CO4940511A1 - HYDRAZINE DERIVATIVES - Google Patents

HYDRAZINE DERIVATIVES

Info

Publication number
CO4940511A1
CO4940511A1 CO98036628A CO98036628A CO4940511A1 CO 4940511 A1 CO4940511 A1 CO 4940511A1 CO 98036628 A CO98036628 A CO 98036628A CO 98036628 A CO98036628 A CO 98036628A CO 4940511 A1 CO4940511 A1 CO 4940511A1
Authority
CO
Colombia
Prior art keywords
alkyl
aryl
cycloalkyl
alkenyl
alkoxy
Prior art date
Application number
CO98036628A
Other languages
Spanish (es)
Inventor
Michael John Broadhurst
William Henry Johnson
Daryl Simon Walter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO4940511A1 publication Critical patent/CO4940511A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compuestos de la fórmula generalEn la queY significa CO o SO2 ;R1 significa alquilo C1 -C7 , alquenilo C2 -C7 , cicloalquilo C3 -C7 , cicloalquilo C3 -C7 -alquilo-C1 -C7 , arilo o arilo-alquilo-C1 -C7 ;R2 significa alquilo C1 -C7 , halo-alquilo-C1 -C7 , arilo-alquilo-C1 -C7 , arilo-alquenilo C2 -C7 o arilo cuando Y significa SO2 , y significa alquilo-C1 -C7 , halo-alquilo-C1 -C7 , alcoxi-C1 -C7 , alcoxi-C1 -C7 -carbonilo, acilo, cicloalquilo C3 -C7 , arilo, arilo-alquilo-C1 -C7 , arilo-alcoxi C1 -C7 o NR5 R6 cuando Y significa CO; y R3 significa hidrógeno, alquilo C1 -C7 sustituido opcionalmente por ciano, amino, hidroxi, alcoxi C1 -C7 alcoxi C1 -C7 carbonilo, heterociclilo o heterociclilcarbonilo, alquenilo C2 -C7 , alquinilo C2 -C7 cicloalquilo C3 -C7 , cicloalquilo C3 -C7 -alquilo-C1 -C7 , arilo-alquilo-C1 -C7 , arilo-alquenilo C2 -C7 , arilo o heterociclilo; oR2 y R3 juntos forman el residuo de un grupo amida cíclica, imida cíclica, sulfonamida cíclica o uretano cíclico de 5-, 6- o 7- miembros;R4 significa alquilo C1 -C7 , alquenilo C2 -C7 , cicloalquilo C3 -C7 , cicloalquilo C3 -C7 -alquilo-C1 -C7 o un grupo de la fórmula X-arilo, X-heteroarilo o -(CH2 )1-2 -CH=CR7 R8 ;X significa un grupo espaciador seleccionado de los grupos de la fórmula -(CH2 )1-5 , -CH2 -CH=CH-, -CH2 -CºC-, -CH2 NHCO-, -(CH2 )1 ó 2 NHCONH-, -(CH2 )1-5 -S, -CH2 NHSO2 -, -CH2 NHCH2 -, -(CH2 )1-5 -O-, -(CH2 )1-5 - y -S-;R5 y R6 cada uno independientemente significan hidrógeno, alquilo C1 -C7 o arilo-alquilo-C1 -C7 ; yR7 y R8 juntos representan un grupo alquileno C1 -C7 en el cual un grupo metileno está reemplazado opcionalmente por un heterátomo; y sales farmacéuticamente aceptables de los mismos.Compounds of the general formula Wherein Y denotes CO or SO2; R1 denotes C1-C7 alkyl, C2-C7 alkenyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C7 alkyl, aryl or aryl-C1-C7-alkyl; R2 means C1-C7-alkyl, halo-C1-C7-alkyl, aryl-C1-C7-alkyl, aryl-C2-C7-alkenyl or aryl when Y means SO2, and means C1-C7-alkyl, halo-C1-alkyl - C7, C1-C7-alkoxy, C1-C7-alkoxy -carbonyl, acyl, C3-C7-cycloalkyl, aryl, aryl-C1-C7-alkyl, aryl-C1-C7-alkoxy or NR5 R6 when Y means CO; and R3 signifies hydrogen, C1-C7 alkyl optionally substituted by cyano, amino, hydroxy, C1-C7 alkoxy, C1-C7 alkoxycarbonyl, heterocyclyl or heterocyclylcarbonyl, C2-C7 alkenyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl -C1-C7-alkyl, aryl-C1-C7-alkyl, aryl-C2-C7-alkenyl, aryl or heterocyclyl; oR2 and R3 together form the residue of a 5-, 6- or 7- membered cyclic amide, cyclic imide, cyclic sulfonamide or cyclic urethane group; R4 means C1-C7 alkyl, C2-C7 alkenyl, C3-C7 cycloalkyl, cycloalkyl C3-C7-C1-C7-alkyl or a group of the formula X-aryl, X-heteroaryl or - (CH2) 1-2 -CH = CR7 R8; X means a spacer group selected from the groups of the formula - ( CH2) 1-5, -CH2 -CH = CH-, -CH2 -CºC-, -CH2 NHCO-, - (CH2) 1 or 2 NHCONH-, - (CH2) 1-5 -S, -CH2 NHSO2 -, -CH2 NHCH2 -, - (CH2) 1-5 -O-, - (CH2) 1-5 - and -S-; R5 and R6 each independently signify hydrogen, C1-C7-alkyl or aryl-C1-C7-alkyl ; and R7 and R8 together represent a C1-C7 alkylene group in which a methylene group is optionally replaced by a hetero atom; and pharmaceutically acceptable salts thereof.

