AR024463A1 - Agonistas de somatostatina - Google Patents
Agonistas de somatostatinaInfo
- Publication number
- AR024463A1 AR024463A1 ARP000103155A ARP000103155A AR024463A1 AR 024463 A1 AR024463 A1 AR 024463A1 AR P000103155 A ARP000103155 A AR P000103155A AR P000103155 A ARP000103155 A AR P000103155A AR 024463 A1 AR024463 A1 AR 024463A1
- Authority
- AR
- Argentina
- Prior art keywords
- trp
- cys
- group
- tyr
- alkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
Abstract
Se refiere a péptidos cíclicos de formula (1): X-A1-ciclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y o su sal farmacéuticamente aceptable, en donde: X es H, formula (2) oformula (3); A1 y A3 son cada uno independientemente el isomero D- o L- de un aminoácidoselecc ionado entre el grupo que consiste en Phe, Tyr, Tyr(I), Trp,3-Pal, 4-Pal, Cpa y NaI; A4 es L-Trp, D-Trp, L-beta-metil-Trp o D-beta-metil-Trp; A6 es -NH-(CHR1)n-CO-, donde n es 2, 3 o 4; A7 es L- o D-Cys; A8 es elisomero D o L de un aminoácidoselecci onado entre el grupo que consiste en Phe, Tyr, Tyr(I), Trp, NaI, Cpa, Val, Leu, IIe, Ser y Thr; Y es NR2R3 donde R2 y R3son cada uno independientemente H o alquilo C1-5; R1 se selecciona entre el grupo que consiste en H, alquilo C1-4 y-CH2-arilo; en donde dicho arilo es unaporcion optativamente sustituida seleccionada entre el grupo que consiste en fenilo, 1-naftilo y 2-naftilo, en donde dicha porcion optativamente sustituida esoptativamente sustituida con uno o más sustituyentescada uno selec cionado independientemente entre el grupo que consiste en alquiloC1-6, alquenilo C2-6,alquinilo C2-6, arilo, arilalquilo C1-6, alcoxi C1-6, -N(R4R5), -COOH, -CON(R4R5), halo, -OH, -CN, y -NO2; R4 y R5 cada uno es, independientementepara cadaaparicio n, H o alquilo C1-3; donde el Cys de A2 está unido al Cys de A7 por un enlace di-sulfuro formado de los grupos tiol de cada Cys; composicionesfarmacéuticas que comprenden dichos péptidos y el uso de las mismas como un agonista delos subtipos del rec eptor de somatostatina. Los péptidos de la presentese unen selectivamente al tipo 5 del receptor de los subtipos de somatostatina y producen un efecto agonista de los receptores de subtipo de somatostatina alas cuales se unenlos péptidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14102899P | 1999-06-25 | 1999-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR024463A1 true AR024463A1 (es) | 2002-10-02 |
Family
ID=22493842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000103155A AR024463A1 (es) | 1999-06-25 | 2000-06-23 | Agonistas de somatostatina |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1189942A1 (es) |
| JP (1) | JP4041311B2 (es) |
| CN (1) | CN1367792A (es) |
| AR (1) | AR024463A1 (es) |
| AU (1) | AU770958B2 (es) |
| BR (1) | BR0011919A (es) |
| CA (1) | CA2377265A1 (es) |
| CZ (1) | CZ20014534A3 (es) |
| HU (1) | HUP0201696A3 (es) |
| IL (1) | IL146941A0 (es) |
| MX (1) | MXPA01013127A (es) |
| PL (1) | PL352763A1 (es) |
| RU (1) | RU2263677C2 (es) |
| WO (1) | WO2001000676A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2352578C2 (ru) * | 2001-03-06 | 2009-04-20 | Иль Консорцио Феррара Ричерке | Способ модуляции пролиферации клеток медуллярной карциномы щитовидной железы |
| WO2003057214A1 (en) | 2001-12-28 | 2003-07-17 | Somatocor Pharmaceuticals, Inc. | Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands |
| EP1522311A1 (fr) * | 2003-10-10 | 2005-04-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Utilisation de la somatostine ou d'un de ses analogues pour préparer un médicament destiné à réguler la réserve folliculaire ovarienne chez la femme non ménopausée |
