MXPA01011804A - Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants. - Google Patents
Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants.Info
- Publication number
- MXPA01011804A MXPA01011804A MXPA01011804A MXPA01011804A MXPA01011804A MX PA01011804 A MXPA01011804 A MX PA01011804A MX PA01011804 A MXPA01011804 A MX PA01011804A MX PA01011804 A MXPA01011804 A MX PA01011804A MX PA01011804 A MXPA01011804 A MX PA01011804A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrymidinones
- anticoagulants
- heteroaryl
- useful
- polycyclic aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13479499P | 1999-05-19 | 1999-05-19 | |
| PCT/US2000/009806 WO2000069832A1 (en) | 1999-05-19 | 2000-05-17 | Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA01011804A true MXPA01011804A (en) | 2003-09-04 |
Family
ID=22465042
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA01011804A MXPA01011804A (en) | 1999-05-19 | 2000-05-17 | Substituted polycyclic aryl and heteroaryl pyrymidinones useful as anticoagulants. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1178970A1 (en) |
| JP (1) | JP2002544262A (en) |
| KR (1) | KR20010114271A (en) |
| CN (1) | CN1157380C (en) |
| AR (1) | AR030021A1 (en) |
| AU (2) | AU771718B2 (en) |
| BR (1) | BR0010758A (en) |
| CA (1) | CA2373614A1 (en) |
| CZ (1) | CZ20014116A3 (en) |
| EA (1) | EA004867B1 (en) |
| HU (1) | HUP0201242A3 (en) |
| IL (1) | IL146243A0 (en) |
| MX (1) | MXPA01011804A (en) |
| NO (1) | NO20015604L (en) |
| NZ (1) | NZ514874A (en) |
| PE (1) | PE20010229A1 (en) |
| PL (1) | PL352827A1 (en) |
| SK (1) | SK15852001A3 (en) |
| TW (1) | TWI222445B (en) |
| UY (1) | UY26156A1 (en) |
| WO (1) | WO2000069832A1 (en) |
| ZA (2) | ZA200109339B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| JP2002544263A (en) * | 1999-05-19 | 2002-12-24 | ファルマシア・コーポレイション | Substituted polycyclic aryl and heteroaryl uracils as anticoagulants |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| AU2001243598A1 (en) | 2000-03-13 | 2001-09-24 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| EP1268428A2 (en) | 2000-04-05 | 2003-01-02 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| PT1268463E (en) | 2000-04-05 | 2005-05-31 | Pharmacia Corp | 4-PYRONES SUBSTITUTED WITH USUAL POLYCYCLIC AERIAL AND HETEROARYL FOR THE SELECTIVE INHIBITION OF COAGULACAO CASCADE |
| WO2001079155A2 (en) | 2000-04-17 | 2001-10-25 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade |
| WO2001087851A1 (en) * | 2000-05-18 | 2001-11-22 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| CA2430037A1 (en) | 2000-11-20 | 2002-05-30 | Michael S. South | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6969715B2 (en) | 2001-10-03 | 2005-11-29 | Pharmacia Corporation | 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| MXPA04003170A (en) | 2001-10-03 | 2004-07-08 | Pharmacia Corp | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade. |
| US20040106626A1 (en) * | 2001-10-03 | 2004-06-03 | Pharmacia Corporation | 6-Membered unsaturated heterocyclic compounds useful for selective inhibition of the coagulation cascade |
| MXPA04007026A (en) * | 2002-02-22 | 2004-10-11 | Pharmacia & Up John Company | Substituted pyrimidinones and pyrimidinthiones. |
| TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
| WO2004103270A2 (en) | 2003-04-02 | 2004-12-02 | Suntory Pharmaceutical Research Laboratories Llc | Compounds and methods for treatment of thrombosis |
| US7182738B2 (en) | 2003-04-23 | 2007-02-27 | Marctec, Llc | Patient monitoring apparatus and method for orthosis and other devices |
