EA199901111A1 - DERIVATIVES OF HYDRAZINE - Google Patents
DERIVATIVES OF HYDRAZINEInfo
- Publication number
- EA199901111A1 EA199901111A1 EA199901111A EA199901111A EA199901111A1 EA 199901111 A1 EA199901111 A1 EA 199901111A1 EA 199901111 A EA199901111 A EA 199901111A EA 199901111 A EA199901111 A EA 199901111A EA 199901111 A1 EA199901111 A1 EA 199901111A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ness
- alkyl
- aryl
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
- C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
В заявке описаны гидразиновые производные формулы (I)в которой Y обозначает CO или SO,Rобозначает (низш.)алкил, (низш.)алкенил, (низш.)циклоалкил, (низш.)циклоалкил (низш.)алкил, арил или арил(низш.)алкил;Rобозначает (низш.)алкил, галоид (низш.)алкил, арил(низш.)алкил, арил(низш.)алкенил или арил, когда Y обозначает SO, и обозначает (низш.)алкил, галоид (низш.)алкил, (низш.)алкокси, (низш.)алкоксикарбонил, ацил, (низш.)циклоалкил, арил, арил(низш.)алкил, арил(низш.)алкокси или NRR, когда Y обозначает CO,Rобозначает водород, (низш.)алкил, необязательно замещенный циано-, аминогруппой, гидроксилом, (низш.)алкокси, (низш.)алкоксикарбонилом, гетероциклилом или гетероциклилкарбонилом, (низш.)алкенил, (низш.)алкинил, (низш.)циклоалкил, (низш.)циклоалкил(низш.)алкил, арил(низш.)алкил, арил(низш.)алкенил, арил или гетероциклил илиRи Rсовместно образуют остаток 5-, 6- или 7-членной циклической амидной, циклической имидной, циклической сульфонамидной или циклической уретановой группы,Rобозначает (низш.)алкил, гидрокси(низш.)алкил, (низш.)алкенил, (низш.)циклоалкил, (низш.)циклоалкил(низш.)алкил или группировку формулы Х-арил, Х-гетероарил или -(CH)-CH=CRR,X обозначает спейсер,Rи Rкаждый независимо друг от друга обозначает водород, (низш.)алкил или арил(низш.)алкил иRи Rсовместно образуют (низш.)алкиленовую группу, в которой одна метиленовая группа необязательно замещена гетероатомом,и их фармацевтически приемлемые соли, которые ингибируют не только выделение из клеток фактора некроза опухоли (ФНО-α) и трансформирующего фактора роста (ТФР-α), но также пролиферацию кератиноцитов. Они могут быть использованы в качестве лекарственных средств, прежде всего при лечении воспалительных процессов, лихорадки, кровотечений, сепсиса, ревматоидногоThe application describes hydrazine derivatives of formula (I) in which Y represents CO or SO, R denotes (lower) alkyl, (lower) alkenyl, (lower) cycloalkyl, (lower) cycloalkyl, (lower) alkyl, aryl or aryl (lower) alkyl; R 4 is lower alkyl, halo (lower) alkyl, aryl (lower) alkyl, aryl (lower) alkenyl, or aryl, when Y is SO, and is lower alkyl, halogen (ness.) alkyl, (ness.) alkoxy, (ness.) alkoxycarbonyl, acyl, (ness.) cycloalkyl, aryl, aryl (ness.) alkyl, aryl (ness.) alkoxy or NRR, when Y represents CO, R is hydrogen, (ness.) alkyl, optionally substituted cyano-, amino, hydroxy, (ness.) alkoxy, (ness.) alkoxycarbonyl, heterocyclyl or heterocyclylcarbonyl, (ness.) alkenyl, (ness.) alkynyl, (ness.) cycloalkyl, (ness.) cycloalkyl (ness.) alkyl, aryl lower alkyl, aryl lower alkenyl, aryl or heterocyclyl or R and R together form a residue of a 5-, 6- or 7-membered cyclic amide, cyclic imide, cyclic sulfonamide or cyclic urethane group, R means (lower) alkyl, hydroxy (ness.) alkyl, (ness.) alkenyl, (ness.) cycloalkyl, (ness.) cycloalkyl (ness.) alkyl or a group of the formula X-aryl, X- etheroaryl or - (CH) -CH = CRR, X is a spacer, R and R each independently of one another denotes hydrogen, (lower) alkyl or aryl (lower) alkyl, and R and R together form a (lower) alkylene group, in which one methylene the group is optionally substituted with a heteroatom, and their pharmaceutically acceptable salts, which inhibit not only the release of tumor necrosis factor (TNF-α) and transforming growth factor (TGF-α) from cells, but also the proliferation of keratinocytes. They can be used as medicines, especially in the treatment of inflammatory processes, fever, bleeding, sepsis, rheumatoid
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9713833.3A GB9713833D0 (en) | 1997-06-30 | 1997-06-30 | Novel hydrazine derivatives |
GBGB9803335.0A GB9803335D0 (en) | 1997-06-30 | 1998-02-17 | Novel hydrazine derivatives |
PCT/EP1998/003683 WO1999001428A1 (en) | 1997-06-30 | 1998-06-18 | Hydrazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
EA199901111A1 true EA199901111A1 (en) | 2000-08-28 |
Family
ID=10815174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199901111A EA199901111A1 (en) | 1997-06-30 | 1998-06-18 | DERIVATIVES OF HYDRAZINE |
Country Status (10)
Country | Link |
---|---|
KR (1) | KR100371122B1 (en) |
AR (1) | AR012258A1 (en) |
CO (1) | CO4940511A1 (en) |
EA (1) | EA199901111A1 (en) |
GB (2) | GB9713833D0 (en) |
HR (1) | HRP980366A2 (en) |
PE (1) | PE86099A1 (en) |
UA (1) | UA58561C2 (en) |
YU (1) | YU70899A (en) |
ZA (1) | ZA985469B (en) |
-
1997
- 1997-06-30 GB GBGB9713833.3A patent/GB9713833D0/en active Pending
-
1998
- 1998-02-17 GB GBGB9803335.0A patent/GB9803335D0/en not_active Ceased
- 1998-06-18 KR KR10-1999-7012477A patent/KR100371122B1/en not_active IP Right Cessation
- 1998-06-18 YU YU70899A patent/YU70899A/en unknown
- 1998-06-18 EA EA199901111A patent/EA199901111A1/en unknown
- 1998-06-18 UA UA99127266A patent/UA58561C2/en unknown
- 1998-06-23 ZA ZA985469A patent/ZA985469B/en unknown
- 1998-06-25 AR ARP980103063A patent/AR012258A1/en active IP Right Grant
- 1998-06-26 CO CO98036628A patent/CO4940511A1/en unknown
- 1998-06-26 PE PE1998000576A patent/PE86099A1/en not_active Application Discontinuation
- 1998-06-30 HR HR9713833.3A patent/HRP980366A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CO4940511A1 (en) | 2000-07-24 |
UA58561C2 (en) | 2003-08-15 |
YU70899A (en) | 2002-06-19 |
PE86099A1 (en) | 1999-09-17 |
ZA985469B (en) | 1998-12-30 |
GB9713833D0 (en) | 1997-09-03 |
AR012258A1 (en) | 2000-09-27 |
HRP980366A2 (en) | 1999-02-28 |
GB9803335D0 (en) | 1998-04-15 |
KR20010014331A (en) | 2001-02-26 |
KR100371122B1 (en) | 2003-02-05 |
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