AR012374A1 - PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSIONS AND USES FOR THE PREPARATION OF MEDICINES. - Google Patents
PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSIONS AND USES FOR THE PREPARATION OF MEDICINES.Info
- Publication number
- AR012374A1 AR012374A1 ARP980101627A ARP980101627A AR012374A1 AR 012374 A1 AR012374 A1 AR 012374A1 AR P980101627 A ARP980101627 A AR P980101627A AR P980101627 A ARP980101627 A AR P980101627A AR 012374 A1 AR012374 A1 AR 012374A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- het
- alkenyl
- cycloalkyl
- roc
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuestos de formula (I), en la cual: X, Y y Z son independientemente N, O, S o CR, con la condicion de que al menos dos de X, Y y Z sonheteroátomos y al menos uno de X, Y y Z es N; o uno de X, Y y Z es C=N, C=C o N=N y los otros dos son CR oN, con la condicion de que X, Y y Z juntoscomprenden al menos dos N, - - - indica un enlace simle o doble; R1 es R, RC(O), RC(S), RSO2, ROC(O), o ROC(O)NRCH(R6)C(O); R2 es H, alquiloC1-6, alquenilo C2-6, Ar-alquilo C0-6, o Het-alquilo c0-6; R3 esH, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquil C3-6-alquilo C0-6, Ar-alquiloC0-6, o Het-alquilo C0-6; R4 es H, alquilo C1-6, alquenilo C2-6, Ar-alquilo C0-6, o Het-alquilo C0-6; R5 es alquilo C1-6, Ar-alquilo C0-6, Het-alquiloC0-6, CH(R6)NRR7, CH(R6)Ar, CH(R6)OAr o NR8R9; cada R6 es independientemente H, alquilo C1-6, alquenilo C2-6, cicloalquil C3-6-alquilo C0-6, Ar-alquiloC0-6, Het-alquilo C0-6; R7 es R, RC(O), RC(S), RSO2, ROC(O), o ROC (O)NRCH(R6)C(O); R8 es H, alquilo C1-6, alquenilo C2-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, o Het-alquilo C0-6, y R9 es alquilo C1-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, o Het-alquilo C0-6; oR8 y R9 se combinan para formar un anillo carboxíclico o heterocíclico monocíclico de 3-7 miembros o bicíclico de 7-10 miembros, sustituidoopcionalmente con 1-4 de alquilo C1-6, Ar-alquilo C0-6, Het-alquilo C0-6, alcoxi C1-6, Ar-alcoxi C0-6, Het-alcoxi C0-6, OH, (CH2)1-6NRR, u O(CH2)1-6NRR; R10 es H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquil C3-6-alquilo C0-6, Ar-alquilo C0-6, o Het-alquilo C0-6; cada R esindependientemente H, alquilo C1-6, alquenilo C2-6, Ar-alquilo C0-6, o Het- alquilo C0-6; cada R es independientemente alquilo C1-6, Ar-alquilo C0-6, oCompounds of formula (I), in which: X, Y and Z are independently N, O, S or CR, with the proviso that at least two of X, Y and Z are heteroatoms and at least one of X, Y and Z is N; or one of X, Y and Z is C = N, C = C or N = N and the other two are CR oN, with the proviso that X, Y and Z together comprise at least two N, - - - indicates a bond single or double; R1 is R, RC (O), RC (S), RSO2, ROC (O), or ROC (O) NRCH (R6) C (O); R 2 is H, C 1-6 alkyl, C 2-6 alkenyl, Ar-C 0-6 alkyl, or Het-C 0-6 alkyl; R3 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl-C0-6 alkyl, Ar-C0-6 alkyl, or Het-C0-6 alkyl; R4 is H, C1-6 alkyl, C2-6 alkenyl, Ar-C0-6 alkyl, or Het-C0-6 alkyl; R5 is C1-6 alkyl, Ar-C0-6 alkyl, Het-C0-6 alkyl, CH (R6) NRR7, CH (R6) Ar, CH (R6) OAr or NR8R9; each R6 is independently H, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C0-6 alkyl, Ar-C0-6 alkyl, Het-C0-6 alkyl; R7 is R, RC (O), RC (S), RSO2, ROC (O), or ROC (O) NRCH (R6) C (O); R8 is H, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl-C0-6 alkyl, Ar-C0-6 alkyl, or Het-C0-6 alkyl, and R9 is C1-6 alkyl, C3- cycloalkyl 6-C0-6-alkyl, Ar-C0-6-alkyl, or Het-C0-6-alkyl; oR8 and R9 combine to form a 3-7 membered monocyclic or 7-10 membered bicyclic carboxylic or heterocyclic ring, optionally substituted with 1-4 C1-6 alkyl, Ar-C0-6 alkyl, Het-C0-6 alkyl , C1-6 alkoxy, Ar-C0-6 alkoxy, Het-C0-6 alkoxy, OH, (CH2) 1-6NRR, or O (CH2) 1-6NRR; R10 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl-C0-6 alkyl, Ar-C0-6 alkyl, or Het-C0-6 alkyl; each R is independently H, C1-6 alkyl, C2-6 alkenyl, Ar-C0-6 alkyl, or Het-C0-6 alkyl; each R is independently C1-6alkyl, Ar-C0-6alkyl, or
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4309697P | 1997-04-15 | 1997-04-15 | |
US4453197P | 1997-04-23 | 1997-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR012374A1 true AR012374A1 (en) | 2000-10-18 |
Family
ID=26720044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980101627A AR012374A1 (en) | 1997-04-15 | 1998-04-08 | PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSIONS AND USES FOR THE PREPARATION OF MEDICINES. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0975612A4 (en) |
JP (1) | JP2002515902A (en) |
AR (1) | AR012374A1 (en) |
AU (1) | AU7252398A (en) |
CA (1) | CA2285601A1 (en) |
CO (1) | CO4950541A1 (en) |
WO (1) | WO1998046582A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6723722B1 (en) | 1999-06-22 | 2004-04-20 | Takeda Chemical Industries, Ltd. | Acylhydrazine derivatives, their production and use |
CN1416346A (en) | 2000-03-21 | 2003-05-07 | 史密丝克莱恩比彻姆公司 | Peotease inhibitors |
HN2002000136A (en) | 2001-06-11 | 2003-07-31 | Basf Ag | INHIBITORS OF THE PROTEASE OF HIV VIRUS, COMPOUNDS CONTAINING THEMSELVES, THEIR PHARMACEUTICAL USES AND THE MATERIALS FOR SYNTHESIS |
EP1465862A1 (en) | 2002-01-17 | 2004-10-13 | SmithKline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors |
WO2012166463A2 (en) * | 2011-05-27 | 2012-12-06 | Neosome Life Sciences, LLC | Aminooxazole inhibitors of cyclin dependent kinases |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0755937B2 (en) * | 1986-07-29 | 1995-06-14 | 日本曹達株式会社 | Oxa (thia) zolidine derivative, its production method and acaricide |
US5244867A (en) * | 1989-09-26 | 1993-09-14 | Basf Aktiengesellschaft | Oxazole- and thiazolecarboxamides |
US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
-
1998
- 1998-04-08 AR ARP980101627A patent/AR012374A1/en unknown
- 1998-04-15 CA CA002285601A patent/CA2285601A1/en not_active Abandoned
- 1998-04-15 CO CO98020566A patent/CO4950541A1/en unknown
- 1998-04-15 WO PCT/US1998/007969 patent/WO1998046582A1/en not_active Application Discontinuation
- 1998-04-15 EP EP98919821A patent/EP0975612A4/en not_active Withdrawn
- 1998-04-15 AU AU72523/98A patent/AU7252398A/en not_active Abandoned
- 1998-04-15 JP JP54437598A patent/JP2002515902A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU7252398A (en) | 1998-11-11 |
WO1998046582A1 (en) | 1998-10-22 |
JP2002515902A (en) | 2002-05-28 |
EP0975612A4 (en) | 2001-06-13 |
CA2285601A1 (en) | 1998-10-22 |
EP0975612A1 (en) | 2000-02-02 |
CO4950541A1 (en) | 2000-09-01 |
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