AR005347A1 - 4,5-DI-HIDRONAF [1,2-C] ISOXASOLES COMPOUNDS, DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS, METHOD OF PREPARATION, USE AS A PHARMACEUTICALLY ACTIVE SUBSTANCE FOR THE MANUFACTURE OF MEDICINES FOR ANXIETY TREATMENT, PSYCHIATRIC ALTERATIONS , PHARMACEUTICAL DEPENDENCE - Google Patents

4,5-DI-HIDRONAF [1,2-C] ISOXASOLES COMPOUNDS, DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS, METHOD OF PREPARATION, USE AS A PHARMACEUTICALLY ACTIVE SUBSTANCE FOR THE MANUFACTURE OF MEDICINES FOR ANXIETY TREATMENT, PSYCHIATRIC ALTERATIONS , PHARMACEUTICAL DEPENDENCE

Info

Publication number
AR005347A1
AR005347A1 ARP970100015A ARP970100015A AR005347A1 AR 005347 A1 AR005347 A1 AR 005347A1 AR P970100015 A ARP970100015 A AR P970100015A AR P970100015 A ARP970100015 A AR P970100015A AR 005347 A1 AR005347 A1 AR 005347A1
Authority
AR
Argentina
Prior art keywords
compounds
pharmaceutical
hydroxy
manufacture
dependence
Prior art date
Application number
ARP970100015A
Other languages
Spanish (es)
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of AR005347A1 publication Critical patent/AR005347A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se desciben compuestos de fórmula (I) donde A es hidrógeno, hidroxi, donde R1 es hidrógeno, un grupo alquilo de 1 a 6 carbonos eventualmente substituídocon substitución hidroxi, alcoxi, o amino; arilo o heteroarilo eventualmente substituído conh alógeno, hidroxi o alcoxi; o bencilo eventualmente substituídocon halógeno, hidroxi o alcoxi; n es un número entero de 1 o 2 ; Z es N, CH o C(CH); m es un número entero de 1 a 3 , y X es hidrógeno, hidroxi o alcoxi, ysus sales farmacéuticamenteace ptables y sus isómeros geométricos u ópticos o las mezclas racémicas, cuando sea aplicable. Los compuestos de fórmula (I) seobtienen mediante el siguiente esquema de reacción de fórmula (II) También se describe uso de dichos copuestos I parala f abricación de medicamentos para eltratamiento de la ansiedad, de alteraciones psiquiatricas, de la náusea, el vómito y de la dependencia de fármacos.Compounds of formula (I) are described where A is hydrogen, hydroxy, where R1 is hydrogen, an alkyl group of 1 to 6 carbons optionally substituted with hydroxy, alkoxy, or amino substitution; aryl or heteroaryl optionally substituted with halogen, hydroxy or alkoxy; or benzyl optionally substituted with halogen, hydroxy or alkoxy; n is an integer of 1 or 2; Z is N, CH or C (CH); m is an integer from 1 to 3, and X is hydrogen, hydroxy or alkoxy, and their pharmaceutically acceptable salts and their geometric or optical isomers or racemic mixtures, where applicable. The compounds of formula (I) are obtained by the following reaction scheme of formula (II). The use of said compounds I for the manufacture of drugs for the treatment of anxiety, psychiatric disorders, nausea, vomiting and drug dependence.

ARP970100015A 1996-01-05 1997-01-03 4,5-DI-HIDRONAF [1,2-C] ISOXASOLES COMPOUNDS, DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS, METHOD OF PREPARATION, USE AS A PHARMACEUTICALLY ACTIVE SUBSTANCE FOR THE MANUFACTURE OF MEDICINES FOR ANXIETY TREATMENT, PSYCHIATRIC ALTERATIONS , PHARMACEUTICAL DEPENDENCE AR005347A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58331996A 1996-01-05 1996-01-05

Publications (1)

