Z se seleccionan independientemente entre hidrógeno, alquilo C1-6 opcionalmente sustituido con 1 a 7 átomos de flúor, y alcoxi C1-6 opcionalmente sustituido con 1 a 7 átomos de flúor, en los que el número de sustituyentes fluoro en los grupos alquilo C1-6 y alcoxi C1-6 anteriores no puede exceder el número de posiciones en tales grupos que están disponibles para sustitución; o Xy Z se seleccionan independientemente entre carboxi, carboalcoxi C1-6, carboxamido, alquil C1-6-tio, sulfoxilo, sulfonilo, halo, nitro, ciano, amino, alquil C1-6-amino y di[alquil C1-6]amino; y R es hidrógeno o alquilo C1-6, preferiblemente hidrógeno o metilo; o una sal farmacéuticamente aceptable del mismo. Estos presentan actividad como inhibidores del transporte de glicina, sus sales farmacéuticamente aceptables, composiciones farmacéuticas que los contienen y su uso para potenciar la cognición y para el tratamiento de síntomas positivos y negativos de la esquizofrenia y de otras psicosis en los mamíferos, incluyendo los seres humanos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21569200P | 2000-06-30 | 2000-06-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR033828A1 true AR033828A1 (es) | 2004-01-07 |
Family
ID=22803976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103089A AR033828A1 (es) | 2000-06-30 | 2001-06-28 | Benzofenonas y sulfonas como inhibidores de la captacion de glicina y composicion farmaceutica |
Country Status (17)
Country | Link |
---|---|
US (1) | US6506780B2 (es) |
EP (1) | EP1294677B1 (es) |
JP (1) | JP3801561B2 (es) |
AP (1) | AP2001002203A0 (es) |
AR (1) | AR033828A1 (es) |
AT (1) | ATE281427T1 (es) |
AU (1) | AU2001274407A1 (es) |
DE (1) | DE60106914T2 (es) |
DK (1) | DK1294677T3 (es) |
DO (1) | DOP2001000189A (es) |
ES (1) | ES2230326T3 (es) |
PA (1) | PA8519901A1 (es) |
PE (1) | PE20020121A1 (es) |
PT (1) | PT1294677E (es) |
TN (1) | TNSN01098A1 (es) |
UY (1) | UY26802A1 (es) |
WO (1) | WO2002000602A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6566550B2 (en) | 2001-06-21 | 2003-05-20 | Pfizer Inc | Substituted aromatic ethers as inhibitors of glycine transport |
IL154318A (en) | 2003-02-06 | 2010-05-31 | Sarah Herzog Memorial Hospital | Pharmaceutical compositions for the treatment of movement disorders |
MXPA05011198A (es) | 2003-04-30 | 2005-12-14 | Lundbeck & Co As H | Derivados de oxifenilo aromaticos y de sulfanilfenilo aromaticos. |
BRPI0413587A (pt) * | 2003-08-21 | 2006-10-17 | Lundbeck & Co As H | usos de um composto e de um inibidor de glyt-1, composição farmacêutica, kit, e, método para o tratamento de doença |
WO2005100301A1 (en) * | 2004-03-31 | 2005-10-27 | Eli Lilly And Company | 2-aryloxyethyl glycine derivatives and their use as glycine transport inhibitors |
JP2008527016A (ja) * | 2005-01-18 | 2008-07-24 | エフ.ホフマン−ラ ロシュ アーゲー | 神経及び神経精神病の疾患の治療のためのグリシントランスポーター1(GlyT−1)阻害剤としての2,5−二置換フェニルメタノン誘導体 |
DE602006010665D1 (en) | 2005-02-07 | 2010-01-07 | Hoffmann La Roche | Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1 |
JP2009535301A (ja) * | 2006-04-05 | 2009-10-01 | グラクソ グループ リミテッド | グリシントランスポーターを阻害する化合物およびその使用 |
PL2699543T3 (pl) | 2011-04-19 | 2016-10-31 | Nowe modulatory mediowanego receptorem dopaminergicznym i nmda glutaminergicznego przekaźnictwa nerwowego zwojów korowych | |
IN2014DN07214A (es) | 2012-03-01 | 2015-04-24 | Toyota Motor Co Ltd | |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1014966T3 (da) * | 1996-05-31 | 2006-12-04 | Allelix Neuroscience Inc | Farmaceutisk præparat til behandling af neurologiske og neuropsykiatriske lidelser |
US6191165B1 (en) * | 1996-05-31 | 2001-02-20 | Allelix Neuroscience Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
-
2001
- 2001-06-15 DO DO2001000189A patent/DOP2001000189A/es unknown
- 2001-06-18 PA PA20018519901A patent/PA8519901A1/es unknown
- 2001-06-22 AP APAP/P/2001/002203A patent/AP2001002203A0/en unknown
- 2001-06-22 WO PCT/IB2001/001139 patent/WO2002000602A1/en active IP Right Grant
- 2001-06-22 EP EP01940919A patent/EP1294677B1/en not_active Expired - Lifetime
- 2001-06-22 AT AT01940919T patent/ATE281427T1/de not_active IP Right Cessation
- 2001-06-22 JP JP2002505351A patent/JP3801561B2/ja not_active Expired - Fee Related
- 2001-06-22 DK DK01940919T patent/DK1294677T3/da active
- 2001-06-22 ES ES01940919T patent/ES2230326T3/es not_active Expired - Lifetime
- 2001-06-22 AU AU2001274407A patent/AU2001274407A1/en not_active Abandoned
- 2001-06-22 PT PT01940919T patent/PT1294677E/pt unknown
- 2001-06-22 DE DE60106914T patent/DE60106914T2/de not_active Expired - Fee Related
- 2001-06-26 PE PE2001000625A patent/PE20020121A1/es not_active Application Discontinuation
- 2001-06-27 UY UY26802A patent/UY26802A1/es unknown
- 2001-06-28 AR ARP010103089A patent/AR033828A1/es unknown
- 2001-06-29 TN TNTNSN01098A patent/TNSN01098A1/fr unknown
- 2001-07-02 US US09/897,261 patent/US6506780B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20020052401A1 (en) | 2002-05-02 |
DE60106914D1 (de) | 2004-12-09 |
PE20020121A1 (es) | 2002-02-16 |
JP2004501892A (ja) | 2004-01-22 |
PA8519901A1 (es) | 2003-06-30 |
WO2002000602A1 (en) | 2002-01-03 |
EP1294677A1 (en) | 2003-03-26 |
PT1294677E (pt) | 2005-01-31 |
DE60106914T2 (de) | 2005-12-08 |
ES2230326T3 (es) | 2005-05-01 |
TNSN01098A1 (fr) | 2005-11-10 |
JP3801561B2 (ja) | 2006-07-26 |
AP2001002203A0 (en) | 2001-09-30 |
DK1294677T3 (da) | 2005-02-07 |
AU2001274407A1 (en) | 2002-01-08 |
ATE281427T1 (de) | 2004-11-15 |
EP1294677B1 (en) | 2004-11-03 |
UY26802A1 (es) | 2002-01-31 |
DOP2001000189A (es) | 2002-03-30 |
US6506780B2 (en) | 2003-01-14 |
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