CO98036628A 1997-06-30 1998-06-26 HYDRAZINE DERIVATIVES CO4940511A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9713833.3A GB9713833D0 (en) 1997-06-30 1997-06-30 Novel hydrazine derivatives

Publications (1)

Publication Number Publication Date
CO4940511A1 true CO4940511A1 (en) 2000-07-24

Family

ID=10815174

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98036628A CO4940511A1 (en) 1997-06-30 1998-06-26 HYDRAZINE DERIVATIVES

Country Status (10)

Country Link
KR (1) KR100371122B1 (en)
AR (1) AR012258A1 (en)
CO (1) CO4940511A1 (en)
EA (1) EA199901111A1 (en)
GB (2) GB9713833D0 (en)
HR (1) HRP980366A2 (en)
PE (1) PE86099A1 (en)
UA (1) UA58561C2 (en)
YU (1) YU70899A (en)
ZA (1) ZA985469B (en)

Also Published As

Publication number Publication date
UA58561C2 (en) 2003-08-15
YU70899A (en) 2002-06-19
PE86099A1 (en) 1999-09-17
ZA985469B (en) 1998-12-30
GB9713833D0 (en) 1997-09-03
AR012258A1 (en) 2000-09-27
HRP980366A2 (en) 1999-02-28
GB9803335D0 (en) 1998-04-15
EA199901111A1 (en) 2000-08-28
KR20010014331A (en) 2001-02-26
KR100371122B1 (en) 2003-02-05

Similar Documents

Publication Publication Date Title
IT1301792B1 (en) DERIVATIVES OF HYDRAZINE
DE69430483D1 (en) Benzoxazinone and benzopyrimidinone piperidinyl compounds as tocolytic oxytocin receptor antagonists
NO20054513L (en) taxanes
DE69840296D1 (en) PHENYLETHYLENAMIN DERIVATIVES
ES2164618T1 (en) CEMENT MIX TO IMPROVE SETTLEMENT TIME.
DE69738225D1 (en) epoxidation
RS50841B (en) Pyrrolidine derivatives as cyclic amp-specific phosphodiesterase inhibitors
PE107898A1 (en) 1,3-DIHETEROCICLIC COMPOUNDS, METALOPROTEASE INHIBITORS
AR040475A1 (en) SPYPRIPERIDINES OR TRICICLIC SPIROPIRROLIDINS
PE20040778A1 (en) SELECTIVELY ACTIVE PIPERAZINE DERIVATIVES ON MC-3 AND MC-4 MELANCORTINE RECEPTORS
DE69224115T2 (en) Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors
CO4940511A1 (en) HYDRAZINE DERIVATIVES
SV1994000031A (en) DERIVATIVES OF 1,5 BENZODIACEPINA REF. 1160CH / SV
KR830006217A (en) Method for preparing 9-amino-1-hydroxyoctahydrobenzo [C] quinoline
DE3876402T2 (en) N- (2-ALKYL-3-MERCAPTO-1,5-DIOXOALKYL) GLYCINAMIDE DERIVATIVES AND THE USE THEREOF AS COLLAGENASE INHIBITORS.
MX9301045A (en) PROCEDURE FOR PREPARING FIBRINOGEN RECEIVING ANTAGONISTS.
CO5040063A1 (en) DIHYDROPIRIDINE UTILIES COMPOUNDS AS OPENERS OF THE POTASSIUM CHANNELS
CO5080785A1 (en) HETEROCICLIC DERIVATIVES
ES2183434T3 (en) CHROMAN DERIVATIVES REPLACED WITH USEFUL CARBOXYL AS ADRENORECEPTORS AGONISTS.
KR950702978A (en) Amide derivatives
Nagashima et al. Novel malonamide derivatives as αvβ3 antagonists. Syntheses and evaluation of 3-(3-indolin-1-yl-3-oxopropanoyl) aminopropanoic acids on vitronectin Interaction with αvβ3
NO20002833L (en) Alicyclic, acylated heterocyclic derivatives
DK0630893T3 (en) N, N'-disubstituted amide derivative
NO942480L (en) Heterocycle-substituted benzylamine derivatives as anti-retroviral compounds
AR007463A1 (en) MONOAZOIC DYES REPLACED BY HALOALKYL CARBAMATE AND SULFONYL FLUORIDE GROUPS