AR012258A1 - HYDRAZIDE-DERIVED COMPOUNDS, THEIR USE, A PROCESS TO MANUFACTURE THEM, CONTAINING MEDICINES, A PROCESS TO PRODUCE A MEDICINAL PRODUCT, USEFUL COMPOUNDS AS INTERMEDIARIES TO PREPARE SUCH COMPOUNDS AND CARBOXYLIC ACIDS FOR SINGLE COMPOUNDS AND UTILITIES. - Google Patents
HYDRAZIDE-DERIVED COMPOUNDS, THEIR USE, A PROCESS TO MANUFACTURE THEM, CONTAINING MEDICINES, A PROCESS TO PRODUCE A MEDICINAL PRODUCT, USEFUL COMPOUNDS AS INTERMEDIARIES TO PREPARE SUCH COMPOUNDS AND CARBOXYLIC ACIDS FOR SINGLE COMPOUNDS AND UTILITIES.Info
- Publication number
- AR012258A1 AR012258A1 ARP980103063A ARP980103063A AR012258A1 AR 012258 A1 AR012258 A1 AR 012258A1 AR P980103063 A ARP980103063 A AR P980103063A AR P980103063 A ARP980103063 A AR P980103063A AR 012258 A1 AR012258 A1 AR 012258A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- compounds
- cycloalkyl
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Compuestos derivados de hidrazina de formula I en la que Y significa CO o SO2; R1 significa alquilo inferior, alquenilo inferior, cicloalquilo-inferior-alquilo-inferior, arilo o arilo-alquilo-inferior; R2 significa alquilo inferior , halo-alquilo-i nferior, arilo-alquilo-inferior, arilo-alquenilo-inferior oarilo, cuando Y significa SO2, y significa alquilo inferior, halo-alquilo-inferior, alcoxi-inferior, alcoxi-inferior-carbonilo, acilo, cicloalquiloinferior, arilo, arilo-alquilo-inferio r,arilo-alcoxi-inferior o NR3R4 cuando Y significa CO; y R3 significa hidrogeno, alquilo inferior substituidoopcionalmente por ciano, amino, hidroxi, alcoxi inferior, alcoxi-inferior- -carbonilo, heterociclilo o heterociclilcarbonilo, alqueniloinferior,alquinilo inferior, cicloalquilo inferior, cicloalquilo-inferior-alquilo- -inferior, arilo-alquilo-inferior, arilo-aquenilo-inferior, arilo oheterociclilo; o R2 y R3 juntos forman el residuo de un grupo amida ciclica, imida ciclica ,sulfonamida ciclica o uretano ciclico de 5-, 6- o 7- miembros;R4 significa alquilo inferior, hidroxi-alquilo-inferior, alquenilo inferior, cicloalquilo inferior, cicloalquilo-inferior-alquilo-inferior o un grupo de laformula X-arilo, X-heteroari loo -(CH2)1-2-CH-CR7R8; X significa un grupo espaciador; R3 y R4 cada uno individualmente significan hidrogeno, alquiloinferior o arilo-alquilo-inferior; y R7 y R8 juntos representan un grupo alquileno inferior en el cual un grupo metil eno estáreemplazado opcionalmentepor un heteroátomo; y sus sales farmacéuticamente aceptables inhiben no solo la liberacion del factor de necrosis tumoral (TNF-alfa) y del factor decrecimiento transformable (TGF-alfa) de las células, sino también laproliferacion de queratinocitos. Son utiles como medicamentos,especialmenteHydrazine-derived compounds of formula I in which Y means CO or SO2; R1 signifies lower alkyl, lower alkenyl, cycloalkyl-lower-lower-alkyl, aryl or aryl-lower-alkyl; R2 means lower alkyl, halo-lower-alkyl, aryl-lower-alkyl, aryl-lower-alkenyl-oaryl, when Y means SO2, and means lower-alkyl, halo-lower-alkyl, lower-alkoxy, lower-alkoxy-carbonyl , acyl, lower cycloalkyl, aryl, aryl-lower-alkyl, aryl-lower-alkoxy or NR3R4 when Y means CO; and R3 signifies hydrogen, lower alkyl optionally substituted by