AR025739A1 - Nuevos derivados de bencimidazolonas que tienen afinidad para receptores mezclados de serotonina y dopamina - Google Patents
Nuevos derivados de bencimidazolonas que tienen afinidad para receptores mezclados de serotonina y dopaminaInfo
- Publication number
- AR025739A1 AR025739A1 ARP000104963A ARP000104963A AR025739A1 AR 025739 A1 AR025739 A1 AR 025739A1 AR P000104963 A ARP000104963 A AR P000104963A AR P000104963 A ARP000104963 A AR P000104963A AR 025739 A1 AR025739 A1 AR 025739A1
- Authority
- AR
- Argentina
- Prior art keywords
- bencimidazolon
- dopamine
- receivers
- affinity
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos de la formula general (1) en la que R1, R2, R3 y R4 significan hidrogeno o hidroxi, con la condicion de que R1, R2, R3 y R4 no puedenrepresentar simultáneamente hidrogeno, a procedimientos para su preparacion y a su uso como compuestos farmacéuticos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI001964A IT1313625B1 (it) | 1999-09-22 | 1999-09-22 | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR025739A1 true AR025739A1 (es) | 2002-12-11 |
Family
ID=11383635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000104963A AR025739A1 (es) | 1999-09-22 | 2000-09-22 | Nuevos derivados de bencimidazolonas que tienen afinidad para receptores mezclados de serotonina y dopamina |
Country Status (16)
Country | Link |
---|---|
US (1) | US6281218B1 (es) |
EP (1) | EP1218352B1 (es) |
JP (2) | JP4989002B2 (es) |
AR (1) | AR025739A1 (es) |
AT (1) | ATE266644T1 (es) |
AU (1) | AU7653700A (es) |
CA (1) | CA2381819C (es) |
CO (1) | CO5210864A1 (es) |
DE (1) | DE60010732T2 (es) |
DK (1) | DK1218352T3 (es) |
ES (1) | ES2220541T3 (es) |
IT (1) | IT1313625B1 (es) |
MX (1) | MXPA02001986A (es) |
PE (1) | PE20010600A1 (es) |
PT (1) | PT1218352E (es) |
WO (1) | WO2001021593A1 (es) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1313625B1 (it) * | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
UA78974C2 (en) * | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
US7033345B2 (en) * | 2002-05-21 | 2006-04-25 | Advanced Cardiovascular Systems, Inc. | Deflectable microimplant delivery system |
US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
US20050215589A1 (en) * | 2003-09-03 | 2005-09-29 | Roger Crossley | Inhibitors of 5-HT2A receptor |
JP2007504220A (ja) * | 2003-09-03 | 2007-03-01 | ガラパゴス・エヌブイ | イミダゾ[1,5−a]ピリジン又はイミダゾ[1,5−a]ピペリジン誘導体および5HT2A受容体関連障害に対する薬剤の製造のためのその使用 |
TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
JP2007533686A (ja) * | 2004-04-22 | 2007-11-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 性的障害ii治療用の新規医薬組成物 |
US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
EP1789048A1 (en) * | 2004-09-03 | 2007-05-30 | Boehringer Ingelheim International GmbH | Method for the treatment of attention deficit hyperactivity disorder |
JP5042028B2 (ja) * | 2004-11-05 | 2012-10-03 | セラヴァンス, インコーポレーテッド | キノリノン−カルボキサミド化合物 |
ES2332808T3 (es) * | 2004-11-05 | 2010-02-12 | Theravance, Inc. | Compuestos agonistas del receptor 5-ht4. |
US7419989B2 (en) * | 2004-12-22 | 2008-09-02 | Theravance, Inc. | Indazole-carboxamide compounds |
BRPI0608392A2 (pt) * | 2005-03-02 | 2009-12-29 | Theravance Inc | compostos de quinolinona como agonistas do receptor 5-ht4 |
EP1858515A2 (en) * | 2005-03-04 | 2007-11-28 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
WO2006096435A1 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of depression |
