AR014406A1 - Sulfonilfenilaminas sustituidas y composiciones farmaceuticas que las comprenden - Google Patents

Sulfonilfenilaminas sustituidas y composiciones farmaceuticas que las comprenden

Info

Publication number
AR014406A1
AR014406A1 ARP980106523A ARP980106523A AR014406A1 AR 014406 A1 AR014406 A1 AR 014406A1 AR P980106523 A ARP980106523 A AR P980106523A AR P980106523 A ARP980106523 A AR P980106523A AR 014406 A1 AR014406 A1 AR 014406A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
substituted
carbamoyl
amino
Prior art date
Application number
ARP980106523A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR014406A1 publication Critical patent/AR014406A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Sulfonilfenilaminas sustituidas de la formula (I), en donde: X es S o NH, e Y y Z son cada uno CH; o X es NH, y una de las variables Y y Z es N, y la otraes CH; R1 y R2, independientemente uno del otro, presentan hidrogeno, alquilo (C1-7), o alquilo (C1-7) sustituido por hidroxi, halogeno, alcoxi (C1-7),carboxi, alcoxi (C1-7)-carbonilo, carbamoílo, alquilo (C1-7)-carbamoílo, dialquilo (C1-7)-carbamoílo, cicloalquilo (C3-8), o por cicloalquilo (C3-8) queestá sustituido por alcoxi (C1-7)-carbonilo, o representan alcanoílo (C2-7); mientras que cuando menos una de las variables R1 y R2 es diferente dehidrogeno; o el grupo NR1R2 es alquileno (C2-6)-amino lineal que está insustituido o sustituido por alquilo (C1-7), hidroxialquilo (C1-7), alcoxi(C1-7), alcoxi (C1-7)-alquilo (C1-7), alcoxi (C1-7)-alcoxi (C1-7)-alquilo (C1-7), tioalquilo (C1-7)-alquilo (C1-7), alcano (C1-7)-sulfinilalquilo (C1-7),alcano (C1-7)-sulfonilalquilo (C1-7), aminoalquilo (C1-7), alquilo (C1-7)- aminoalquilo (C1-7), dialquilo (C1-7)-aminoalquilo (C1-7), hidroxi, ciano,amino, alquilo (C1-7)-amino, dialquilo (C1-7)-amino, alcanoílo (C1-7), hidroxilimino-alquilo (C2-7), carboxi, alcoxi (C1-7)-carbonilo, carbamoílo,alquilo (C1-7)-carbamoílo, dialquilo (C1-7)-carbamoílo, o por oxo, o es morfolino, tiomorfolino, 4-alquilo (C1-7)-piperazino, 4-piridil-piperazino,tetrahidroquinolin-1-ilo, tetrahidroiso-quinolin-2-ilo, dihidroindol-1-ilo, o dihidroindol-1-ilo sustituido por alcoxi (C1-7)-carbonilo, o es un grupo de laformula (II); y en donde el anillo A, aparte de estar sustituido por -SO2NR1R2 y -NH-, está insustituido o sustituido una o más veces por un sustituyenteseleccionado a partir del grupo que consisteen alquilo (C1-7), alcoxi (C1-7), alcoxi (C1-7)-alcoxi (C1-7), hidroxi, halogeno, y CF3; y en donde el anillo B
ARP980106523A 1997-12-22 1998-12-18 Sulfonilfenilaminas sustituidas y composiciones farmaceuticas que las comprenden AR014406A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19757248 1997-12-22

Publications (1)

Publication Number Publication Date
AR014406A1 true AR014406A1 (es) 2001-02-28

Family

ID=7853006

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980106523A AR014406A1 (es) 1997-12-22 1998-12-18 Sulfonilfenilaminas sustituidas y composiciones farmaceuticas que las comprenden

Country Status (6)

Country Link
AR (1) AR014406A1 (es)
AU (1) AU2415299A (es)
CO (1) CO5011105A1 (es)
PE (1) PE20000127A1 (es)
WO (1) WO1999032466A1 (es)
ZA (1) ZA9811705B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE314371T1 (de) 1998-11-10 2006-01-15 Merck & Co Inc Spiro-indole als y5-rezeptor antagonisten
FR2792314B1 (fr) * 1999-04-15 2001-06-01 Adir Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6218408B1 (en) 1999-06-30 2001-04-17 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US6989379B1 (en) 1999-04-22 2006-01-24 H. Lundbick A/S Selective NPY (Y5) antagonists
DE60034783T2 (de) * 1999-04-22 2008-01-31 H. Lundbeck A/S, Valby Selektive npy(y5)-antagonisten
US6340683B1 (en) 1999-04-22 2002-01-22 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (triazines)
US6225330B1 (en) 1999-06-30 2001-05-01 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
US6214853B1 (en) 1999-06-30 2001-04-10 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (bicyclics)
US7273880B2 (en) 1999-06-30 2007-09-25 H. Lunbeck A/S Selective NPY (Y5) antagonists
US6222040B1 (en) 1999-06-30 2001-04-24 Synaptic Pharmaceutical Corporation Selective NPY (Y5) antagonists (tricyclics)
KR100733752B1 (ko) 1999-11-26 2007-06-29 시오노기세이야쿠가부시키가이샤 Ｎｐｙｙ５ 길항제
AU2001237401B2 (en) 2000-03-01 2006-11-09 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
FR2815346B1 (fr) * 2000-10-13 2004-02-20 Servier Lab Nouveaux composes aminotriazolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2005508841A (ja) * 2001-03-29 2005-04-07 スミスクライン・ビーチャム・コーポレイション 化合物および方法
CA2403307A1 (en) 2001-10-23 2003-04-23 Neurogen Corporation Substituted 2-cyclohexyl-4-phenyl-1h-imidazole derivatives
TW200303742A (en) 2001-11-21 2003-09-16 Novartis Ag Organic compounds
BRPI0409447A (pt) * 2003-04-14 2006-04-18 Inst For Pharm Discovery Inc ácidos fenilalcanóicos substituìdos
KR20060006953A (ko) 2003-04-30 2006-01-20 디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 치환된 카르복실산
EP1797049A4 (en) * 2004-10-08 2009-06-17 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLYLAMINOARYL (HETEROARYL) SULFONAMIDE DERIVATIVES
GB0526257D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
US9353078B2 (en) * 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof
CA3162388A1 (en) * 2019-12-20 2021-06-24 Alfredo C. Castro 4-phenyl-n-(phenyl)thiazol-2-amine derivatives and related compounds as aryl hydrocarbon receptor (ahr) agonists for the treatment of e.g. angiogenesis implicated or inflammatory disorder