Publication Number Publication Date
AR005347A1 true AR005347A1 (en) 1999-04-28

Family

ID=24332609

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100015A AR005347A1 (en) 1996-01-05 1997-01-03 4,5-DI-HIDRONAF [1,2-C] ISOXASOLES COMPOUNDS, DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS, METHOD OF PREPARATION, USE AS A PHARMACEUTICALLY ACTIVE SUBSTANCE FOR THE MANUFACTURE OF MEDICINES FOR ANXIETY TREATMENT, PSYCHIATRIC ALTERATIONS , PHARMACEUTICAL DEPENDENCE

Country Status (14)

Country Link
EP (1) EP0874833A1 (en)
JP (1) JP3161737B2 (en)
KR (1) KR100308748B1 (en)
CN (1) CN1214046A (en)
AR (1) AR005347A1 (en)
AU (1) AU710059B2 (en)
BR (1) BR9612578A (en)
CA (1) CA2241845C (en)
HU (1) HUP9903706A3 (en)
IL (1) IL125197A0 (en)
NO (1) NO983100L (en)
NZ (1) NZ325587A (en)
WO (1) WO1997025317A1 (en)
ZA (1) ZA9725B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002015906A1 (en) * 2000-08-21 2002-02-28 Georgetown University 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon
CN100349897C (en) * 2002-04-02 2007-11-21 詹森药业有限公司 Substituted amino isoxazoline derivatives and their use as anti-depressants
TW200409777A (en) * 2002-08-12 2004-06-16 Janssen Pharmaceutica Nv C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants
ES2339444T3 (en) * 2002-08-15 2010-05-20 Janssen Pharmaceutica Nv CONDENSED HETEROCICLIC ISOXAZOLINE DERIVATIVES AND ITS USE AS ANTIDEPRESSANTS.
CA2495058C (en) 2002-08-21 2012-01-03 Janssen Pharmaceutica N.V. C6- and c9-substituted isoxazoline derivatives and their use as anti-depressants
US8025859B2 (en) 2007-05-18 2011-09-27 Cesl Limited Process for gold and silver recovery from a sulphide concentrate
EP2597089A1 (en) 2009-10-29 2013-05-29 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds
US10633354B2 (en) 2016-09-02 2020-04-28 Bristol-Myers Squibb Company Substituted tricyclic heterocyclic compounds
US11046646B2 (en) 2017-08-09 2021-06-29 Bristol-Myers Squibb Company Alkylphenyl compounds
WO2019032631A1 (en) 2017-08-09 2019-02-14 Bristol-Myers Squibb Company Oxime ether compounds
KR102002633B1 (en) 2018-07-19 2019-07-22 김태효 Non slip foot wear with separating cushion part
KR102429797B1 (en) 2019-12-31 2022-08-05 주식회사 제이패션 Functional non-sewn overshoes and manufacturing method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2119977A1 (en) * 1971-04-23 1971-12-16 Teikoku Hormone Manufacturing Co , Ltd, Tokio Antiphlogistic and antisecretory napththisoxazoles - from 1-hydroxyim - 2-carbonyl derivs by intramolecular condensation
ES2076253T3 (en) * 1989-05-19 1995-11-01 Hoechst Roussel Pharma N- (ARYLOXYALKYL) -HETEROARILPIPERIDINES AND -HETEROARILPIPERAZINAS, A PROCEDURE FOR ITS PREPARATION AND USE AS MEDICINES.
US5670522A (en) * 1992-10-23 1997-09-23 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands

Also Published As

Publication number Publication date
KR100308748B1 (en) 2001-12-12
KR19990077033A (en) 1999-10-25
AU1412697A (en) 1997-08-01
CN1214046A (en) 1999-04-14
ZA9725B (en) 1997-07-07
AU710059B2 (en) 1999-09-09
IL125197A0 (en) 1999-03-12
CA2241845C (en) 2002-10-01
WO1997025317A1 (en) 1997-07-17
NZ325587A (en) 1999-02-25
EP0874833A1 (en) 1998-11-04
JPH11510816A (en) 1999-09-21
CA2241845A1 (en) 1997-07-17
JP3161737B2 (en) 2001-04-25
NO983100L (en) 1998-09-04
BR9612578A (en) 1999-07-27
HUP9903706A3 (en) 2000-09-28
NO983100D0 (en) 1998-07-03
HUP9903706A2 (en) 2000-08-28

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