AR030021A1 - COMPOSITE OF A REPLACED PYRIMIDINONES, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF USEFUL MEDICINES FOR THE SELECTIVE INHIBITION OF THE COAGULATION CASCADE - Google Patents

COMPOSITE OF A REPLACED PYRIMIDINONES, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF USEFUL MEDICINES FOR THE SELECTIVE INHIBITION OF THE COAGULATION CASCADE

Info

Publication number
AR030021A1
AR030021A1 ARP000102446A ARP000102446A AR030021A1 AR 030021 A1 AR030021 A1 AR 030021A1 AR P000102446 A ARP000102446 A AR P000102446A AR P000102446 A ARP000102446 A AR P000102446A AR 030021 A1 AR030021 A1 AR 030021A1
Authority
AR
Argentina
Prior art keywords
composition
manufacture
coagulation cascade
compound
pharmaceutical composition
Prior art date
Application number
ARP000102446A
Other languages
Spanish (es)
Inventor
Michael S South
Ashton Hamme
William Neumann
Darin E Jones
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of AR030021A1 publication Critical patent/AR030021A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuesto de pirimidinona sustituido de formula (1) o una sal aceptable para uso farmacéutico del mismo, donde los sustituyentes son tal como se describen en la memoria descriptiva y reivindicaciones; composicion farmacéutica que lo comprende y el uso de dichos compuestos y composiciones en la fabricacion de medicamentos utiles como inhibidores de serina proteasas de la cascada de coagulacion y para el tratamiento y prevencion de diversas afecciones tromboticas que incluyen enfermedades de la arteria coronaria y enfermedades cerebrovasculares.Substituted pyrimidinone compound of formula (1) or a salt acceptable for pharmaceutical use thereof, wherein the substituents are as described in the specification and claims; pharmaceutical composition comprising it and the use of said compounds and compositions in the manufacture of useful drugs as serine protease inhibitors of the coagulation cascade and for the treatment and prevention of various thrombotic conditions including coronary artery diseases and cerebrovascular diseases.

ARP000102446A 1999-05-19 2000-05-19 COMPOSITE OF A REPLACED PYRIMIDINONES, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF USEFUL MEDICINES FOR THE SELECTIVE INHIBITION OF THE COAGULATION CASCADE AR030021A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13479499P 1999-05-19 1999-05-19

Publications (1)

Publication Number Publication Date
AR030021A1 true AR030021A1 (en) 2003-08-13

Family

ID=22465042

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000102446A AR030021A1 (en) 1999-05-19 2000-05-19 COMPOSITE OF A REPLACED PYRIMIDINONES, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF USEFUL MEDICINES FOR THE SELECTIVE INHIBITION OF THE COAGULATION CASCADE

Country Status (22)

