MA33103B1 - Derivatives 6 - (substitute 6 - triazolopridzine - sulfanil 5) (A-fluoro-benzotiazole and 5-fluoro-benzimidazole: preparation and use as drugs and as inhibitors) - Google Patents
Derivatives 6 - (substitute 6 - triazolopridzine - sulfanil 5) (A-fluoro-benzotiazole and 5-fluoro-benzimidazole: preparation and use as drugs and as inhibitors)Info
- Publication number
- MA33103B1 MA33103B1 MA34148A MA34148A MA33103B1 MA 33103 B1 MA33103 B1 MA 33103B1 MA 34148 A MA34148 A MA 34148A MA 34148 A MA34148 A MA 34148A MA 33103 B1 MA33103 B1 MA 33103B1
- Authority
- MA
- Morocco
- Prior art keywords
- phenyl
- fluoro
- cycloalkyl
- heterocycloalkyl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne les nouveaux produits de formule (I): dans laquelle (II) représente une liaison simple ou double; F représente un atome de fluor, Ra représente H, HaI, alcoxy, O-cycloalkyle, -O- hétérocycloalkyle; -NH-cycloalkyle, -NH-hétérocycloalkyle, hétéroaryle,phényle, NHCOaIk, NHCOcycloalk ou NR1 R2; X représente S, SO ou SO2, A représente NH ou S; W représente H, alkyle ou COR avec R représente cycloalkyle; alkyle éventuellement substitué par NR3R4, alcoxy, hydroxy, phényle, hétéroaryle, ou hétérocycloalkyle; alcoxy éventuellement substitué par NR3R4, càd un radical O-(CH2)n-NR3R4, un radical O-phényle ou O-(CH2)n-phényle, avec phényle éventuellement substitué et n= 1 à 4; ou le radical NR1 R2; R1 représente H ou al k et R2 représente H, cycloalkyle ou alkyle; R3 et R4 représentent H, alk, cycloalkyle, hétéroaryle ou phényle; R1, R2 et/ou R3,R4 forment avec N un cycle renfermant éventuellement O, S, N et/ou NH; tous hétérocycloalkyle, hétéroaryle et phényle et cycliques étant éventuellement substitués; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de MET.The invention relates to novel products of formula (I): wherein (II) represents a single or double bond; F represents a fluorine atom, Ra represents H, Ha, alkoxy, O-cycloalkyl, -O-heterocycloalkyl; -NH-cycloalkyl, -NH-heterocycloalkyl, heteroaryl, phenyl, NHCOaIk, NHCOcycloalk or NR1 R2; X is S, SO or SO 2, A is NH or S; W is H, alkyl or COR with R is cycloalkyl; alkyl optionally substituted with NR3R4, alkoxy, hydroxy, phenyl, heteroaryl, or heterocycloalkyl; alkoxy optionally substituted with NR 3 R 4, ie O- (CH 2) n -NR 3 R 4, O-phenyl or O- (CH 2) n -phenyl, with optionally substituted phenyl and n = 1 to 4; or the radical NR1 R2; R1 is H or alk and R2 is H, cycloalkyl or alkyl; R3 and R4 are H, alk, cycloalkyl, heteroaryl or phenyl; R1, R2 and / or R3, R4 form with N a ring optionally containing O, S, N and / or NH; all heterocycloalkyl, heteroaryl and phenyl and cyclic being optionally substituted; these products being in all isomeric forms and salts, as medicaments especially as MET inhibitors.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0900514A FR2941952B1 (en) | 2009-02-06 | 2009-02-06 | 6- (6-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) DERIVATIVES 5-FLUORO-BENZOTHIAZOLES AND 5-FLUORO-BENZIMIDAZOLES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS INHIBITORS OF MET. |
PCT/FR2010/050180 WO2010089509A1 (en) | 2009-02-06 | 2010-02-04 | Derivatives of 6-(6-substituted-triazolopyridazine-sulfanyl) 5-fluoro-benzothiazoles and 5-fluoro-benzimidazoles, preparation thereof, use thereof as drugs, and use thereof as met inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MA33103B1 true MA33103B1 (en) | 2012-03-01 |
Family
ID=40886775
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA34148A MA33103B1 (en) | 2009-02-06 | 2010-02-04 | Derivatives 6 - (substitute 6 - triazolopridzine - sulfanil 5) (A-fluoro-benzotiazole and 5-fluoro-benzimidazole: preparation and use as drugs and as inhibitors) |
Country Status (19)
Country | Link |
---|---|
US (1) | US20120165326A1 (en) |
EP (1) | EP2393793A1 (en) |
JP (1) | JP2012517410A (en) |
KR (1) | KR20110126659A (en) |
CN (1) | CN102369191A (en) |
AR (1) | AR075251A1 (en) |