CA2608249A1 (en) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug abuse with flibanserin |
EP1888071A1 (en) * | 2005-05-19 | 2008-02-20 | Boehringer Ingelheim International GmbH | Method for the treatment of drug-induced sexual dysfunction |
US20060264512A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunction due to medical conditions |
US7317022B2 (en) * | 2005-06-07 | 2008-01-08 | Theravance, Inc. | Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists |
PL1912650T3 (pl) | 2005-08-03 | 2018-01-31 | Sprout Pharmaceuticals Inc | Zastosowanie flibanseryny w leczeniu otyłości |
WO2007048803A1 (en) * | 2005-10-29 | 2007-05-03 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders |
US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
MY143574A (en) * | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
CA2642101A1 (en) * | 2006-02-20 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivatives for the treatment of urinary incontinence |
JP2009536176A (ja) * | 2006-05-09 | 2009-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 閉経後の性的欲求障害の治療のためのフリバンセリンの使用 |
US20090312242A1 (en) * | 2006-06-30 | 2009-12-17 | Ramiro Castro | Flibanserin for the treatment of urinary incontinence and related diseases |
EP2043648A1 (en) * | 2006-07-14 | 2009-04-08 | Boehringer Ingelheim International GmbH | Use of flibanserin for the treatment of sexual disorders in females |
CL2007002214A1 (es) * | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
AR062320A1 (es) * | 2006-08-14 | 2008-10-29 | Boehringer Ingelheim Int | Formulaciones de flibanserina y metodo para fabricarlas |
CN104721168A (zh) * | 2006-08-25 | 2015-06-24 | 贝林格尔·英格海姆国际有限公司 | 控制释放系统及其制造方法 |
WO2008061968A1 (en) * | 2006-11-22 | 2008-05-29 | Boehringer Ingelheim International Gmbh | Benzimidazolone derivates in the treatment of pulmonary arterial hypertension |
JP2010513390A (ja) * | 2006-12-20 | 2010-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 混合セロトニン受容体親和性を有する硫酸化ベンズイミダゾロン誘導体 |
US8304601B2 (en) * | 2007-01-23 | 2012-11-06 | Keiko Fujikawa | Mouse model for eye disease |
UY31335A1 (es) * | 2007-09-12 | 2009-04-30 | Tratamiento de sintomas vasomotores | |
WO2009092720A1 (en) * | 2008-01-24 | 2009-07-30 | Neurosearch A/S | 4-phenyl-piperazin-1-yl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
CA2686480A1 (en) | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
BRPI1003506B1 (pt) | 2010-09-24 | 2019-12-03 | Ache Int Bvi Ltd | composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
IT1313625B1 (it) * | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
-
1999
- 1999-09-22 IT IT1999MI001964A patent/IT1313625B1/it active
-
2000
- 2000-08-08 US US09/634,120 patent/US6281218B1/en not_active Expired - Lifetime
- 2000-09-12 WO PCT/EP2000/008891 patent/WO2001021593A1/en active IP Right Grant
- 2000-09-12 DK DK00965975T patent/DK1218352T3/da active
- 2000-09-12 DE DE60010732T patent/DE60010732T2/de not_active Expired - Lifetime
- 2000-09-12 JP JP2001524972A patent/JP4989002B2/ja not_active Expired - Fee Related
- 2000-09-12 EP EP00965975A patent/EP1218352B1/en not_active Expired - Lifetime
- 2000-09-12 AT AT00965975T patent/ATE266644T1/de active
- 2000-09-12 PT PT00965975T patent/PT1218352E/pt unknown
- 2000-09-12 AU AU76537/00A patent/AU7653700A/en not_active Abandoned
- 2000-09-12 ES ES00965975T patent/ES2220541T3/es not_active Expired - Lifetime
- 2000-09-12 MX MXPA02001986A patent/MXPA02001986A/es active IP Right Grant
- 2000-09-12 CA CA002381819A patent/CA2381819C/en not_active Expired - Fee Related
- 2000-09-20 PE PE2000000977A patent/PE20010600A1/es not_active Application Discontinuation
- 2000-09-21 CO CO00071863A patent/CO5210864A1/es not_active Application Discontinuation
- 2000-09-22 AR ARP000104963A patent/AR025739A1/es unknown
-
2011
- 2011-10-14 JP JP2011226651A patent/JP2012067105A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US6281218B1 (en) | 2001-08-28 |
EP1218352A1 (en) | 2002-07-03 |
CA2381819A1 (en) | 2001-03-29 |
ATE266644T1 (de) | 2004-05-15 |
DE60010732T2 (de) | 2005-05-25 |
CA2381819C (en) | 2007-03-13 |
ES2220541T3 (es) | 2004-12-16 |
CO5210864A1 (es) | 2002-10-30 |
DE60010732D1 (de) | 2004-06-17 |
IT1313625B1 (it) | 2002-09-09 |
JP2003509496A (ja) | 2003-03-11 |
EP1218352B1 (en) | 2004-05-12 |
ITMI991964A1 (it) | 2001-03-22 |
JP2012067105A (ja) | 2012-04-05 |
JP4989002B2 (ja) | 2012-08-01 |
ITMI991964A0 (it) | 1999-09-22 |
DK1218352T3 (da) | 2004-06-28 |
PT1218352E (pt) | 2004-09-30 |
WO2001021593A1 (en) | 2001-03-29 |
PE20010600A1 (es) | 2001-06-04 |
MXPA02001986A (es) | 2002-10-31 |
AU7653700A (en) | 2001-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR025739A1 (es) | Nuevos derivados de bencimidazolonas que tienen afinidad para receptores mezclados de serotonina y dopamina | |
SV2004001432A (es) | 2-tio-3,5-diciano-4-4fenil-6-aminopiridinas substituidas y su uso ref. lea 35 640-sv | |
HN2002000275A (es) | Derivados de 1,8 naftiridina y su uso para el tratamiento de diabetes y trastornos relacionados | |
SV1999000118A (es) | Nuevos derivados de pirazol substituidos ref. lea 33188-sv | |
UY26495A1 (es) | " derivados de tiazolilamida" | |
SV2003001172A (es) | 2-tio-3,5-diciano-4-fenil-6-aminopiridinas substituidas y su uso ref. lea 35510-sv | |
AR057325A1 (es) | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos | |
SV1997000009A (es) | Nuevas oxazolidinonas sustituidas ref. lea 31534-sv | |
SV2001000004A (es) | Difenil ureas w-carboxyaril sustituidas, composición farmacéutica que las comprende y su uso como inhibidores de raf quinasa | |
ECSP066541A (es) | Nuevos derivados de piridazin-3(2h)-ona | |
PA8575601A1 (es) | Procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso | |
UY29892A1 (es) | Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones | |
PA8532001A1 (es) | Bifenilcarboxamidas utiles como agentes reductores de lipidos | |
ECSP034531A (es) | Derivados sustituidos de c-ciclohexilmetilamina | |
AR018162A1 (es) | Pirroles substituidos, composicion farmaceutica y el uso de los mismos para la preparacion de dicha composicion farmaceutica | |
UY30356A1 (es) | Derivados de 3-halo-n-(2.(4-fluorofenil)-4-oxobutil)-n-metil-5-(trifluorometil)benzamida y composiciones de los mismos. | |
SV1999000006A (es) | Nuevas sulfonamidas naftil- y anilido-substituidas ref. lea 32809-sv | |
AR020563A1 (es) | Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion | |
AR027575A1 (es) | Benzoilciclohexenonas substituidas | |
ES2174297T3 (es) | Nuevos derivados de piranosidos. | |
BR0115139A (pt) | Compostos bis-heterocìclicos com atividade antitumor e quimiossensibilizante | |
SV1997000010A (es) | Nuevas heteroariloxazolidinonas ref. lea 31535-sv | |
BRPI0414732A (pt) | piridilacetilenos para uso como radiotraçadores e agentes de imageamento | |
ECSP045271A (es) | Derivados de quinolina | |
ECSP003667A (es) | Nuevos derivados de bencimidazolonas que tienen afinidad para receptores mezclados de serotonina y dopamina |