Country Link
EP (1) EP1178970A1 (en)
JP (1) JP2002544262A (en)
KR (1) KR20010114271A (en)
CN (1) CN1157380C (en)
AR (1) AR030021A1 (en)
AU (2) AU771718B2 (en)
BR (1) BR0010758A (en)
CA (1) CA2373614A1 (en)
CZ (1) CZ20014116A3 (en)
EA (1) EA004867B1 (en)
HU (1) HUP0201242A3 (en)
IL (1) IL146243A0 (en)
MX (1) MXPA01011804A (en)
NO (1) NO20015604L (en)
NZ (1) NZ514874A (en)
PE (1) PE20010229A1 (en)
PL (1) PL352827A1 (en)
SK (1) SK15852001A3 (en)
TW (1) TWI222445B (en)
UY (1) UY26156A1 (en)
WO (1) WO2000069832A1 (en)
ZA (2) ZA200109339B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
CN1152023C (en) * 1999-05-19 2004-06-02 法玛西雅公司 Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
WO2001068605A1 (en) 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
CA2405306A1 (en) 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
WO2001077097A2 (en) 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
US20040171616A9 (en) 2000-04-17 2004-09-02 South Michael S. Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
AU2001222501A1 (en) * 2000-05-18 2001-11-26 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
CA2430037A1 (en) 2000-11-20 2002-05-30 Michael S. South Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
BR0213099A (en) 2001-10-03 2004-10-19 Pharmacia Corp Substituted 5-membered polycyclic compounds useful for selective inhibition of coagulation cascade
CA2462647A1 (en) * 2001-10-03 2003-04-10 Michael S. South 6-membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade
CA2462305A1 (en) 2001-10-03 2003-04-10 Michael S. South 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
MXPA04007026A (en) * 2002-02-22 2004-10-11 Pharmacia & Up John Company Substituted pyrimidinones and pyrimidinthiones.
TW200307667A (en) 2002-05-06 2003-12-16 Bristol Myers Squibb Co Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
WO2004103270A2 (en) 2003-04-02 2004-12-02 Suntory Pharmaceutical Research Laboratories Llc Compounds and methods for treatment of thrombosis
US7182738B2 (en) 2003-04-23 2007-02-27 Marctec, Llc Patient monitoring apparatus and method for orthosis and other devices
US8350043B2 (en) * 2005-06-07 2013-01-08 Pharmacopeia, Inc. Azinone and diazinone V3 inhibitors for depression and stress disorders
CN104311537B (en) * 2014-09-19 2016-08-24 广东东阳光药业有限公司 Containing pyrimidone acetyl substituents pyrazole compound and combinations thereof thing and purposes
CN115779953B (en) * 2022-12-19 2024-06-21 中南大学 Copper-loaded carbon-based monoatomic material, and preparation method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5441960A (en) * 1992-04-16 1995-08-15 Zeneca Limited 1-pyrimidinylacetamide human leukocyte elastate inhibitors
US5948785A (en) * 1995-04-27 1999-09-07 The Green Cross Corporation Heterocyclic amide compounds and pharmaceutical use of the same

Also Published As

Publication number Publication date
AU4973400A (en) 2000-12-05
CN1351593A (en) 2002-05-29
MXPA01011804A (en) 2003-09-04
EA200101214A1 (en) 2002-06-27
CZ20014116A3 (en) 2002-06-12
HUP0201242A2 (en) 2002-12-28
NZ514874A (en) 2004-11-26
ZA200400448B (en) 2004-09-29
ZA200109339B (en) 2004-05-26
CA2373614A1 (en) 2000-11-23
EA004867B1 (en) 2004-08-26
AU771718B2 (en) 2004-04-01
EP1178970A1 (en) 2002-02-13
HUP0201242A3 (en) 2003-02-28
NO20015604L (en) 2002-01-11
SK15852001A3 (en) 2003-06-03
IL146243A0 (en) 2002-07-25
CN1157380C (en) 2004-07-14
AU2004202375A1 (en) 2004-06-24
NO20015604D0 (en) 2001-11-16
PL352827A1 (en) 2003-09-08
BR0010758A (en) 2003-06-10
PE20010229A1 (en) 2001-03-07
KR20010114271A (en) 2001-12-31
WO2000069832A1 (en) 2000-11-23
UY26156A1 (en) 2000-12-29
TWI222445B (en) 2004-10-21
JP2002544262A (en) 2002-12-24