AU (1) | AU2010212234A1 (en) |
BR (1) | BRPI1008019A2 (en) |
CA (1) | CA2751474A1 (en) |
CO (1) | CO6420339A2 (en) |
EA (1) | EA201171012A1 (en) |
FR (1) | FR2941952B1 (en) |
IL (1) | IL214408A0 (en) |
MA (1) | MA33103B1 (en) |
MX (1) | MX2011008290A (en) |
SG (1) | SG173561A1 (en) |
TW (1) | TW201036977A (en) |
UY (1) | UY32422A (en) |
WO (1) | WO2010089509A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2966151B1 (en) * | 2010-10-14 | 2012-11-09 | Sanofi Aventis | 6- (ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS |
EP2755976B1 (en) | 2011-09-15 | 2018-07-18 | Novartis AG | 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors |
US11324729B2 (en) | 2017-12-07 | 2022-05-10 | The Regents Of The University Of Michigan | NSD family inhibitors and methods of treatment therewith |
AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1298125A1 (en) | 2001-09-26 | 2003-04-02 | Aventis Pharma S.A. | Substituted benzimidazole compounds and their use for the treatment of cancer |
BRPI0619252A2 (en) * | 2005-11-30 | 2011-09-20 | Vertex Pharma | c-met inhibitors and their uses |
ME02736B (en) * | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolopyridazines as tyrosine kinase modulators |
WO2007138472A2 (en) * | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Triazolopyridazine derivatives |
PE20121506A1 (en) * | 2006-07-14 | 2012-11-26 | Amgen Inc | TRIAZOLOPYRIDINE COMPOUNDS AS C-MET INHIBITORS |
KR20090071612A (en) * | 2006-10-23 | 2009-07-01 | 에스지엑스 파마슈티컬스, 인코포레이티드 | Bicyclic triazoles as protein kinase modulators |
PA8792501A1 (en) * | 2007-08-09 | 2009-04-23 | Sanofi Aventis | NEW DERIVATIVES OF 6-TRIAZOLOPIRIDACINA-SULFANIL BENZOTIAZOL AND BENCIMIDAZOL, ITS PREPARATION PROCEDURE, ITS APPLICATION AS MEDICATIONS, PHARMACEUTICAL COMPOSITIONS AND NEW MAIN USE AS MET INHIBITORS. |
-
2009
- 2009-02-06 FR FR0900514A patent/FR2941952B1/en not_active Expired - Fee Related
-
2010
- 2010-02-04 JP JP2011548753A patent/JP2012517410A/en not_active Withdrawn
- 2010-02-04 CN CN2010800155638A patent/CN102369191A/en active Pending
- 2010-02-04 AU AU2010212234A patent/AU2010212234A1/en not_active Abandoned
- 2010-02-04 BR BRPI1008019A patent/BRPI1008019A2/en not_active Application Discontinuation
- 2010-02-04 WO PCT/FR2010/050180 patent/WO2010089509A1/en active Application Filing
- 2010-02-04 KR KR1020117020675A patent/KR20110126659A/en not_active Application Discontinuation
- 2010-02-04 CA CA2751474A patent/CA2751474A1/en not_active Abandoned
- 2010-02-04 MA MA34148A patent/MA33103B1/en unknown
- 2010-02-04 EP EP10708280A patent/EP2393793A1/en not_active Withdrawn
- 2010-02-04 US US13/147,644 patent/US20120165326A1/en not_active Abandoned
- 2010-02-04 SG SG2011056504A patent/SG173561A1/en unknown
- 2010-02-04 EA EA201171012A patent/EA201171012A1/en unknown
- 2010-02-04 MX MX2011008290A patent/MX2011008290A/en not_active Application Discontinuation
- 2010-02-05 TW TW099103557A patent/TW201036977A/en unknown
- 2010-02-05 AR ARP100100319A patent/AR075251A1/en unknown
- 2010-02-05 UY UY0001032422A patent/UY32422A/en not_active Application Discontinuation
-
2011
- 2011-08-02 IL IL214408A patent/IL214408A0/en unknown
- 2011-08-05 CO CO11099118A patent/CO6420339A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SG173561A1 (en) | 2011-09-29 |
CO6420339A2 (en) | 2012-04-16 |
TW201036977A (en) | 2010-10-16 |
WO2010089509A1 (en) | 2010-08-12 |
US20120165326A1 (en) | 2012-06-28 |
IL214408A0 (en) | 2011-09-27 |
FR2941952A1 (en) | 2010-08-13 |
KR20110126659A (en) | 2011-11-23 |
EA201171012A1 (en) | 2012-03-30 |
FR2941952B1 (en) | 2011-04-01 |
MX2011008290A (en) | 2011-11-04 |
CA2751474A1 (en) | 2010-08-12 |
AU2010212234A1 (en) | 2011-08-25 |
JP2012517410A (en) | 2012-08-02 |
EP2393793A1 (en) | 2011-12-14 |
UY32422A (en) | 2010-09-30 |
CN102369191A (en) | 2012-03-07 |
BRPI1008019A2 (en) | 2016-03-15 |
AR075251A1 (en) | 2011-03-16 |
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