| MX2007015427A (en) * | 2005-06-07 | 2008-04-16 | Pharmacopeia Inc | Azinone and diazinone v3 inhibitors for depression and stress disorders. |
| CN104311537B (en) * | 2014-09-19 | 2016-08-24 | 广东东阳光药业有限公司 | Containing pyrimidone acetyl substituents pyrazole compound and combinations thereof thing and purposes |
| CN115779953B (en) * | 2022-12-19 | 2024-06-21 | 中南大学 | Copper-loaded carbon-based monoatomic material, and preparation method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| EP0826671B1 (en) * | 1995-04-27 | 2004-12-29 | Mitsubishi Pharma Corporation | Heterocyclic amide compounds and medicinal use of the same |
-
2000
- 2000-05-17 EP EP00931928A patent/EP1178970A1/en not_active Withdrawn
- 2000-05-17 HU HU0201242A patent/HUP0201242A3/en unknown
- 2000-05-17 AU AU49734/00A patent/AU771718B2/en not_active Ceased
- 2000-05-17 IL IL14624300A patent/IL146243A0/en unknown
- 2000-05-17 WO PCT/US2000/009806 patent/WO2000069832A1/en not_active Application Discontinuation
- 2000-05-17 MX MXPA01011804A patent/MXPA01011804A/en unknown
- 2000-05-17 SK SK1585-2001A patent/SK15852001A3/en unknown
- 2000-05-17 CZ CZ20014116A patent/CZ20014116A3/en unknown
- 2000-05-17 BR BR0010758-1A patent/BR0010758A/en not_active IP Right Cessation
- 2000-05-17 JP JP2000618249A patent/JP2002544262A/en active Pending
- 2000-05-17 PL PL00352827A patent/PL352827A1/en not_active Application Discontinuation
- 2000-05-17 KR KR1020017014753A patent/KR20010114271A/en not_active Application Discontinuation
- 2000-05-17 NZ NZ514874A patent/NZ514874A/en unknown
- 2000-05-17 EA EA200101214A patent/EA004867B1/en not_active IP Right Cessation
- 2000-05-17 CN CNB008077479A patent/CN1157380C/en not_active Expired - Fee Related
- 2000-05-17 CA CA002373614A patent/CA2373614A1/en not_active Abandoned
- 2000-05-19 UY UY26156A patent/UY26156A1/en not_active Application Discontinuation
- 2000-05-19 AR ARP000102446A patent/AR030021A1/en unknown
- 2000-06-09 PE PE2000000575A patent/PE20010229A1/en not_active Application Discontinuation
- 2000-07-25 TW TW089109595A patent/TWI222445B/en not_active IP Right Cessation
-
2001
- 2001-11-13 ZA ZA200109339A patent/ZA200109339B/en unknown
- 2001-11-16 NO NO20015604A patent/NO20015604L/en not_active Application Discontinuation
-
2004
- 2004-01-21 ZA ZA200400448A patent/ZA200400448B/en unknown
- 2004-05-31 AU AU2004202375A patent/AU2004202375A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TWI222445B (en) | 2004-10-21 |
| CN1351593A (en) | 2002-05-29 |
| SK15852001A3 (en) | 2003-06-03 |
| EA200101214A1 (en) | 2002-06-27 |
| PL352827A1 (en) | 2003-09-08 |
| ZA200109339B (en) | 2004-05-26 |
| NZ514874A (en) | 2004-11-26 |
| KR20010114271A (en) | 2001-12-31 |
| AU2004202375A1 (en) | 2004-06-24 |
| HUP0201242A3 (en) | 2003-02-28 |
| NO20015604L (en) | 2002-01-11 |
| CN1157380C (en) | 2004-07-14 |
| UY26156A1 (en) | 2000-12-29 |
| JP2002544262A (en) | 2002-12-24 |
| ZA200400448B (en) | 2004-09-29 |
| EA004867B1 (en) | 2004-08-26 |
| WO2000069832A1 (en) | 2000-11-23 |
| AR030021A1 (en) | 2003-08-13 |
| BR0010758A (en) | 2003-06-10 |
| AU771718B2 (en) | 2004-04-01 |
| CA2373614A1 (en) | 2000-11-23 |
| EP1178970A1 (en) | 2002-02-13 |
| NO20015604D0 (en) | 2001-11-16 |
| IL146243A0 (en) | 2002-07-25 |
| AU4973400A (en) | 2000-12-05 |
| PE20010229A1 (en) | 2001-03-07 |
| HUP0201242A2 (en) | 2002-12-28 |
| CZ20014116A3 (en) | 2002-06-12 |
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