| WO2008132737A1 (en) | 2007-04-30 | 2008-11-06 | Technion Research & Development Foundation Ltd. | Novel antimicrobial agents |
| WO2008132738A2 (en) * | 2007-04-30 | 2008-11-06 | Technion Research & Development Foundation Ltd. | Anticancerous polymeric agents |
| AU2010321738B2 (en) * | 2009-11-23 | 2016-07-14 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific cyclic peptides |
| WO2011151782A1 (en) | 2010-06-02 | 2011-12-08 | Preglem Sa | A role for somatostatin to modulate initiation of follicular growth in the human ovary |
| WO2013119800A1 (en) | 2012-02-07 | 2013-08-15 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| US9724396B2 (en) | 2013-03-15 | 2017-08-08 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| US10317418B2 (en) | 2015-02-24 | 2019-06-11 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3264693D1 (en) * | 1981-12-24 | 1985-08-14 | Ciba Geigy Ag | Cyclic octapeptides and pharmaceutical compositions thereof, and processes for their production and use |
| HU207104B (en) * | 1991-01-25 | 1993-03-01 | Biosignal Kutato Fejlesztoe Kf | Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds |
| US5663146A (en) * | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| EP1288224B1 (en) * | 1993-08-09 | 2008-06-25 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Therapeutic peptide derivatives |
| PL334089A1 (en) * | 1996-12-04 | 2000-01-31 | Sod Conseils Rech Applic | Compounds antagonistic in respect to somatostatin |
| PT979098E (pt) * | 1997-05-01 | 2003-07-31 | Cedars Sinai Medical Center | Metodo para o tratamento da hiperprolactinemia e de prolactinomas |
| AU7655098A (en) * | 1997-05-13 | 1998-12-08 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Somatostatin and somatostatin agonists for decreasing body weight |
| PT980253E (pt) * | 1997-05-13 | 2004-08-31 | Conseils De Rec Appl Scient S | Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x |
| EP0981364B1 (en) * | 1997-05-13 | 2006-03-01 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Method and compositions for treating hyperlipidemia |
-
2000
- 2000-06-23 CN CN00811189A patent/CN1367792A/zh active Pending
- 2000-06-23 EP EP00948520A patent/EP1189942A1/en not_active Ceased
- 2000-06-23 CZ CZ20014534A patent/CZ20014534A3/cs unknown
- 2000-06-23 AR ARP000103155A patent/AR024463A1/es unknown
- 2000-06-23 HU HU0201696A patent/HUP0201696A3/hu unknown
- 2000-06-23 MX MXPA01013127A patent/MXPA01013127A/es unknown
- 2000-06-23 CA CA002377265A patent/CA2377265A1/en not_active Abandoned
- 2000-06-23 RU RU2002101732/04A patent/RU2263677C2/ru not_active IP Right Cessation
- 2000-06-23 WO PCT/US2000/017401 patent/WO2001000676A1/en not_active Ceased
- 2000-06-23 PL PL00352763A patent/PL352763A1/xx not_active Application Discontinuation
- 2000-06-23 BR BR0011919-9A patent/BR0011919A/pt not_active Application Discontinuation
- 2000-06-23 AU AU62000/00A patent/AU770958B2/en not_active Ceased
- 2000-06-23 JP JP2001506685A patent/JP4041311B2/ja not_active Expired - Fee Related
- 2000-06-23 IL IL14694100A patent/IL146941A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001000676A1 (en) | 2001-01-04 |
| RU2263677C2 (ru) | 2005-11-10 |
| IL146941A0 (en) | 2002-08-14 |
| JP2003503369A (ja) | 2003-01-28 |
| CZ20014534A3 (cs) | 2002-06-12 |
| AU770958B2 (en) | 2004-03-11 |
| HUP0201696A3 (en) | 2002-10-28 |
| CA2377265A1 (en) | 2001-01-04 |
| EP1189942A1 (en) | 2002-03-27 |
| AU6200000A (en) | 2001-01-31 |
| JP4041311B2 (ja) | 2008-01-30 |
| BR0011919A (pt) | 2002-03-19 |
| MXPA01013127A (es) | 2002-11-04 |
| PL352763A1 (en) | 2003-09-08 |
| CN1367792A (zh) | 2002-09-04 |
| HUP0201696A2 (en) | 2002-09-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |