AR015726A1 - Vector para la introduccion de un acido nucleico en una celula, procedimiento para su preparacion, polietilenimina de bajo peso molecular, procedimientopara su preparacion, empleo de una polietilenimina de bajo peso molecular para la preparacion de un vector y de un medicamento, empleo de un vector - Google Patents
Vector para la introduccion de un acido nucleico en una celula, procedimiento para su preparacion, polietilenimina de bajo peso molecular, procedimientopara su preparacion, empleo de una polietilenimina de bajo peso molecular para la preparacion de un vector y de un medicamento, empleo de un vectorInfo
- Publication number
- AR015726A1 AR015726A1 ARP980104829A ARP980104829A AR015726A1 AR 015726 A1 AR015726 A1 AR 015726A1 AR P980104829 A ARP980104829 A AR P980104829A AR P980104829 A ARP980104829 A AR P980104829A AR 015726 A1 AR015726 A1 AR 015726A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- vector
- procedure
- low weight
- molecular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Developing Agents For Electrophotography (AREA)
- Lubricants (AREA)
Abstract
Se describe un vector para la introduccion de un ácido nucleico en una célula, que contiene una polietilenimina de bajo peso molecular (LMW-PEI) y unácido nucleico, presentado la LMW-PEI un peso molecular inferior a 50.000 Da. Además se describe unp rocedimiento para su preparacion, polietilenimina de bajopeso molecular, procedimiento para su preparacion, empleo de una polietilenimina de bajo peso molecular para la preparacion de un vector y un medicamento,empleo de un vector para lapreparacion de un medicamento, procedimiento para la preparacion de una célula transfectada, empleo de dicha célula y medicamento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19743135A DE19743135A1 (de) | 1997-09-30 | 1997-09-30 | Biologisch verträgliche niedermolekular Polyethylenimine |
Publications (1)
Publication Number | Publication Date |
---|---|
AR015726A1 true AR015726A1 (es) | 2001-05-16 |
Family
ID=7844109
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980104829A AR015726A1 (es) | 1997-09-30 | 1998-09-28 | Vector para la introduccion de un acido nucleico en una celula, procedimiento para su preparacion, polietilenimina de bajo peso molecular, procedimientopara su preparacion, empleo de una polietilenimina de bajo peso molecular para la preparacion de un vector y de un medicamento, empleo de un vector |
Country Status (19)
Country | Link |
---|---|
US (2) | US8003734B2 (es) |
EP (1) | EP0905254B1 (es) |
JP (1) | JP4399042B2 (es) |
KR (1) | KR19990030290A (es) |
AR (1) | AR015726A1 (es) |
AT (1) | ATE324397T1 (es) |
AU (1) | AU758239B2 (es) |
BR (1) | BR9803982A (es) |
CA (1) | CA2249058A1 (es) |
CY (1) | CY1105109T1 (es) |
CZ (1) | CZ310598A3 (es) |
DE (2) | DE19743135A1 (es) |
DK (1) | DK0905254T3 (es) |
ES (1) | ES2264180T3 (es) |
HU (1) | HUP9802157A3 (es) |
ID (1) | ID20973A (es) |
PL (1) | PL328910A1 (es) |
PT (1) | PT905254E (es) |
TR (1) | TR199801933A2 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19956029A1 (de) * | 1999-11-22 | 2001-05-23 | Aventis Pharma Gmbh | Trägersysteme enthaltend Hüllsubstanzen mit enzymatisch abspaltbaren Seitengruppen |
DE19960206A1 (de) * | 1999-12-14 | 2001-07-19 | Frank Czubayko | Komplexierung von RNS mit Polyethyleniminen zur deren Stabilisierung und zellulären Einschleusung |
FR2805271B1 (fr) * | 2000-02-18 | 2002-04-26 | Aventis Pharma Sa | Procede de preparation de polyalkylenimines fonctionnalises, compositions les contenant et leurs utilisations |
DE60119711T2 (de) * | 2000-02-18 | 2007-02-22 | Centelion | Verfahren zur herstellung von funktionalierten polyalkyleniminen, diese enthaltende zusammenstellungen und ihre verwendungen |
US6696038B1 (en) * | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
CN1479632A (zh) * | 2000-10-09 | 2004-03-03 | 拜尔公司 | 用于将核酸导入细胞的复合物 |
DE10145134A1 (de) * | 2000-10-09 | 2002-05-16 | Bayer Ag | Komplexe zur Einführung von Nukleinsäuren in Zellen |
WO2003038103A1 (en) * | 2001-10-29 | 2003-05-08 | Atso Raasmaja | Method for gene transfection using synergistic combinations of cationic lipids and cationic polymers |
US7824910B2 (en) | 2001-11-29 | 2010-11-02 | Nippon Shokubai Co., Ltd. | Method of transducing a protein into cells |
EP1476492A1 (en) * | 2002-02-22 | 2004-11-17 | Insert Therapeutics Inc. | Carbohydrate-modified polymers, compositions and uses related thereto |
US20040048260A1 (en) * | 2002-09-10 | 2004-03-11 | Fu-Hsiung Chang | Transfection of nucleic acid |
US20040138154A1 (en) | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
US7153905B2 (en) * | 2003-03-21 | 2006-12-26 | The General Hospital Corporation | Hyperbranched dendron and methods of synthesis and use thereof |
JP2007043972A (ja) * | 2005-08-10 | 2007-02-22 | Tokyo Institute Of Technology | アパタイト粒子及びその作製方法、遺伝子−アパタイト粒子複合体及びその作製方法、並びに遺伝子導入方法及び遺伝子導入用キット |
US20080145893A1 (en) * | 2006-09-17 | 2008-06-19 | Excellegene Sa | Method for producing a recombinant protein at high specific productivity, high batch yield and high volumetric yield by means of transient transfection |
KR20100050523A (ko) * | 2007-07-31 | 2010-05-13 | 뽈리쁠뤼스-트랑스펙씨옹 | 트랜스펙션을 위한 선형 폴리에틸렌이민(pei)의 제조 방법 및 이러한 방법으로 얻은 선형 pei |
FR2928373B1 (fr) * | 2008-03-05 | 2010-12-31 | Centre Nat Rech Scient | Polymere derive de la polyethylenimine lineaire pour le transfert de gene. |
EP2623117A1 (en) | 2009-04-30 | 2013-08-07 | Genetic Immunity Kft. | Immunogenic nanomedicine composition and preparation and uses thereof |
US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
US10722462B2 (en) * | 2014-12-10 | 2020-07-28 | Council Of Scientific And Industrial Research | Discontinuous reverse micellar composition in cubic FD3M phase for sustained release of therapeutic drugs |
JP6873418B2 (ja) * | 2016-11-11 | 2021-05-19 | 国立大学法人北陸先端科学技術大学院大学 | 遺伝子導入された細胞の製造方法及びポリエチレンイミンの置換体ポリマー |
CN110023755A (zh) | 2016-12-01 | 2019-07-16 | 诺伯特·格雷茨 | 用于组织结构的可视化的装置和方法 |
CN112237633B (zh) * | 2020-10-22 | 2023-06-27 | 林君玉 | 一种pei/on复合物及其制备方法和用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2182306A (en) * | 1935-05-10 | 1939-12-05 | Ig Farbenindustrie Ag | Polymerization of ethylene imines |
NL45673C (es) * | 1935-05-11 | |||
DE2530042C3 (de) * | 1975-07-04 | 1982-04-22 | Institut neftechimičeskogo sinteza imeni A.V. Topčieva Akademii Nauk SSSR, Moskva | Verfahren zur Herstellung von linearem Polyäthylenimin |
US4032480A (en) * | 1975-07-11 | 1977-06-28 | David Solomonovich Zhuk | Method of producing linear polyethylenimine |
GB2128625B (en) * | 1982-10-07 | 1986-01-08 | Inst Neftechimicheskogo Sintez | Method for preparing branched polyethylenimine |
US4599400A (en) | 1984-12-18 | 1986-07-08 | The Dow Chemical Company | Star/comb-branched polyamide |
GB8621337D0 (en) * | 1986-09-04 | 1986-10-15 | Agricultural Genetics Co | Non-radioactive nucleic acid hybridization probes |
US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
JPH08510761A (ja) | 1994-03-07 | 1996-11-12 | ザ・ダウ・ケミカル・カンパニー | 生物活性及び/又はターゲテッドデンドリマー複合体 |
FR2722506B1 (fr) * | 1994-07-13 | 1996-08-14 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucleiques, preparation et utilisations |
US5919442A (en) | 1995-08-11 | 1999-07-06 | Dendritech, Inc. | Hyper comb-branched polymer conjugates |
CN1196711A (zh) * | 1995-09-18 | 1998-10-21 | 德尔塔化学有限公司 | 聚氯化铝和聚氯硫酸铝的制备方法及组合物 |
DE19605279A1 (de) | 1996-02-13 | 1997-08-14 | Hoechst Ag | Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung |
US5962429A (en) * | 1996-11-22 | 1999-10-05 | University Of Iowa | Complexes of adenovirus with cationic molecules |
DE19649645A1 (de) | 1996-11-29 | 1998-06-04 | Hoechst Ag | Mehrfach funktionelles Ligandensystem zur zielzellspezifischen Übertragung von Nukleotidsequenzen |
US5830730A (en) | 1997-05-08 | 1998-11-03 | The Regents Of The University Of California | Enhanced adenovirus-assisted transfection composition and method |
-
1997
- 1997-09-30 DE DE19743135A patent/DE19743135A1/de not_active Withdrawn
-
1998
- 1998-09-18 PT PT98117722T patent/PT905254E/pt unknown
- 1998-09-18 ES ES98117722T patent/ES2264180T3/es not_active Expired - Lifetime
- 1998-09-18 EP EP98117722A patent/EP0905254B1/de not_active Expired - Lifetime
- 1998-09-18 AT AT98117722T patent/ATE324397T1/de active
- 1998-09-18 DE DE59813507T patent/DE59813507D1/de not_active Expired - Lifetime
- 1998-09-18 DK DK98117722T patent/DK0905254T3/da active
- 1998-09-28 AR ARP980104829A patent/AR015726A1/es unknown
- 1998-09-28 ID IDP981293A patent/ID20973A/id unknown
- 1998-09-28 CZ CZ983105A patent/CZ310598A3/cs unknown
- 1998-09-28 TR TR1998/01933A patent/TR199801933A2/xx unknown
- 1998-09-28 HU HU9802157A patent/HUP9802157A3/hu unknown
- 1998-09-29 CA CA002249058A patent/CA2249058A1/en not_active Abandoned
- 1998-09-29 AU AU87148/98A patent/AU758239B2/en not_active Ceased
- 1998-09-29 BR BR9803982-2A patent/BR9803982A/pt not_active IP Right Cessation
- 1998-09-30 KR KR1019980040775A patent/KR19990030290A/ko not_active Application Discontinuation
- 1998-09-30 JP JP27863998A patent/JP4399042B2/ja not_active Expired - Fee Related
- 1998-09-30 PL PL98328910A patent/PL328910A1/xx unknown
-
2002
- 2002-10-07 US US10/265,539 patent/US8003734B2/en not_active Expired - Fee Related
-
2006
- 2006-07-26 CY CY20061101036T patent/CY1105109T1/el unknown
-
2011
- 2011-07-18 US US13/185,436 patent/US20110306656A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0905254A3 (de) | 2002-01-02 |
CY1105109T1 (el) | 2009-11-04 |
US20110306656A1 (en) | 2011-12-15 |
ATE324397T1 (de) | 2006-05-15 |
DE19743135A1 (de) | 1999-04-01 |
PT905254E (pt) | 2006-08-31 |
KR19990030290A (ko) | 1999-04-26 |
ID20973A (id) | 1999-04-01 |
CA2249058A1 (en) | 1999-03-30 |
CZ310598A3 (cs) | 1999-04-14 |
DE59813507D1 (de) | 2006-06-01 |
JP4399042B2 (ja) | 2010-01-13 |
EP0905254B1 (de) | 2006-04-26 |
AU8714898A (en) | 1999-04-22 |
HUP9802157A2 (hu) | 1999-06-28 |
AU758239B2 (en) | 2003-03-20 |
HUP9802157A3 (en) | 2003-02-28 |
JPH11187874A (ja) | 1999-07-13 |
BR9803982A (pt) | 2000-03-28 |
US8003734B2 (en) | 2011-08-23 |
TR199801933A2 (xx) | 1999-04-21 |
PL328910A1 (en) | 1999-04-12 |
HU9802157D0 (en) | 1998-12-28 |
EP0905254A2 (de) | 1999-03-31 |
ES2264180T3 (es) | 2006-12-16 |
US20030027784A1 (en) | 2003-02-06 |
DK0905254T3 (da) | 2006-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR015726A1 (es) | Vector para la introduccion de un acido nucleico en una celula, procedimiento para su preparacion, polietilenimina de bajo peso molecular, procedimientopara su preparacion, empleo de una polietilenimina de bajo peso molecular para la preparacion de un vector y de un medicamento, empleo de un vector | |
AU4835396A (en) | Composition containing nucleic acids, preparation and use | |
BR0014087A (pt) | Composições com pérolas de caroteno - xantofila estáveis e métodos de uso | |
BR9906597A (pt) | Produto de prostaglandina | |
MX9700270A (es) | Composicion que contiene acidos nucleicos, preparacion y utilizacion. | |
AU4861890A (en) | Alkylated polyethylenimine derivatives, process for their preparation, their use as pharmaceuticals and pharmaceutical preparations | |
AU1458395A (en) | Composition containing nucleic acids, preparation and uses | |
BR9909394A (pt) | Composição de aerossol, composição farmacêutica, recipiente, dispositivo de inalação, processo para preparar uma composição de aerossol, mistura de um primeiro material particulado, e, processo para administrar um medicamento particulado | |
AU1265097A (en) | Nucleic acid constructs for the cell cycle-regulated expression of genes, cells containing such constructs and their use for preparing drugs | |
AU5217286A (en) | Process for making polymer particles, polymer particles and their use | |
DE60113121T2 (de) | Herstellung von vernetzter Hyaluronsäure und dessen Hydrogel, daraus hergestellte Produkte und deren Verwendung | |
AU6117696A (en) | Nucleic acid respiratory syncytial virus vaccines | |
MX9603560A (es) | Composiciones de prostaglandinas estables en almacenamiento. | |
ZA200102105B (en) | Stable concentrated insulin preparations for pulmonary. | |
WO1998022097A3 (en) | Controlled release matrix composition using polar polymer or monomer and poly(acrylic acid) blend | |
AR021800A1 (es) | Implantes medicinales recubiertos con polimeros o una mezcla de polimeros solucion esteril que contiene tales polimeros y empleo de los mismos yprocedimiento para la preparacion de estos implantes medicinales. | |
AU7695694A (en) | Blocking the accumulation of germs on human cells | |
DE69811061D1 (de) | Kosmetische zusammensetzungen enthaltend ein kationisches polymer mit niedrigem molekulargewicht und einem silikon sowie deren verwendungen | |
CA2231176A1 (en) | Long active composition for rectal administration | |
NO303325B1 (no) | Nµringsmidler eller kosmetiske kremer inneholdende skum | |
EP1270586A3 (de) | Zusammensetzung zum zellspezifischen Transfer von Wirkstoffen | |
DE3881691T2 (de) | Polydeoxyribonukleotide, pharmazeutische zusammensetzungen, verwendung und herstellung von polydeoxyribonukleotiden. | |
BR0211149A (pt) | Preparados farmacêuticos contendo resinas trocadoras de ìons carregadas com substância ativa | |
CA2199624A1 (en) | Polymerizable aromatic carboxylic acids and carboxyanhydrides with cyclic carbonate groups, as well as preparations containing these compounds | |
EP0652242A3 (en) | Polymerizable monomer with an electrolytic polymerizable group, polymer made therefrom and use of this polymer. |