Similar Documents

Publication Publication Date Title
AR030021A1 (en) COMPOSITE OF A REPLACED PYRIMIDINONES, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF USEFUL MEDICINES FOR THE SELECTIVE INHIBITION OF THE COAGULATION CASCADE
AR029635A1 (en) COMPOUND DERIVED FROM A REPLACED POLYCLICAL PIRIDONE, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOUND AND SUCH COMPOSITION IN THE MANUFACTURE OF USEFUL DRUGS FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL
GT200500007A (en) [1,8] NAFTIRIDIN-2-WAVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CHICHOPHRENIA.
AR005053A1 (en) DIPHENYLHEXANE COMPOUNDS, A PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH COMPOUNDS, AND PROCEDURES FOR THE MANUFACTURE OF MEDICINES TO INHIBIT HIV INFECTION
SV2004001414A (en) INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION WATERFALL. PC20535
PA8591701A1 (en) PIRROLOPIRIMIDINE DERIVATIVES
ECSP066383A (en) DERIVATIVES OF 5-PHENYL-4-METHYL-TIAZOL-2-IL-AMINA AS INHIBITORS OF KINASA ENZYMES PHOSFATIDILINOSITOL 3 (PI3) FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE RESPIRATORY ROUTES
PA8551001A1 (en) NEW COMPOUNDS
AR063555A1 (en) DERIVATIVES OF ANDROSTANO, ITS USE IN THE MANUFACTURE OF MEDICINES, PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND AND PROCESSES TO PREPARE THEM
CO4930259A1 (en) DERIVATIVES 6,6-HETEROBICICLICOS SUBSTITUTED AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
MX9404749A (en) PHENYL HETERO CYCLES AS COX-2 INHIBITORS.
ATE296826T1 (en) PYRAZOLO(1,5)PYRIDINE DERIVATIVES
AR032136A1 (en) USEFUL ESPIROHETEROCICLIC COMPOUNDS AS REVERSIBLE CISTEINE-PROTEASES INHIBITORS
CL2004000849A1 (en) COMPOUNDS DERIVED FROM BENZAMIDAS-2-HIDROXI-3-DIAMINOALCANS, USEFUL FOR THE TREATMENT OR PREVENTION OF ALZHEIMER, DOWN SYNDROME, HEREDITARY CEREBRAL HEMORRAGY, DEGENERATIVE DEMENCIES AND OTHERS.
AR028810A1 (en) DERIVATIVES OF ARILPIPERAZINIL-CICLOHEXIL INDOL, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF DEPRESSION
UY26157A1 (en) SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL USEFUL FOR THE SELECTIVE I NHIBITION OF THE COAGULATION WATERFALL
AR029752A1 (en) COMPOUND DERIVED FROM POLICE, REPLACED PIRAZINONA, COMPOSITION THAT INCLUDES IT AND THE USE OF SUCH COMPOSITION AND SUCH COMPOUND IN THE MANUFACTURE OF USEFUL MEDICINES FOR THE SELECTIVE INHIBITION OF THE COAGULATION WATERFALL
ATE349448T1 (en) PYRAZOLE-3,4-D-PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF H.PYLORI INFECTIONS
ATE422201T1 (en) 4-(HETEROCYCLYL)-BENZENESULFOXIMINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISEASES
PA8525801A1 (en) PIRAZOL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS TO MODULATE AND / OR INHIBIT THE ACTIVITY OF ERAB / HADH2
ES2147973T3 (en) RENTED STYLES AS COX-2 INHIBITOR PROPHARMACS.
ES2182035T3 (en) DERIVATIVES OF BISARILCICLOBUTENO AS CICLOOXIGENASA INHIBITORS
UY27399A1 (en) PROCESS FOR PREPARATION OF QUINAZOLINS
ATE480526T1 (en) RITONAVIR ANALOGUE COMPOUND SUITABLE AS A RETROVIRAL PROTEASE INHIBITOR, PREPARATION OF THE RITONAVIR ANALOGUE COMPOUND AND PHARMACEUTICAL COMPOSITION FOR THE RITONAVIR ANALOGUE COMPOUND
AR028987A1 (en) COMPOSITE DERIVED FROM CYCLOPENTAPIRIDIN-KETONE, PHARMACEUTICAL COMPOSITION CONTAINING IT AND ITS USE IN THE MANUFACTURE OF A USEFUL MEDICINAL PRODUCT TO TREAT A DISEASE

Legal Events

Date Code Title Description
FB Suspension of granting procedure