cyano, amino, hydroxy, lower alkoxy, lower alkoxy- -carbonyl, heterocyclyl or heterocyclylcarbonyl, lower alkenyl, lower alkynyl, cycloalkyl, cycloalkyl-lower-lower-alkyl, aryl-lower-alkyl. lower, aryl-lower-achenyl, aryl or heterocyclyl; or R2 and R3 together form the residue of a 5-, 6- or 7- membered cyclic amide, cyclic imide, cyclic sulfonamide or cyclic urethane group; R4 means lower alkyl, hydroxy-lower alkyl, lower alkenyl, lower cycloalkyl, cycloalkyl-lower-lower-alkyl or a group of the formula X-aryl, X-heteroari loo - (CH2) 1-2-CH-CR7R8; X means a spacer group; R3 and R4 each individually signify hydrogen, lower alkyl or aryl-lower alkyl; and R7 and R8 together represent a lower alkylene group in which a methyl ene group is optionally replaced by a heteroatom; and its pharmaceutically acceptable salts inhibit not only the release of tumor necrosis factor (TNF-alpha) and transformable growth factor (TGF-alpha) from cells, but also the proliferation of keratinocytes. They are useful as medicines, especially
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9713833.3A GB9713833D0 (en) | 1997-06-30 | 1997-06-30 | Novel hydrazine derivatives |
GBGB9803335.0A GB9803335D0 (en) | 1997-06-30 | 1998-02-17 | Novel hydrazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
AR012258A1 true AR012258A1 (en) | 2000-09-27 |
Family
ID=10815174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980103063A AR012258A1 (en) | 1997-06-30 | 1998-06-25 | HYDRAZIDE-DERIVED COMPOUNDS, THEIR USE, A PROCESS TO MANUFACTURE THEM, CONTAINING MEDICINES, A PROCESS TO PRODUCE A MEDICINAL PRODUCT, USEFUL COMPOUNDS AS INTERMEDIARIES TO PREPARE SUCH COMPOUNDS AND CARBOXYLIC ACIDS FOR SINGLE COMPOUNDS AND UTILITIES. |
Country Status (10)
Country | Link |
---|---|
KR (1) | KR100371122B1 (en) |
AR (1) | AR012258A1 (en) |
CO (1) | CO4940511A1 (en) |
EA (1) | EA199901111A1 (en) |
GB (2) | GB9713833D0 (en) |
HR (1) | HRP980366A2 (en) |
PE (1) | PE86099A1 (en) |
UA (1) | UA58561C2 (en) |
YU (1) | YU70899A (en) |
ZA (1) | ZA985469B (en) |
-
1997
- 1997-06-30 GB GBGB9713833.3A patent/GB9713833D0/en active Pending
-
1998
- 1998-02-17 GB GBGB9803335.0A patent/GB9803335D0/en not_active Ceased
- 1998-06-18 KR KR10-1999-7012477A patent/KR100371122B1/en not_active IP Right Cessation
- 1998-06-18 YU YU70899A patent/YU70899A/en unknown
- 1998-06-18 EA EA199901111A patent/EA199901111A1/en unknown
- 1998-06-18 UA UA99127266A patent/UA58561C2/en unknown
- 1998-06-23 ZA ZA985469A patent/ZA985469B/en unknown
- 1998-06-25 AR ARP980103063A patent/AR012258A1/en active IP Right Grant
- 1998-06-26 CO CO98036628A patent/CO4940511A1/en unknown
- 1998-06-26 PE PE1998000576A patent/PE86099A1/en not_active Application Discontinuation
- 1998-06-30 HR HR9713833.3A patent/HRP980366A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO4940511A1 (en) | 2000-07-24 |
UA58561C2 (en) | 2003-08-15 |
YU70899A (en) | 2002-06-19 |
PE86099A1 (en) | 1999-09-17 |
ZA985469B (en) | 1998-12-30 |
GB9713833D0 (en) | 1997-09-03 |
HRP980366A2 (en) | 1999-02-28 |
GB9803335D0 (en) | 1998-04-15 |
EA199901111A1 (en) | 2000-08-28 |
KR20010014331A (en) | 2001-02-26 |
KR100371122B1 (en) | 2003-02-05 |
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