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776765A (en) * 1972-02-28 1973-12-04 Cities Service Co Process for protecting a substrate with an n{11 substituted aminoarylsulfonamide intumescent agent
FR2701480B1 (fr) * 1993-02-15 1995-05-24 Sanofi Elf Composés à groupe sulfamoyle et amidino, leur procédé de préparation et les compositions pharmaceutiques les contenant.
WO1996003392A1 (en) * 1994-07-27 1996-02-08 G.D. Searle & Co. Substituted thiazoles for the treatment of inflammation

Also Published As

Publication number Publication date
CO5011105A1 (es) 2001-02-28
PE20000127A1 (es) 2000-03-14
AU2415299A (en) 1999-07-12
WO1999032466A1 (en) 1999-07-01
ZA9811705B (en) 1999-09-07

Similar Documents

Publication Publication Date Title
AR014406A1 (es) Sulfonilfenilaminas sustituidas y composiciones farmaceuticas que las comprenden
DK0639577T3 (da) Phosphonooxymethyl- eller methylthiomethylestere af taxanderivater som antitumormidler
BR0213924A (pt) Composição polimerizável, polimerizato fotocrÈmico e artigo fotocrÈmico
BR0307833A (pt) Sìntese controlada de ziprasidona e suas composições
CO5540344A2 (es) Medicamentos
CR6592A (es) Compuestos para el tratamiento de la isquemia
PA8539801A1 (es) Derivados del ácido isoftálico como inhibidores de metaloproteinasas de la matriz
AR015439A1 (es) Derivados de pirimidin-4-ona y pirimidin-4-tiona, composicion para controlar y prevenir plagas, el uso de dichos compuestos para la proteccion de plantas,metodo para controlar o prevenir la infestacion de plantas cultivadas por microorganismos fitopatogenicos, metodo de preparacion de dichos derivad
BR0210464A (pt) Composto, composição farmacêutica, processo para preparar um composto, e, uso de um composto
DE68927697D1 (de) Fluor substituierte Benzocycloheptapyridine, Zusammensetzungen und Verfahren zur Verwendung derselben als antihistaminische Verbindungen
BR9917067A (pt) Artigo e artigo fotocrÈmico
BR9909110A (pt) Usos de esmilagenina e anzurogenina d, compoisção farmacêutica tendo propriedades intensificadoras da função cognitiva, processo para intensificar a função cognitiva, e, composição para uso do mesmo
DE60330181D1 (de) Actriib-fusionspolypeptide und verwendungen dafür
BR0212023A (pt) Composto, composições e método para controle de pragas invertebradas
GT200600174A (es) Pirrolopiridinas sustituidas, composiciones que las contienen, proceso de fabricacion y utilizacion
AR017852A1 (es) COMPUESTOS DE PIRAZOLO (3,4-b)PIRIDINA Y SUS SALES, UTILES COMO INHIBIDORES DE LAS PROTEINA-QUINASAS DEPENDIENTES DE CICLINA, Y LAS COMPOSICIONESFARMACEUTICAS QUE LOS CONTIENEN, EVENTUALMENTE ASOCIADOS CON UN AGENTE ANTICANCER.
NO20062040L (no) Modulatorer for atp-bindende kassett-transportere inneholdende cykloalkyl eller pyranylgrupper
ES2174989T3 (es) Pirido(3,2-e)pirazinonas con antiasmatica y procedimiento para su preparacion.
BR0000654A (pt) Preparação de composição de borracha vulcanizada com peróxido e artigos tendo ela pelo menos como um dos seus componentes
BR9813391C1 (pt) processo para produzir uma composição de epo e processo para aumentar a atividade específica de uma composição de epo
BR0109109A (pt) Composto, uso do mesmo, processo para prepará-lo, composição farmacêutica, e, método de tratar um estado doentio mediado por ccr5 em mamìferos
DK0811001T3 (da) Benzothiazindioxider som endothelinantagonister
PT979079E (pt) Utilizacao de derivados da tetra-hidropiridina para a preparacao de medicamentospara o tratamento das doencas que provocam uma desmielinizacao
AR009145A1 (es) Compuetos heterociclicos de guanidinilo utiles como agonistas de alfa-2 adrenoreceptores y composiciones farmaceuticas que los comprenden
BR0210238A (pt) Novos análogos de aril-amino-propano e seu uso para o tratamento de glaucoma